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The map label for this gene is glxR [H]

Identifier: 17548000

GI number: 17548000

Start: 3533964

End: 3534875

Strand: Direct

Name: glxR [H]

Synonym: RSc3283

Alternate gene names: 17548000

Gene position: 3533964-3534875 (Clockwise)

Preceding gene: 17547999

Following gene: 17548002

Centisome position: 95.09

GC content: 69.19

Gene sequence:

>912_bases
ATGGCAACCTCCCTCAACCTCGGCTTCATCGGCCTCGGCATCATGGGCGCCCCCATGGCCGGCCACCTGCGCGCCGCCGG
CCACACGCTGTTCGTGCACGACGTCAATCCGGCCCCGGCCGCGCTGGTGGAAGCGGGCGTGACGGTCTGCACCAGCGCGG
AGGAAGTCGCCAAGCGCGCCGACATCGTGTTCATCATGGTCCCCGACACGCCGCATGTGGAAGCGGTGCTGTTCGGCGAG
AAGGGCGTGGCCAAGGCGCTCAAGGATGCAGGCAAGGCCGCCGCGGCTGGCAGGATCGTCGTCGACATGAGCTCGATCTC
GCCGATCGCCACCAAGGACTTCGCCGCGCGCGTCAACAAGCTGGGTGCGCAGTATCTGGACGCGCCGGTGTCCGGCGGCG
AGGTGGGCGCACGGGCCGCGTCGCTGACGATCATGGTCGGCGGCGCGCAGGCCGCGTTCGAGCGCGTGCTGCCGCTGTTC
CAGCGCATGGGCAAGCACATCACGCTGGTGGGCGGCAACGGCGACGGCCAGACCACCAAGGTGGCCAACCAGATCATCGT
GGCGCTGAACATCCAGGCGGTGTCGGAGGCGCTGCTATTCGCCTCCAAGGCGGGTGCCGATCCGGCCAGGGTGCGCGAGG
CGCTGATGGGCGGCTTCGCGGCGTCGCGCATCCTGGAGGTGCACGGCGACCGCATGGTCAAGCGCACCTTCGACCCGGGT
TTCCGCATCGAACTGCACCAGAAGGACCTGAACCTGGCCCTGCAAGGCGCGAAGGCGCTGGGCGTGGCGCTGCCCAACAC
CGCCACCGCCCAGGAGCTGTTCAACACCTGCGCGGCCAACGGCCTGGGCAAGCAGGATCACTCGGCGCTGTGCCGCGCGA
TCGAGATCATGTCGAACCACGCGATCGCCTGA

Upstream 100 bases:

>100_bases
GGCAAGACAAAGAAAGTGAGTCGGCCCCGGCAGGGGACGAAACAAGGAATGAACCACCAAGGTTCAAACACACATCAATC
CAACCAAGGAGCCCCTCACC

Downstream 100 bases:

>100_bases
GCCGCGCGGCCGAGGCAGCGACTTCCGGCCCGGGCGCTCAGACGACCTTGGAGTAGCGCGGGACGCCGCCCACAGTCGGC
ACCTGCACGTGGACCGCGTG

Product: transmembrane 2-hydroxy-3-oxopropionate reductase oxidoreductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MATSLNLGFIGLGIMGAPMAGHLRAAGHTLFVHDVNPAPAALVEAGVTVCTSAEEVAKRADIVFIMVPDTPHVEAVLFGE
KGVAKALKDAGKAAAAGRIVVDMSSISPIATKDFAARVNKLGAQYLDAPVSGGEVGARAASLTIMVGGAQAAFERVLPLF
QRMGKHITLVGGNGDGQTTKVANQIIVALNIQAVSEALLFASKAGADPARVREALMGGFAASRILEVHGDRMVKRTFDPG
FRIELHQKDLNLALQGAKALGVALPNTATAQELFNTCAANGLGKQDHSALCRAIEIMSNHAIA

Sequences:

>Translated_303_residues
MATSLNLGFIGLGIMGAPMAGHLRAAGHTLFVHDVNPAPAALVEAGVTVCTSAEEVAKRADIVFIMVPDTPHVEAVLFGE
KGVAKALKDAGKAAAAGRIVVDMSSISPIATKDFAARVNKLGAQYLDAPVSGGEVGARAASLTIMVGGAQAAFERVLPLF
QRMGKHITLVGGNGDGQTTKVANQIIVALNIQAVSEALLFASKAGADPARVREALMGGFAASRILEVHGDRMVKRTFDPG
FRIELHQKDLNLALQGAKALGVALPNTATAQELFNTCAANGLGKQDHSALCRAIEIMSNHAIA
>Mature_302_residues
ATSLNLGFIGLGIMGAPMAGHLRAAGHTLFVHDVNPAPAALVEAGVTVCTSAEEVAKRADIVFIMVPDTPHVEAVLFGEK
GVAKALKDAGKAAAAGRIVVDMSSISPIATKDFAARVNKLGAQYLDAPVSGGEVGARAASLTIMVGGAQAAFERVLPLFQ
RMGKHITLVGGNGDGQTTKVANQIIVALNIQAVSEALLFASKAGADPARVREALMGGFAASRILEVHGDRMVKRTFDPGF
RIELHQKDLNLALQGAKALGVALPNTATAQELFNTCAANGLGKQDHSALCRAIEIMSNHAIA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=308, Percent_Identity=30.8441558441558, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI40556376, Length=292, Percent_Identity=26.7123287671233, Blast_Score=104, Evalue=8e-23,
Organism=Escherichia coli, GI1786719, Length=299, Percent_Identity=67.5585284280936, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI145693186, Length=292, Percent_Identity=42.8082191780822, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1790315, Length=294, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=31.3993174061433, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17557316, Length=289, Percent_Identity=31.4878892733564, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24655230, Length=293, Percent_Identity=36.1774744027304, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI19922568, Length=293, Percent_Identity=36.1774744027304, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI28574115, Length=285, Percent_Identity=27.3684210526316, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31301; Mature: 31169

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATSLNLGFIGLGIMGAPMAGHLRAAGHTLFVHDVNPAPAALVEAGVTVCTSAEEVAKRA
CCCCCCCCEEEECHHCCCCCCCHHHCCCEEEEEECCCCHHHHHHCCCCEECCHHHHHHHC
DIVFIMVPDTPHVEAVLFGEKGVAKALKDAGKAAAAGRIVVDMSSISPIATKDFAARVNK
CEEEEEECCCCCEEEEEECCCHHHHHHHHCCCHHHCCEEEEEECCCCCCHHHHHHHHHHH
LGAQYLDAPVSGGEVGARAASLTIMVGGAQAAFERVLPLFQRMGKHITLVGGNGDGQTTK
HHHHHHCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHH
VANQIIVALNIQAVSEALLFASKAGADPARVREALMGGFAASRILEVHGDRMVKRTFDPG
HHCEEEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
FRIELHQKDLNLALQGAKALGVALPNTATAQELFNTCAANGLGKQDHSALCRAIEIMSNH
CEEEEECCCCCEEEECCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
AIA
CCC
>Mature Secondary Structure 
ATSLNLGFIGLGIMGAPMAGHLRAAGHTLFVHDVNPAPAALVEAGVTVCTSAEEVAKRA
CCCCCCCEEEECHHCCCCCCCHHHCCCEEEEEECCCCHHHHHHCCCCEECCHHHHHHHC
DIVFIMVPDTPHVEAVLFGEKGVAKALKDAGKAAAAGRIVVDMSSISPIATKDFAARVNK
CEEEEEECCCCCEEEEEECCCHHHHHHHHCCCHHHCCEEEEEECCCCCCHHHHHHHHHHH
LGAQYLDAPVSGGEVGARAASLTIMVGGAQAAFERVLPLFQRMGKHITLVGGNGDGQTTK
HHHHHHCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHH
VANQIIVALNIQAVSEALLFASKAGADPARVREALMGGFAASRILEVHGDRMVKRTFDPG
HHCEEEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
FRIELHQKDLNLALQGAKALGVALPNTATAQELFNTCAANGLGKQDHSALCRAIEIMSNH
CEEEEECCCCCEEEECCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
AIA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]