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The map label for this gene is nodT [H]

Identifier: 17547927

GI number: 17547927

Start: 3469781

End: 3471241

Strand: Direct

Name: nodT [H]

Synonym: RSc3208

Alternate gene names: 17547927

Gene position: 3469781-3471241 (Clockwise)

Preceding gene: 17547920

Following gene: 17547928

Centisome position: 93.36

GC content: 66.19

Gene sequence:

>1461_bases
ATGTTGCCAAAACGCTCCCTTGCGGCCCTTTTCGTTGCCAGCCTGGCAACCGGTTGTGCCGTCGGCCCCGATTATGTGAA
GCCCGATGTGCCGGTTCCACAACGACTCCAGGGCCAGACGGCGGTCGAGCAGCGCACCGCCAATGCTGCAGCCGATCTCT
CCGCATGGTGGGCCGGCTTTGGCGATCCGCAACTCACGCGGTTCGTGCTGCTCTCGCTGGAACAGAACCTGGACCTCGCA
CAGGCATTCGCCCGCGTCACGCAAGCGCGTGCGGGCCTTGGCGCTGCCAATGCCGCGTTGCTGCCCTCCGGCAATGTCAC
GGGCCAGGCCGCGCGTGCGTACCAGTCCGTCGAAACCCCTTTGGGCCGCGTCTTGAATTCGAGGCCCGGCTTCGACCGCT
ACGGCAACGCTTTTGAGGCCGATGTCAACGCAAGCTGGGAGTTGGACGTATTCGGCGGCCTACGCCGTGGCCGCGAGGCG
GCACTTGCCGACTACCAGGCCTCCCAAGCCGGCGCAGTCGCCACACGGCTGGTCGTGGCCGCACAGACTGCCGATATCTA
CATCACCATCCGCGGCTTGCAGACGCGCCTGAAGGTGGCCCGCCATCAGGTACAGACGCAAGAGGAATTGCTCTCCACCG
TCAACCTGCTGTACGGCAAGGGACTGGCGGCCGAGCTTCAAGTCAGGCAGGCCGAAGGCGCACTCGCTCAGGTTCGCGCT
TCCATCCCACAGCTTGAGGCGGGCCTCGATGCGGCGATGAACGCGCTGGACGTGATGCTCGGCTCGCTGCCGGGCACGCA
CCGGGCCAAACTGGCAGAAGGCGGCGACATCCCGGCCGCCCCGCAGGTTGCAATTATCGGATCCCCCGGCGAACTGCTGA
GGCGCCGCCCCGACCTCATCGTCGCCGAGCGCCGCCTAGCCGCTTCCAACGCGCGCATTGGCGTCGCCATTGCCGAGTAC
TACCCGAAGTTCTCGCTCAGCGGCCTGCTCGGCAGCGCCACATCCGTGGGAGCCGGCAGTCTATTCGGCAGCGGCGCCAG
TCAATTTGCCGGCGTGCTCGGCCTGCGCTGGCGCCTGTTCGACTTCGGCCGTATTAATGCGCAAATCGATCAGGCCAAGG
GGCAAGAGGCGGAGATGCTCGCCGCGTACCGGCTCGCCGTGCTGCGCGCCACGGAAGACGTGGAAGACGCCTTCTCTGCC
CTGGTCAAGCGCGAGGAGCAAGCGGCCGTGCTCACGCAAGGCGTGGATTCGCTTGGCCGCGCCCGAAACGCTTCGTTTGC
CGCTTACCAGAAAGGCGTCGTCAGCCTGATTGAAGTCCTGCAAGCCGACGAAAGCCTGTTGCGTGCATCAGACGCGCGCG
CCCAGGCGCAAACGGAATCGGCGCGCGCTGCCGTCGCGGCATTCAAGGCGCTGGGCGGCGGCTGGCAGCCTGACGAATCG
ACCGCCGTTGCAAGCAAATAG

Upstream 100 bases:

>100_bases
GGGGTGGTCTTCATGGGCTCCAGCTTACGCGAGTCGCGATAGTTGAACAACTTGTGACCATTTTGTACTATAGTCACTAA
AAATCCGATGGAAGAACCCC

Downstream 100 bases:

>100_bases
TCCCCCCGCGAATGAGGCTGCGCATCCAGCGTGGCTCATCGCAACAACCGATTTACCGCCGCTCCAATTCACCCATACAG
AAAGAAACTGCCATGTCCAA

Product: drug efflux lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MLPKRSLAALFVASLATGCAVGPDYVKPDVPVPQRLQGQTAVEQRTANAAADLSAWWAGFGDPQLTRFVLLSLEQNLDLA
QAFARVTQARAGLGAANAALLPSGNVTGQAARAYQSVETPLGRVLNSRPGFDRYGNAFEADVNASWELDVFGGLRRGREA
ALADYQASQAGAVATRLVVAAQTADIYITIRGLQTRLKVARHQVQTQEELLSTVNLLYGKGLAAELQVRQAEGALAQVRA
SIPQLEAGLDAAMNALDVMLGSLPGTHRAKLAEGGDIPAAPQVAIIGSPGELLRRRPDLIVAERRLAASNARIGVAIAEY
YPKFSLSGLLGSATSVGAGSLFGSGASQFAGVLGLRWRLFDFGRINAQIDQAKGQEAEMLAAYRLAVLRATEDVEDAFSA
LVKREEQAAVLTQGVDSLGRARNASFAAYQKGVVSLIEVLQADESLLRASDARAQAQTESARAAVAAFKALGGGWQPDES
TAVASK

Sequences:

>Translated_486_residues
MLPKRSLAALFVASLATGCAVGPDYVKPDVPVPQRLQGQTAVEQRTANAAADLSAWWAGFGDPQLTRFVLLSLEQNLDLA
QAFARVTQARAGLGAANAALLPSGNVTGQAARAYQSVETPLGRVLNSRPGFDRYGNAFEADVNASWELDVFGGLRRGREA
ALADYQASQAGAVATRLVVAAQTADIYITIRGLQTRLKVARHQVQTQEELLSTVNLLYGKGLAAELQVRQAEGALAQVRA
SIPQLEAGLDAAMNALDVMLGSLPGTHRAKLAEGGDIPAAPQVAIIGSPGELLRRRPDLIVAERRLAASNARIGVAIAEY
YPKFSLSGLLGSATSVGAGSLFGSGASQFAGVLGLRWRLFDFGRINAQIDQAKGQEAEMLAAYRLAVLRATEDVEDAFSA
LVKREEQAAVLTQGVDSLGRARNASFAAYQKGVVSLIEVLQADESLLRASDARAQAQTESARAAVAAFKALGGGWQPDES
TAVASK
>Mature_486_residues
MLPKRSLAALFVASLATGCAVGPDYVKPDVPVPQRLQGQTAVEQRTANAAADLSAWWAGFGDPQLTRFVLLSLEQNLDLA
QAFARVTQARAGLGAANAALLPSGNVTGQAARAYQSVETPLGRVLNSRPGFDRYGNAFEADVNASWELDVFGGLRRGREA
ALADYQASQAGAVATRLVVAAQTADIYITIRGLQTRLKVARHQVQTQEELLSTVNLLYGKGLAAELQVRQAEGALAQVRA
SIPQLEAGLDAAMNALDVMLGSLPGTHRAKLAEGGDIPAAPQVAIIGSPGELLRRRPDLIVAERRLAASNARIGVAIAEY
YPKFSLSGLLGSATSVGAGSLFGSGASQFAGVLGLRWRLFDFGRINAQIDQAKGQEAEMLAAYRLAVLRATEDVEDAFSA
LVKREEQAAVLTQGVDSLGRARNASFAAYQKGVVSLIEVLQADESLLRASDARAQAQTESARAAVAAFKALGGGWQPDES
TAVASK

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=477, Percent_Identity=26.6247379454927, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI2367348, Length=502, Percent_Identity=25.8964143426295, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51102; Mature: 51102

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPKRSLAALFVASLATGCAVGPDYVKPDVPVPQRLQGQTAVEQRTANAAADLSAWWAGF
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCC
GDPQLTRFVLLSLEQNLDLAQAFARVTQARAGLGAANAALLPSGNVTGQAARAYQSVETP
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHH
LGRVLNSRPGFDRYGNAFEADVNASWELDVFGGLRRGREAALADYQASQAGAVATRLVVA
HHHHHCCCCCCCCCCCCEEECCCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHE
AQTADIYITIRGLQTRLKVARHQVQTQEELLSTVNLLYGKGLAAELQVRQAEGALAQVRA
EEECEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
SIPQLEAGLDAAMNALDVMLGSLPGTHRAKLAEGGDIPAAPQVAIIGSPGELLRRRPDLI
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEEECCCHHHHHCCCCCE
VAERRLAASNARIGVAIAEYYPKFSLSGLLGSATSVGAGSLFGSGASQFAGVLGLRWRLF
EHHHHHHHCCCCEEEEHHHHCCCHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHEE
DFGRINAQIDQAKGQEAEMLAAYRLAVLRATEDVEDAFSALVKREEQAAVLTQGVDSLGR
ECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARNASFAAYQKGVVSLIEVLQADESLLRASDARAQAQTESARAAVAAFKALGGGWQPDES
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TAVASK
CCCCCC
>Mature Secondary Structure
MLPKRSLAALFVASLATGCAVGPDYVKPDVPVPQRLQGQTAVEQRTANAAADLSAWWAGF
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCC
GDPQLTRFVLLSLEQNLDLAQAFARVTQARAGLGAANAALLPSGNVTGQAARAYQSVETP
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHH
LGRVLNSRPGFDRYGNAFEADVNASWELDVFGGLRRGREAALADYQASQAGAVATRLVVA
HHHHHCCCCCCCCCCCCEEECCCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHE
AQTADIYITIRGLQTRLKVARHQVQTQEELLSTVNLLYGKGLAAELQVRQAEGALAQVRA
EEECEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
SIPQLEAGLDAAMNALDVMLGSLPGTHRAKLAEGGDIPAAPQVAIIGSPGELLRRRPDLI
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEEECCCHHHHHCCCCCE
VAERRLAASNARIGVAIAEYYPKFSLSGLLGSATSVGAGSLFGSGASQFAGVLGLRWRLF
EHHHHHHHCCCCEEEEHHHHCCCHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHEE
DFGRINAQIDQAKGQEAEMLAAYRLAVLRATEDVEDAFSALVKREEQAAVLTQGVDSLGR
ECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARNASFAAYQKGVVSLIEVLQADESLLRASDARAQAQTESARAAVAAFKALGGGWQPDES
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TAVASK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]