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The map label for this gene is hemK [H]

Identifier: 17547622

GI number: 17547622

Start: 3130149

End: 3131069

Strand: Direct

Name: hemK [H]

Synonym: RSc2903

Alternate gene names: 17547622

Gene position: 3130149-3131069 (Clockwise)

Preceding gene: 17547621

Following gene: 17547623

Centisome position: 84.23

GC content: 73.29

Gene sequence:

>921_bases
GTGCGCCCCGCCCTGCTCAACGACGGACCTGCCGTGCCTTCCACCTTCGCGATTCCACCCGATACGCTGCCGCGCGTGGC
CGATGCGCTCGCCGTGCTGACCGGCGCCGGCCTGCCCGCCCTGGAAGCACGCATGCTGGTGTCGCATGTGACCGGCCTGT
CGCGCGTGCAGCTGATCACGCAGGACACCTGCGGCATCGACGATGGCACACGCACACGACTGGCCGAGCTGGCGACCCGC
CGCCTGGCAGGCGAGCCGATGGCCTATCTGCTGGGCGAACGCGAATTCTTCGGGCGCATGTTCCAGGTGACGCCGGCCGT
GCTGATCCCGCGCCCGGACACCGAACTGCTGGTCGAGCAGGCGCTCGACCGCATCGACGACCGCGACGCGCCCGCCGTGC
TGGACCTCGGCACGGGCAGCGGCATTATCGCCGTCACCATTGCGCTGGCCAGGCGCGATGCGCGGGTGTGGGCCACCGAC
ACCTCCGCCGATGCGCTGGCCGTGGCCGTCCGCAATGCCCAGGCGCTCGGTGCCGCCAACATGCACGCCGCCCTGGGCGA
CTGGTACGCCGCCTTGCCCGAGAGCGACGCCCCGCCGGTGTTCGACCTCATCGTCAGCAACCCGCCCTACATTGCATCGA
CCGACGCGCACCTGGGCCAGGGCGACCTGCGCTTCGAACCCGCCGGCGCGCTCACCGACCACGGCGACGGCCTGCGCCAC
CTGCGCACCATCGTCGCCGGCGCGCCGGCGCGGCTGGCGGCCGACGGCTGGCTGCTGCTGGAGCACGGCTACGACCAGGG
CCCCGCGGTGCGCGCGCTGCTGGCCGACGCGGGTTTCGCCGATGTCTTCACCGCCCAGGACCTCACCGGCCACGACCGCT
GCAGCGGCGGCCGGCACCCGGCCGCGCAGAACGCGGCCTGA

Upstream 100 bases:

>100_bases
GACAAGGTCAAGGAAGCCGCCAAGCAGTAAGCCCGGCGCGTCCGCTCTCGCTGCAGCCCGACACGGGCCCGTGCCGATAT
GGCCGGGCCCGTGTTATTTT

Downstream 100 bases:

>100_bases
CGAACCTCGCTAGAATAGGCGGGTTTTCCATGCGGCCCGGGCCTGCCCGTGCCCTCAACGAATCGAGCCTCCCCATGAGC
ACCACGCACGAAAAGATCGA

Product: methyltransferase

Products: NA

Alternate protein names: M.XfaHemK2P [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MRPALLNDGPAVPSTFAIPPDTLPRVADALAVLTGAGLPALEARMLVSHVTGLSRVQLITQDTCGIDDGTRTRLAELATR
RLAGEPMAYLLGEREFFGRMFQVTPAVLIPRPDTELLVEQALDRIDDRDAPAVLDLGTGSGIIAVTIALARRDARVWATD
TSADALAVAVRNAQALGAANMHAALGDWYAALPESDAPPVFDLIVSNPPYIASTDAHLGQGDLRFEPAGALTDHGDGLRH
LRTIVAGAPARLAADGWLLLEHGYDQGPAVRALLADAGFADVFTAQDLTGHDRCSGGRHPAAQNAA

Sequences:

