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The map label for this gene is hisS [H]

Identifier: 182678747

GI number: 182678747

Start: 2013291

End: 2014793

Strand: Reverse

Name: hisS [H]

Synonym: Bind_1776

Alternate gene names: 182678747

Gene position: 2014793-2013291 (Counterclockwise)

Preceding gene: 182678750

Following gene: 182678746

Centisome position: 48.31

GC content: 59.75

Gene sequence:

>1503_bases
ATGACCGCCCCGAAAACCCCCCCCCGCGCGAGTGCTAAACTGCCGCGGGGCCTGATCGACCGTGGCCCCGCGGCTCTTGC
GGCGACGGATAAGATGCTCGCGACGATCAAAGCCTCTTATGAACTCTATGGGTTCGAGGCGGTGGAAACGCCCTTCATTG
AATATACGGAGGCCTTGGGCAAGTTTCTGCCCGATCTCGACCGGCCTAACGAAGGCGTCTTTTCGTTCAAGGATGACGAC
GAGCAATGGCTGTCTTTGCGTTATGATCTGACGGCGCCGCTTGCCCGTTATGTCGCCGAGCATTTTGATCAATTGCCAAA
GCCCTATCGGTCTTATCGGGCGGGCTATGTGTTTCGTAATGAAAAGCCGGGTCCCGGCCGTTTCCGTCAATTCATGCAAT
TCGATGCCGATACGGTCGGCGCCGCTTCCGTTGCCGCCGATGCCGAAATCTGCATGATGGCGGCGCAAACCCTGGAAAAG
CTTGGCATTAAACGCGGCGATTATCTTATCAAGGTCAATAATCGCAAAGTGCTTGATGGGGTTATGGAAGCGATTGGCCT
TGGCGGCGATGAGAATGCGGGGCGGCGCCTGACGGTTTTAAGGGCGATCGATAAATTCGACCGGCTCGGCCACGAAGGGG
TTAGCCTGTTGCTGGGCGCTGGCCGCAAGGACGAATCGGGAGATTTCACCAAGGGCGCCGGCCTTGATGCTACGCAGATC
GCCCAGGTCTTCGCTCTTCTCGAAGCAGGCGGAAAGGACAATGCCGAAACCGTCGCGCGTTTTGCTGAGGTTTTCGCCTC
GACGCCGCGTGGGCAGGAAGGCACGGCCGAACTGAAAACCATCGCCGAGCTCGTCGAAGCCGCAGGCTTTGCCGATCGCA
TCCGCATCGACCCGGCTGTGGTGCGTGGCCTTGAATATTACACTGGCCCCGTTTTTGAGGCCGAATTGACCTTCGAGGTG
CAGGACGACGAGGGCCGGCCGATCCGCTTCGGTTCGGTCGGCGGCGGTGGCCGCTATGATGGACTCGTGGGACGGTTCAG
GGGCGAGGACGTGCCTGCCACCGGCTTTTCGATCGGCGTTTCGCGCCTGTTTTCAGCTTTGACAGCCATCAAATCGCCGA
TCGTGACAAGCAGCATGCAACGGGGACCTGTGGTCGTCCTGGTTCTCGATAAGGATCACGTCGCCCGTTACCAGGGTTTC
GTCACGGCATTGCGCGAGGCCGGCATCCGCTCTGAGCTTTATCTCGGCAGTTCCGGTATGAATGCGCAATTGAAATATGC
CGACAAGCGCGGCTCTCTCTGCGGCATCATTCAAGGCTCGAACGAGCGCGACCATGCCGATGGCCCGCAGGTGACGATTC
GCGATTTGGCGCTCGGCGCCGAATTGGCCGCCTCCAGCAAGGATCGCGCGGATTATCTCGAATTGCGCGCCAAGGCGCAA
TTTGCGGTGCCCGAGAGCGAATTGGTCGCGGCGGTGCGCGAAGTGCTCGCGCGGCACGGATAA

Upstream 100 bases:

