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The map label for this gene is ada [H]

Identifier: 17547224

GI number: 17547224

Start: 2711629

End: 2713101

Strand: Direct

Name: ada [H]

Synonym: RSc2505

Alternate gene names: 17547224

Gene position: 2711629-2713101 (Clockwise)

Preceding gene: 17547222

Following gene: 17547225

Centisome position: 72.96

GC content: 73.52

Gene sequence:

>1473_bases
ATGCACCTCGACCCCGACGCCTGCTACCACGCCGTGCAATCGCGCGACCGGCGCTTCGATGGCTGGTTCTTCGTCGGCGT
CACCTCCACCGGCGTCTATTGCCGCCCGATCTGCGCGGTGCGCACGCCGCTGCAGAAGAACTGCCGCTTCTTCGCCTCCG
CCGCCGCGGCCGAGAAGGCGGGTTTCCGCCCGTGCCTGCGCTGCCGCCCCGAGCTGGCGCCGGGCCACAGCCTGGCCGAG
ATGTCATCCAGCCTCGCCCGCGCCGCCGCGCGCATGATCGACGAAGGCTTCCTGCAGCAGCACGATCTGGCCGCGCTGGC
GGCAGCGGTGGGCGTGACGGATCGCCACCTGCGCCGCATCTTCCGCGCCGAATTCGACGTCTCGCCCATCGAGTACGCGC
AGACGCAGCGCCTGCTGCTCGCCAAGCGGCTGCTGACGGACACCGCCATGCCGGTCGGCGACGTCGCATATGCGGCCGGC
TTCGGCAGCGTGCGGCGGCTCAACAGCGGGTTCGCCGAGCACTACGGCTTCGCGCCGACACGGCTGCGCACCCGCGCCGC
ACCGGTATCGCGCGGCGACGACGGCGCCACGCTGATGCTGGGTTACCGCCCGCCCTTCGCCTGGCACGCGCTGCTCGACT
TCCTGCGCGCGCGTGCCGTGGACGGCGTCGAGGTGGTCGACGCGCACAGCTACGCCCGCACCATCGCGCTCGACTATGCC
GGGCGCCGTCATGCCGGCTGGCTGCGCGCGCGCGACGTGCCGCAACGGCATGCGATCGCACTCACGCTGTCGGCCAGCCT
GGTGCAGGCGATGCCGCCGGTCCTGGCCCGCGTGCGCCGCCTGTTCGATCTCGATTGCCGGCCCGACCTGGTCGACACGC
ACCTCGGCACGCTTGCCGCCGGCACGCCCGGCCTGCGCGTGCCGGGGGCGGTGGACGGCTTCGAGATCGCCGTGCGCGCC
ATCGCCGGGCAGGTCGTTTCGCTGGCGCGGGCGCGGCGCATCCTGGCCCGCCTGGCGGCTGCCTATGGCACGCCGCTGGC
GCAGCCGCGCGCCGGATTGCCGACCGCCTTCCCGTCCGCCACCGCGCTGGCGAGCGTGGACCCGCAGGCGCTGTCCGGCG
AAACCGGCCTGCAGGCCAGCCGTGCCGCCGCCATGGTGGAAATCGCCCGCGCCATCGACGCCGGCCGCCTGCGCCTGGAA
CCGCTGGTGCCGCTCGCGCCCACGCTGGCGGCGCTGCAAGCGCTGTCCGGCATCGGCGAATGGACCGCGCAATACATCGC
CATGCGCGCGCTGGGCTGGCCGAATGCGTTTCCGCTGGGCGACTACGTGCTGCGCAAGCGCCTGGCCGATCACGATGGCA
CGCTGCCGACACGCCACGCCATGGCCACCCGGGCGGAAGACTGGGCGCCATGGCGCGCCTATGCCGCCATGCACCTGTGG
CACCGCGACGATGCCCAGGCTCCGACCCCATGA

Upstream 100 bases:

>100_bases
CCTTCCGAGGGCGGCGTGTGACCGAGGGAAATGTCCGAATCCGGCCAACGCGATGCGCCCGCCGGGACTACACTGGGCCG
CGAATCCACCGGCCTTCACC

Downstream 100 bases:

>100_bases
CCGCCATGCTCCGCCTCACCTTCGCCTGCCCGCTCGGCGACCTGCTGCTGATCGCCACCGACACCCACCTGACCGGCGCG
TTCTTCACCGGGCAGAAGAC

Product: transcription regulator protein

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MHLDPDACYHAVQSRDRRFDGWFFVGVTSTGVYCRPICAVRTPLQKNCRFFASAAAAEKAGFRPCLRCRPELAPGHSLAE
MSSSLARAAARMIDEGFLQQHDLAALAAAVGVTDRHLRRIFRAEFDVSPIEYAQTQRLLLAKRLLTDTAMPVGDVAYAAG
FGSVRRLNSGFAEHYGFAPTRLRTRAAPVSRGDDGATLMLGYRPPFAWHALLDFLRARAVDGVEVVDAHSYARTIALDYA
GRRHAGWLRARDVPQRHAIALTLSASLVQAMPPVLARVRRLFDLDCRPDLVDTHLGTLAAGTPGLRVPGAVDGFEIAVRA
IAGQVVSLARARRILARLAAAYGTPLAQPRAGLPTAFPSATALASVDPQALSGETGLQASRAAAMVEIARAIDAGRLRLE
PLVPLAPTLAALQALSGIGEWTAQYIAMRALGWPNAFPLGDYVLRKRLADHDGTLPTRHAMATRAEDWAPWRAYAAMHLW
HRDDAQAPTP

Sequences:

>Translated_490_residues
MHLDPDACYHAVQSRDRRFDGWFFVGVTSTGVYCRPICAVRTPLQKNCRFFASAAAAEKAGFRPCLRCRPELAPGHSLAE
MSSSLARAAARMIDEGFLQQHDLAALAAAVGVTDRHLRRIFRAEFDVSPIEYAQTQRLLLAKRLLTDTAMPVGDVAYAAG
FGSVRRLNSGFAEHYGFAPTRLRTRAAPVSRGDDGATLMLGYRPPFAWHALLDFLRARAVDGVEVVDAHSYARTIALDYA
GRRHAGWLRARDVPQRHAIALTLSASLVQAMPPVLARVRRLFDLDCRPDLVDTHLGTLAAGTPGLRVPGAVDGFEIAVRA
IAGQVVSLARARRILARLAAAYGTPLAQPRAGLPTAFPSATALASVDPQALSGETGLQASRAAAMVEIARAIDAGRLRLE
PLVPLAPTLAALQALSGIGEWTAQYIAMRALGWPNAFPLGDYVLRKRLADHDGTLPTRHAMATRAEDWAPWRAYAAMHLW
HRDDAQAPTP
>Mature_490_residues
MHLDPDACYHAVQSRDRRFDGWFFVGVTSTGVYCRPICAVRTPLQKNCRFFASAAAAEKAGFRPCLRCRPELAPGHSLAE
MSSSLARAAARMIDEGFLQQHDLAALAAAVGVTDRHLRRIFRAEFDVSPIEYAQTQRLLLAKRLLTDTAMPVGDVAYAAG
FGSVRRLNSGFAEHYGFAPTRLRTRAAPVSRGDDGATLMLGYRPPFAWHALLDFLRARAVDGVEVVDAHSYARTIALDYA
GRRHAGWLRARDVPQRHAIALTLSASLVQAMPPVLARVRRLFDLDCRPDLVDTHLGTLAAGTPGLRVPGAVDGFEIAVRA
IAGQVVSLARARRILARLAAAYGTPLAQPRAGLPTAFPSATALASVDPQALSGETGLQASRAAAMVEIARAIDAGRLRLE
PLVPLAPTLAALQALSGIGEWTAQYIAMRALGWPNAFPLGDYVLRKRLADHDGTLPTRHAMATRAEDWAPWRAYAAMHLW
HRDDAQAPTP

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=289, Percent_Identity=38.7543252595156, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1788542, Length=144, Percent_Identity=36.8055555555556, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 53132; Mature: 53132

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLDPDACYHAVQSRDRRFDGWFFVGVTSTGVYCRPICAVRTPLQKNCRFFASAAAAEKA
CCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCEECCHHHHCCCHHHHHHHHHHHHHHHHC
GFRPCLRCRPELAPGHSLAEMSSSLARAAARMIDEGFLQQHDLAALAAAVGVTDRHLRRI
CCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
FRAEFDVSPIEYAQTQRLLLAKRLLTDTAMPVGDVAYAAGFGSVRRLNSGFAEHYGFAPT
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCH
RLRTRAAPVSRGDDGATLMLGYRPPFAWHALLDFLRARAVDGVEVVDAHSYARTIALDYA
HHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
GRRHAGWLRARDVPQRHAIALTLSASLVQAMPPVLARVRRLFDLDCRPDLVDTHLGTLAA
CCCCCCCHHHCCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
GTPGLRVPGAVDGFEIAVRAIAGQVVSLARARRILARLAAAYGTPLAQPRAGLPTAFPSA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
TALASVDPQALSGETGLQASRAAAMVEIARAIDAGRLRLEPLVPLAPTLAALQALSGIGE
HHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHH
WTAQYIAMRALGWPNAFPLGDYVLRKRLADHDGTLPTRHAMATRAEDWAPWRAYAAMHLW
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
HRDDAQAPTP
CCCCCCCCCC
>Mature Secondary Structure
MHLDPDACYHAVQSRDRRFDGWFFVGVTSTGVYCRPICAVRTPLQKNCRFFASAAAAEKA
CCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCEECCHHHHCCCHHHHHHHHHHHHHHHHC
GFRPCLRCRPELAPGHSLAEMSSSLARAAARMIDEGFLQQHDLAALAAAVGVTDRHLRRI
CCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
FRAEFDVSPIEYAQTQRLLLAKRLLTDTAMPVGDVAYAAGFGSVRRLNSGFAEHYGFAPT
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCH
RLRTRAAPVSRGDDGATLMLGYRPPFAWHALLDFLRARAVDGVEVVDAHSYARTIALDYA
HHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
GRRHAGWLRARDVPQRHAIALTLSASLVQAMPPVLARVRRLFDLDCRPDLVDTHLGTLAA
CCCCCCCHHHCCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
GTPGLRVPGAVDGFEIAVRAIAGQVVSLARARRILARLAAAYGTPLAQPRAGLPTAFPSA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
TALASVDPQALSGETGLQASRAAAMVEIARAIDAGRLRLEPLVPLAPTLAALQALSGIGE
HHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHH
WTAQYIAMRALGWPNAFPLGDYVLRKRLADHDGTLPTRHAMATRAEDWAPWRAYAAMHLW
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
HRDDAQAPTP
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]