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The map label for this gene is dnaA [H]

Identifier: 182677005

GI number: 182677005

Start: 1509

End: 3041

Strand: Direct

Name: dnaA [H]

Synonym: Bind_0003

Alternate gene names: 182677005

Gene position: 1509-3041 (Clockwise)

Preceding gene: 182677004

Following gene: 182677006

Centisome position: 0.04

GC content: 58.51

Gene sequence:

>1533_bases
ATGCCGGATGCGCGTGGACTTATGGCTCTGCCACAACAGATCGAAGACGACAACGAGACGGGACGTAGGGTGAACCTTGG
GGTGAACAAAGACGAAGCCTGGGAGCGAATCTGCCGCAGGCTGCGCGCCGAACTCGGTGAAGATGTCTTTGCGTCCTGGT
TCGGCCGTCTCGAGCTCGATCAGGTTGCCGATGGCACGGCCTTTCTTTCCGTGCCGACGAAATTTCTGAAGAGCTGGATA
CAGTCGCATTATACCGACAAGATTCTGGCGATTCTTGCCGATGAATTTGGCAATGCCAAACGCATTTCCATCGGCGTGCG
CCCCACGAGCCGAGTCGGGCGCTCCTTTCCCGCCGATGCCGAACGCGACAATTCTCCTGAGAATGCTGAACCAGCCGCGC
GGCCGGCGCGGTCGCCCGTTGGCGCGGAAGTGAAATTCTTCACGGGCCCGGACAAGAAAACAGTTCGCGAGATAAGTGAT
GCCGAAGCGCTCAATGGTTCGCCGCTTGACCGGCGCCTGAGCTTTGCCAATTTCCTCGTCGGACGCTCGAATCAATTGGC
CTTTGCCGCGGCCAAGGGGATTGCCGCGGCTGATCCCAATGATCCGCTCTTATCGAATCCGCTCTATCTTCACGCCTCGG
TGGGGCTCGGCAAGACGCATCTTCTGCAAGCCATCGCCCATGATGCCATGATCATGAAGCGGCGCGTCATTTATCTGACG
GCCGAAAAGTTCATGTATGGCTTCGTGGCCGCGCTCAAGGCGCAGACGGCGATCGCCTTCAAGGAAAAATTGCGGACGAT
CGACATTCTCGTCATCGATGATGTCCAGTTCCTGCAAGGCAAATCGATCCAGCAGGAATTCTGCCATACACTCAATGCCT
TGATCGATGCTGGCCGGCAGATCGTCATTGCCGCCGATCGCCCGCCGGCCGATCTCGAAAGCCTCGACGAACGGGTCCGT
TCGCGTCTTGCTGGCGGTCTTTGCGTCGAAATGGGCGCGCTCGACGAGGCTTTGCGGATCAAGATCCTCGAGACCCGGAT
CGGCGCGGCCAAGCTCGTCCATCCTTATTTCGATGTGCCGCAACCGGTCATTGCCTATGTCGCGAGTGTCATCCAGACCA
ATGGCCGCGATCTCGATGGCGCGGTCAATCGCCTGCTCGCCCATGCCTCGCTCACCAGCGTGCCGCTGACCATTGAAATC
GCCGAGACCGCGATCAGGGATCTGGTGCGCACCAAGGAGCCGAAACGGGTTAAGATCGAGGAGATCCAGAAACTCGTCGC
GAGCCATTTCAATGTGAGCCGCGCCGATATTCTCTCCTCGCGCCGCACGGCCAATGTCGTGCGGCCGCGTCAGATCGCCA
TGTATCTTTCAAAAATCATGACCCTGCGCTCGCTGCCGGAAATCGGCCGCCGGTTCGGTGGACGCGATCACACGACAGTG
CTGCATGCAGTGCGCAAGATTGAAAACCTGGCCTCGACCGACAATCATTTGTCCGAGGAGCTCGAATTGCTCAAACGCAT
GCTGATGGAATAG

Upstream 100 bases:

>100_bases
GGAAGAAGCGATGGCGATGCGCCACGTTGAAATCTGCCTGCGGCTGAAAGCAAAGCTGTTTGGACGCCTCTGTTCCTAAT
TTTACGACAGAAGAATGAAA

Downstream 100 bases:

>100_bases
AAAGATTCTTTCAGCTTGTGAGAGACTCATGCCCGCCAGAAAGTCCGCCGCGTCTTTCTCCTCCAGATCGTGCGGAAGAC
AATCTGGCGGGAGGAAATCC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MPDARGLMALPQQIEDDNETGRRVNLGVNKDEAWERICRRLRAELGEDVFASWFGRLELDQVADGTAFLSVPTKFLKSWI
QSHYTDKILAILADEFGNAKRISIGVRPTSRVGRSFPADAERDNSPENAEPAARPARSPVGAEVKFFTGPDKKTVREISD
AEALNGSPLDRRLSFANFLVGRSNQLAFAAAKGIAAADPNDPLLSNPLYLHASVGLGKTHLLQAIAHDAMIMKRRVIYLT
AEKFMYGFVAALKAQTAIAFKEKLRTIDILVIDDVQFLQGKSIQQEFCHTLNALIDAGRQIVIAADRPPADLESLDERVR
SRLAGGLCVEMGALDEALRIKILETRIGAAKLVHPYFDVPQPVIAYVASVIQTNGRDLDGAVNRLLAHASLTSVPLTIEI
AETAIRDLVRTKEPKRVKIEEIQKLVASHFNVSRADILSSRRTANVVRPRQIAMYLSKIMTLRSLPEIGRRFGGRDHTTV
LHAVRKIENLASTDNHLSEELELLKRMLME

Sequences:

>Translated_510_residues
MPDARGLMALPQQIEDDNETGRRVNLGVNKDEAWERICRRLRAELGEDVFASWFGRLELDQVADGTAFLSVPTKFLKSWI
QSHYTDKILAILADEFGNAKRISIGVRPTSRVGRSFPADAERDNSPENAEPAARPARSPVGAEVKFFTGPDKKTVREISD
AEALNGSPLDRRLSFANFLVGRSNQLAFAAAKGIAAADPNDPLLSNPLYLHASVGLGKTHLLQAIAHDAMIMKRRVIYLT
AEKFMYGFVAALKAQTAIAFKEKLRTIDILVIDDVQFLQGKSIQQEFCHTLNALIDAGRQIVIAADRPPADLESLDERVR
SRLAGGLCVEMGALDEALRIKILETRIGAAKLVHPYFDVPQPVIAYVASVIQTNGRDLDGAVNRLLAHASLTSVPLTIEI
AETAIRDLVRTKEPKRVKIEEIQKLVASHFNVSRADILSSRRTANVVRPRQIAMYLSKIMTLRSLPEIGRRFGGRDHTTV
LHAVRKIENLASTDNHLSEELELLKRMLME
>Mature_509_residues
PDARGLMALPQQIEDDNETGRRVNLGVNKDEAWERICRRLRAELGEDVFASWFGRLELDQVADGTAFLSVPTKFLKSWIQ
SHYTDKILAILADEFGNAKRISIGVRPTSRVGRSFPADAERDNSPENAEPAARPARSPVGAEVKFFTGPDKKTVREISDA
EALNGSPLDRRLSFANFLVGRSNQLAFAAAKGIAAADPNDPLLSNPLYLHASVGLGKTHLLQAIAHDAMIMKRRVIYLTA
EKFMYGFVAALKAQTAIAFKEKLRTIDILVIDDVQFLQGKSIQQEFCHTLNALIDAGRQIVIAADRPPADLESLDERVRS
RLAGGLCVEMGALDEALRIKILETRIGAAKLVHPYFDVPQPVIAYVASVIQTNGRDLDGAVNRLLAHASLTSVPLTIEIA
ETAIRDLVRTKEPKRVKIEEIQKLVASHFNVSRADILSSRRTANVVRPRQIAMYLSKIMTLRSLPEIGRRFGGRDHTTVL
HAVRKIENLASTDNHLSEELELLKRMLME

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=487, Percent_Identity=35.7289527720739, Blast_Score=279, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 56541; Mature: 56410

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDARGLMALPQQIEDDNETGRRVNLGVNKDEAWERICRRLRAELGEDVFASWFGRLELD
CCCCCCHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHCCCCHH
QVADGTAFLSVPTKFLKSWIQSHYTDKILAILADEFGNAKRISIGVRPTSRVGRSFPADA
HHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCCCCCCCC
ERDNSPENAEPAARPARSPVGAEVKFFTGPDKKTVREISDAEALNGSPLDRRLSFANFLV
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
GRSNQLAFAAAKGIAAADPNDPLLSNPLYLHASVGLGKTHLLQAIAHDAMIMKRRVIYLT
CCCCCEEHHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEE
AEKFMYGFVAALKAQTAIAFKEKLRTIDILVIDDVQFLQGKSIQQEFCHTLNALIDAGRQ
HHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHCCCCHHHHHHHHHHHHHHCCCE
IVIAADRPPADLESLDERVRSRLAGGLCVEMGALDEALRIKILETRIGAAKLVHPYFDVP
EEEECCCCCCCHHHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHHHCHHHHHCCCCCCC
QPVIAYVASVIQTNGRDLDGAVNRLLAHASLTSVPLTIEIAETAIRDLVRTKEPKRVKIE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCHH
EIQKLVASHFNVSRADILSSRRTANVVRPRQIAMYLSKIMTLRSLPEIGRRFGGRDHTTV
HHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LHAVRKIENLASTDNHLSEELELLKRMLME
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PDARGLMALPQQIEDDNETGRRVNLGVNKDEAWERICRRLRAELGEDVFASWFGRLELD
CCCCCHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHCCCCHH
QVADGTAFLSVPTKFLKSWIQSHYTDKILAILADEFGNAKRISIGVRPTSRVGRSFPADA
HHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCCCCCCCC
ERDNSPENAEPAARPARSPVGAEVKFFTGPDKKTVREISDAEALNGSPLDRRLSFANFLV
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
GRSNQLAFAAAKGIAAADPNDPLLSNPLYLHASVGLGKTHLLQAIAHDAMIMKRRVIYLT
CCCCCEEHHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEE
AEKFMYGFVAALKAQTAIAFKEKLRTIDILVIDDVQFLQGKSIQQEFCHTLNALIDAGRQ
HHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHCCCCHHHHHHHHHHHHHHCCCE
IVIAADRPPADLESLDERVRSRLAGGLCVEMGALDEALRIKILETRIGAAKLVHPYFDVP
EEEECCCCCCCHHHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHHHCHHHHHCCCCCCC
QPVIAYVASVIQTNGRDLDGAVNRLLAHASLTSVPLTIEIAETAIRDLVRTKEPKRVKIE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCHH
EIQKLVASHFNVSRADILSSRRTANVVRPRQIAMYLSKIMTLRSLPEIGRRFGGRDHTTV
HHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LHAVRKIENLASTDNHLSEELELLKRMLME
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA