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The map label for this gene is kefC [H]

Identifier: 182678224

GI number: 182678224

Start: 1440540

End: 1442366

Strand: Direct

Name: kefC [H]

Synonym: Bind_1239

Alternate gene names: 182678224

Gene position: 1440540-1442366 (Clockwise)

Preceding gene: 182678220

Following gene: 182678225

Centisome position: 34.54

GC content: 59.93

Gene sequence:

>1827_bases
ATGACATCGTTCGAGCCAGGACAATATAAAGAAACGCTGCTGTTCCTGGCGACCGCCGGTCTTGTCGTCCCCTTGTTCCG
CCGGCTCAGAATCAGTCCCATCCTCGGCTTTCTCTTGGCGGGAGTCGCGCTCGGGCCCTATGGCCTTGGCGCGCTCGCCC
ATGGACCGGCTTCCTGGCTCGCTTTCCTGAGCCTGGAAAGGGTCGAGGAGATCGAGCCCATCGCCGAATTCGGTGTTGTG
TTTCTCCTGTTCATGATCGGGCTTGAGCTGTCTTGGGAACGTCTCGCGCGTATGCGCGCCTTGATTTTCGGCCTCGGGTC
ATTGCAGGTTTTCGGCTGCGCCGCGGCCTTTGTGGCGATCGCGCTCGCTTTGGGGCAGGAGCCGCCGGCTGCTTTGGTGC
TCGGTTTCGCGCTTTCTCTGTCTTCCACGGCTATTGTCATCCCGGCGCTCGCCGAAAAGAAGCGACTGGGAACCTCGGCC
GGGCGCACCATTTTTTCGGTCCTGTTGTTTCAAGATCTCATGGTGGCGCCGCTCTTGTTCATGGTGACGGTGCTCGACAC
GCGCAGCGGTGATTTCACCTCGGCTGTCGTTTCGACCTTGTTGCCAGCCATTGCCGCCTTGAGCCTCATCGTGCTCGGCG
GCCGGCTGCTCATGCGGCCTTTCTTCCATCTGGTGGCGGCGGCTGGTTCGACGGAATTTTTCATCGCGGCTTGTCTCTTC
ACGGTGATCGGGATCAGCGTGATCGCGGCAATGAGCGGTCTTTCGATGGGGCTTGGTGCCTTCATCGCGGGCCTGCTCCT
GGCCGAGACGGAATATAGGCGCGAGATCGAAGTCACGATCGAACCGTTCAAGGGTTTGTTGCTGGGTTTGTTTTTCGTCT
CGATTGGCGCCAGCCTCAACCCATCCGAGGTTGTCGCGGCGCCGCTCGAGACAATCGGCATCGCGCTTGGCTTCATCGCA
ATCAAATTCCTCCTGACGGTGCTGGCGGGCTTTGTCATGCGACTCAACGGCCGGGTTGTCACGGAAGCGGCTTTTCTTTT
GGGGCCGGGTGGAGAATTCGCTTTTGTGCTCCTCAGCGCCGCTTTGGCGGCCAAGCTCATGCCGGCAAAGATGGCCGGCG
ATGTCGAAATAGCGGTCACACTCTCCATGTTTCTCGTGCCGACGCTGGCCGAACTCGGCCGGAAATTCGGCCGCAAATCC
GCATCCATCGCGCCGGATCTTTCCGAATTGCCTGAATCTCATGACGATAGCGAAGCGCCCGAGGCCATTCTCATCGGCTA
TGGTCGTGTTGGCCGGCTCGTGGGCGAACTTCTGCACGTCCACAAGATCCGTTTTCTGGCGGTCGATCAGGACGCTGGCG
TCGTCAAGGAGGCACGGGAGGAGGGAGCGGATATCTGCTGGGGCAATGCCACGCGGATGGATTTTCTGCATCGCTGCGGG
ATCAGTAAAGCCAAGGCCCTGATCATCACCATGGACGCCAATGCGATCGCCGAGGAAATCGTCGCCATGGTGCGCGCCGC
CTATCCCTGGATCATCATCGTCGCCCGCGCCCGCGACGCAAAACATGCGACCGTGCTCTACAAGCTCGGCGTGAATAATG
CCGTGCCGGAGACCATCGAGGCGAGCCTGCAATTATCGGAAGCCACTTTGATCGATCTCGGCGTGCCGATGGGGCTCGTC
ATCGCCTCGATCCACGAGAAACGGGATGAATTCCGCAAAATCCTGCAACCCGAGGTGGATGGCGCAGCGGAACGCTATGA
GCTCAAGCGAACAAATCGCCTGAAAGACTGGGGCAAGCGGCGGGTCAAGACTGTCGTTGAAGAGTGA

