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The map label for this gene is barA [C]

Identifier: 182678613

GI number: 182678613

Start: 1852643

End: 1854394

Strand: Reverse

Name: barA [C]

Synonym: Bind_1639

Alternate gene names: 182678613

Gene position: 1854394-1852643 (Counterclockwise)

Preceding gene: 182678616

Following gene: 182678612

Centisome position: 44.47

GC content: 58.96

Gene sequence:

>1752_bases
ATGCTGCGTCAGGGCCTGCATTGTCTCGCGGTCCTCATCGGCATGCCGCTTTTTTTTGCTTTGCATAAGGCGCCGCATTG
GCCCGAGGCGGTCGTGTTCATGACCATGCTGTTACCGCTCAGCGCGCTGGTTTTTGTCGCGCTGACGGATGTTCTGCATT
GGGCGCAGATTCTCGTCTCCTTCAGCCTTTGCCTCATGGCCATGGCTTTGGCCTCGGCTGGTGCGGGCATGGGCAGCGTC
GGTGCCGCTTTGTTTCTCGCCGCGGTCGAGGCTTTCATCACGTTCGACCCTGTCATGATCGGCCTTGCCGCCTTGGCGAC
GGCCGGAGCCGTCGCGGGAATCAGCCTTTTGCGGGCTCCGCTGTCCCTCCCGGCCAGTACGATCAGCGTCTTGGACTTGC
TTTGCCTCGCGGGTAGCCTTTTCTACGGCCTCGCTCTGATGCTTCATGCCGTGCACCTCCATAAGGTGGAAGCGCAGCGA
GCCAGGCGGAGAAATCCCGATCTTTTGCCTCTGATCCATCAGTTGGGCGATTTCGTTGTCGTGCATGATCGCAGCGGCAC
GGCCTGGGCGCTCAATCGCCATTTCGAACATCATTTGGGTCTTCCACCGGACGATTTGATGGGGCGTGGATTGTTCGACC
ATGTCCATGTCCTGGATCGCCCGGCCTTTCTGCGGGCCATCGCCGATGCCGCCGGCGGAGAAGGGGCCTCGAACATCACC
ATCCGGTTGCGGGGCAGGGGGGAGGACCTTTCCTCGGTCGAACCGTGTTTTCGCTGGTTCGATGTCTGTATCAATCGCTT
CGAGAATGGCCACGCCAAGAAGCGAGAGGAAGCGGAGGCAGACGATCAAGCCATGATCATCGGCGTCTACCGCGATATCA
GCGCGATGAGACGCGTTGAACAGGAATTGGATGCGGCGCGTGTGGCGGCGGAAACGGCGAATCAGGCGAAAGATCGCTTC
CTCGCCAATATGAGTCATGAATTACGCACGCCGTTGAATGCCATCATCGGCTTTTCCGAAATGCTCGCCGACCCGCAGCT
TTGTCCTCAAGATCCGCTGAAACAGCGCGAATATGCGGCAATCATTCATAGTTCAGGCGAACATCTCCTTCATGTCGTGA
ATTCCATTCTCGACATGTCGAAAATTCATTCCGGCACTTTCCCCCTGCAGCCGCAACCCATTGTCCTCGCGCCGTTGATC
GCTTCTTGCTGCGCCATGCTGCGGCCACAAGCGGAGGCCAAGGAAATCGAACTCGTGCAGATCCATGCTGATCCATGGGA
CGAGATCGTGGCCGACCAGCAGGCTTGCAAACAGATCCTGCTCAATCTGCTCTCGAACGCCGTCAAATTCACGCCGCGGC
GGGGCCGTGTCACGATTGCCGTGGATTGCGTTGTGGATTGTCTCGACGATATCCAGATCGCCGTTCAAGATACGGGTATT
GGCATCAGCGCCGACGATCTCACGCGGCTTGGCGAACCCTTCTTTCAAGCCATGGTGCGGCAAGAGCGGCCCCATGAAGG
AACCGGGCTGGGCCTGTCCATCGTTCGCGGCCTCGTCGAATTGCACGGCGGCACGCTGCTGATCGAAAGCGAGCCAGACC
AGGGAACATCCATGATCGTCCGCTTGCCGCGTGAGGGACGCCCCCAGGATAAGACAGAAGGTCGAGAGTGGCGGACCGAG
ACACAAACCCGTCGTGGCGTGCCTGCGGAAATTTCGGTGCTCAAGGAAGCAAAGGTGAAGAAAATTGCGTGA