>100_bases
CGTTTCATCGAGGTGGCACTTGCCCCTTGCGTGAAGGGCACGTAAGAGCAGGCGCAAATCTCTGCCTGCGTTAAATTTAC
TTCATGAGGCTTTCCTCGAA

Downstream 100 bases:

>100_bases
TTAACGGATTAATCCGAGAACTTATCTCCATCTTTGAAGAGAAAACGACATAATTTCTTTTCAAGAGAGAAAAGCATCCG
GCCACATGGCATAAAGCAAC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MTAPKTPPRASAKLPRGLIDRGPAALAATDKMLATIKASYELYGFEAVETPFIEYTEALGKFLPDLDRPNEGVFSFKDDD
EQWLSLRYDLTAPLARYVAEHFDQLPKPYRSYRAGYVFRNEKPGPGRFRQFMQFDADTVGAASVAADAEICMMAAQTLEK
LGIKRGDYLIKVNNRKVLDGVMEAIGLGGDENAGRRLTVLRAIDKFDRLGHEGVSLLLGAGRKDESGDFTKGAGLDATQI
AQVFALLEAGGKDNAETVARFAEVFASTPRGQEGTAELKTIAELVEAAGFADRIRIDPAVVRGLEYYTGPVFEAELTFEV
QDDEGRPIRFGSVGGGGRYDGLVGRFRGEDVPATGFSIGVSRLFSALTAIKSPIVTSSMQRGPVVVLVLDKDHVARYQGF
VTALREAGIRSELYLGSSGMNAQLKYADKRGSLCGIIQGSNERDHADGPQVTIRDLALGAELAASSKDRADYLELRAKAQ
FAVPESELVAAVREVLARHG

Sequences:

>Translated_500_residues
MTAPKTPPRASAKLPRGLIDRGPAALAATDKMLATIKASYELYGFEAVETPFIEYTEALGKFLPDLDRPNEGVFSFKDDD
EQWLSLRYDLTAPLARYVAEHFDQLPKPYRSYRAGYVFRNEKPGPGRFRQFMQFDADTVGAASVAADAEICMMAAQTLEK
LGIKRGDYLIKVNNRKVLDGVMEAIGLGGDENAGRRLTVLRAIDKFDRLGHEGVSLLLGAGRKDESGDFTKGAGLDATQI
AQVFALLEAGGKDNAETVARFAEVFASTPRGQEGTAELKTIAELVEAAGFADRIRIDPAVVRGLEYYTGPVFEAELTFEV
QDDEGRPIRFGSVGGGGRYDGLVGRFRGEDVPATGFSIGVSRLFSALTAIKSPIVTSSMQRGPVVVLVLDKDHVARYQGF
VTALREAGIRSELYLGSSGMNAQLKYADKRGSLCGIIQGSNERDHADGPQVTIRDLALGAELAASSKDRADYLELRAKAQ
FAVPESELVAAVREVLARHG
>Mature_499_residues
TAPKTPPRASAKLPRGLIDRGPAALAATDKMLATIKASYELYGFEAVETPFIEYTEALGKFLPDLDRPNEGVFSFKDDDE
QWLSLRYDLTAPLARYVAEHFDQLPKPYRSYRAGYVFRNEKPGPGRFRQFMQFDADTVGAASVAADAEICMMAAQTLEKL
GIKRGDYLIKVNNRKVLDGVMEAIGLGGDENAGRRLTVLRAIDKFDRLGHEGVSLLLGAGRKDESGDFTKGAGLDATQIA
QVFALLEAGGKDNAETVARFAEVFASTPRGQEGTAELKTIAELVEAAGFADRIRIDPAVVRGLEYYTGPVFEAELTFEVQ
DDEGRPIRFGSVGGGGRYDGLVGRFRGEDVPATGFSIGVSRLFSALTAIKSPIVTSSMQRGPVVVLVLDKDHVARYQGFV
TALREAGIRSELYLGSSGMNAQLKYADKRGSLCGIIQGSNERDHADGPQVTIRDLALGAELAASSKDRADYLELRAKAQF
AVPESELVAAVREVLARHG

