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The map label for this gene is dfp [H]

Identifier: 17547180

GI number: 17547180

Start: 2669480

End: 2670685

Strand: Direct

Name: dfp [H]

Synonym: RSc2461

Alternate gene names: 17547180

Gene position: 2669480-2670685 (Clockwise)

Preceding gene: 17547178

Following gene: 17547181

Centisome position: 71.83

GC content: 71.06

Gene sequence:

>1206_bases
ATGGAACTGCAAGGCAAACATTTCGTGCTCGGCCTGACCGGCGGCATCGCATGCTACAAGTCGGCCGAGCTGGTGCGGCT
GCTGACCAAGGCCGGCGCCACCGTGCAGGTGGTGATGACCGACGCGGCCACGCATTTCATCACGCCGGTGACGATGCAGG
CGCTGTCCGGGCGGACGGTGTTCACGTCGCAGTGGGACGACCGCGTCGGCAACAACATGGCGCACATCGACCTGTCGCGC
GAGGCGGACGCCATTGTCGTTGCGCCGGCCTCCACGGATTTCCTCGCCAAGCTCGCGCACGGCCTGGCCGACGACCTGCT
CTCCACGCTGTGCATCGCGCGCGACTGCCCGCTGCTGGTGGCGCCCGCCATGAACCGCCAGATGTGGGCCGCGCCCGCCA
CCCGGCGCAACGCCGCCCAGCTGCGCGCCGACGATGTCACCCTGCTCGGCCCGGACGCCGGCGACCAGGCCTGCGGTGAG
GTCGGCGACGGCCGCATGCTGGAGCCGGAGGCCATTGTCGAGGCGCTCATCGGCTTCTTCCAGCCCAAGCTGCTGCGCGG
ACGCCGCGTGCTGCTGACCGCCGGCCCGACCTTCGAGCCGATCGACCCGGTGCGCGGCATCACCAACCTCTCCAGCGGCA
AGATGGGCTTCGCGCTGGCGCGCGCCGCCGCGCAGGCCGGCGCGGACGTGGCGCTGGTCGCCGGCCCCTGTCACCAGGAC
ACGCCCGCCGGCGTGCTGCGCATCGACGTGCAGACCGCCCAGCAGATGCACGACGCGGTGATGCGCGAGCTGGACACCGC
CCGCACCGACGTCTTCATCGCGGTCGCCGCCGTGGCCGACTGGCGCGTCGCCCAGGCCGCCGACAACAAGCTCAAGAAGC
AGAGCGACACCGATGTGCCCGCACTGTCGCTCACGCAAAACCCCGACATCCTCGCCACTGTCGCGCGCCGCGCCGATGCG
CCGTTCTGCGTCGGCTTCGCGGCCGAGACCGAACGGCTCGAAGAATTCGGCGAAGCCAAGCGCCGGAAGAAGGGCATCCC
GCTGCTGGTCGGCAATCTCGGCCACAAGACCTTCGGCCGCGACGACAACGAAGTCGCCCTCTTCGACCCCGCCGGCATCA
CCCGCCTGCCGCGCGCCGACAAGCTGACGCTGGCGCGCCAGATCGTCGCCGCCATCGCCGAGCGCGTGCAGGGCGCACGG
CCATGA

Upstream 100 bases:

>100_bases
GGGCAAGCCGGTATCATCGCCACTGTCCGGCAGGACGAACCGGCCCCGGGTTGTATCCTGCCCTCGCGCATTGCGTCAAT
CGATTTCCAGACGGGCTCCC

Downstream 100 bases:

>100_bases
GCCGCGATACGGCCGTCCGCCTGTCCATTCTCGACCAGAGCCCGGTCATCCACGGCCACAGCGCGCGCGACGCCATCGCC
GCCACGGTGGACCTGGCCCA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MELQGKHFVLGLTGGIACYKSAELVRLLTKAGATVQVVMTDAATHFITPVTMQALSGRTVFTSQWDDRVGNNMAHIDLSR
EADAIVVAPASTDFLAKLAHGLADDLLSTLCIARDCPLLVAPAMNRQMWAAPATRRNAAQLRADDVTLLGPDAGDQACGE
VGDGRMLEPEAIVEALIGFFQPKLLRGRRVLLTAGPTFEPIDPVRGITNLSSGKMGFALARAAAQAGADVALVAGPCHQD
TPAGVLRIDVQTAQQMHDAVMRELDTARTDVFIAVAAVADWRVAQAADNKLKKQSDTDVPALSLTQNPDILATVARRADA
PFCVGFAAETERLEEFGEAKRRKKGIPLLVGNLGHKTFGRDDNEVALFDPAGITRLPRADKLTLARQIVAAIAERVQGAR
P

Sequences:

>Translated_401_residues
MELQGKHFVLGLTGGIACYKSAELVRLLTKAGATVQVVMTDAATHFITPVTMQALSGRTVFTSQWDDRVGNNMAHIDLSR
EADAIVVAPASTDFLAKLAHGLADDLLSTLCIARDCPLLVAPAMNRQMWAAPATRRNAAQLRADDVTLLGPDAGDQACGE
VGDGRMLEPEAIVEALIGFFQPKLLRGRRVLLTAGPTFEPIDPVRGITNLSSGKMGFALARAAAQAGADVALVAGPCHQD
TPAGVLRIDVQTAQQMHDAVMRELDTARTDVFIAVAAVADWRVAQAADNKLKKQSDTDVPALSLTQNPDILATVARRADA
PFCVGFAAETERLEEFGEAKRRKKGIPLLVGNLGHKTFGRDDNEVALFDPAGITRLPRADKLTLARQIVAAIAERVQGAR
P
>Mature_401_residues
MELQGKHFVLGLTGGIACYKSAELVRLLTKAGATVQVVMTDAATHFITPVTMQALSGRTVFTSQWDDRVGNNMAHIDLSR
EADAIVVAPASTDFLAKLAHGLADDLLSTLCIARDCPLLVAPAMNRQMWAAPATRRNAAQLRADDVTLLGPDAGDQACGE
VGDGRMLEPEAIVEALIGFFQPKLLRGRRVLLTAGPTFEPIDPVRGITNLSSGKMGFALARAAAQAGADVALVAGPCHQD
TPAGVLRIDVQTAQQMHDAVMRELDTARTDVFIAVAAVADWRVAQAADNKLKKQSDTDVPALSLTQNPDILATVARRADA
PFCVGFAAETERLEEFGEAKRRKKGIPLLVGNLGHKTFGRDDNEVALFDPAGITRLPRADKLTLARQIVAAIAERVQGAR
P

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=175, Percent_Identity=37.1428571428571, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI87082301, Length=401, Percent_Identity=45.6359102244389, Blast_Score=306, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17560194, Length=176, Percent_Identity=33.5227272727273, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=187, Percent_Identity=30.4812834224599, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=32.8042328042328, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42749; Mature: 42749

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELQGKHFVLGLTGGIACYKSAELVRLLTKAGATVQVVMTDAATHFITPVTMQALSGRTV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCEE
FTSQWDDRVGNNMAHIDLSREADAIVVAPASTDFLAKLAHGLADDLLSTLCIARDCPLLV
EECCCHHHHCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
APAMNRQMWAAPATRRNAAQLRADDVTLLGPDAGDQACGEVGDGRMLEPEAIVEALIGFF
ECCCCCCEECCCCCCCCHHHEECCCEEEECCCCCCHHHHCCCCCCEECHHHHHHHHHHHH
QPKLLRGRRVLLTAGPTFEPIDPVRGITNLSSGKMGFALARAAAQAGADVALVAGPCHQD
CHHHHCCCEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCC
TPAGVLRIDVQTAQQMHDAVMRELDTARTDVFIAVAAVADWRVAQAADNKLKKQSDTDVP
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHCCCCCCCC
ALSLTQNPDILATVARRADAPFCVGFAAETERLEEFGEAKRRKKGIPLLVGNLGHKTFGR
EEEECCCCCHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
DDNEVALFDPAGITRLPRADKLTLARQIVAAIAERVQGARP
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MELQGKHFVLGLTGGIACYKSAELVRLLTKAGATVQVVMTDAATHFITPVTMQALSGRTV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCEE
FTSQWDDRVGNNMAHIDLSREADAIVVAPASTDFLAKLAHGLADDLLSTLCIARDCPLLV
EECCCHHHHCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
APAMNRQMWAAPATRRNAAQLRADDVTLLGPDAGDQACGEVGDGRMLEPEAIVEALIGFF
ECCCCCCEECCCCCCCCHHHEECCCEEEECCCCCCHHHHCCCCCCEECHHHHHHHHHHHH
QPKLLRGRRVLLTAGPTFEPIDPVRGITNLSSGKMGFALARAAAQAGADVALVAGPCHQD
CHHHHCCCEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCC
TPAGVLRIDVQTAQQMHDAVMRELDTARTDVFIAVAAVADWRVAQAADNKLKKQSDTDVP
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHCCCCCCCC
ALSLTQNPDILATVARRADAPFCVGFAAETERLEEFGEAKRRKKGIPLLVGNLGHKTFGR
EEEECCCCCHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
DDNEVALFDPAGITRLPRADKLTLARQIVAAIAERVQGARP
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]