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The map label for this gene is pdhR [H]

Identifier: 182678692

GI number: 182678692

Start: 1943108

End: 1943872

Strand: Reverse

Name: pdhR [H]

Synonym: Bind_1719

Alternate gene names: 182678692

Gene position: 1943872-1943108 (Counterclockwise)

Preceding gene: 182678693

Following gene: 182678691

Centisome position: 46.61

GC content: 55.42

Gene sequence:

>765_bases
ATGACGGCGTTGATCCAGCCGATCCGGCTCGCCGATAAAATCGCGCAATATATCGAACGGCTTATTCTGGAAGGCGTTTT
GCGTGCCGGGGAAAGATTGAGCTCCGAGCGTGACCTTGCCGAAAAGCTCGGTGTCTCGCGGCCTTCCCTGCGCGATGGGA
TCGCACGGCTCGAACAAAGGGGATTATTGGTGACGACAAAGGCCGGAACTTTCGTGGCGGATTTCATGGCACCATTGTCC
GAACCCCTCGCCGCATTATTCAGCAACGAACCGCGTATGTTGAAGGATTATTTCGAATTTCGCCGTTTGCTCGAAGGACA
GGGAGCAGCGTTCGCGGCCGAACGCGCGACGGATATCGATCGAGAAAAGATCAGTGCCTGCCTTGAGCACATGCGTGTTT
TGCATGAACTGGATGATCCACGCGACGAGGCTCAGCAGGATGTCGATCTGCATATCCTGATTTACGAGGCGACGCATAAT
CTCGTTTTACAGCATACGATGCGCATGTTCTCGGATATGCTGAAAAAAGGGATCTTCTACAGCAGGATCAGGCTCTACGA
ACGTCCCGAAGTCCGAGCCGCCATGCTGGAACAACATATTTCATTGGCGACGGCCATTCTCGAAGGTCGACCGCGAGAGG
CCGAAGCGGCGGCCCATGCGCATATCGATTATACCGCACGCGCCACGGCCATCATGGCTGAGGAAGACGAGCGCCTTGCG
GCTTCCCAGCTCCGCCTGAATCGTGAGGATCTCGTTGCTGAATAG

Upstream 100 bases:

>100_bases
TGATCAATGCCATTCTCGACGGGGAAAGAGAGCATGGGAGAGGTGATCTCGACGCTGGAGCCGTCGAGACGTGAACAAAA
AAGACCAAGGGAAGGGACAA

Downstream 100 bases:

>100_bases
AATGAATCGGACCTTGCGATAGCCAATGGGTGGACCCAAACGCATTCTCATTCTCGGGCCCAGTGGGGCCGGTAAGTCAA
CACTCGCGCGTGCCATCGGC

Product: GntR domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MTALIQPIRLADKIAQYIERLILEGVLRAGERLSSERDLAEKLGVSRPSLRDGIARLEQRGLLVTTKAGTFVADFMAPLS
EPLAALFSNEPRMLKDYFEFRRLLEGQGAAFAAERATDIDREKISACLEHMRVLHELDDPRDEAQQDVDLHILIYEATHN
LVLQHTMRMFSDMLKKGIFYSRIRLYERPEVRAAMLEQHISLATAILEGRPREAEAAAHAHIDYTARATAIMAEEDERLA
ASQLRLNREDLVAE

Sequences:

>Translated_254_residues
MTALIQPIRLADKIAQYIERLILEGVLRAGERLSSERDLAEKLGVSRPSLRDGIARLEQRGLLVTTKAGTFVADFMAPLS
EPLAALFSNEPRMLKDYFEFRRLLEGQGAAFAAERATDIDREKISACLEHMRVLHELDDPRDEAQQDVDLHILIYEATHN
LVLQHTMRMFSDMLKKGIFYSRIRLYERPEVRAAMLEQHISLATAILEGRPREAEAAAHAHIDYTARATAIMAEEDERLA
ASQLRLNREDLVAE
>Mature_253_residues
TALIQPIRLADKIAQYIERLILEGVLRAGERLSSERDLAEKLGVSRPSLRDGIARLEQRGLLVTTKAGTFVADFMAPLSE
PLAALFSNEPRMLKDYFEFRRLLEGQGAAFAAERATDIDREKISACLEHMRVLHELDDPRDEAQQDVDLHILIYEATHNL
VLQHTMRMFSDMLKKGIFYSRIRLYERPEVRAAMLEQHISLATAILEGRPREAEAAAHAHIDYTARATAIMAEEDERLAA
SQLRLNREDLVAE

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=221, Percent_Identity=38.9140271493213, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790032, Length=228, Percent_Identity=39.4736842105263, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1789353, Length=218, Percent_Identity=37.1559633027523, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28848; Mature: 28716

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALIQPIRLADKIAQYIERLILEGVLRAGERLSSERDLAEKLGVSRPSLRDGIARLEQR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHC
GLLVTTKAGTFVADFMAPLSEPLAALFSNEPRMLKDYFEFRRLLEGQGAAFAAERATDID
CCEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
REKISACLEHMRVLHELDDPRDEAQQDVDLHILIYEATHNLVLQHTMRMFSDMLKKGIFY
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
SRIRLYERPEVRAAMLEQHISLATAILEGRPREAEAAAHAHIDYTARATAIMAEEDERLA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCHHHHH
ASQLRLNREDLVAE
HHHHHCCHHHHCCC
>Mature Secondary Structure 
TALIQPIRLADKIAQYIERLILEGVLRAGERLSSERDLAEKLGVSRPSLRDGIARLEQR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHC
GLLVTTKAGTFVADFMAPLSEPLAALFSNEPRMLKDYFEFRRLLEGQGAAFAAERATDID
CCEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
REKISACLEHMRVLHELDDPRDEAQQDVDLHILIYEATHNLVLQHTMRMFSDMLKKGIFY
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
SRIRLYERPEVRAAMLEQHISLATAILEGRPREAEAAAHAHIDYTARATAIMAEEDERLA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCHHHHH
ASQLRLNREDLVAE
HHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]