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=484, Percent_Identity=31.404958677686, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI15029520, Length=478, Percent_Identity=30.3347280334728, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1788861, Length=475, Percent_Identity=25.8947368421053, Blast_Score=112, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71993693, Length=463, Percent_Identity=29.1576673866091, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI71993686, Length=463, Percent_Identity=29.1576673866091, Blast_Score=171, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6325290, Length=485, Percent_Identity=28.0412371134021, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24643061, Length=389, Percent_Identity=33.4190231362468, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24643059, Length=408, Percent_Identity=31.8627450980392, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 54157; Mature: 54026

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPKTPPRASAKLPRGLIDRGPAALAATDKMLATIKASYELYGFEAVETPFIEYTEALG
CCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHEECCHHHCCCHHHHHHHHH
KFLPDLDRPNEGVFSFKDDDEQWLSLRYDLTAPLARYVAEHFDQLPKPYRSYRAGYVFRN
HHCCCCCCCCCCCEEECCCCHHHHEEEECCHHHHHHHHHHHHHHCCCHHHHHCCCEEEEC
EKPGPGRFRQFMQFDADTVGAASVAADAEICMMAAQTLEKLGIKRGDYLIKVNNRKVLDG
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
VMEAIGLGGDENAGRRLTVLRAIDKFDRLGHEGVSLLLGAGRKDESGDFTKGAGLDATQI
HHHHHCCCCCCCCCCEEHHHHHHHHHHHCCHHCHHHEEECCCCCCCCCCCCCCCCCHHHH
AQVFALLEAGGKDNAETVARFAEVFASTPRGQEGTAELKTIAELVEAAGFADRIRIDPAV
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHEECCHHH
VRGLEYYTGPVFEAELTFEVQDDEGRPIRFGSVGGGGRYDGLVGRFRGEDVPATGFSIGV
HHHHHHHCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCCHHHHCCCCCCCCCHHHHHH
SRLFSALTAIKSPIVTSSMQRGPVVVLVLDKDHVARYQGFVTALREAGIRSELYLGSSGM
HHHHHHHHHHHCCHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEECCCCC
NAQLKYADKRGSLCGIIQGSNERDHADGPQVTIRDLALGAELAASSKDRADYLELRAKAQ
CCEEEEECCCCCEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHH
FAVPESELVAAVREVLARHG
CCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAPKTPPRASAKLPRGLIDRGPAALAATDKMLATIKASYELYGFEAVETPFIEYTEALG
CCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHEECCHHHCCCHHHHHHHHH
KFLPDLDRPNEGVFSFKDDDEQWLSLRYDLTAPLARYVAEHFDQLPKPYRSYRAGYVFRN
HHCCCCCCCCCCCEEECCCCHHHHEEEECCHHHHHHHHHHHHHHCCCHHHHHCCCEEEEC
EKPGPGRFRQFMQFDADTVGAASVAADAEICMMAAQTLEKLGIKRGDYLIKVNNRKVLDG
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
VMEAIGLGGDENAGRRLTVLRAIDKFDRLGHEGVSLLLGAGRKDESGDFTKGAGLDATQI
HHHHHCCCCCCCCCCEEHHHHHHHHHHHCCHHCHHHEEECCCCCCCCCCCCCCCCCHHHH
AQVFALLEAGGKDNAETVARFAEVFASTPRGQEGTAELKTIAELVEAAGFADRIRIDPAV
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHEECCHHH
VRGLEYYTGPVFEAELTFEVQDDEGRPIRFGSVGGGGRYDGLVGRFRGEDVPATGFSIGV
HHHHHHHCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCCHHHHCCCCCCCCCHHHHHH
SRLFSALTAIKSPIVTSSMQRGPVVVLVLDKDHVARYQGFVTALREAGIRSELYLGSSGM
HHHHHHHHHHHCCHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEECCCCC
NAQLKYADKRGSLCGIIQGSNERDHADGPQVTIRDLALGAELAASSKDRADYLELRAKAQ
CCEEEEECCCCCEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHH
FAVPESELVAAVREVLARHG
CCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA