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The map label for this gene is folD1 [H]

Identifier: 182677798

GI number: 182677798

Start: 895903

End: 896865

Strand: Direct

Name: folD1 [H]

Synonym: Bind_0805

Alternate gene names: 182677798

Gene position: 895903-896865 (Clockwise)

Preceding gene: 182677797

Following gene: 182677799

Centisome position: 21.48

GC content: 60.75

Gene sequence:

>963_bases
ATGGGAATGGAGACGAAAACCGGGGTTTTGGACGAGACTGGAATTCTACGCCCTTCCACTGGCAGCGCTCTCCTGATCGA
TGGCAAACGCGCATCCGAGCGGATGTTGGCCTCCATCGCCGAAAAAGCCCAAATCCTTATCAATGGCGGCATCAAGCCGG
GACTCGCCGTCATTCTGGTCGGGGAGGATCCAGCGAGCCAGGTCTATGTCAAATCGAAGGGCCATACGGCCGTGGCCTGC
GGCTTCCATTCGGTGCAGCATGATCTGCCGGTCTCGACCACCGAGGAGGAAATTCTCGACCTTATCGCAAGGCTCAACGC
TGATCCGACGATTCATGGCATTTTGATGCAATTGCCCTTGCCGGGCGGCGCCGATCCCACAAGGATCATCGAATCGATCG
CGCCCTCCAAGGATGTCGATGGGCTGCATCCGCTCAATGCCGGACTTTTGGCAGTCGGGAATTTTCACCGCGCACTCATT
CCCTGCACGCCGGCTGGATGTGTGCATCTGCTTGATCAGACAGCGGCGGAGCTCGGCGTTGATCTGGCCGGGGCGGAAGC
GGTTGTCGTCGGCCGATCCAATCTCGTCGGGAAGCCGATCGCTCAATTGCTGCTTGCCCGCAATGCGACCGTGACCCTGG
CGCATTCGAAAAGCCGGGATTTGCCCGCTATCATCAGCCGCGCCGATCTTCTCGTCGCCGCGGTCGGGCGGCCGGAAATG
ATCCGTGGGAACTGGATCAAGCCCGGTGCCATCGTCCTTGATGTCGGCATTAATCGCCTGCCGGCTGAGGGATTAACCGC
TTCCGGCAAGCCAAAGAGCCGGCTCGTCGGCGATGTCGCGCGCGAGGAGGCGTTGACACGCGCGGCCGCTATCACGCCCG
TGCCGGGTGGCGTCGGCCCCATGACGATTGCCATGTTGATGGCCAATACATTGCGCGCGGCTGAAGCTTACGCTGGTCTA
TAG

Upstream 100 bases:

>100_bases
AGGGGATATCCCTTTCCGGTTCGATGCTCTAGAAACGCCGCATCTTTTCCATTCTCCCGCGCGGAGGATGGATGTTTGGA
TACGGCCGGAGGCGGGACGC

Downstream 100 bases:

>100_bases
AGGCGACTTGCGAGGATAGTCGCTTTTTGGCCACAGGGTTTTATGAAATGTCGTTTATTTTATCTTTGTTAACCTTGCGG
CAACCTTAAACCTTTTTGAT

Product: methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MGMETKTGVLDETGILRPSTGSALLIDGKRASERMLASIAEKAQILINGGIKPGLAVILVGEDPASQVYVKSKGHTAVAC
GFHSVQHDLPVSTTEEEILDLIARLNADPTIHGILMQLPLPGGADPTRIIESIAPSKDVDGLHPLNAGLLAVGNFHRALI
PCTPAGCVHLLDQTAAELGVDLAGAEAVVVGRSNLVGKPIAQLLLARNATVTLAHSKSRDLPAIISRADLLVAAVGRPEM
IRGNWIKPGAIVLDVGINRLPAEGLTASGKPKSRLVGDVAREEALTRAAAITPVPGGVGPMTIAMLMANTLRAAEAYAGL

Sequences:

>Translated_320_residues
MGMETKTGVLDETGILRPSTGSALLIDGKRASERMLASIAEKAQILINGGIKPGLAVILVGEDPASQVYVKSKGHTAVAC
GFHSVQHDLPVSTTEEEILDLIARLNADPTIHGILMQLPLPGGADPTRIIESIAPSKDVDGLHPLNAGLLAVGNFHRALI
PCTPAGCVHLLDQTAAELGVDLAGAEAVVVGRSNLVGKPIAQLLLARNATVTLAHSKSRDLPAIISRADLLVAAVGRPEM
IRGNWIKPGAIVLDVGINRLPAEGLTASGKPKSRLVGDVAREEALTRAAAITPVPGGVGPMTIAMLMANTLRAAEAYAGL
>Mature_319_residues
GMETKTGVLDETGILRPSTGSALLIDGKRASERMLASIAEKAQILINGGIKPGLAVILVGEDPASQVYVKSKGHTAVACG
FHSVQHDLPVSTTEEEILDLIARLNADPTIHGILMQLPLPGGADPTRIIESIAPSKDVDGLHPLNAGLLAVGNFHRALIP
CTPAGCVHLLDQTAAELGVDLAGAEAVVVGRSNLVGKPIAQLLLARNATVTLAHSKSRDLPAIISRADLLVAAVGRPEMI
RGNWIKPGAIVLDVGINRLPAEGLTASGKPKSRLVGDVAREEALTRAAAITPVPGGVGPMTIAMLMANTLRAAEAYAGL

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate [H]

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=300, Percent_Identity=46, Blast_Score=251, Evalue=6e-67,
Organism=Homo sapiens, GI222418558, Length=307, Percent_Identity=40.0651465798046, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI94721354, Length=306, Percent_Identity=40.8496732026144, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI36796743, Length=275, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1786741, Length=299, Percent_Identity=48.8294314381271, Blast_Score=263, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17568735, Length=264, Percent_Identity=43.1818181818182, Blast_Score=198, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6319558, Length=288, Percent_Identity=44.4444444444444, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6321643, Length=302, Percent_Identity=42.0529801324503, Blast_Score=225, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6322933, Length=292, Percent_Identity=27.0547945205479, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI62472483, Length=267, Percent_Identity=49.812734082397, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI45551871, Length=267, Percent_Identity=49.812734082397, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24645718, Length=267, Percent_Identity=49.812734082397, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI17137370, Length=267, Percent_Identity=49.812734082397, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI17136816, Length=310, Percent_Identity=42.9032258064516, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI17136818, Length=303, Percent_Identity=43.5643564356436, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631 [H]

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C [H]

EC number: =1.5.1.5; =3.5.4.9 [H]

Molecular weight: Translated: 33046; Mature: 32915

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00766 THF_DHG_CYH_1 ; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMETKTGVLDETGILRPSTGSALLIDGKRASERMLASIAEKAQILINGGIKPGLAVILV
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCEEEEECCCCCCEEEEEE
GEDPASQVYVKSKGHTAVACGFHSVQHDLPVSTTEEEILDLIARLNADPTIHGILMQLPL
CCCCCCEEEEECCCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECC
PGGADPTRIIESIAPSKDVDGLHPLNAGLLAVGNFHRALIPCTPAGCVHLLDQTAAELGV
CCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHCC
DLAGAEAVVVGRSNLVGKPIAQLLLARNATVTLAHSKSRDLPAIISRADLLVAAVGRPEM
EECCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHEEEEECCCCCE
IRGNWIKPGAIVLDVGINRLPAEGLTASGKPKSRLVGDVAREEALTRAAAITPVPGGVGP
ECCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
MTIAMLMANTLRAAEAYAGL
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GMETKTGVLDETGILRPSTGSALLIDGKRASERMLASIAEKAQILINGGIKPGLAVILV
CCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCEEEEECCCCCCEEEEEE
GEDPASQVYVKSKGHTAVACGFHSVQHDLPVSTTEEEILDLIARLNADPTIHGILMQLPL
CCCCCCEEEEECCCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECC
PGGADPTRIIESIAPSKDVDGLHPLNAGLLAVGNFHRALIPCTPAGCVHLLDQTAAELGV
CCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHCC
DLAGAEAVVVGRSNLVGKPIAQLLLARNATVTLAHSKSRDLPAIISRADLLVAAVGRPEM
EECCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHEEEEECCCCCE
IRGNWIKPGAIVLDVGINRLPAEGLTASGKPKSRLVGDVAREEALTRAAAITPVPGGVGP
ECCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
MTIAMLMANTLRAAEAYAGL
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]