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The map label for this gene is adk [H]

Identifier: 17547252

GI number: 17547252

Start: 2740594

End: 2741262

Strand: Direct

Name: adk [H]

Synonym: RSc2533

Alternate gene names: 17547252

Gene position: 2740594-2741262 (Clockwise)

Preceding gene: 17547251

Following gene: 17547253

Centisome position: 73.74

GC content: 65.17

Gene sequence:

>669_bases
ATGCGGTTGATTCTGTTGGGCGCACCCGGCGCCGGCAAAGGTACGCAAGCCAAATTCATCTGCGAACGCTTCGGCATTCC
GCAGATCTCCACCGGCGACATGCTGCGCGCCGCCGTCAAGGCCGGCACCCCGCTGGGCATCGAAGCCAAGAAGGTGATGG
ACGCCGGCGGCCTGGTGTCCGACGACATCATCATCGGCCTGGTGAAGGACCGCCTGCAGCAGTCCGACTGCAAGAACGGC
TACCTGTTCGACGGCTTCCCGCGCACCATCCCCCAGGCCGAAGCCATGAAGGATGCCGGCGTGCCGATCGACTACGTGCT
GGAAATCGACGTGCCGTTCGACGCCATCATCGAGCGCATGAGCGGCCGCCGCGTGCACGTGGCCTCGGGCCGGACCTATC
ACGTCAAGTACAACCCGCCCAAGAACGAGGGCCAGGACGACGAAACCGGCGATCCGCTGATCCAGCGCGACGACGACAAG
GAAGAAACCGTCCGCAAGCGCCTGTCCGTGTACGAGAACCAGACCCGCCCGCTGGTGGACTACTACTCCGGCTGGGCCGA
GAACGGCAACGGTGCCGCCAAGGTGGCGCCGCCCAAGTACCGCAAGATCAGCGGGATCGGCAACGTGGAAGACATCACCG
GCCGCGTGTTCGGCGCACTGGAAGCCTGA

Upstream 100 bases:

>100_bases
CACCAGACGTTTTGGGAATCGGTCCCGCGCACCGGACCGATTCCCAACGCGTTTCAAGCAATTGGCGCACCGGAATTTAA
AACTTGAGGAACTCGTCACC

Downstream 100 bases:

>100_bases
CCCGGCCGCTACACCGCACCACCGAAACGCTCCGCTTGCCGGAGCGTTTTTTTTTTTGCGCGCGCCGACCGCCCGGCCTG
CCGTCCACCGCCGGCTTCGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MRLILLGAPGAGKGTQAKFICERFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVSDDIIIGLVKDRLQQSDCKNG
YLFDGFPRTIPQAEAMKDAGVPIDYVLEIDVPFDAIIERMSGRRVHVASGRTYHVKYNPPKNEGQDDETGDPLIQRDDDK
EETVRKRLSVYENQTRPLVDYYSGWAENGNGAAKVAPPKYRKISGIGNVEDITGRVFGALEA

Sequences:

>Translated_222_residues
MRLILLGAPGAGKGTQAKFICERFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVSDDIIIGLVKDRLQQSDCKNG
YLFDGFPRTIPQAEAMKDAGVPIDYVLEIDVPFDAIIERMSGRRVHVASGRTYHVKYNPPKNEGQDDETGDPLIQRDDDK
EETVRKRLSVYENQTRPLVDYYSGWAENGNGAAKVAPPKYRKISGIGNVEDITGRVFGALEA
>Mature_222_residues
MRLILLGAPGAGKGTQAKFICERFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVSDDIIIGLVKDRLQQSDCKNG
YLFDGFPRTIPQAEAMKDAGVPIDYVLEIDVPFDAIIERMSGRRVHVASGRTYHVKYNPPKNEGQDDETGDPLIQRDDDK
EETVRKRLSVYENQTRPLVDYYSGWAENGNGAAKVAPPKYRKISGIGNVEDITGRVFGALEA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=186, Percent_Identity=48.3870967741936, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI4502013, Length=186, Percent_Identity=48.3870967741936, Blast_Score=191, Evalue=3e-49,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=47.2527472527472, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=40.1098901098901, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=40.1098901098901, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=40.1098901098901, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=40.1098901098901, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI22749187, Length=191, Percent_Identity=30.3664921465969, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI4502011, Length=222, Percent_Identity=27.027027027027, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI7706497, Length=188, Percent_Identity=29.7872340425532, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI28144899, Length=223, Percent_Identity=25.1121076233184, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI28144897, Length=223, Percent_Identity=25.1121076233184, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=25.1798561151079, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1786680, Length=212, Percent_Identity=62.7358490566038, Blast_Score=276, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=46.7741935483871, Blast_Score=188, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17537943, Length=184, Percent_Identity=36.4130434782609, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17567503, Length=221, Percent_Identity=28.9592760180996, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=28.804347826087, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=27.1739130434783, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=194, Percent_Identity=50, Blast_Score=209, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6321018, Length=186, Percent_Identity=44.6236559139785, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=28.4153005464481, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=50.2732240437158, Blast_Score=196, Evalue=8e-51,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=42.8571428571429, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=42.8571428571429, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI17647141, Length=219, Percent_Identity=28.7671232876712, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24663208, Length=219, Percent_Identity=28.7671232876712, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221459597, Length=186, Percent_Identity=27.9569892473118, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356893, Length=186, Percent_Identity=27.9569892473118, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24224; Mature: 24224

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQAKFICERFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCC
DDIIIGLVKDRLQQSDCKNGYLFDGFPRTIPQAEAMKDAGVPIDYVLEIDVPFDAIIERM
CHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHCCCCEEEEEEECCCHHHHHHHH
SGRRVHVASGRTYHVKYNPPKNEGQDDETGDPLIQRDDDKEETVRKRLSVYENQTRPLVD
CCCEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHH
YYSGWAENGNGAAKVAPPKYRKISGIGNVEDITGRVFGALEA
HHCCCCCCCCCCEEECCCCHHEECCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQAKFICERFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCC
DDIIIGLVKDRLQQSDCKNGYLFDGFPRTIPQAEAMKDAGVPIDYVLEIDVPFDAIIERM
CHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHCCCCEEEEEEECCCHHHHHHHH
SGRRVHVASGRTYHVKYNPPKNEGQDDETGDPLIQRDDDKEETVRKRLSVYENQTRPLVD
CCCEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHH
YYSGWAENGNGAAKVAPPKYRKISGIGNVEDITGRVFGALEA
HHCCCCCCCCCCEEECCCCHHEECCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA