Click here to switch to the map view.

The map label for this gene is hisG [H]

Identifier: 182678745

GI number: 182678745

Start: 2011050

End: 2012027

Strand: Reverse

Name: hisG [H]

Synonym: Bind_1774

Alternate gene names: 182678745

Gene position: 2012027-2011050 (Counterclockwise)

Preceding gene: 182678746

Following gene: 182678744

Centisome position: 48.25

GC content: 58.9

Gene sequence:

>978_bases
ATGAGTGAGATGCAGGCACCGCTCGTTCTGGCTGTCCCCTCCAAGGGGCGTTTACAGGAAAATGTCGCGGCCTTCTTCGC
ACGCGCCGGGCTCAGCCTCGTTCAGGGCCGGGGTTCGCGTGATTATCGCGGCACGCTGAAGGGCATCGAGGGGGTCGAGG
TCGCTTTTGTTTCGGCGTCCGACATTGTCACTCATCTGGCCGCCGGCAGCGCTCATCTCGGTGTCACCGGCGAGGATTTG
ATCCGCGAAACCCTATCGGATTCCGATCGCAAGATCGCTTTGCTGACGCCGCTTGGCTTTGGCTTCGCCAATGTTGTGGT
TGCCGTGCCGCAGGCCTGGATCGATGTGCGGACCATGGCCGATCTGGACGATGTCGCCGTGCTCCATCGCGCGCGGCGCG
GCGAGCGGATGCGCGTCGCAACCAAATATATCAATCTGACACGGCGCTTTTTTGCCAGCCAGCATGTCACGGATTATCGT
ATTGTTGAAAGTCTGGGGGCAACCGAAGGCGCGCCAGCGGCGGGGCAGGCTGAACTCATCGTCGATATTACGACGACGGG
CGCGACGCTCTCGGCCAATGCGCTTAAAATCCTTGATGACGGTGTGATCCTGCGCTCGGAGGCGAATCTGGCAGCATCGC
TCAATGCCGATTGGAATGAGGCCAATCGGGAAAAGGCGCGGCTTATCCTATCGCATATAGCGGCGGAGGAGGAAGGCCGC
ACGACGCGTGAGGTCTCGACCGTTCTGGAAAATGTGGCGACGGACAGCTTTGAGGAGGCCCAAAAGCTGTTTGCGGCTCG
CGTGCGCCTTTATGGGAAAGACGGTCATTTGATCTTTGGCTGTCCCAGCGACAAGGTCGCTGCCTTGGCCGATTGGTTGA
TTGCCCAAGGGGCTTCCCATGTGGGTGTCACCGCTCAGGATTATGTCTTCTCTGCCAAAAATCCGCTTTATGAAAAGCTT
GTCGATCGTCTTGCATGA

Upstream 100 bases:

>100_bases
AATTATTGCGTCAACTGGGCGCGCCGCAGGATATTTCAGCGGTCGGCGCGGCGATCTGGATCGAGGCGCTTGACGCCATG
AACAAGGGCGGAGCCGCTTG

Downstream 100 bases:

>100_bases
TCGCGCTTTCAGCGGCGTGACAGCAGGGCAGGCGAGTGGAAGCAGGATCGGCGTGATCCGCCGCCGAGGCGGGAACTAAC
ATCACAGGCCAGCACTATAA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSEMQAPLVLAVPSKGRLQENVAAFFARAGLSLVQGRGSRDYRGTLKGIEGVEVAFVSASDIVTHLAAGSAHLGVTGEDL
IRETLSDSDRKIALLTPLGFGFANVVVAVPQAWIDVRTMADLDDVAVLHRARRGERMRVATKYINLTRRFFASQHVTDYR
IVESLGATEGAPAAGQAELIVDITTTGATLSANALKILDDGVILRSEANLAASLNADWNEANREKARLILSHIAAEEEGR
TTREVSTVLENVATDSFEEAQKLFAARVRLYGKDGHLIFGCPSDKVAALADWLIAQGASHVGVTAQDYVFSAKNPLYEKL
VDRLA

