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The map label for this gene is pcoS [H]

Identifier: 17547655

GI number: 17547655

Start: 3167052

End: 3168554

Strand: Direct

Name: pcoS [H]

Synonym: RSc2936

Alternate gene names: 17547655

Gene position: 3167052-3168554 (Clockwise)

Preceding gene: 17547654

Following gene: 17547656

Centisome position: 85.22

GC content: 71.86

Gene sequence:

>1503_bases
ATGACGCGACGCTTTGCCCTGCTGCCGCGCAGCCTCAAGCTGACGCTGCTGTGGCTCCTGCTGCCGGGGCTGGTCGGCGT
GCTGGCGATCGATACGCTGTCGGCGTACCAGTCGCTGCGCACGGCGACCGACCGCGCCTATGACCGCGCGCTGCTCGGCT
CGGTGCGCGCCATCGAGAACGGCGTGACGATCGAGCGCGGGCAGGTGCAGGTCAACGTGCCATACGTCGCGCTGTCGATG
TTCGAGTCGACCGCGCAGAGCAACGTGTACTACCGGGTCGCCTACGAACAGGCGGCCGGGGCGGCGGCCCTCACCGGCTA
CGCCGACCTGCCGCTGCCGGCCGGCGCGCTCGACAACGACACGCCCCGCTTCTACGACACGCTATACCACGGCGAGCCGG
TACGGATCGCGGCCGTGGCCAAGCCGCTGTACCAGCCGGGGCTGCCGGCGCGCATCGTGATCCAGGTGGCCGAGACCATC
GAGACGCGGCGCGCGCTGCAGCAAGCGGTGTGGCGTGGCATGCTGGCCCGCGATGCGGCGCTGGTGGCGATAAGCGTGGC
GCTGCTGTGGCTGGGCGTGACGTTGGCGCTGCGGCCGCTCAAGCGGCTAGCACGCGGCATTGCCGCGCGCGCCTCCGATG
ACCTGCGCCCGCTCGACGCCACCGACGTGCCGGCCGAAGTGCGGCCGCTGGTGCAGGCGATCAATCACCACATCCATCGC
TATGCCGAACTGGCGGCGGCGCAGAGCCAGTTCCTGGCCGATGCGTCGCACCAGCTGCGCACGCCGCTGGCGGTGCTGCT
GACCCAGGCCGAGTACGCACTGCGCGAGACCGATCCGGTGCGGGTGCGCGAGGGCCTGGCCGCCATCATCGCGCGGCTGC
AGTCCACCAATCGCCTGACCTCCCAGTTGCTGGCGCTGGCGCGTGCCCGCCACGCCGGCCAGGATGCGCCGCCCGAGACC
TTCGATCTGGGCGAGCTCGCGCGCAGCGTGGTGGTCGATGCGCTACCGCTGGCGCGCGAAAAGCAGCAGGACCTGGGCTG
GGACGACAGCGGACTGGCCGCGGCGCTGCCGGTGTCGGGCTATCCGGCGTTCCTGCGCGAGGCGCTGTCCAACCTCGTGC
ACAACGCCATCCGCTATACGCCGCCGGGCGGCCGCATCACCGTGCGCGCCATCAAGGACAGCGACGCCGCACTCGTTTGC
GTGGACGACACGGGCCCCGGCATGAATGCCGTGGAACGTGCCCATGCCTTCGAGCGCTTCCGCCGCGCGCACGAGGGCGG
GACGCTGCCGGGCGGCCCCAAGGATGCGCGCTATGCCGCCGAAGGCTCGGGGCTGGGGCTGGCCATCGCGCGCGCCTATG
CCGCCCGCAGCGGTGGGCGGATCGAGCTGGCCGACGGCGAGCCGAACAGCCGTGGCGGCGTGGGGCTTTCCGCCCGGATC
CGGGTACCGCTGACAAGGACCGCCACCGGCACTCAGCATGCTGCGACGCAGCAGGTGCAATGA

Upstream 100 bases:

>100_bases
CGGGGTCCGGTGTGCAGATCGTCACGGTGCGCGGGCTGGGCTACCTGCTCGAAGCCGAAGCGAGCGGCGTCCCGCAGGCG
GCGGGCGACACATCCGCGCC

Downstream 100 bases:

>100_bases
AAGCATGACGAAAGCGCGCGATTTCTATAATCCGCCGCACCTGGGGTCATCTGTACAGAGCCGCGCAAGAAAAAGCGGCC
GACTCCATGCCATCACAAGC

Product: transmembrane sensor kinase transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MTRRFALLPRSLKLTLLWLLLPGLVGVLAIDTLSAYQSLRTATDRAYDRALLGSVRAIENGVTIERGQVQVNVPYVALSM
FESTAQSNVYYRVAYEQAAGAAALTGYADLPLPAGALDNDTPRFYDTLYHGEPVRIAAVAKPLYQPGLPARIVIQVAETI
ETRRALQQAVWRGMLARDAALVAISVALLWLGVTLALRPLKRLARGIAARASDDLRPLDATDVPAEVRPLVQAINHHIHR
YAELAAAQSQFLADASHQLRTPLAVLLTQAEYALRETDPVRVREGLAAIIARLQSTNRLTSQLLALARARHAGQDAPPET
FDLGELARSVVVDALPLAREKQQDLGWDDSGLAAALPVSGYPAFLREALSNLVHNAIRYTPPGGRITVRAIKDSDAALVC
VDDTGPGMNAVERAHAFERFRRAHEGGTLPGGPKDARYAAEGSGLGLAIARAYAARSGGRIELADGEPNSRGGVGLSARI
RVPLTRTATGTQHAATQQVQ

Sequences:

>Translated_500_residues
MTRRFALLPRSLKLTLLWLLLPGLVGVLAIDTLSAYQSLRTATDRAYDRALLGSVRAIENGVTIERGQVQVNVPYVALSM
FESTAQSNVYYRVAYEQAAGAAALTGYADLPLPAGALDNDTPRFYDTLYHGEPVRIAAVAKPLYQPGLPARIVIQVAETI
ETRRALQQAVWRGMLARDAALVAISVALLWLGVTLALRPLKRLARGIAARASDDLRPLDATDVPAEVRPLVQAINHHIHR
YAELAAAQSQFLADASHQLRTPLAVLLTQAEYALRETDPVRVREGLAAIIARLQSTNRLTSQLLALARARHAGQDAPPET
FDLGELARSVVVDALPLAREKQQDLGWDDSGLAAALPVSGYPAFLREALSNLVHNAIRYTPPGGRITVRAIKDSDAALVC
VDDTGPGMNAVERAHAFERFRRAHEGGTLPGGPKDARYAAEGSGLGLAIARAYAARSGGRIELADGEPNSRGGVGLSARI
RVPLTRTATGTQHAATQQVQ
>Mature_499_residues
TRRFALLPRSLKLTLLWLLLPGLVGVLAIDTLSAYQSLRTATDRAYDRALLGSVRAIENGVTIERGQVQVNVPYVALSMF
ESTAQSNVYYRVAYEQAAGAAALTGYADLPLPAGALDNDTPRFYDTLYHGEPVRIAAVAKPLYQPGLPARIVIQVAETIE
TRRALQQAVWRGMLARDAALVAISVALLWLGVTLALRPLKRLARGIAARASDDLRPLDATDVPAEVRPLVQAINHHIHRY
AELAAAQSQFLADASHQLRTPLAVLLTQAEYALRETDPVRVREGLAAIIARLQSTNRLTSQLLALARARHAGQDAPPETF
DLGELARSVVVDALPLAREKQQDLGWDDSGLAAALPVSGYPAFLREALSNLVHNAIRYTPPGGRITVRAIKDSDAALVCV
DDTGPGMNAVERAHAFERFRRAHEGGTLPGGPKDARYAAEGSGLGLAIARAYAARSGGRIELADGEPNSRGGVGLSARIR
VPLTRTATGTQHAATQQVQ

Specific function: Probable member of a two-component regulatory system pcoS/pcoR. May activate pcoR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789403, Length=317, Percent_Identity=32.1766561514196, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1786783, Length=340, Percent_Identity=27.3529411764706, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790551, Length=294, Percent_Identity=30.6122448979592, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788279, Length=296, Percent_Identity=29.0540540540541, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=33.9285714285714, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1789808, Length=313, Percent_Identity=28.4345047923323, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=28.099173553719, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788393, Length=296, Percent_Identity=29.0540540540541, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082128, Length=312, Percent_Identity=27.5641025641026, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=27.8481012658228, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790861, Length=330, Percent_Identity=28.7878787878788, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788713, Length=268, Percent_Identity=25, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787374, Length=329, Percent_Identity=24.0121580547112, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53730; Mature: 53599

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRFALLPRSLKLTLLWLLLPGLVGVLAIDTLSAYQSLRTATDRAYDRALLGSVRAIEN
CCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVTIERGQVQVNVPYVALSMFESTAQSNVYYRVAYEQAAGAAALTGYADLPLPAGALDND
CCEEECCEEEEECCHHHHHHHHHHHHCCEEEEEEEHHCCCCCEECCCCCCCCCCCCCCCC
TPRFYDTLYHGEPVRIAAVAKPLYQPGLPARIVIQVAETIETRRALQQAVWRGMLARDAA
CCHHHHHHHCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAISVALLWLGVTLALRPLKRLARGIAARASDDLRPLDATDVPAEVRPLVQAINHHIHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
YAELAAAQSQFLADASHQLRTPLAVLLTQAEYALRETDPVRVREGLAAIIARLQSTNRLT
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SQLLALARARHAGQDAPPETFDLGELARSVVVDALPLAREKQQDLGWDDSGLAAALPVSG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCC
YPAFLREALSNLVHNAIRYTPPGGRITVRAIKDSDAALVCVDDTGPGMNAVERAHAFERF
CHHHHHHHHHHHHHHHHEECCCCCEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHH
RRAHEGGTLPGGPKDARYAAEGSGLGLAIARAYAARSGGRIELADGEPNSRGGVGLSARI
HHHHCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEE
RVPLTRTATGTQHAATQQVQ
EEEEEECCCCCHHHHHCCCC
>Mature Secondary Structure 
TRRFALLPRSLKLTLLWLLLPGLVGVLAIDTLSAYQSLRTATDRAYDRALLGSVRAIEN
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVTIERGQVQVNVPYVALSMFESTAQSNVYYRVAYEQAAGAAALTGYADLPLPAGALDND
CCEEECCEEEEECCHHHHHHHHHHHHCCEEEEEEEHHCCCCCEECCCCCCCCCCCCCCCC
TPRFYDTLYHGEPVRIAAVAKPLYQPGLPARIVIQVAETIETRRALQQAVWRGMLARDAA
CCHHHHHHHCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAISVALLWLGVTLALRPLKRLARGIAARASDDLRPLDATDVPAEVRPLVQAINHHIHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
YAELAAAQSQFLADASHQLRTPLAVLLTQAEYALRETDPVRVREGLAAIIARLQSTNRLT
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SQLLALARARHAGQDAPPETFDLGELARSVVVDALPLAREKQQDLGWDDSGLAAALPVSG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCC
YPAFLREALSNLVHNAIRYTPPGGRITVRAIKDSDAALVCVDDTGPGMNAVERAHAFERF
CHHHHHHHHHHHHHHHHEECCCCCEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHH
RRAHEGGTLPGGPKDARYAAEGSGLGLAIARAYAARSGGRIELADGEPNSRGGVGLSARI
HHHHCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEE
RVPLTRTATGTQHAATQQVQ
EEEEEECCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]