>Translated_306_residues
MRPALLNDGPAVPSTFAIPPDTLPRVADALAVLTGAGLPALEARMLVSHVTGLSRVQLITQDTCGIDDGTRTRLAELATR
RLAGEPMAYLLGEREFFGRMFQVTPAVLIPRPDTELLVEQALDRIDDRDAPAVLDLGTGSGIIAVTIALARRDARVWATD
TSADALAVAVRNAQALGAANMHAALGDWYAALPESDAPPVFDLIVSNPPYIASTDAHLGQGDLRFEPAGALTDHGDGLRH
LRTIVAGAPARLAADGWLLLEHGYDQGPAVRALLADAGFADVFTAQDLTGHDRCSGGRHPAAQNAA
>Mature_306_residues
MRPALLNDGPAVPSTFAIPPDTLPRVADALAVLTGAGLPALEARMLVSHVTGLSRVQLITQDTCGIDDGTRTRLAELATR
RLAGEPMAYLLGEREFFGRMFQVTPAVLIPRPDTELLVEQALDRIDDRDAPAVLDLGTGSGIIAVTIALARRDARVWATD
TSADALAVAVRNAQALGAANMHAALGDWYAALPESDAPPVFDLIVSNPPYIASTDAHLGQGDLRFEPAGALTDHGDGLRH
LRTIVAGAPARLAADGWLLLEHGYDQGPAVRALLADAGFADVFTAQDLTGHDRCSGGRHPAAQNAA

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=259, Percent_Identity=31.6602316602317, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787463, Length=272, Percent_Identity=43.0147058823529, Blast_Score=200, Evalue=9e-53,
Organism=Escherichia coli, GI87082085, Length=203, Percent_Identity=35.4679802955665, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24582226, Length=280, Percent_Identity=27.8571428571429, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 32118; Mature: 32118

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPALLNDGPAVPSTFAIPPDTLPRVADALAVLTGAGLPALEARMLVSHVTGLSRVQLIT
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHEEEEE
QDTCGIDDGTRTRLAELATRRLAGEPMAYLLGEREFFGRMFQVTPAVLIPRPDTELLVEQ
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCEEEECCCCHHHHHHH
ALDRIDDRDAPAVLDLGTGSGIIAVTIALARRDARVWATDTSADALAVAVRNAQALGAAN
HHHHCCCCCCCEEEEECCCCCCEEEEEEHHHCCCEEEEECCCCCEEHHHHHHHHHHCCCH
MHAALGDWYAALPESDAPPVFDLIVSNPPYIASTDAHLGQGDLRFEPAGALTDHGDGLRH
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCEECCCCCCCCCCEEECCCCCCCCCCCHHHH
LRTIVAGAPARLAADGWLLLEHGYDQGPAVRALLADAGFADVFTAQDLTGHDRCSGGRHP
HHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCC
AAQNAA
CCCCCC
>Mature Secondary Structure
MRPALLNDGPAVPSTFAIPPDTLPRVADALAVLTGAGLPALEARMLVSHVTGLSRVQLIT
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHEEEEE
QDTCGIDDGTRTRLAELATRRLAGEPMAYLLGEREFFGRMFQVTPAVLIPRPDTELLVEQ
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCEEEECCCCHHHHHHH
ALDRIDDRDAPAVLDLGTGSGIIAVTIALARRDARVWATDTSADALAVAVRNAQALGAAN
HHHHCCCCCCCEEEEECCCCCCEEEEEEHHHCCCEEEEECCCCCEEHHHHHHHHHHCCCH
MHAALGDWYAALPESDAPPVFDLIVSNPPYIASTDAHLGQGDLRFEPAGALTDHGDGLRH
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCEECCCCCCCCCCEEECCCCCCCCCCCHHHH
LRTIVAGAPARLAADGWLLLEHGYDQGPAVRALLADAGFADVFTAQDLTGHDRCSGGRHP
HHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCC
AAQNAA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]