Sequences:

>Translated_325_residues
MSEMQAPLVLAVPSKGRLQENVAAFFARAGLSLVQGRGSRDYRGTLKGIEGVEVAFVSASDIVTHLAAGSAHLGVTGEDL
IRETLSDSDRKIALLTPLGFGFANVVVAVPQAWIDVRTMADLDDVAVLHRARRGERMRVATKYINLTRRFFASQHVTDYR
IVESLGATEGAPAAGQAELIVDITTTGATLSANALKILDDGVILRSEANLAASLNADWNEANREKARLILSHIAAEEEGR
TTREVSTVLENVATDSFEEAQKLFAARVRLYGKDGHLIFGCPSDKVAALADWLIAQGASHVGVTAQDYVFSAKNPLYEKL
VDRLA
>Mature_324_residues
SEMQAPLVLAVPSKGRLQENVAAFFARAGLSLVQGRGSRDYRGTLKGIEGVEVAFVSASDIVTHLAAGSAHLGVTGEDLI
RETLSDSDRKIALLTPLGFGFANVVVAVPQAWIDVRTMADLDDVAVLHRARRGERMRVATKYINLTRRFFASQHVTDYRI
VESLGATEGAPAAGQAELIVDITTTGATLSANALKILDDGVILRSEANLAASLNADWNEANREKARLILSHIAAEEEGRT
TREVSTVLENVATDSFEEAQKLFAARVRLYGKDGHLIFGCPSDKVAALADWLIAQGASHVGVTAQDYVFSAKNPLYEKLV
DRLA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 34984; Mature: 34853

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEMQAPLVLAVPSKGRLQENVAAFFARAGLSLVQGRGSRDYRGTLKGIEGVEVAFVSAS
CCCCCCCEEEECCCCCCHHHHHHHHHHHHCHHHHHCCCCCCCHHHHCCCCCEEEEEEEHH
DIVTHLAAGSAHLGVTGEDLIRETLSDSDRKIALLTPLGFGFANVVVAVPQAWIDVRTMA
HHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHC
DLDDVAVLHRARRGERMRVATKYINLTRRFFASQHVTDYRIVESLGATEGAPAAGQAELI
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEE
VDITTTGATLSANALKILDDGVILRSEANLAASLNADWNEANREKARLILSHIAAEEEGR
EEEECCCCEEECCEEEEECCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
TTREVSTVLENVATDSFEEAQKLFAARVRLYGKDGHLIFGCPSDKVAALADWLIAQGASH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCCCCEEEECCCHHHHHHHHHHHHCCCCC
VGVTAQDYVFSAKNPLYEKLVDRLA
CCCCHHHHEECCCCHHHHHHHHHCC
>Mature Secondary Structure 
SEMQAPLVLAVPSKGRLQENVAAFFARAGLSLVQGRGSRDYRGTLKGIEGVEVAFVSAS
CCCCCCEEEECCCCCCHHHHHHHHHHHHCHHHHHCCCCCCCHHHHCCCCCEEEEEEEHH
DIVTHLAAGSAHLGVTGEDLIRETLSDSDRKIALLTPLGFGFANVVVAVPQAWIDVRTMA
HHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHC
DLDDVAVLHRARRGERMRVATKYINLTRRFFASQHVTDYRIVESLGATEGAPAAGQAELI
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEE
VDITTTGATLSANALKILDDGVILRSEANLAASLNADWNEANREKARLILSHIAAEEEGR
EEEECCCCEEECCEEEEECCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
TTREVSTVLENVATDSFEEAQKLFAARVRLYGKDGHLIFGCPSDKVAALADWLIAQGASH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCCCCEEEECCCHHHHHHHHHHHHCCCCC
VGVTAQDYVFSAKNPLYEKLVDRLA
CCCCHHHHEECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA