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The map label for this gene is hyi [H]

Identifier: 17547999

GI number: 17547999

Start: 3532701

End: 3533483

Strand: Direct

Name: hyi [H]

Synonym: RSc3282

Alternate gene names: 17547999

Gene position: 3532701-3533483 (Clockwise)

Preceding gene: 17547998

Following gene: 17548000

Centisome position: 95.06

GC content: 65.64

Gene sequence:

>783_bases
ATGCCGAAGCTGGCTGCCAACCTGACCATGCTGTTCAACGAACACGCCTTCCTCGAGCGCTTCGAAGCCGCCGCGCGCGC
GGGCTTCCGCGGCGTGGAGTTCCTGTTCCCCTACGCCTGCCACGCCGACCAGATCGCCGATCGGCTGCACCGCTTCCAGC
TCGACCTGGTGCTGCACAACCTGCCTGCCGGCCACTGGGATGCCGGCGAACGCGGCATCGCCGTGCTGCCCGATCGCGTG
GGCGAGTTCCAGGACGGCGTGGGTGAGGCGATCCGGTACGCCAAGGTGCTGGGCGTGCGGCAACTCAACTGCCTGGCGGG
CATCCGCCCCGAATCGGTGAGCGAGGATGTGGCGCGCCGCACGCTGGTCGACAACCTGACGTTCGCGGCCAAGGCACTGG
CGGCCGAGCAGATCGATCTGCTGATCGAGCCGATCAACACCTTCGATCTGCCCGGCTTCTATCTGTGCCGCACGCAGCAG
GCACTGGACCTGATCGCCGACGTGGGCGCGGACAACCTGTTCGTGCAGTACGACATCTATCACATGCAGCGGATGGAGGG
CGAGGTGGCCAACACGCTGCGCCGTCATCTCGACCGCATCCGCCATGTGCAGTTGGCGGACACCCCCGGGCGCAATGAGC
CCGGCACCGGCGAGATCAACTACCCGTTCCTGTTCCGATGGCTGGATGAGATTGGCTACGACGGCTGGGTTGGATGTGAG
TACAAACCCAAGGCTGGGACGGTTGAGGGGCTGGGCTGGAGGTCGGCTTACAAGGTTGCTTGA

Upstream 100 bases:

>100_bases
ACGTGGTCGAGTTCGACACGCCCCTCGACCTGCAAGACACGCTGGACGAAGCCGAAGGCGCCACCACCTGAGCACACGCA
CCACAGACACGGAGACCGAC

Downstream 100 bases:

>100_bases
TGGGGTGTTTGCCTTTGTTTGGGTGTTGGTGGTGCAGCGGTGCTGGGCTTGGTGGTGCAACCCTTGTTTCATCCCCTGCC
GGGGCTGACTCACTTTCTTT

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MPKLAANLTMLFNEHAFLERFEAAARAGFRGVEFLFPYACHADQIADRLHRFQLDLVLHNLPAGHWDAGERGIAVLPDRV
GEFQDGVGEAIRYAKVLGVRQLNCLAGIRPESVSEDVARRTLVDNLTFAAKALAAEQIDLLIEPINTFDLPGFYLCRTQQ
ALDLIADVGADNLFVQYDIYHMQRMEGEVANTLRRHLDRIRHVQLADTPGRNEPGTGEINYPFLFRWLDEIGYDGWVGCE
YKPKAGTVEGLGWRSAYKVA

Sequences:

>Translated_260_residues
MPKLAANLTMLFNEHAFLERFEAAARAGFRGVEFLFPYACHADQIADRLHRFQLDLVLHNLPAGHWDAGERGIAVLPDRV
GEFQDGVGEAIRYAKVLGVRQLNCLAGIRPESVSEDVARRTLVDNLTFAAKALAAEQIDLLIEPINTFDLPGFYLCRTQQ
ALDLIADVGADNLFVQYDIYHMQRMEGEVANTLRRHLDRIRHVQLADTPGRNEPGTGEINYPFLFRWLDEIGYDGWVGCE
YKPKAGTVEGLGWRSAYKVA
>Mature_259_residues
PKLAANLTMLFNEHAFLERFEAAARAGFRGVEFLFPYACHADQIADRLHRFQLDLVLHNLPAGHWDAGERGIAVLPDRVG
EFQDGVGEAIRYAKVLGVRQLNCLAGIRPESVSEDVARRTLVDNLTFAAKALAAEQIDLLIEPINTFDLPGFYLCRTQQA
LDLIADVGADNLFVQYDIYHMQRMEGEVANTLRRHLDRIRHVQLADTPGRNEPGTGEINYPFLFRWLDEIGYDGWVGCEY
KPKAGTVEGLGWRSAYKVA

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=262, Percent_Identity=40.0763358778626, Blast_Score=184, Evalue=6e-47,
Organism=Homo sapiens, GI300068964, Length=243, Percent_Identity=38.6831275720165, Blast_Score=158, Evalue=5e-39,
Organism=Escherichia coli, GI1786718, Length=258, Percent_Identity=56.2015503875969, Blast_Score=298, Evalue=2e-82,
Organism=Escherichia coli, GI1789095, Length=258, Percent_Identity=41.4728682170543, Blast_Score=217, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17552022, Length=254, Percent_Identity=35.8267716535433, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17530883, Length=257, Percent_Identity=37.7431906614786, Blast_Score=166, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 29259; Mature: 29127

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLAANLTMLFNEHAFLERFEAAARAGFRGVEFLFPYACHADQIADRLHRFQLDLVLHN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LPAGHWDAGERGIAVLPDRVGEFQDGVGEAIRYAKVLGVRQLNCLAGIRPESVSEDVARR
CCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
TLVDNLTFAAKALAAEQIDLLIEPINTFDLPGFYLCRTQQALDLIADVGADNLFVQYDIY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEHHH
HMQRMEGEVANTLRRHLDRIRHVQLADTPGRNEPGTGEINYPFLFRWLDEIGYDGWVGCE
HHHHHCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCE
YKPKAGTVEGLGWRSAYKVA
ECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PKLAANLTMLFNEHAFLERFEAAARAGFRGVEFLFPYACHADQIADRLHRFQLDLVLHN
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LPAGHWDAGERGIAVLPDRVGEFQDGVGEAIRYAKVLGVRQLNCLAGIRPESVSEDVARR
CCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
TLVDNLTFAAKALAAEQIDLLIEPINTFDLPGFYLCRTQQALDLIADVGADNLFVQYDIY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEHHH
HMQRMEGEVANTLRRHLDRIRHVQLADTPGRNEPGTGEINYPFLFRWLDEIGYDGWVGCE
HHHHHCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCE
YKPKAGTVEGLGWRSAYKVA
ECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]