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The map label for this gene is mtnA [H]

Identifier: 182677658

GI number: 182677658

Start: 746505

End: 747593

Strand: Direct

Name: mtnA [H]

Synonym: Bind_0665

Alternate gene names: 182677658

Gene position: 746505-747593 (Clockwise)

Preceding gene: 182677655

Following gene: 182677662

Centisome position: 17.9

GC content: 57.58

Gene sequence:

>1089_bases
ATGCGCGTCAATGGTGAGCCATTCAAATCGATCTGGCCTGAACCGGATCGCTCCCGCGTCAATATTATTGATCAAACCCA
ATTGCCGCATGTCTTTGCCGTGGCGCATTTGCGCACTCTCCAAGAAGCGGCGCATGCCATCAAGGCCATGCTGGTGCGCG
GTGCCCCGTTGATCGGGGTCACGGCGGCCTATGGTCTTTCGCTCGCCTTGCAAAAAGATGCTTCCGATGACGGTTTGCGT
CGGGCGAGCGAGATTTTGCTGGCGACGCGTCCCACGGCCGTCAATTTGCAATGGGCCTTGCGGGAAATGGCTGACAAGCT
TCTGGTCTTGCCACAGGAACAGCGCGCCGAAGCAGCCTGGAACCATGCCGGCGTGCTCGCTGAGGATGATATTCGTCTTT
GTGAGGCCATGGGTGATCACGGCCTGGTTTTGATCGAGGAGATTGCTCGGCGCAAACAGGGCGAACGCGTCAATATTCTC
ACTCATTGCAATGCTGGCTGGCTCGCCACGGTCGATTGGGGCACCGCGACCGCGCCCATGTACAAGGCGCAGGAAGCCGG
AATTCCGATTCATGTCTATGTCGATGAGACACGTCCGCGCAATCAGGGCGCCTCGCTTACGGCTTGGGAGCTGGGACAGC
ATGGTGTGCCGCATACAGTCATCGTTGATAATGCCGGCGGCCATCTCATGCAGCATGGTCTCGTCGATCTCGTGATTGTC
GGCACGGACAGGACCACGGCGAGCGGCGATGTCTGCAATAAAATCGGCACTTATCTCAAAGCGCTGGCGGCTTTTGACAA
TGATGTGCCCTTCTATGTCTGCGCGCCTTCACCCTCGATCGATTTTTCGATTTCAGATGGTCTGCGTGACATTCCGATCG
AAGAGAGATCACCCTTGGAAGTCACGCATCTGAAGGGGCTGACGGAAGACAAGCGTATCGAGACGATCCGCATCACCCCG
GAAAACAGCGAGGCCTTGAACTATGCCTTCGATGTGACGCCGGCTCGTCTGGTGACAGGCTTGATCACGGAGCGTGGCAC
CATCGCCGCCAATGCCGAGGCTCTCGCGAAAACTTTCCCCGACCGATAG

Upstream 100 bases:

>100_bases
AGAGCATGTCCCGATCCTCTCGAAGCGGGATGTGCTCTTGTGGAACCTATGCTATTTCAGGCTCTCGATCGTGGATGCGA
GAGTGTGGGAGCTGGGTCTG

Downstream 100 bases:

>100_bases
GGATTCTCAAGGCTGGCGCTGTCTACAATCCGCCGATCGGGCGATAGTCCAGAAGCTCCTCGATCCGCGTGAGAAGCCCA
TCACGTACCTGTCTATAGGC

Product: aIF-2BI family translation initiation factor

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MRVNGEPFKSIWPEPDRSRVNIIDQTQLPHVFAVAHLRTLQEAAHAIKAMLVRGAPLIGVTAAYGLSLALQKDASDDGLR
RASEILLATRPTAVNLQWALREMADKLLVLPQEQRAEAAWNHAGVLAEDDIRLCEAMGDHGLVLIEEIARRKQGERVNIL
THCNAGWLATVDWGTATAPMYKAQEAGIPIHVYVDETRPRNQGASLTAWELGQHGVPHTVIVDNAGGHLMQHGLVDLVIV
GTDRTTASGDVCNKIGTYLKALAAFDNDVPFYVCAPSPSIDFSISDGLRDIPIEERSPLEVTHLKGLTEDKRIETIRITP
ENSEALNYAFDVTPARLVTGLITERGTIAANAEALAKTFPDR

Sequences:

>Translated_362_residues
MRVNGEPFKSIWPEPDRSRVNIIDQTQLPHVFAVAHLRTLQEAAHAIKAMLVRGAPLIGVTAAYGLSLALQKDASDDGLR
RASEILLATRPTAVNLQWALREMADKLLVLPQEQRAEAAWNHAGVLAEDDIRLCEAMGDHGLVLIEEIARRKQGERVNIL
THCNAGWLATVDWGTATAPMYKAQEAGIPIHVYVDETRPRNQGASLTAWELGQHGVPHTVIVDNAGGHLMQHGLVDLVIV
GTDRTTASGDVCNKIGTYLKALAAFDNDVPFYVCAPSPSIDFSISDGLRDIPIEERSPLEVTHLKGLTEDKRIETIRITP
ENSEALNYAFDVTPARLVTGLITERGTIAANAEALAKTFPDR
>Mature_362_residues
MRVNGEPFKSIWPEPDRSRVNIIDQTQLPHVFAVAHLRTLQEAAHAIKAMLVRGAPLIGVTAAYGLSLALQKDASDDGLR
RASEILLATRPTAVNLQWALREMADKLLVLPQEQRAEAAWNHAGVLAEDDIRLCEAMGDHGLVLIEEIARRKQGERVNIL
THCNAGWLATVDWGTATAPMYKAQEAGIPIHVYVDETRPRNQGASLTAWELGQHGVPHTVIVDNAGGHLMQHGLVDLVIV
GTDRTTASGDVCNKIGTYLKALAAFDNDVPFYVCAPSPSIDFSISDGLRDIPIEERSPLEVTHLKGLTEDKRIETIRITP
ENSEALNYAFDVTPARLVTGLITERGTIAANAEALAKTFPDR

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=352, Percent_Identity=38.0681818181818, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI23943880, Length=342, Percent_Identity=34.5029239766082, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17557462, Length=344, Percent_Identity=32.5581395348837, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17557123, Length=169, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325375, Length=393, Percent_Identity=29.2620865139949, Blast_Score=149, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21357667, Length=356, Percent_Identity=37.3595505617978, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24651647, Length=356, Percent_Identity=37.3595505617978, Blast_Score=183, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 39525; Mature: 39525

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVNGEPFKSIWPEPDRSRVNIIDQTQLPHVFAVAHLRTLQEAAHAIKAMLVRGAPLIGV
CCCCCCCHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TAAYGLSLALQKDASDDGLRRASEILLATRPTAVNLQWALREMADKLLVLPQEQRAEAAW
HHHHCEEEEEECCCCCHHHHHHHHHEEEECCCEEEHHHHHHHHHHHHEECCCHHHHHHHH
NHAGVLAEDDIRLCEAMGDHGLVLIEEIARRKQGERVNILTHCNAGWLATVDWGTATAPM
CCCCCEECCHHHHHHHCCCCCEEHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCC
YKAQEAGIPIHVYVDETRPRNQGASLTAWELGQHGVPHTVIVDNAGGHLMQHGLVDLVIV
HHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHCCCEEEEEE
GTDRTTASGDVCNKIGTYLKALAAFDNDVPFYVCAPSPSIDFSISDGLRDIPIEERSPLE
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEECCCCCCCCCCCCCCCE
VTHLKGLTEDKRIETIRITPENSEALNYAFDVTPARLVTGLITERGTIAANAEALAKTFP
EHHHCCCCCCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHCCCCEEECHHHHHHHCC
DR
CC
>Mature Secondary Structure
MRVNGEPFKSIWPEPDRSRVNIIDQTQLPHVFAVAHLRTLQEAAHAIKAMLVRGAPLIGV
CCCCCCCHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TAAYGLSLALQKDASDDGLRRASEILLATRPTAVNLQWALREMADKLLVLPQEQRAEAAW
HHHHCEEEEEECCCCCHHHHHHHHHEEEECCCEEEHHHHHHHHHHHHEECCCHHHHHHHH
NHAGVLAEDDIRLCEAMGDHGLVLIEEIARRKQGERVNILTHCNAGWLATVDWGTATAPM
CCCCCEECCHHHHHHHCCCCCEEHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCC
YKAQEAGIPIHVYVDETRPRNQGASLTAWELGQHGVPHTVIVDNAGGHLMQHGLVDLVIV
HHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHCCCEEEEEE
GTDRTTASGDVCNKIGTYLKALAAFDNDVPFYVCAPSPSIDFSISDGLRDIPIEERSPLE
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEECCCCCCCCCCCCCCCE
VTHLKGLTEDKRIETIRITPENSEALNYAFDVTPARLVTGLITERGTIAANAEALAKTFP
EHHHCCCCCCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHCCCCEEECHHHHHHHCC
DR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA