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The map label for this gene is lpxK

Identifier: 17547249

GI number: 17547249

Start: 2738152

End: 2739201

Strand: Direct

Name: lpxK

Synonym: RSc2530

Alternate gene names: 17547249

Gene position: 2738152-2739201 (Clockwise)

Preceding gene: 17547248

Following gene: 17547250

Centisome position: 73.68

GC content: 71.33

Gene sequence:

>1050_bases
ATGCCCGTTGCCCAGCACCGCCTAGCCAGCTTCGTCACCCGCCAATGGCAGCGGCGCGGCTGGTTTGCGCGGATGCTGTG
GCCGCTGTCGCTGCTGTTCGGGGCCGTCAGCGGGCTGCGCCGGCGGCTGTTCCGCTGGGGCTGGCTGCGCTCGGTGCGCC
TGCCAGTGCCGGTGGTGGTGGTCGGCAATGTCACCGTCGGCGGCGCCGGCAAGACGCCGGCCGTGATCGCGCTGGCCTCG
GCGCTGGCCGACGCGGGCCTGCGCCCCGGCATCGTCTCGCGCGGCTACGGCGCGCAGCTCAAGCACCCGCGCCCGGTGCG
CGAGCATTCCCGCGCGGAAGACGTCGGCGACGAGCCCCTGCTGATCGCCCGCGCCACCGATCTTCCGGTCTGGGTCTACC
CCGACCGTGTGCTGTGCGCGCAGACATTGCTGGCCTCGCACCCCGGCTGCAACGTGATCGTCTGCGACGACGGCCTGCAG
CACTACCGCCTGCGCCGCGACATCGAGATCGTGGTGTTCGACCTGCGCATGGGCGGCAACGGCTTCCTGCTGCCGGCCGG
CCCGCTACGCGAGCCGATGACCCGCCGCCGCGACGCCACGCTGATCAACGACCCCAACTACCGCGCCACGCACGACCGCC
CCGACATCTACGGCATGCGGCTGGACCTGCAGGATGCGTACAACCTGGCCGATCCGGCGCTGCGCCGTCCGCTGAGCCAG
TTCGCGCGGCTGTCGGGCGATCAGTTGCTGGCCGCCGCGGGCATCGGCAACCCCGAGCGCTTCTTCGCCTCGCTGCGCGC
CGCCGGGCTCCAGCCGGCCACCCTGCCGCTGCCCGACCACTACGACTTTGCAGACAACCCGTTCGCGGATGCCGGCGCCG
AAACCATCCTGATCACCGAAAAGGATGCCGTAAAATGCGGCCATCTCGACGACCCGCGCATCTGGGTGGTGCCGACCACG
CCGGTGGTCGATGCCGCGCTGGTCGAACAGGTCTGCCGGCGCGTGCGCGCCCTGGCCGATCGCTCAACTTCTCAGGCTGG
CGCACAATAA

Upstream 100 bases:

>100_bases
TGTCGTCAACGTGATGGAAGCCGCCCGCGTGGCCGGCTTGTCGCACCTGACCTTCGCCACCCAGACCGGCAACGCCGCTC
GCTGACCCCGCCCGCACCGC

Downstream 100 bases:

>100_bases
CGACTGTGCCCCCGCCGCATCGGCGGGCTGCCGTGCCGCCCGCCCGGAGCCTTACCGTCATGGACAATCGCCTGCTGGAA
ATCCTGGTCTGCCCGCTGTG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MPVAQHRLASFVTRQWQRRGWFARMLWPLSLLFGAVSGLRRRLFRWGWLRSVRLPVPVVVVGNVTVGGAGKTPAVIALAS
ALADAGLRPGIVSRGYGAQLKHPRPVREHSRAEDVGDEPLLIARATDLPVWVYPDRVLCAQTLLASHPGCNVIVCDDGLQ
HYRLRRDIEIVVFDLRMGGNGFLLPAGPLREPMTRRRDATLINDPNYRATHDRPDIYGMRLDLQDAYNLADPALRRPLSQ
FARLSGDQLLAAAGIGNPERFFASLRAAGLQPATLPLPDHYDFADNPFADAGAETILITEKDAVKCGHLDDPRIWVVPTT
PVVDAALVEQVCRRVRALADRSTSQAGAQ

Sequences:

>Translated_349_residues
MPVAQHRLASFVTRQWQRRGWFARMLWPLSLLFGAVSGLRRRLFRWGWLRSVRLPVPVVVVGNVTVGGAGKTPAVIALAS
ALADAGLRPGIVSRGYGAQLKHPRPVREHSRAEDVGDEPLLIARATDLPVWVYPDRVLCAQTLLASHPGCNVIVCDDGLQ
HYRLRRDIEIVVFDLRMGGNGFLLPAGPLREPMTRRRDATLINDPNYRATHDRPDIYGMRLDLQDAYNLADPALRRPLSQ
FARLSGDQLLAAAGIGNPERFFASLRAAGLQPATLPLPDHYDFADNPFADAGAETILITEKDAVKCGHLDDPRIWVVPTT
PVVDAALVEQVCRRVRALADRSTSQAGAQ
>Mature_348_residues
PVAQHRLASFVTRQWQRRGWFARMLWPLSLLFGAVSGLRRRLFRWGWLRSVRLPVPVVVVGNVTVGGAGKTPAVIALASA
LADAGLRPGIVSRGYGAQLKHPRPVREHSRAEDVGDEPLLIARATDLPVWVYPDRVLCAQTLLASHPGCNVIVCDDGLQH
YRLRRDIEIVVFDLRMGGNGFLLPAGPLREPMTRRRDATLINDPNYRATHDRPDIYGMRLDLQDAYNLADPALRRPLSQF
ARLSGDQLLAAAGIGNPERFFASLRAAGLQPATLPLPDHYDFADNPFADAGAETILITEKDAVKCGHLDDPRIWVVPTTP
VVDAALVEQVCRRVRALADRSTSQAGAQ

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=324, Percent_Identity=41.9753086419753, Blast_Score=208, Evalue=4e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_RALSO (Q8XWE4)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520651.1
- GeneID:   1221377
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2530
- NMPDR:   fig|267608.1.peg.2530
- HOGENOM:   HBG663914
- OMA:   GNIHAGG
- ProtClustDB:   PRK01906
- BioCyc:   RSOL267608:RSC2530-MONOMER
- BRENDA:   2.7.1.130
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 38469; Mature: 38338

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVAQHRLASFVTRQWQRRGWFARMLWPLSLLFGAVSGLRRRLFRWGWLRSVRLPVPVVV
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
VGNVTVGGAGKTPAVIALASALADAGLRPGIVSRGYGAQLKHPRPVREHSRAEDVGDEPL
ECCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCE
LIARATDLPVWVYPDRVLCAQTLLASHPGCNVIVCDDGLQHYRLRRDIEIVVFDLRMGGN
EEEEECCCEEEECCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCCEEEEEEEEEECCC
GFLLPAGPLREPMTRRRDATLINDPNYRATHDRPDIYGMRLDLQDAYNLADPALRRPLSQ
EEEECCCCCHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEEEHHHHHCCCCHHHHHHHHH
FARLSGDQLLAAAGIGNPERFFASLRAAGLQPATLPLPDHYDFADNPFADAGAETILITE
HHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
KDAVKCGHLDDPRIWVVPTTPVVDAALVEQVCRRVRALADRSTSQAGAQ
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PVAQHRLASFVTRQWQRRGWFARMLWPLSLLFGAVSGLRRRLFRWGWLRSVRLPVPVVV
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
VGNVTVGGAGKTPAVIALASALADAGLRPGIVSRGYGAQLKHPRPVREHSRAEDVGDEPL
ECCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCE
LIARATDLPVWVYPDRVLCAQTLLASHPGCNVIVCDDGLQHYRLRRDIEIVVFDLRMGGN
EEEEECCCEEEECCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCCEEEEEEEEEECCC
GFLLPAGPLREPMTRRRDATLINDPNYRATHDRPDIYGMRLDLQDAYNLADPALRRPLSQ
EEEECCCCCHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEEEHHHHHCCCCHHHHHHHHH
FARLSGDQLLAAAGIGNPERFFASLRAAGLQPATLPLPDHYDFADNPFADAGAETILITE
HHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
KDAVKCGHLDDPRIWVVPTTPVVDAALVEQVCRRVRALADRSTSQAGAQ
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852