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The map label for this gene is gcvT [H]

Identifier: 17548010

GI number: 17548010

Start: 3545939

End: 3547066

Strand: Direct

Name: gcvT [H]

Synonym: RSc3293

Alternate gene names: 17548010

Gene position: 3545939-3547066 (Clockwise)

Preceding gene: 17548008

Following gene: 17548011

Centisome position: 95.41

GC content: 69.68

Gene sequence:

>1128_bases
ATGACGCTCCAACACACGCCGCTCAATGCCATCCACCGCTCGCTGGGCGCCCGCATGGTCGACTTTGGCGGCTGGGACAT
GCCGGTCAACTACGGCTCCCAGATCGAGGAACATCACGCCGTGCGCCGCGATGCCGGCATCTTCGACGTCTCGCACATGT
GCGTGGTCGACCTGACCGGTGCGCGGGTGCGCGATTTCCTGCGCGGGCTGCTCGCCAACAACATCGACAAGCTGCAGACC
CCGGGCAAAGCGCTCTACACCTGCATGCTCAACCCCAAGGGCGGCGTGATCGATGACCTGATCGTCTATTTCTTCCGCGA
GGACTGGTTCCGCCTGGTGGTCAACGCCGGCACCGCGCCGACCGACATCGAGTGGATCACCGCGCAGAACGCCGCCGCCG
GCACGGGCGTGGCCATCACGCCGCGCCGCTCCGACAACAACGCGGGCGCGGAACCCCTCGGCATCGTGGCCGTGCAGGGC
CCGAACGCGCGCGCCAAGGCCTACGCCGCCTTGCCGGGCACGCAGGCGGTGGGCGAGGCGCTCAAGCCGTTCAACGCTGG
CTTCGCCACCATCGACGGCGTGGGCGAGATCATGGTCGCGCGCACCGGCTACACGGGGGAAGACGGCTTCGAGCTGGTGG
TGCCCGCCGCGCAGATCGCCGGCGTCTGGGAGCGCCTGCTGCAGGCCGGCGTGCGCCCCTGCGGCCTGGGCGCGCGCGAC
ACGCTGCGCCTGGAAGCCGGCATGAACCTCTACGGCCAGGACATGGACGAGCACGTCTCGCCGCTGGACGCGGGCCTGGC
CTGGACGGTCGACCTGCAAAGCGAGCGCGACTTCAACGGCAAGGCGGCGCTCGCCGCCAACGGCCAGCGCGACCAGTTCG
TCGGCCTGCTGCTGCGCGACAAGGGCGGCGTGCTGCGCGCCCACCAGAAAGTCATCACGGCCGCCGGTGACGGCGAAATC
ACCAGCGGCACCTTCAGCCCCAGCCTGTCGCAGTCGATCGCGCTGGCGCGCCTGCCCAAGGACGTGGCCATCGGCGCGGA
CGTGCAGGTCGAGATCCGCGACCGCAGGCTGACCGCGACTGTGGTTAAACTGCCGTTCGTGCGCAATGGCAAGGCGCTGG
TCAGCTGA

Upstream 100 bases:

>100_bases
TGAGGCGTCAGGCTGCGCGGGTGGCCTTTTTGCTTTTTGGCCCCGAACCACACGCGCCGCGCGCCCAGGCCACCTGGCGG
CGCTCCTGCCGAGAGATTCC

Downstream 100 bases:

>100_bases
ATCCCGAATTCGAACCCATCCTCATCCTTCTTCCGGAGAACCCTTCATGAGCAACACGCCCGTAGAGCTGAAGTACACCG
AATCCCACGAGTGGGTCCGC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MTLQHTPLNAIHRSLGARMVDFGGWDMPVNYGSQIEEHHAVRRDAGIFDVSHMCVVDLTGARVRDFLRGLLANNIDKLQT
PGKALYTCMLNPKGGVIDDLIVYFFREDWFRLVVNAGTAPTDIEWITAQNAAAGTGVAITPRRSDNNAGAEPLGIVAVQG
PNARAKAYAALPGTQAVGEALKPFNAGFATIDGVGEIMVARTGYTGEDGFELVVPAAQIAGVWERLLQAGVRPCGLGARD
TLRLEAGMNLYGQDMDEHVSPLDAGLAWTVDLQSERDFNGKAALAANGQRDQFVGLLLRDKGGVLRAHQKVITAAGDGEI
TSGTFSPSLSQSIALARLPKDVAIGADVQVEIRDRRLTATVVKLPFVRNGKALVS

Sequences:

>Translated_375_residues
MTLQHTPLNAIHRSLGARMVDFGGWDMPVNYGSQIEEHHAVRRDAGIFDVSHMCVVDLTGARVRDFLRGLLANNIDKLQT
PGKALYTCMLNPKGGVIDDLIVYFFREDWFRLVVNAGTAPTDIEWITAQNAAAGTGVAITPRRSDNNAGAEPLGIVAVQG
PNARAKAYAALPGTQAVGEALKPFNAGFATIDGVGEIMVARTGYTGEDGFELVVPAAQIAGVWERLLQAGVRPCGLGARD
TLRLEAGMNLYGQDMDEHVSPLDAGLAWTVDLQSERDFNGKAALAANGQRDQFVGLLLRDKGGVLRAHQKVITAAGDGEI
TSGTFSPSLSQSIALARLPKDVAIGADVQVEIRDRRLTATVVKLPFVRNGKALVS
>Mature_374_residues
TLQHTPLNAIHRSLGARMVDFGGWDMPVNYGSQIEEHHAVRRDAGIFDVSHMCVVDLTGARVRDFLRGLLANNIDKLQTP
GKALYTCMLNPKGGVIDDLIVYFFREDWFRLVVNAGTAPTDIEWITAQNAAAGTGVAITPRRSDNNAGAEPLGIVAVQGP
NARAKAYAALPGTQAVGEALKPFNAGFATIDGVGEIMVARTGYTGEDGFELVVPAAQIAGVWERLLQAGVRPCGLGARDT
LRLEAGMNLYGQDMDEHVSPLDAGLAWTVDLQSERDFNGKAALAANGQRDQFVGLLLRDKGGVLRAHQKVITAAGDGEIT
SGTFSPSLSQSIALARLPKDVAIGADVQVEIRDRRLTATVVKLPFVRNGKALVS

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=384, Percent_Identity=34.1145833333333, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI257796258, Length=359, Percent_Identity=33.7047353760446, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI257796254, Length=379, Percent_Identity=31.1345646437995, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI257796256, Length=320, Percent_Identity=33.4375, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI24797151, Length=352, Percent_Identity=27.5568181818182, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI197927446, Length=298, Percent_Identity=28.5234899328859, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI21361378, Length=298, Percent_Identity=28.5234899328859, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1789272, Length=379, Percent_Identity=53.0343007915567, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17560118, Length=381, Percent_Identity=35.1706036745407, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71994045, Length=380, Percent_Identity=23.1578947368421, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994052, Length=380, Percent_Identity=23.1578947368421, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32563613, Length=274, Percent_Identity=27.007299270073, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320222, Length=393, Percent_Identity=35.3689567430025, Blast_Score=180, Evalue=4e-46,
Organism=Drosophila melanogaster, GI20129441, Length=383, Percent_Identity=34.7258485639687, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20130091, Length=296, Percent_Identity=29.0540540540541, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28571104, Length=274, Percent_Identity=27.007299270073, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40049; Mature: 39918

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQHTPLNAIHRSLGARMVDFGGWDMPVNYGSQIEEHHAVRRDAGIFDVSHMCVVDLTG
CCCCCCCHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEEECC
ARVRDFLRGLLANNIDKLQTPGKALYTCMLNPKGGVIDDLIVYFFREDWFRLVVNAGTAP
HHHHHHHHHHHHCCHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEEEEECCCCC
TDIEWITAQNAAAGTGVAITPRRSDNNAGAEPLGIVAVQGPNARAKAYAALPGTQAVGEA
CCEEEEEECCCCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCHHHHHHH
LKPFNAGFATIDGVGEIMVARTGYTGEDGFELVVPAAQIAGVWERLLQAGVRPCGLGARD
HCCCCCCCEEECCCCEEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCC
TLRLEAGMNLYGQDMDEHVSPLDAGLAWTVDLQSERDFNGKAALAANGQRDQFVGLLLRD
EEEEECCCCCCCCCHHHHCCHHCCCEEEEEEECCCCCCCCCEEEEECCCCCCEEEEEEEC
KGGVLRAHQKVITAAGDGEITSGTFSPSLSQSIALARLPKDVAIGADVQVEIRDRRLTAT
CCCEEEECCEEEEECCCCCEECCCCCCCHHHHHHHHHCCCCCEECCCEEEEEECCEEEEE
VVKLPFVRNGKALVS
EEECCEEECCCHHCC
>Mature Secondary Structure 
TLQHTPLNAIHRSLGARMVDFGGWDMPVNYGSQIEEHHAVRRDAGIFDVSHMCVVDLTG
CCCCCCHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEEECC
ARVRDFLRGLLANNIDKLQTPGKALYTCMLNPKGGVIDDLIVYFFREDWFRLVVNAGTAP
HHHHHHHHHHHHCCHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEEEEECCCCC
TDIEWITAQNAAAGTGVAITPRRSDNNAGAEPLGIVAVQGPNARAKAYAALPGTQAVGEA
CCEEEEEECCCCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCHHHHHHH
LKPFNAGFATIDGVGEIMVARTGYTGEDGFELVVPAAQIAGVWERLLQAGVRPCGLGARD
HCCCCCCCEEECCCCEEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCC
TLRLEAGMNLYGQDMDEHVSPLDAGLAWTVDLQSERDFNGKAALAANGQRDQFVGLLLRD
EEEEECCCCCCCCCHHHHCCHHCCCEEEEEEECCCCCCCCCEEEEECCCCCCEEEEEEEC
KGGVLRAHQKVITAAGDGEITSGTFSPSLSQSIALARLPKDVAIGADVQVEIRDRRLTAT
CCCEEEECCEEEEECCCCCEECCCCCCCHHHHHHHHHCCCCCEECCCEEEEEECCEEEEE
VVKLPFVRNGKALVS
EEECCEEECCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA