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The map label for this gene is vsrB [H]

Identifier: 17547175

GI number: 17547175

Start: 2662138

End: 2664054

Strand: Reverse

Name: vsrB [H]

Synonym: RSc2456

Alternate gene names: 17547175

Gene position: 2664054-2662138 (Counterclockwise)

Preceding gene: 17547179

Following gene: 17547173

Centisome position: 71.68

GC content: 69.01

Gene sequence:

>1917_bases
ATGCGCCACGTGCATGGCGTCCCCGCGGGGAACGGGCTTGCGGCACAATCCGTTATTCCCGATCCGATTCCCTGCACACC
ATTGACCGCTTCGCTGCGACCTCTCTTGACCAAACTCGGGCTGGCCAGCCGCGCGCCGCTTGAACTCGATGCGCGCGCCA
AGCTGCTGGCCGCCGTCCACCGTGGCGCGCCCATGGGGATCGCGGCCTCGGTGGTCCTGCCGGTCCTGACACTGGCCGCC
TTCTGGGACTCCGGCAACCGCCTCGCGCTGGCGGGCTGGTGCCTGATCATGCTGTGCCTGACGGCCTCCGGGCTGCGCTT
CTATTTCGGCTACCGCTATGACATGACCCGCATGACGCTGGCGGCGCACACCCGCAAGTGGTGGACGGGCATGCGCATCA
TGTCGGCGGTGGGAGGGCTGGCCTGGGGCAGTTCGGCGGGGCTTTACCTGGTCTCGCCGTCGCTGGAGTTCAGCAGCCTG
CTGATGATCGTCATCATCGGCGTGGCAGCGGGGGCGGTGCTGTCGCAGGCGCCGGTGCCGTCCAACCTGCTGATTCTCGG
GACCGGCATCCTGACGCCCCATTTCGCGCTGGCCGAGCAGGCCTTCCCCGAGCACGGCCTGTACGTGCGTTGCGTACTGC
TGTTCTTTGCGGCGTTCCTGGCGCGCCATGCCGCCAACATCCACAGCACGCTGGTGCGCGAGATCCAGCTCGAGAACGAG
AGCCGCCAGCTGGCCCGCCGCTACCAGGACGAGAAACAGCGCGCACTGTCCGCCTCGGAAGAGAAGTCGCGCTTCCTGGC
CGCCGCCAGCCACGATCTGCGCCAGCCGGTGCACGCGCTGGTGCTGCTGGTCGAGGCGTTGCGGGCGCGCAACCAGTCCG
AGTCGCTGGCGCCGCTGGTGGAGCAGCTCGCGTCGGGCGCGCAGACCATCGACCTGCTGTTCCGCTCGCTGCTCGACCTG
TCCAAGCTGGAAAGCCGCAAGACCTCGCCGACGCTGGAGCCGGTCGACCTGGGCGAGGTGATCACGGAAGTGGTGCAGCA
GTTCCTGCCCGATGCGCGCGCCAAGGGCCTCGCGCTTACCCAGCGGATTCCGCCGCTGCCGGTGTTCGGCATGGCCGAGC
CGGTGCTGCTGCGCCGCGCGCTGTTCAACCTGTTGCAGAATGCTTTGCGCTACACCTCGCACGGCGGCGTGATGGTGGCG
CTGCGGGTGCGGCAGAAGCACCTGCGCATCGAAGTGTGGGACACCGGCATCGGCATCGCGCCGGAGCACCAGAAGGACAT
TTTCTCGTCGTACTACCAGGTCGAGAACCCCGAGCGCGATCCGAGCCAGGGGCTGGGCCTGGGGCTGGCGATCTACAAGG
AGTGCGTGCGGTTGCTGCGGGGCACCCACGGCGTGCGCTCGGTCCCCGGGCGCGGCTCGATGTTCTGGATGGCGCTGCGG
CCCGTGCCGGCCGAGATCAAGGCGCCGCTGGCCGCCCAGCCGCGCAGCGAGCAGAAGCGCGCCGTGCTGGAGCAGCCTCG
CTTTTCCGGCGTGGTGCTCGTGGTGGACGACGATGCCCAGATCCGCAATGCCTGGCATGCGCTGCTCGAGGCATGGGGGG
TGGAAGTGCACAGCGCGGCAGACGGCCCCACGGCCGATCACCTGCTGATGCGCGGCCTGCGGCCCCAGATCATCTTCTGT
GATCTGCGCCTGCCCGGCAAGGAAGACGGCCTGCAGCTGCTGGAGCGCTGGCAGGTCAGCCATCCCGAGGCCCACGCCGT
GCTGCTGACCGGCGATCGCAATTCGGCGGCGCTGGCCCGTGCCGAGGAGGCAGGCTATCTGCTGCTGGCCAAGCCGATGG
ACCCGAACATGCTGCGCGTGCTGCTCAAGCGCTGGCTGCGCGGCCGCGCAGCCGAGCCGCAAGTGGCGGCTTATTGA

