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The map label for this gene is murB

Identifier: 17547269

GI number: 17547269

Start: 2758680

End: 2759708

Strand: Direct

Name: murB

Synonym: RSc2550

Alternate gene names: 17547269

Gene position: 2758680-2759708 (Clockwise)

Preceding gene: 17547266

Following gene: 17547271

Centisome position: 74.23

GC content: 70.94

Gene sequence:

>1029_bases
ATGGCGTTGCTCGACCCGCATTATCCCCTAGGCCGGCACAACACGTTCCGTTTCGAGGCCGCCGCCCGCTATGCCGCGCA
CGTGCGCGCAGCGCAGGACATTGCCGAGGCACTGACCGATCCGCGCGCGCGGGGCCTGCCGGTGCTGGTGCTGGGCGGCG
GCAGCAACATCGTGCTCACGCGCGACTTCGACGGCCTGGTGCTGCTGATGGAGATTCCCGGCGTGCAGGTCGGCCGGGCG
ACCCTGGACGGACGCGCCGTCCACACCGTCACGGCCGGCGCGGGCGAATCGTGGCACGGCCTCGTTGCCCGCACCGTCGC
CGACGGACTGCCGGGGCTGGAGAACCTGGCGCTGATCCCCGGCACCGTGGGCGCCGCGCCCATCCAGAACATCGGCGCGT
ACGGCGTCGAGATCAAGGACCGCTTCCACTCCCTGCGCGCCTACGACCGCCATGCCGGCGAATTCGTCACGCTGGATGCC
GCCGACTGCGCCTTCGGCTACCGCGACAGCCTCTTCAAGCGCGCCGGCGCCGACCGCTACGTCATCGCCGAAGTCACCTT
CGCGCTGCCCGTGGACTGGCAGCCCGACACGCACTACGCAGAACTGGCCCGCGAGCTGGCCGCGCGGGACATCGCCGCGC
CGGCGGCGCAGGACATCTTCGATGCCGTGGTCGCCATCCGCCGCCGCAAGCTGCCCGATCCGGCCGAGATCGGCAACGCG
GGCAGCTTCTTCAAGAACCCCATCGTCGATACCGCCACGCGCGATGCGCTGCTGGCGCGGTTCCCCGGCCTGGTCGGCTA
CGCGCAGCCGGATGGCAGCTACAAGCTCGCCGCCGGCTGGATGATCGACCAGTGCGGCTTCAAGGGCCGGCAAAGCGGCG
CGGTGGGGGTGTACGACAAGCAGGCACTGGTGCTGGTGCACCGGGGCGGCGGCAGCGCCGTGCAGCTGATGACGCTGGCA
CGCGAAATCCAGGACACGGTGCATGCGCGCTTCGGCGTGCGCATCGAGCCCGAGCCCGTCGTCATCTGA

Upstream 100 bases:

>100_bases
TTCTCCTTGCAGACTTGAATTGGGGATCCAGCGGTGGCGCGCGCGGGCCACCCCGCGCCATGGCTCTTATAATTCCAGCT
TTTCCAGCCAACCCTGCGCC

Downstream 100 bases:

>100_bases
CGGCGCGACGCGCACCGCCCGGGAGTCTAGACCTCCTGCCCGCGCAGGTATTCGTTCTGGATATCGACGGTGCCGTTCCT
GCCGACATCGTCGAAATGCT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MALLDPHYPLGRHNTFRFEAAARYAAHVRAAQDIAEALTDPRARGLPVLVLGGGSNIVLTRDFDGLVLLMEIPGVQVGRA
TLDGRAVHTVTAGAGESWHGLVARTVADGLPGLENLALIPGTVGAAPIQNIGAYGVEIKDRFHSLRAYDRHAGEFVTLDA
ADCAFGYRDSLFKRAGADRYVIAEVTFALPVDWQPDTHYAELARELAARDIAAPAAQDIFDAVVAIRRRKLPDPAEIGNA
GSFFKNPIVDTATRDALLARFPGLVGYAQPDGSYKLAAGWMIDQCGFKGRQSGAVGVYDKQALVLVHRGGGSAVQLMTLA
REIQDTVHARFGVRIEPEPVVI

Sequences:

>Translated_342_residues
MALLDPHYPLGRHNTFRFEAAARYAAHVRAAQDIAEALTDPRARGLPVLVLGGGSNIVLTRDFDGLVLLMEIPGVQVGRA
TLDGRAVHTVTAGAGESWHGLVARTVADGLPGLENLALIPGTVGAAPIQNIGAYGVEIKDRFHSLRAYDRHAGEFVTLDA
ADCAFGYRDSLFKRAGADRYVIAEVTFALPVDWQPDTHYAELARELAARDIAAPAAQDIFDAVVAIRRRKLPDPAEIGNA
GSFFKNPIVDTATRDALLARFPGLVGYAQPDGSYKLAAGWMIDQCGFKGRQSGAVGVYDKQALVLVHRGGGSAVQLMTLA
REIQDTVHARFGVRIEPEPVVI
>Mature_341_residues
ALLDPHYPLGRHNTFRFEAAARYAAHVRAAQDIAEALTDPRARGLPVLVLGGGSNIVLTRDFDGLVLLMEIPGVQVGRAT
LDGRAVHTVTAGAGESWHGLVARTVADGLPGLENLALIPGTVGAAPIQNIGAYGVEIKDRFHSLRAYDRHAGEFVTLDAA
DCAFGYRDSLFKRAGADRYVIAEVTFALPVDWQPDTHYAELARELAARDIAAPAAQDIFDAVVAIRRRKLPDPAEIGNAG
SFFKNPIVDTATRDALLARFPGLVGYAQPDGSYKLAAGWMIDQCGFKGRQSGAVGVYDKQALVLVHRGGGSAVQLMTLAR
EIQDTVHARFGVRIEPEPVVI

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=332, Percent_Identity=43.3734939759036, Blast_Score=273, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_RALSO (Q8XWC4)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520671.1
- ProteinModelPortal:   Q8XWC4
- SMR:   Q8XWC4
- GeneID:   1221397
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2550
- NMPDR:   fig|267608.1.peg.2550
- HOGENOM:   HBG686573
- OMA:   GAAPMQN
- ProtClustDB:   PRK00046
- BioCyc:   RSOL267608:RSC2550-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 36665; Mature: 36534

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 168-168 ACT_SITE 242-242 ACT_SITE 338-338

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLDPHYPLGRHNTFRFEAAARYAAHVRAAQDIAEALTDPRARGLPVLVLGGGSNIVLT
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEE
RDFDGLVLLMEIPGVQVGRATLDGRAVHTVTAGAGESWHGLVARTVADGLPGLENLALIP
ECCCCEEEEEECCCCEECCEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEECC
GTVGAAPIQNIGAYGVEIKDRFHSLRAYDRHAGEFVTLDAADCAFGYRDSLFKRAGADRY
CCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHCCCHHHHHHHHCCCCCE
VIAEVTFALPVDWQPDTHYAELARELAARDIAAPAAQDIFDAVVAIRRRKLPDPAEIGNA
EEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHCCCC
GSFFKNPIVDTATRDALLARFPGLVGYAQPDGSYKLAAGWMIDQCGFKGRQSGAVGVYDK
CCHHCCCCCCHHHHHHHHHHCCCCEEEECCCCCEEEEECEEEHHCCCCCCCCCCEEEECC
QALVLVHRGGGSAVQLMTLAREIQDTVHARFGVRIEPEPVVI
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure 
ALLDPHYPLGRHNTFRFEAAARYAAHVRAAQDIAEALTDPRARGLPVLVLGGGSNIVLT
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEE
RDFDGLVLLMEIPGVQVGRATLDGRAVHTVTAGAGESWHGLVARTVADGLPGLENLALIP
ECCCCEEEEEECCCCEECCEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEECC
GTVGAAPIQNIGAYGVEIKDRFHSLRAYDRHAGEFVTLDAADCAFGYRDSLFKRAGADRY
CCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHCCCHHHHHHHHCCCCCE
VIAEVTFALPVDWQPDTHYAELARELAARDIAAPAAQDIFDAVVAIRRRKLPDPAEIGNA
EEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHCCCC
GSFFKNPIVDTATRDALLARFPGLVGYAQPDGSYKLAAGWMIDQCGFKGRQSGAVGVYDK
CCHHCCCCCCHHHHHHHHHHCCCCEEEECCCCCEEEEECEEEHHCCCCCCCCCCEEEECC
QALVLVHRGGGSAVQLMTLAREIQDTVHARFGVRIEPEPVVI
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852