Upstream 100 bases:

>100_bases
GGCCGAACTTTTCGAAAAGGGGGCCGGGTCGGAGTATGATGCGTTGAGTCTTTTGCGCAGCCTTGAAAATCCTCTCGCCT
TGCCTCGGCAGCAGGCCTTC

Downstream 100 bases:

>100_bases
AGCCCTGGCAGCCACTGATTATGATTTCGTGATGGCCGAACCCAAGAAGAAATCGCCGGCACGAAAGAAAGACGGCGCGC
GGAAATCCGGCGGCCAAGCG

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MLRQGLHCLAVLIGMPLFFALHKAPHWPEAVVFMTMLLPLSALVFVALTDVLHWAQILVSFSLCLMAMALASAGAGMGSV
GAALFLAAVEAFITFDPVMIGLAALATAGAVAGISLLRAPLSLPASTISVLDLLCLAGSLFYGLALMLHAVHLHKVEAQR
ARRRNPDLLPLIHQLGDFVVVHDRSGTAWALNRHFEHHLGLPPDDLMGRGLFDHVHVLDRPAFLRAIADAAGGEGASNIT
IRLRGRGEDLSSVEPCFRWFDVCINRFENGHAKKREEAEADDQAMIIGVYRDISAMRRVEQELDAARVAAETANQAKDRF
LANMSHELRTPLNAIIGFSEMLADPQLCPQDPLKQREYAAIIHSSGEHLLHVVNSILDMSKIHSGTFPLQPQPIVLAPLI
ASCCAMLRPQAEAKEIELVQIHADPWDEIVADQQACKQILLNLLSNAVKFTPRRGRVTIAVDCVVDCLDDIQIAVQDTGI
GISADDLTRLGEPFFQAMVRQERPHEGTGLGLSIVRGLVELHGGTLLIESEPDQGTSMIVRLPREGRPQDKTEGREWRTE
TQTRRGVPAEISVLKEAKVKKIA

Sequences:

>Translated_583_residues
MLRQGLHCLAVLIGMPLFFALHKAPHWPEAVVFMTMLLPLSALVFVALTDVLHWAQILVSFSLCLMAMALASAGAGMGSV
GAALFLAAVEAFITFDPVMIGLAALATAGAVAGISLLRAPLSLPASTISVLDLLCLAGSLFYGLALMLHAVHLHKVEAQR
ARRRNPDLLPLIHQLGDFVVVHDRSGTAWALNRHFEHHLGLPPDDLMGRGLFDHVHVLDRPAFLRAIADAAGGEGASNIT
IRLRGRGEDLSSVEPCFRWFDVCINRFENGHAKKREEAEADDQAMIIGVYRDISAMRRVEQELDAARVAAETANQAKDRF
LANMSHELRTPLNAIIGFSEMLADPQLCPQDPLKQREYAAIIHSSGEHLLHVVNSILDMSKIHSGTFPLQPQPIVLAPLI
ASCCAMLRPQAEAKEIELVQIHADPWDEIVADQQACKQILLNLLSNAVKFTPRRGRVTIAVDCVVDCLDDIQIAVQDTGI
GISADDLTRLGEPFFQAMVRQERPHEGTGLGLSIVRGLVELHGGTLLIESEPDQGTSMIVRLPREGRPQDKTEGREWRTE
TQTRRGVPAEISVLKEAKVKKIA
>Mature_583_residues
MLRQGLHCLAVLIGMPLFFALHKAPHWPEAVVFMTMLLPLSALVFVALTDVLHWAQILVSFSLCLMAMALASAGAGMGSV
GAALFLAAVEAFITFDPVMIGLAALATAGAVAGISLLRAPLSLPASTISVLDLLCLAGSLFYGLALMLHAVHLHKVEAQR
ARRRNPDLLPLIHQLGDFVVVHDRSGTAWALNRHFEHHLGLPPDDLMGRGLFDHVHVLDRPAFLRAIADAAGGEGASNIT
IRLRGRGEDLSSVEPCFRWFDVCINRFENGHAKKREEAEADDQAMIIGVYRDISAMRRVEQELDAARVAAETANQAKDRF
LANMSHELRTPLNAIIGFSEMLADPQLCPQDPLKQREYAAIIHSSGEHLLHVVNSILDMSKIHSGTFPLQPQPIVLAPLI
ASCCAMLRPQAEAKEIELVQIHADPWDEIVADQQACKQILLNLLSNAVKFTPRRGRVTIAVDCVVDCLDDIQIAVQDTGI
GISADDLTRLGEPFFQAMVRQERPHEGTGLGLSIVRGLVELHGGTLLIESEPDQGTSMIVRLPREGRPQDKTEGREWRTE
TQTRRGVPAEISVLKEAKVKKIA

Specific function: Member Of The Two-Component Regulatory System Uvry/Bara Involved In The Regulation Of Carbon Metabolism Via The Csra/Csrb Regulatory System. Phosphorylates Uvry, Probably Via A Four-Step Phosphorelay. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=256, Percent_Identity=37.5, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1788713, Length=436, Percent_Identity=28.8990825688073, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI145693157, Length=287, Percent_Identity=34.4947735191638, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI48994928, Length=262, Percent_Identity=32.4427480916031, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87081816, Length=242, Percent_Identity=35.9504132231405, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786912, Length=249, Percent_Identity=31.7269076305221, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=30.0448430493274, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=391, Percent_Identity=24.0409207161125, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=26.4, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=28.8793103448276, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786783, Length=231, Percent_Identity=28.1385281385281, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786600, Length=261, Percent_Identity=26.0536398467433, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=259, Percent_Identity=27.027027027027, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1790346, Length=238, Percent_Identity=27.7310924369748, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63703; Mature: 63703

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRQGLHCLAVLIGMPLFFALHKAPHWPEAVVFMTMLLPLSALVFVALTDVLHWAQILVS
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSLCLMAMALASAGAGMGSVGAALFLAAVEAFITFDPVMIGLAALATAGAVAGISLLRAP
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLPASTISVLDLLCLAGSLFYGLALMLHAVHLHKVEAQRARRRNPDLLPLIHQLGDFVV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEE
VHDRSGTAWALNRHFEHHLGLPPDDLMGRGLFDHVHVLDRPAFLRAIADAAGGEGASNIT
EECCCCCEEHHHHHHHHHCCCCCHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEE
IRLRGRGEDLSSVEPCFRWFDVCINRFENGHAKKREEAEADDQAMIIGVYRDISAMRRVE
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEHHHHHHHHHHHHH
QELDAARVAAETANQAKDRFLANMSHELRTPLNAIIGFSEMLADPQLCPQDPLKQREYAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
IIHSSGEHLLHVVNSILDMSKIHSGTFPLQPQPIVLAPLIASCCAMLRPQAEAKEIELVQ
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEE
IHADPWDEIVADQQACKQILLNLLSNAVKFTPRRGRVTIAVDCVVDCLDDIQIAVQDTGI
EECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHEEEEEECCC
GISADDLTRLGEPFFQAMVRQERPHEGTGLGLSIVRGLVELHGGTLLIESEPDQGTSMIV
CCCHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEE
RLPREGRPQDKTEGREWRTETQTRRGVPAEISVLKEAKVKKIA
ECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRQGLHCLAVLIGMPLFFALHKAPHWPEAVVFMTMLLPLSALVFVALTDVLHWAQILVS
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSLCLMAMALASAGAGMGSVGAALFLAAVEAFITFDPVMIGLAALATAGAVAGISLLRAP
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLPASTISVLDLLCLAGSLFYGLALMLHAVHLHKVEAQRARRRNPDLLPLIHQLGDFVV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEE
VHDRSGTAWALNRHFEHHLGLPPDDLMGRGLFDHVHVLDRPAFLRAIADAAGGEGASNIT
EECCCCCEEHHHHHHHHHCCCCCHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEE
IRLRGRGEDLSSVEPCFRWFDVCINRFENGHAKKREEAEADDQAMIIGVYRDISAMRRVE
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEHHHHHHHHHHHHH
QELDAARVAAETANQAKDRFLANMSHELRTPLNAIIGFSEMLADPQLCPQDPLKQREYAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
IIHSSGEHLLHVVNSILDMSKIHSGTFPLQPQPIVLAPLIASCCAMLRPQAEAKEIELVQ
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEE
IHADPWDEIVADQQACKQILLNLLSNAVKFTPRRGRVTIAVDCVVDCLDDIQIAVQDTGI
EECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHEEEEEECCC
GISADDLTRLGEPFFQAMVRQERPHEGTGLGLSIVRGLVELHGGTLLIESEPDQGTSMIV
CCCHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEE
RLPREGRPQDKTEGREWRTETQTRRGVPAEISVLKEAKVKKIA
ECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 7756693 [H]