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The map label for this gene is lspA

Identifier: 17547178

GI number: 17547178

Start: 2668195

End: 2668716

Strand: Direct

Name: lspA

Synonym: RSc2459

Alternate gene names: 17547178

Gene position: 2668195-2668716 (Clockwise)

Preceding gene: 17547177

Following gene: 17547180

Centisome position: 71.79

GC content: 66.86

Gene sequence:

>522_bases
ATGGCCACTCGCAACAACGGCAAGAGCAAGGCCGCAGGCAGCAAAAGCGGCGGCGGCCATGGCGTGGGCCCCTGGCTGGG
CCTGGGCGTCATCTGGATCCTGCTGGACCAGTTGACCAAAATCGCCATCCTCAAAACCTTCGCCTACGGCGAGTCGCGCC
CGATCACCGGGTTCTTCAACCTGGTGCTGGCCTACAACCGGGGCGCGGCATTCTCGTTCCTGGCGGCGGCAGGCGGCTGG
CAGCGCTGGTTCTTCACCGGCCTGGGCGTGGCCGCGGCGCTGTTCATCGTGTGGCTGCTCAAGCGCCACAGCGGGCAGAA
GCTGTTCTGCTTTGCGCTGGCGCTGATCCTCGGCGGGGCGCTGGGCAACGTGATCGACCGTCTCGTCTACGGCCACGTGG
TGGACTTCCTCGACTTCCACCTGCGCGGCTACCACTGGCCCGCGTTCAACGTCGCCGATTGCGGCATCTGCATCGGCGCG
GTGCTGCTGATCATCGACGAGCTGCGGCGGGTTCGCCGCTAG

Upstream 100 bases:

>100_bases
ACTATCGCGCCGATGTCGGCCACGACACGGCCCACCCGACCCTGTGCAAGCGCTGCACCGACAACCTGTTCGGCGCCGGC
GAACAACGGAGCGCTGCCTG

Downstream 100 bases:

>100_bases
GGCGCCCGGGCGCGGCGGCGCGTGGGTGCGGCAAGCGGATCAATACCGCACCGCGTACCACGCCCGCTTGATGTACTCCG
CCAGGATCGATCCGCTTTCG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MATRNNGKSKAAGSKSGGGHGVGPWLGLGVIWILLDQLTKIAILKTFAYGESRPITGFFNLVLAYNRGAAFSFLAAAGGW
QRWFFTGLGVAAALFIVWLLKRHSGQKLFCFALALILGGALGNVIDRLVYGHVVDFLDFHLRGYHWPAFNVADCGICIGA
VLLIIDELRRVRR

Sequences:

>Translated_173_residues
MATRNNGKSKAAGSKSGGGHGVGPWLGLGVIWILLDQLTKIAILKTFAYGESRPITGFFNLVLAYNRGAAFSFLAAAGGW
QRWFFTGLGVAAALFIVWLLKRHSGQKLFCFALALILGGALGNVIDRLVYGHVVDFLDFHLRGYHWPAFNVADCGICIGA
VLLIIDELRRVRR
>Mature_172_residues
ATRNNGKSKAAGSKSGGGHGVGPWLGLGVIWILLDQLTKIAILKTFAYGESRPITGFFNLVLAYNRGAAFSFLAAAGGWQ
RWFFTGLGVAAALFIVWLLKRHSGQKLFCFALALILGGALGNVIDRLVYGHVVDFLDFHLRGYHWPAFNVADCGICIGAV
LLIIDELRRVRR

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=143, Percent_Identity=46.1538461538462, Blast_Score=126, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_RALSO (Q8XWL5)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520580.1
- MEROPS:   A08.001
- GeneID:   1221306
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2459
- NMPDR:   fig|267608.1.peg.2459
- HOGENOM:   HBG724422
- OMA:   MATRNNG
- ProtClustDB:   PRK00376
- BioCyc:   RSOL267608:RSC2459-MONOMER
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18834; Mature: 18703

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 126-126 ACT_SITE 153-153

Signals:

None

Transmembrane regions:

HASH(0xe35a8e0)-; HASH(0xe949d8c)-; HASH(0xe7caaf4)-; HASH(0xe8f6e0c)-; HASH(0xe74df4c)-;

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRNNGKSKAAGSKSGGGHGVGPWLGLGVIWILLDQLTKIAILKTFAYGESRPITGFFN
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LVLAYNRGAAFSFLAAAGGWQRWFFTGLGVAAALFIVWLLKRHSGQKLFCFALALILGGA
HHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LGNVIDRLVYGHVVDFLDFHLRGYHWPAFNVADCGICIGAVLLIIDELRRVRR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
ATRNNGKSKAAGSKSGGGHGVGPWLGLGVIWILLDQLTKIAILKTFAYGESRPITGFFN
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LVLAYNRGAAFSFLAAAGGWQRWFFTGLGVAAALFIVWLLKRHSGQKLFCFALALILGGA
HHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LGNVIDRLVYGHVVDFLDFHLRGYHWPAFNVADCGICIGAVLLIIDELRRVRR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11823852