Upstream 100 bases:

>100_bases
CTTGAATTTTCGCTCTCGCTTTGAAAAAGCGAAAATTCAAGAAAGGAACCAAAGGTCGTTCTTTACGACCTTTGGTATAA
ATCATGGGAAGGGAGGTCGG

Downstream 100 bases:

>100_bases
TCTCGCAACAGGTTCTGGATTAACCATGGCTTGGTTTGACCCAGGTGATGGTCGTACTGACAAGGATTAAGCGTCTCGCC
TCGTTCATGGAGATCATGGG

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MTSFEPGQYKETLLFLATAGLVVPLFRRLRISPILGFLLAGVALGPYGLGALAHGPASWLAFLSLERVEEIEPIAEFGVV
FLLFMIGLELSWERLARMRALIFGLGSLQVFGCAAAFVAIALALGQEPPAALVLGFALSLSSTAIVIPALAEKKRLGTSA
GRTIFSVLLFQDLMVAPLLFMVTVLDTRSGDFTSAVVSTLLPAIAALSLIVLGGRLLMRPFFHLVAAAGSTEFFIAACLF
TVIGISVIAAMSGLSMGLGAFIAGLLLAETEYRREIEVTIEPFKGLLLGLFFVSIGASLNPSEVVAAPLETIGIALGFIA
IKFLLTVLAGFVMRLNGRVVTEAAFLLGPGGEFAFVLLSAALAAKLMPAKMAGDVEIAVTLSMFLVPTLAELGRKFGRKS
ASIAPDLSELPESHDDSEAPEAILIGYGRVGRLVGELLHVHKIRFLAVDQDAGVVKEAREEGADICWGNATRMDFLHRCG
ISKAKALIITMDANAIAEEIVAMVRAAYPWIIIVARARDAKHATVLYKLGVNNAVPETIEASLQLSEATLIDLGVPMGLV
IASIHEKRDEFRKILQPEVDGAAERYELKRTNRLKDWGKRRVKTVVEE

Sequences:

>Translated_608_residues
MTSFEPGQYKETLLFLATAGLVVPLFRRLRISPILGFLLAGVALGPYGLGALAHGPASWLAFLSLERVEEIEPIAEFGVV
FLLFMIGLELSWERLARMRALIFGLGSLQVFGCAAAFVAIALALGQEPPAALVLGFALSLSSTAIVIPALAEKKRLGTSA
GRTIFSVLLFQDLMVAPLLFMVTVLDTRSGDFTSAVVSTLLPAIAALSLIVLGGRLLMRPFFHLVAAAGSTEFFIAACLF
TVIGISVIAAMSGLSMGLGAFIAGLLLAETEYRREIEVTIEPFKGLLLGLFFVSIGASLNPSEVVAAPLETIGIALGFIA
IKFLLTVLAGFVMRLNGRVVTEAAFLLGPGGEFAFVLLSAALAAKLMPAKMAGDVEIAVTLSMFLVPTLAELGRKFGRKS
ASIAPDLSELPESHDDSEAPEAILIGYGRVGRLVGELLHVHKIRFLAVDQDAGVVKEAREEGADICWGNATRMDFLHRCG
ISKAKALIITMDANAIAEEIVAMVRAAYPWIIIVARARDAKHATVLYKLGVNNAVPETIEASLQLSEATLIDLGVPMGLV
IASIHEKRDEFRKILQPEVDGAAERYELKRTNRLKDWGKRRVKTVVEE
>Mature_607_residues
TSFEPGQYKETLLFLATAGLVVPLFRRLRISPILGFLLAGVALGPYGLGALAHGPASWLAFLSLERVEEIEPIAEFGVVF
LLFMIGLELSWERLARMRALIFGLGSLQVFGCAAAFVAIALALGQEPPAALVLGFALSLSSTAIVIPALAEKKRLGTSAG
RTIFSVLLFQDLMVAPLLFMVTVLDTRSGDFTSAVVSTLLPAIAALSLIVLGGRLLMRPFFHLVAAAGSTEFFIAACLFT
VIGISVIAAMSGLSMGLGAFIAGLLLAETEYRREIEVTIEPFKGLLLGLFFVSIGASLNPSEVVAAPLETIGIALGFIAI
KFLLTVLAGFVMRLNGRVVTEAAFLLGPGGEFAFVLLSAALAAKLMPAKMAGDVEIAVTLSMFLVPTLAELGRKFGRKSA
SIAPDLSELPESHDDSEAPEAILIGYGRVGRLVGELLHVHKIRFLAVDQDAGVVKEAREEGADICWGNATRMDFLHRCGI
SKAKALIITMDANAIAEEIVAMVRAAYPWIIIVARARDAKHATVLYKLGVNNAVPETIEASLQLSEATLIDLGVPMGLVI
ASIHEKRDEFRKILQPEVDGAAERYELKRTNRLKDWGKRRVKTVVEE

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=360, Percent_Identity=28.3333333333333, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1786232, Length=564, Percent_Identity=36.8794326241135, Blast_Score=324, Evalue=8e-90,
Organism=Escherichia coli, GI1789749, Length=561, Percent_Identity=37.4331550802139, Blast_Score=301, Evalue=1e-82,
Organism=Escherichia coli, GI1786685, Length=528, Percent_Identity=29.7348484848485, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 65122; Mature: 64991

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSFEPGQYKETLLFLATAGLVVPLFRRLRISPILGFLLAGVALGPYGLGALAHGPASWL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHH
AFLSLERVEEIEPIAEFGVVFLLFMIGLELSWERLARMRALIFGLGSLQVFGCAAAFVAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ALALGQEPPAALVLGFALSLSSTAIVIPALAEKKRLGTSAGRTIFSVLLFQDLMVAPLLF
HHHHCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
MVTVLDTRSGDFTSAVVSTLLPAIAALSLIVLGGRLLMRPFFHLVAAAGSTEFFIAACLF
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TVIGISVIAAMSGLSMGLGAFIAGLLLAETEYRREIEVTIEPFKGLLLGLFFVSIGASLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHCCCCC
PSEVVAAPLETIGIALGFIAIKFLLTVLAGFVMRLNGRVVTEAAFLLGPGGEFAFVLLSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHCCCCCHHHHHHHHH
ALAAKLMPAKMAGDVEIAVTLSMFLVPTLAELGRKFGRKSASIAPDLSELPESHDDSEAP
HHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCC
EAILIGYGRVGRLVGELLHVHKIRFLAVDQDAGVVKEAREEGADICWGNATRMDFLHRCG
CEEEEECHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHCCCCEECCCCHHHHHHHHCC
ISKAKALIITMDANAIAEEIVAMVRAAYPWIIIVARARDAKHATVLYKLGVNNAVPETIE
CCCCCEEEEEECHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEECCCCCCCHHHH
ASLQLSEATLIDLGVPMGLVIASIHEKRDEFRKILQPEVDGAAERYELKRTNRLKDWGKR
HHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
RVKTVVEE
HHHHHHCC
>Mature Secondary Structure 
TSFEPGQYKETLLFLATAGLVVPLFRRLRISPILGFLLAGVALGPYGLGALAHGPASWL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHH
AFLSLERVEEIEPIAEFGVVFLLFMIGLELSWERLARMRALIFGLGSLQVFGCAAAFVAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ALALGQEPPAALVLGFALSLSSTAIVIPALAEKKRLGTSAGRTIFSVLLFQDLMVAPLLF
HHHHCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
MVTVLDTRSGDFTSAVVSTLLPAIAALSLIVLGGRLLMRPFFHLVAAAGSTEFFIAACLF
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TVIGISVIAAMSGLSMGLGAFIAGLLLAETEYRREIEVTIEPFKGLLLGLFFVSIGASLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHCCCCC
PSEVVAAPLETIGIALGFIAIKFLLTVLAGFVMRLNGRVVTEAAFLLGPGGEFAFVLLSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHCCCCCHHHHHHHHH
ALAAKLMPAKMAGDVEIAVTLSMFLVPTLAELGRKFGRKSASIAPDLSELPESHDDSEAP
HHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCC
EAILIGYGRVGRLVGELLHVHKIRFLAVDQDAGVVKEAREEGADICWGNATRMDFLHRCG
CEEEEECHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHCCCCEECCCCHHHHHHHHCC
ISKAKALIITMDANAIAEEIVAMVRAAYPWIIIVARARDAKHATVLYKLGVNNAVPETIE
CCCCCEEEEEECHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEECCCCCCCHHHH
ASLQLSEATLIDLGVPMGLVIASIHEKRDEFRKILQPEVDGAAERYELKRTNRLKDWGKR
HHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
RVKTVVEE
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA