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The map label for this gene is nadB1

Identifier: 17547166

GI number: 17547166

Start: 2651688

End: 2653289

Strand: Direct

Name: nadB1

Synonym: RSc2447

Alternate gene names: 17547166

Gene position: 2651688-2653289 (Clockwise)

Preceding gene: 17547165

Following gene: 17547174

Centisome position: 71.35

GC content: 68.16

Gene sequence:

>1602_bases
ATGAATTTCGATGTTGCCGTTGTCGGCAGTGGCCTGGCGGGCCTGACCGTCGCCCTGCACCTCGCCGATCACCGCCGCGT
GGTCGTCATCAGCAAACGCACACTGCCCGAAGGCGCGAGCGACTGGGCCCAAGGCGGCATCGCCGCGGTGCTCGACTCGA
ACGACAGCCATGACGAGCACGTCGACGACACCCTGATCGCGGGCGCCGGCCTCTGCGACGAAGCGGCCACCCGCTACATC
GTCGAAAACGGCCGCGCCGCCATCGAATGGCTGATCGGCCATGGCGTCCCCTTCACGCGCGACGCACGGGCCGAACTCGG
CTTCCACCTGACGCGCGAGGGCGGCCACCGGCACCGCCGCATCATCCACGCCGCCGATGCCACCGGGCATGCCGTGGTGA
CCACGCTGGTCGACAAGGTGCGCGCGCATCCGAACATCACGCTGCTGGAAGACCATTTCGCCATCGACCTGGTCACCGAC
GCCAAGCTGGGGCTGCCGGGCATGCGCTGCCACGGCCTGTACGTGCTCGATTGCAAGCGCGGCGACGTCAAGACGATCAT
CGCCAGCCAGACCGTGCTGGCGACCGGCGGTGCCGGCAAGGTCTACCTGTACACGACCAACCCCGACACCGCCACCGGCG
ACGGCATCGCGATGGCGTGGCGCGCGGGCTGCCGCGTGGCGAACATGGAGTTCATCCAGTTCCACCCGACCTGCCTGTAC
CACCCGTTCGCCAAATCCTTCCTGATCAGCGAGGCGGTGCGCGGCGAAGGCGGCAAGCTGGTCCTGCCCGACGGCACGCG
CTTCATGCCCGCCCACGACGAGCGGGCCGAACTGGCCCCGCGCGACATCGTGGCCCGCGCCATCGACTTCGAGATGAAAA
AGCGCGGCCTGGACTGCGTCTACCTCGACATCAGCCACCAGAGCCCCGCCTTCATTCAGGAACACTTCCCGACCATCCTC
GCCCGATGCCTGGAACTGGGCATCGACATCACGCGCCAGCCGATCCCGGTGGTGCCGGCCGCGCACTACACCTGCGGCGG
CGTGGTGACCGACCAGCTCGGCCGCACCGACATCGCGGGCCTGTACGCGGTAGGCGAAACGGCCTACACCGGCCTGCACG
GCGCCAACCGGCTGGCCAGCAATTCGCTGCTGGAATGCATGGTGATCGGGCGCGGCGCGGCGCAGGACATCCTGGGCCAG
CCTGCCACGGCGCCGACCCCGACCCCGATCCCGGCCTGGGACGAAAGCCGCGTGACGGACGCCGACGAGGAAGTCGTCGT
CTCGCACAACTGGGACGAACTGCGCCGCATGATGTGGAATTACGTCGGCATCGTGCGCACCAACAAGCGACTGGAACGCG
CACAGCACCGCATCGCCCTGCTGCGCGAAGAGATCGCAGAGTACTACGCCAACTTCCGCGTCAGCCACGACCTGCTGGAG
CTGCGCAATCTGGTGGAGGCGGCCTCGTTGATCGTCGACAGCGCGCTGTCACGCCACGAAAGCCGCGGCCTGCATTTCTC
GCGCGACTACCCGCAGACCCTGCCCAAGGCGCTGCCGACGGTGATGCAACCCGCGCATCGGCGCACCTCGCGCAAGCACT
GA

Upstream 100 bases:

>100_bases
AGCCCGCGAGAGCACGGTGTACACTGCGTCTCTTTCCGGTTCCGATTGACCCGCGGCTGCGCCGGCCGCTGACATACCCC
GCGTCCCGCACGGGTTTTCC

Downstream 100 bases:

>100_bases
GCCGTCTTATTCGACGACGCGCAGGGAGTAGTCGGTCGCGCGCACGTCCTTGGTCAGCGCACCGACGGAGATGCGGTCCA
CACCGGTCTGCGCAAACGCG

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO 1; Quinolinate synthase B 1

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MNFDVAVVGSGLAGLTVALHLADHRRVVVISKRTLPEGASDWAQGGIAAVLDSNDSHDEHVDDTLIAGAGLCDEAATRYI
VENGRAAIEWLIGHGVPFTRDARAELGFHLTREGGHRHRRIIHAADATGHAVVTTLVDKVRAHPNITLLEDHFAIDLVTD
AKLGLPGMRCHGLYVLDCKRGDVKTIIASQTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVANMEFIQFHPTCLY
HPFAKSFLISEAVRGEGGKLVLPDGTRFMPAHDERAELAPRDIVARAIDFEMKKRGLDCVYLDISHQSPAFIQEHFPTIL
ARCLELGIDITRQPIPVVPAAHYTCGGVVTDQLGRTDIAGLYAVGETAYTGLHGANRLASNSLLECMVIGRGAAQDILGQ
PATAPTPTPIPAWDESRVTDADEEVVVSHNWDELRRMMWNYVGIVRTNKRLERAQHRIALLREEIAEYYANFRVSHDLLE
LRNLVEAASLIVDSALSRHESRGLHFSRDYPQTLPKALPTVMQPAHRRTSRKH

Sequences:

>Translated_533_residues
MNFDVAVVGSGLAGLTVALHLADHRRVVVISKRTLPEGASDWAQGGIAAVLDSNDSHDEHVDDTLIAGAGLCDEAATRYI
VENGRAAIEWLIGHGVPFTRDARAELGFHLTREGGHRHRRIIHAADATGHAVVTTLVDKVRAHPNITLLEDHFAIDLVTD
AKLGLPGMRCHGLYVLDCKRGDVKTIIASQTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVANMEFIQFHPTCLY
HPFAKSFLISEAVRGEGGKLVLPDGTRFMPAHDERAELAPRDIVARAIDFEMKKRGLDCVYLDISHQSPAFIQEHFPTIL
ARCLELGIDITRQPIPVVPAAHYTCGGVVTDQLGRTDIAGLYAVGETAYTGLHGANRLASNSLLECMVIGRGAAQDILGQ
PATAPTPTPIPAWDESRVTDADEEVVVSHNWDELRRMMWNYVGIVRTNKRLERAQHRIALLREEIAEYYANFRVSHDLLE
LRNLVEAASLIVDSALSRHESRGLHFSRDYPQTLPKALPTVMQPAHRRTSRKH
>Mature_533_residues
MNFDVAVVGSGLAGLTVALHLADHRRVVVISKRTLPEGASDWAQGGIAAVLDSNDSHDEHVDDTLIAGAGLCDEAATRYI
VENGRAAIEWLIGHGVPFTRDARAELGFHLTREGGHRHRRIIHAADATGHAVVTTLVDKVRAHPNITLLEDHFAIDLVTD
AKLGLPGMRCHGLYVLDCKRGDVKTIIASQTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVANMEFIQFHPTCLY
HPFAKSFLISEAVRGEGGKLVLPDGTRFMPAHDERAELAPRDIVARAIDFEMKKRGLDCVYLDISHQSPAFIQEHFPTIL
ARCLELGIDITRQPIPVVPAAHYTCGGVVTDQLGRTDIAGLYAVGETAYTGLHGANRLASNSLLECMVIGRGAAQDILGQ
PATAPTPTPIPAWDESRVTDADEEVVVSHNWDELRRMMWNYVGIVRTNKRLERAQHRIALLREEIAEYYANFRVSHDLLE
LRNLVEAASLIVDSALSRHESRGLHFSRDYPQTLPKALPTVMQPAHRRTSRKH

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily

Homologues:

Organism=Homo sapiens, GI156416003, Length=505, Percent_Identity=34.0594059405941, Blast_Score=229, Evalue=4e-60,
Organism=Escherichia coli, GI1788928, Length=531, Percent_Identity=60.075329566855, Blast_Score=651, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=520, Percent_Identity=34.8076923076923, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1786942, Length=551, Percent_Identity=32.3049001814882, Blast_Score=202, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17505833, Length=533, Percent_Identity=32.4577861163227, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17550100, Length=531, Percent_Identity=32.2033898305085, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71986328, Length=467, Percent_Identity=26.9807280513919, Blast_Score=105, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6322701, Length=509, Percent_Identity=33.5952848722986, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6322416, Length=513, Percent_Identity=33.3333333333333, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6320788, Length=484, Percent_Identity=27.4793388429752, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6322511, Length=477, Percent_Identity=27.2536687631027, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17137288, Length=533, Percent_Identity=33.0206378986867, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24655642, Length=533, Percent_Identity=33.0206378986867, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24655647, Length=533, Percent_Identity=33.0206378986867, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24663005, Length=549, Percent_Identity=32.4225865209472, Blast_Score=223, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADB1_RALSO (Q8XWM7)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520568.1
- ProteinModelPortal:   Q8XWM7
- SMR:   Q8XWM7
- GeneID:   1221294
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2447
- NMPDR:   fig|267608.1.peg.2447
- HOGENOM:   HBG293998
- OMA:   GAYIWNR
- ProtClustDB:   PRK09077
- BioCyc:   RSOL267608:RSC2447-MONOMER
- BRENDA:   1.4.3.16
- GO:   GO:0005737
- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288
- Gene3D:   G3DSA:1.20.58.100
- PRINTS:   PR00368
- TIGRFAMs:   TIGR00551

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C; SSF46977 Succ_DH_flav_C

EC number: =1.4.3.16

Molecular weight: Translated: 58453; Mature: 58453

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: ACT_SITE 235-235 ACT_SITE 254-254

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDVAVVGSGLAGLTVALHLADHRRVVVISKRTLPEGASDWAQGGIAAVLDSNDSHDEH
CCCEEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHCCCEEEEECCCCCCCHH
VDDTLIAGAGLCDEAATRYIVENGRAAIEWLIGHGVPFTRDARAELGFHLTREGGHRHRR
CCHHHHHCCCCHHHHHHHHHHHCCCCEEEEHHHCCCCCCCCCHHHCCEEEECCCCCCCEE
IIHAADATGHAVVTTLVDKVRAHPNITLLEDHFAIDLVTDAKLGLPGMRCHGLYVLDCKR
EEEECCCCCHHHHHHHHHHHHCCCCEEEEECCEEEEEEECCCCCCCCCEECCEEEEEECC
GDVKTIIASQTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVANMEFIQFHPTCLY
CCEEEEEECCEEEEECCCCEEEEEECCCCCCCCCCEEEHHHCCCEEECEEEEEECCCCEE
HPFAKSFLISEAVRGEGGKLVLPDGTRFMPAHDERAELAPRDIVARAIDFEMKKRGLDCV
CHHHHHHHHHHHHCCCCCEEECCCCCEECCCCCCHHHCCHHHHHHHHHHHHHHHCCCCEE
YLDISHQSPAFIQEHFPTILARCLELGIDITRQPIPVVPAAHYTCGGVVTDQLGRTDIAG
EEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
LYAVGETAYTGLHGANRLASNSLLECMVIGRGAAQDILGQPATAPTPTPIPAWDESRVTD
EEEECCHHHCCCCCHHHHHHCCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCC
ADEEVVVSHNWDELRRMMWNYVGIVRTNKRLERAQHRIALLREEIAEYYANFRVSHDLLE
CCCCEEEECCHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LRNLVEAASLIVDSALSRHESRGLHFSRDYPQTLPKALPTVMQPAHRRTSRKH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCHHHHHCCCCC
>Mature Secondary Structure
MNFDVAVVGSGLAGLTVALHLADHRRVVVISKRTLPEGASDWAQGGIAAVLDSNDSHDEH
CCCEEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHCCCEEEEECCCCCCCHH
VDDTLIAGAGLCDEAATRYIVENGRAAIEWLIGHGVPFTRDARAELGFHLTREGGHRHRR
CCHHHHHCCCCHHHHHHHHHHHCCCCEEEEHHHCCCCCCCCCHHHCCEEEECCCCCCCEE
IIHAADATGHAVVTTLVDKVRAHPNITLLEDHFAIDLVTDAKLGLPGMRCHGLYVLDCKR
EEEECCCCCHHHHHHHHHHHHCCCCEEEEECCEEEEEEECCCCCCCCCEECCEEEEEECC
GDVKTIIASQTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVANMEFIQFHPTCLY
CCEEEEEECCEEEEECCCCEEEEEECCCCCCCCCCEEEHHHCCCEEECEEEEEECCCCEE
HPFAKSFLISEAVRGEGGKLVLPDGTRFMPAHDERAELAPRDIVARAIDFEMKKRGLDCV
CHHHHHHHHHHHHCCCCCEEECCCCCEECCCCCCHHHCCHHHHHHHHHHHHHHHCCCCEE
YLDISHQSPAFIQEHFPTILARCLELGIDITRQPIPVVPAAHYTCGGVVTDQLGRTDIAG
EEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
LYAVGETAYTGLHGANRLASNSLLECMVIGRGAAQDILGQPATAPTPTPIPAWDESRVTD
EEEECCHHHCCCCCHHHHHHCCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCC
ADEEVVVSHNWDELRRMMWNYVGIVRTNKRLERAQHRIALLREEIAEYYANFRVSHDLLE
CCCCEEEECCHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LRNLVEAASLIVDSALSRHESRGLHFSRDYPQTLPKALPTVMQPAHRRTSRKH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852