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The map label for this gene is pccB [H]

Identifier: 182678300

GI number: 182678300

Start: 1522975

End: 1524507

Strand: Direct

Name: pccB [H]

Synonym: Bind_1317

Alternate gene names: 182678300

Gene position: 1522975-1524507 (Clockwise)

Preceding gene: 182678299

Following gene: 182678301

Centisome position: 36.52

GC content: 56.16

Gene sequence:

>1533_bases
GTGAAGACTATTTTGGAACGGCTTGACGAGCGTGAGGCAATTGCTCGCTTGGGTGGAGGCGTTGAAAGGCTACAGGCGCA
GCACAATCGGGGCAAGCTGACTGCGCGGGAGCGTATCGAGCTCTTACTCGATCAGGATTCCTTTGAAGAATTCGATATGT
TCGTCCAGCACCGGGCGATCGATTTCGGTATGGACAGCGTCAAAATCCCGGGGGATGGCGTGGTGACGGGCTGGGGCACC
GTCAATGGCCGTACTGTTTTCGTTTTCGCTAAGGATTTCACGGTTTTCGGCGGTTCGCTTTCGGAAACCCATGCGCAGAA
GATTCTCAAGCTGCAGGACATGGCCTTGCGCAACCGCGCGCCGATCATCGGCCTGTTCGATGCGGGCGGTGCACGCATTC
AGGAAGGTGTCGCGGCCCTTGGCGGTTATGGCGAAGTGTTCCAGCGTAATGTGCTTGCTTCCGGTGTCATTCCGCAAATC
TCGCTGATCATGGGACCTTGCGCCGGCGGTGACGTTTATTCACCGGCGATGACAGATTTCATCTTTATGGTCAAGGATAC
GAGCTATATGTTCGTGACCGGACCCGATGTCGTGAAAACCGTCACCAATGAAAACGTCACGGCGGAGCAGCTCGGCGGCG
CCAGTGTGCATACGACACAGAGCTCGATCGCAGATCATGCCTATGAAAACGATGTCGAGGCTCTGTTGCAGATGCGTCGG
CTCATCGATTTTCTGCCGGCCTCCAATGTCGCGCCTCTGCCTGAATGGCCGAGCTTCGATACAGCCGACAGGGTTGATTT
CTCGCTCGATACCTTGATCCCCGATAATCCAAACAAGCCCTATGATGTCAAGGAATTGATCGCCAAGACGGTGGACGAGG
GGGATTTCTTCGAGATCCAGCAGGCGCATGCGCGCAATATTGTTGTCGGTTTTGGCCGTATGGAAGGGCGTACAGTCGGC
ATTGTCGCCAATCAGCCTTTGGTGCTCGCCGGTGTGCTCGATTCCGATGCCTCGCGCAAGGCTGGTCGTTTCGTTCGCTT
TTGCGATTGTTTCAACATTCCGATCGTGACCTTCGTGGACGTGCCGGGCTTTCTGCCGGGTGTCGCGCAGGAACATGGCG
GGCTCATCAAGCATGGCGCGAAATTGCTCTTCGCCTATGCTGAAGCCACAGTGCCGAAAATCACCATCATTACACGCAAG
GCTTTCGGCGGCGCCTATGACGTCATGGCCTCGAAACATTTGCGGGGCGATGTCAATTATGCGTGGCCGACCGCGCAGAT
CGCCGTCATGGGCGCCAAGGGCGCGGTCGAGATCATCTTCCGCAAGGATCTGGCCGATCCGGAAAAGATCGCCAAACATA
CAAAGGATTACGAAGAGCGCTTTCTCTCACCCTTCGTCGCTGCCGAGCGCGGCTATATCGATGAAGTCATTCAGCCGCAT
ACGACACGCAAGCGCGTGGCACGGGTGCTCGCCCTCCTGCGCAGCAAGAACTTGGAAAATCCCTGGAAAAAACACGACAA
TATTCCGCTGTAG

Upstream 100 bases:

>100_bases
CTGCCGAAAGTCAGCTTGCAAGTTTTTGTAAGTAGGTCATACGTCGTTTACAATCGTTAAAGAGTTGTAGTTTCAAGGCT
AGCAGGCGGCGGGGGGTTGC

Downstream 100 bases:

>100_bases
AAACATGATCGCCCCCGCGTGATGGCGGGTTGATTGACTCGGCGCATACATCATAAAATTTCCGGAGCGTTCCATGTTCA
AGAAAATCCTTATCGCCAAT

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKTILERLDEREAIARLGGGVERLQAQHNRGKLTARERIELLLDQDSFEEFDMFVQHRAIDFGMDSVKIPGDGVVTGWGT
VNGRTVFVFAKDFTVFGGSLSETHAQKILKLQDMALRNRAPIIGLFDAGGARIQEGVAALGGYGEVFQRNVLASGVIPQI
SLIMGPCAGGDVYSPAMTDFIFMVKDTSYMFVTGPDVVKTVTNENVTAEQLGGASVHTTQSSIADHAYENDVEALLQMRR
LIDFLPASNVAPLPEWPSFDTADRVDFSLDTLIPDNPNKPYDVKELIAKTVDEGDFFEIQQAHARNIVVGFGRMEGRTVG
IVANQPLVLAGVLDSDASRKAGRFVRFCDCFNIPIVTFVDVPGFLPGVAQEHGGLIKHGAKLLFAYAEATVPKITIITRK
AFGGAYDVMASKHLRGDVNYAWPTAQIAVMGAKGAVEIIFRKDLADPEKIAKHTKDYEERFLSPFVAAERGYIDEVIQPH
TTRKRVARVLALLRSKNLENPWKKHDNIPL

Sequences:

>Translated_510_residues
MKTILERLDEREAIARLGGGVERLQAQHNRGKLTARERIELLLDQDSFEEFDMFVQHRAIDFGMDSVKIPGDGVVTGWGT
VNGRTVFVFAKDFTVFGGSLSETHAQKILKLQDMALRNRAPIIGLFDAGGARIQEGVAALGGYGEVFQRNVLASGVIPQI
SLIMGPCAGGDVYSPAMTDFIFMVKDTSYMFVTGPDVVKTVTNENVTAEQLGGASVHTTQSSIADHAYENDVEALLQMRR
LIDFLPASNVAPLPEWPSFDTADRVDFSLDTLIPDNPNKPYDVKELIAKTVDEGDFFEIQQAHARNIVVGFGRMEGRTVG
IVANQPLVLAGVLDSDASRKAGRFVRFCDCFNIPIVTFVDVPGFLPGVAQEHGGLIKHGAKLLFAYAEATVPKITIITRK
AFGGAYDVMASKHLRGDVNYAWPTAQIAVMGAKGAVEIIFRKDLADPEKIAKHTKDYEERFLSPFVAAERGYIDEVIQPH
TTRKRVARVLALLRSKNLENPWKKHDNIPL
>Mature_510_residues
MKTILERLDEREAIARLGGGVERLQAQHNRGKLTARERIELLLDQDSFEEFDMFVQHRAIDFGMDSVKIPGDGVVTGWGT
VNGRTVFVFAKDFTVFGGSLSETHAQKILKLQDMALRNRAPIIGLFDAGGARIQEGVAALGGYGEVFQRNVLASGVIPQI
SLIMGPCAGGDVYSPAMTDFIFMVKDTSYMFVTGPDVVKTVTNENVTAEQLGGASVHTTQSSIADHAYENDVEALLQMRR
LIDFLPASNVAPLPEWPSFDTADRVDFSLDTLIPDNPNKPYDVKELIAKTVDEGDFFEIQQAHARNIVVGFGRMEGRTVG
IVANQPLVLAGVLDSDASRKAGRFVRFCDCFNIPIVTFVDVPGFLPGVAQEHGGLIKHGAKLLFAYAEATVPKITIITRK
AFGGAYDVMASKHLRGDVNYAWPTAQIAVMGAKGAVEIIFRKDLADPEKIAKHTKDYEERFLSPFVAAERGYIDEVIQPH
TTRKRVARVLALLRSKNLENPWKKHDNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=510, Percent_Identity=62.156862745098, Blast_Score=659, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=530, Percent_Identity=60, Blast_Score=647, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=525, Percent_Identity=33.7142857142857, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI38679974, Length=352, Percent_Identity=26.7045454545455, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI38679971, Length=352, Percent_Identity=26.7045454545455, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI38679977, Length=352, Percent_Identity=26.7045454545455, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI38679967, Length=352, Percent_Identity=26.7045454545455, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI38679960, Length=352, Percent_Identity=26.7045454545455, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=62.32741617357, Blast_Score=666, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=62.32741617357, Blast_Score=665, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=525, Percent_Identity=33.3333333333333, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71997163, Length=366, Percent_Identity=24.3169398907104, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24586065, Length=505, Percent_Identity=33.6633663366337, Blast_Score=248, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56101; Mature: 56101

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTILERLDEREAIARLGGGVERLQAQHNRGKLTARERIELLLDQDSFEEFDMFVQHRAI
CCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
DFGMDSVKIPGDGVVTGWGTVNGRTVFVFAKDFTVFGGSLSETHAQKILKLQDMALRNRA
HCCCCCEECCCCCEEEECCCCCCEEEEEEEECEEEECCCHHHHHHHHHHHHHHHHHHCCC
PIIGLFDAGGARIQEGVAALGGYGEVFQRNVLASGVIPQISLIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEHHEECCCCCCCCCCCHHHHE
IFMVKDTSYMFVTGPDVVKTVTNENVTAEQLGGASVHTTQSSIADHAYENDVEALLQMRR
EEEEECCCEEEEECCHHHHHHCCCCCCHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
LIDFLPASNVAPLPEWPSFDTADRVDFSLDTLIPDNPNKPYDVKELIAKTVDEGDFFEIQ
HHHHCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHH
QAHARNIVVGFGRMEGRTVGIVANQPLVLAGVLDSDASRKAGRFVRFCDCFNIPIVTFVD
HHCCCEEEEEECCCCCEEEEEEECCCEEEEEECCCCCCHHHCCEEEEEECCCCCEEEEEC
VPGFLPGVAQEHGGLIKHGAKLLFAYAEATVPKITIITRKAFGGAYDVMASKHLRGDVNY
CCCCCCCHHHHCCCHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCC
AWPTAQIAVMGAKGAVEIIFRKDLADPEKIAKHTKDYEERFLSPFVAAERGYIDEVIQPH
CCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
TTRKRVARVLALLRSKNLENPWKKHDNIPL
HHHHHHHHHHHHHHHCCCCCCHHCCCCCCC
>Mature Secondary Structure
MKTILERLDEREAIARLGGGVERLQAQHNRGKLTARERIELLLDQDSFEEFDMFVQHRAI
CCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
DFGMDSVKIPGDGVVTGWGTVNGRTVFVFAKDFTVFGGSLSETHAQKILKLQDMALRNRA
HCCCCCEECCCCCEEEECCCCCCEEEEEEEECEEEECCCHHHHHHHHHHHHHHHHHHCCC
PIIGLFDAGGARIQEGVAALGGYGEVFQRNVLASGVIPQISLIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEHHEECCCCCCCCCCCHHHHE
IFMVKDTSYMFVTGPDVVKTVTNENVTAEQLGGASVHTTQSSIADHAYENDVEALLQMRR
EEEEECCCEEEEECCHHHHHHCCCCCCHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
LIDFLPASNVAPLPEWPSFDTADRVDFSLDTLIPDNPNKPYDVKELIAKTVDEGDFFEIQ
HHHHCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHH
QAHARNIVVGFGRMEGRTVGIVANQPLVLAGVLDSDASRKAGRFVRFCDCFNIPIVTFVD
HHCCCEEEEEECCCCCEEEEEEECCCEEEEEECCCCCCHHHCCEEEEEECCCCCEEEEEC
VPGFLPGVAQEHGGLIKHGAKLLFAYAEATVPKITIITRKAFGGAYDVMASKHLRGDVNY
CCCCCCCHHHHCCCHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCC
AWPTAQIAVMGAKGAVEIIFRKDLADPEKIAKHTKDYEERFLSPFVAAERGYIDEVIQPH
CCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
TTRKRVARVLALLRSKNLENPWKKHDNIPL
HHHHHHHHHHHHHHHCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]