Upstream 100 bases:

>100_bases
ACGCGCGGTCGCCCGCAAAAAACCGGCAAAACCCACATTATATAAGGTAATGCCATGCTTCCCGGTGGCCGGCGGGATGC
AGGGCGTTGCACAATTGCCC

Downstream 100 bases:

>100_bases
AGGGAAGGAATGCGTGTGAGTGGCGCCGCAGCGGGCGGCGGCGCCTGCGTCAGGCCGAGCCGGTCAGGCGGAAGCGCTCC
ATGCGCGAGATGATCTGGAT

Product: composite two-component regulatory (sensor kinase and response regulator hybrid) transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MRHVHGVPAGNGLAAQSVIPDPIPCTPLTASLRPLLTKLGLASRAPLELDARAKLLAAVHRGAPMGIAASVVLPVLTLAA
FWDSGNRLALAGWCLIMLCLTASGLRFYFGYRYDMTRMTLAAHTRKWWTGMRIMSAVGGLAWGSSAGLYLVSPSLEFSSL
LMIVIIGVAAGAVLSQAPVPSNLLILGTGILTPHFALAEQAFPEHGLYVRCVLLFFAAFLARHAANIHSTLVREIQLENE
SRQLARRYQDEKQRALSASEEKSRFLAAASHDLRQPVHALVLLVEALRARNQSESLAPLVEQLASGAQTIDLLFRSLLDL
SKLESRKTSPTLEPVDLGEVITEVVQQFLPDARAKGLALTQRIPPLPVFGMAEPVLLRRALFNLLQNALRYTSHGGVMVA
LRVRQKHLRIEVWDTGIGIAPEHQKDIFSSYYQVENPERDPSQGLGLGLAIYKECVRLLRGTHGVRSVPGRGSMFWMALR
PVPAEIKAPLAAQPRSEQKRAVLEQPRFSGVVLVVDDDAQIRNAWHALLEAWGVEVHSAADGPTADHLLMRGLRPQIIFC
DLRLPGKEDGLQLLERWQVSHPEAHAVLLTGDRNSAALARAEEAGYLLLAKPMDPNMLRVLLKRWLRGRAAEPQVAAY

Sequences:

>Translated_638_residues
MRHVHGVPAGNGLAAQSVIPDPIPCTPLTASLRPLLTKLGLASRAPLELDARAKLLAAVHRGAPMGIAASVVLPVLTLAA
FWDSGNRLALAGWCLIMLCLTASGLRFYFGYRYDMTRMTLAAHTRKWWTGMRIMSAVGGLAWGSSAGLYLVSPSLEFSSL
LMIVIIGVAAGAVLSQAPVPSNLLILGTGILTPHFALAEQAFPEHGLYVRCVLLFFAAFLARHAANIHSTLVREIQLENE
SRQLARRYQDEKQRALSASEEKSRFLAAASHDLRQPVHALVLLVEALRARNQSESLAPLVEQLASGAQTIDLLFRSLLDL
SKLESRKTSPTLEPVDLGEVITEVVQQFLPDARAKGLALTQRIPPLPVFGMAEPVLLRRALFNLLQNALRYTSHGGVMVA
LRVRQKHLRIEVWDTGIGIAPEHQKDIFSSYYQVENPERDPSQGLGLGLAIYKECVRLLRGTHGVRSVPGRGSMFWMALR
PVPAEIKAPLAAQPRSEQKRAVLEQPRFSGVVLVVDDDAQIRNAWHALLEAWGVEVHSAADGPTADHLLMRGLRPQIIFC
DLRLPGKEDGLQLLERWQVSHPEAHAVLLTGDRNSAALARAEEAGYLLLAKPMDPNMLRVLLKRWLRGRAAEPQVAAY
>Mature_638_residues
MRHVHGVPAGNGLAAQSVIPDPIPCTPLTASLRPLLTKLGLASRAPLELDARAKLLAAVHRGAPMGIAASVVLPVLTLAA
FWDSGNRLALAGWCLIMLCLTASGLRFYFGYRYDMTRMTLAAHTRKWWTGMRIMSAVGGLAWGSSAGLYLVSPSLEFSSL
LMIVIIGVAAGAVLSQAPVPSNLLILGTGILTPHFALAEQAFPEHGLYVRCVLLFFAAFLARHAANIHSTLVREIQLENE
SRQLARRYQDEKQRALSASEEKSRFLAAASHDLRQPVHALVLLVEALRARNQSESLAPLVEQLASGAQTIDLLFRSLLDL
SKLESRKTSPTLEPVDLGEVITEVVQQFLPDARAKGLALTQRIPPLPVFGMAEPVLLRRALFNLLQNALRYTSHGGVMVA
LRVRQKHLRIEVWDTGIGIAPEHQKDIFSSYYQVENPERDPSQGLGLGLAIYKECVRLLRGTHGVRSVPGRGSMFWMALR
PVPAEIKAPLAAQPRSEQKRAVLEQPRFSGVVLVVDDDAQIRNAWHALLEAWGVEVHSAADGPTADHLLMRGLRPQIIFC
DLRLPGKEDGLQLLERWQVSHPEAHAVLLTGDRNSAALARAEEAGYLLLAKPMDPNMLRVLLKRWLRGRAAEPQVAAY

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=236, Percent_Identity=31.3559322033898, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI48994928, Length=325, Percent_Identity=29.8461538461538, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1788713, Length=408, Percent_Identity=26.2254901960784, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1789149, Length=298, Percent_Identity=26.510067114094, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790346, Length=201, Percent_Identity=32.8358208955224, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1786783, Length=247, Percent_Identity=30.3643724696356, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87081816, Length=430, Percent_Identity=25.1162790697674, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790861, Length=240, Percent_Identity=29.5833333333333, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=30.4166666666667, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=27.0386266094421, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=30.316742081448, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=259, Percent_Identity=29.3436293436293, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI87082128, Length=224, Percent_Identity=27.2321428571429, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=245, Percent_Identity=26.530612244898, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 69945; Mature: 69945

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN ; PS00589 PTS_HPR_SER ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHVHGVPAGNGLAAQSVIPDPIPCTPLTASLRPLLTKLGLASRAPLELDARAKLLAAVH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
RGAPMGIAASVVLPVLTLAAFWDSGNRLALAGWCLIMLCLTASGLRFYFGYRYDMTRMTL
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCEEEEEEEECHHHHHH
AAHTRKWWTGMRIMSAVGGLAWGSSAGLYLVSPSLEFSSLLMIVIIGVAAGAVLSQAPVP
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
SNLLILGTGILTPHFALAEQAFPEHGLYVRCVLLFFAAFLARHAANIHSTLVREIQLENE
CCEEEEECCHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SRQLARRYQDEKQRALSASEEKSRFLAAASHDLRQPVHALVLLVEALRARNQSESLAPLV
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
EQLASGAQTIDLLFRSLLDLSKLESRKTSPTLEPVDLGEVITEVVQQFLPDARAKGLALT
HHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHCCCCHH
QRIPPLPVFGMAEPVLLRRALFNLLQNALRYTSHGGVMVALRVRQKHLRIEVWDTGIGIA
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCC
PEHQKDIFSSYYQVENPERDPSQGLGLGLAIYKECVRLLRGTHGVRSVPGRGSMFWMALR
CCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEC
PVPAEIKAPLAAQPRSEQKRAVLEQPRFSGVVLVVDDDAQIRNAWHALLEAWGVEVHSAA
CCCHHHCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCEEECCC
DGPTADHLLMRGLRPQIIFCDLRLPGKEDGLQLLERWQVSHPEAHAVLLTGDRNSAALAR
CCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHH
AEEAGYLLLAKPMDPNMLRVLLKRWLRGRAAEPQVAAY
HCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRHVHGVPAGNGLAAQSVIPDPIPCTPLTASLRPLLTKLGLASRAPLELDARAKLLAAVH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
RGAPMGIAASVVLPVLTLAAFWDSGNRLALAGWCLIMLCLTASGLRFYFGYRYDMTRMTL
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCEEEEEEEECHHHHHH
AAHTRKWWTGMRIMSAVGGLAWGSSAGLYLVSPSLEFSSLLMIVIIGVAAGAVLSQAPVP
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
SNLLILGTGILTPHFALAEQAFPEHGLYVRCVLLFFAAFLARHAANIHSTLVREIQLENE
CCEEEEECCHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SRQLARRYQDEKQRALSASEEKSRFLAAASHDLRQPVHALVLLVEALRARNQSESLAPLV
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
EQLASGAQTIDLLFRSLLDLSKLESRKTSPTLEPVDLGEVITEVVQQFLPDARAKGLALT
HHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHCCCCHH
QRIPPLPVFGMAEPVLLRRALFNLLQNALRYTSHGGVMVALRVRQKHLRIEVWDTGIGIA
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCC
PEHQKDIFSSYYQVENPERDPSQGLGLGLAIYKECVRLLRGTHGVRSVPGRGSMFWMALR
CCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEC
PVPAEIKAPLAAQPRSEQKRAVLEQPRFSGVVLVVDDDAQIRNAWHALLEAWGVEVHSAA
CCCHHHCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCEEECCC
DGPTADHLLMRGLRPQIIFCDLRLPGKEDGLQLLERWQVSHPEAHAVLLTGDRNSAALAR
CCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHH
AEEAGYLLLAKPMDPNMLRVLLKRWLRGRAAEPQVAAY
HCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]