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The map label for this gene is aapM [H]

Identifier: 182678575

GI number: 182678575

Start: 1805054

End: 1806211

Strand: Reverse

Name: aapM [H]

Synonym: Bind_1600

Alternate gene names: 182678575

Gene position: 1806211-1805054 (Counterclockwise)

Preceding gene: 182678576

Following gene: 182678574

Centisome position: 43.31

GC content: 60.28

Gene sequence:

>1158_bases
ATGTCTGCTCATTCCTTCGCCCCCGGCAATTCCTATCTCCGGCAAGAAAGCGCGCCCCTTCTGCCGCCGCCAAAAGATCG
AACCTCTCTTCTCGAGAGGATAAGGCGCGGCTTTTTCTCCAGCCTGTCCTCCAGCCTGCTGACATTGGCGGCAGGCGCAC
TCATCCTTTGGCTATTACCGGACCTCCTGCGCTTCACCCTCATCGACGCGGTCTGGAGCGCGCCGGACGGTGCCGCCTGT
CGGGCGCCAGACGCCGGTGCCTGCTGGGCTTTCGTCGCGCAAAAATTGCCCTATTTCACATTCGGCTCTTATCCCGTGGC
CGAGCGTTGGCGGGTCGTGACCGTGCTGCTCCTCGGGTTTGTGCTGATTGCCTGGCTTTTATGGCCGATCCGCAAAGGCG
CCCATACGGATAAGCGCGTCGCGGCGCTCCTGTTCTTCCTGCTTTATCCGCTCATCGCGCTGATCTTGCTGCGGGGGACG
CCCTGGCTTGGCCTGCCTTTGGTCGATACGGATCTCTGGGGTGGTATTTTCCTCAGTCTGGTGGTTGCCGGCGTCGGTAT
TGTTGTCTCCTTGCCGCTCGGCATTTTCCTGGCGCTTGGCCGGCGCTCCACTTTGCCTGTCGTGTCGCTCGCCAGCACTT
TATTCATCGAATTCGTCCGCGGCGTACCGATGATCACCGTCCTGTTCATGGCCAATTTCATGCTGCCGCTGTTTCTTCCA
GCGTCGATGAGCGTGGACCGGCTCATCCGGCCGCTTATTGGCGTGGCCCTCTTCGCATCGGCCTATATGGCGGAAGTGGT
GCGCGGTGGCTTGCAAGCCGTACCCAAGGGCCAGTTTGAGGGAGCGGCTGCACTCGGTCTTCCGCCCTGGAAAACCTTGC
AACTCGTCGTTCTGCCGCAAGCCCTGGCCCATGTCATTCCGGGCATCGTGAATACATTTATCGGCTTGTTCAAGGATACG
ACACTCGTCGCGGCCGTTGGCATTTTCGATTTTCTGCGTACCGTCGATTCAGCGCGTCTTGACCCAGCCTGGGCCGGGCC
GACGATCAGCGCCAGCGGTTATCTTTTCGCGGCTTTGTTCTATTTTGTGTTCTGTTTCGGCATGTCGCGCTATTCGATCG
GCGTCGAGCGCCGGCTTGCCAGGGGACAGGCGCGGTAA

Upstream 100 bases:

>100_bases
TCATCTTCATCACCATGGCCGTCTATCTTGCTGTGTCGCTGGTGACCTCGTTCGCCATGAATCTCATCAATCGCCGCATG
GCGCTCGTGGAGCGATAGCC

Downstream 100 bases:

>100_bases
TGGCTGCACGCGCAGCGAGCGCCAGGGAGAGAAAGATCTTGCCGGGAGAACAGAACGAATATGCGGTCTCGATCCGGGGC
TTGAACAAATGGTATGGCGC

Product: polar amino acid ABC transporter inner membrane subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MSAHSFAPGNSYLRQESAPLLPPPKDRTSLLERIRRGFFSSLSSSLLTLAAGALILWLLPDLLRFTLIDAVWSAPDGAAC
RAPDAGACWAFVAQKLPYFTFGSYPVAERWRVVTVLLLGFVLIAWLLWPIRKGAHTDKRVAALLFFLLYPLIALILLRGT
PWLGLPLVDTDLWGGIFLSLVVAGVGIVVSLPLGIFLALGRRSTLPVVSLASTLFIEFVRGVPMITVLFMANFMLPLFLP
ASMSVDRLIRPLIGVALFASAYMAEVVRGGLQAVPKGQFEGAAALGLPPWKTLQLVVLPQALAHVIPGIVNTFIGLFKDT
TLVAAVGIFDFLRTVDSARLDPAWAGPTISASGYLFAALFYFVFCFGMSRYSIGVERRLARGQAR

Sequences:

>Translated_385_residues
MSAHSFAPGNSYLRQESAPLLPPPKDRTSLLERIRRGFFSSLSSSLLTLAAGALILWLLPDLLRFTLIDAVWSAPDGAAC
RAPDAGACWAFVAQKLPYFTFGSYPVAERWRVVTVLLLGFVLIAWLLWPIRKGAHTDKRVAALLFFLLYPLIALILLRGT
PWLGLPLVDTDLWGGIFLSLVVAGVGIVVSLPLGIFLALGRRSTLPVVSLASTLFIEFVRGVPMITVLFMANFMLPLFLP
ASMSVDRLIRPLIGVALFASAYMAEVVRGGLQAVPKGQFEGAAALGLPPWKTLQLVVLPQALAHVIPGIVNTFIGLFKDT
TLVAAVGIFDFLRTVDSARLDPAWAGPTISASGYLFAALFYFVFCFGMSRYSIGVERRLARGQAR
>Mature_384_residues
SAHSFAPGNSYLRQESAPLLPPPKDRTSLLERIRRGFFSSLSSSLLTLAAGALILWLLPDLLRFTLIDAVWSAPDGAACR
APDAGACWAFVAQKLPYFTFGSYPVAERWRVVTVLLLGFVLIAWLLWPIRKGAHTDKRVAALLFFLLYPLIALILLRGTP
WLGLPLVDTDLWGGIFLSLVVAGVGIVVSLPLGIFLALGRRSTLPVVSLASTLFIEFVRGVPMITVLFMANFMLPLFLPA
SMSVDRLIRPLIGVALFASAYMAEVVRGGLQAVPKGQFEGAAALGLPPWKTLQLVVLPQALAHVIPGIVNTFIGLFKDTT
LVAAVGIFDFLRTVDSARLDPAWAGPTISASGYLFAALFYFVFCFGMSRYSIGVERRLARGQAR

Specific function: Part of a binding-protein-dependent transport system for L-amino acids, affects the uptake as well as efflux of these amino acids. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI87082239, Length=368, Percent_Identity=49.1847826086957, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1788226, Length=201, Percent_Identity=32.8358208955224, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1786873, Length=214, Percent_Identity=28.9719626168224, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1787030, Length=205, Percent_Identity=26.3414634146341, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI48994930, Length=80, Percent_Identity=41.25, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787087, Length=230, Percent_Identity=27.3913043478261, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786874, Length=169, Percent_Identity=23.6686390532544, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788646, Length=214, Percent_Identity=24.2990654205607, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788645, Length=189, Percent_Identity=25.9259259259259, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 41833; Mature: 41702

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAHSFAPGNSYLRQESAPLLPPPKDRTSLLERIRRGFFSSLSSSLLTLAAGALILWLLP
CCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLRFTLIDAVWSAPDGAACRAPDAGACWAFVAQKLPYFTFGSYPVAERWRVVTVLLLGF
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
VLIAWLLWPIRKGAHTDKRVAALLFFLLYPLIALILLRGTPWLGLPLVDTDLWGGIFLSL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
VVAGVGIVVSLPLGIFLALGRRSTLPVVSLASTLFIEFVRGVPMITVLFMANFMLPLFLP
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
ASMSVDRLIRPLIGVALFASAYMAEVVRGGLQAVPKGQFEGAAALGLPPWKTLQLVVLPQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHH
ALAHVIPGIVNTFIGLFKDTTLVAAVGIFDFLRTVDSARLDPAWAGPTISASGYLFAALF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
YFVFCFGMSRYSIGVERRLARGQAR
HHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SAHSFAPGNSYLRQESAPLLPPPKDRTSLLERIRRGFFSSLSSSLLTLAAGALILWLLP
CCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLRFTLIDAVWSAPDGAACRAPDAGACWAFVAQKLPYFTFGSYPVAERWRVVTVLLLGF
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
VLIAWLLWPIRKGAHTDKRVAALLFFLLYPLIALILLRGTPWLGLPLVDTDLWGGIFLSL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
VVAGVGIVVSLPLGIFLALGRRSTLPVVSLASTLFIEFVRGVPMITVLFMANFMLPLFLP
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
ASMSVDRLIRPLIGVALFASAYMAEVVRGGLQAVPKGQFEGAAALGLPPWKTLQLVVLPQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHH
ALAHVIPGIVNTFIGLFKDTTLVAAVGIFDFLRTVDSARLDPAWAGPTISASGYLFAALF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
YFVFCFGMSRYSIGVERRLARGQAR
HHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]