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The map label for this gene is clcA [H]

Identifier: 17547150

GI number: 17547150

Start: 2635464

End: 2637263

Strand: Direct

Name: clcA [H]

Synonym: RSc2431

Alternate gene names: 17547150

Gene position: 2635464-2637263 (Clockwise)

Preceding gene: 17547149

Following gene: 17547153

Centisome position: 70.91

GC content: 71.0

Gene sequence:

>1800_bases
ATGCAAACCCACGTCCTCCGGCGCGATTTCGCCACCGACACCACCCTGTTCCGCACCGTCGCGCTAGCGGCGGTCATCGC
CGCGCTCGCCACGGTCGCGGCAGCGGTGCTGCTCGGTCTGATCCGCTTCTTCACCAACCTGTTCTTCTTCCAAACGCTAT
CGTTCGCGGACCATTCGCCGGCCGGCAACACGCTGGGCCTGTGGGTCATCGCGGTGCCGGTCATCGGCGGGCTGATCGTG
GGCCTGATGGCGCGCTTCGGCTCGGACAAGATCCGCGGCCACGGCATCCCCGAGGCAATCGAAGCGATCCTGTTCGGCAA
AAGCCGGATGTCGCCCAGGGTGGCGGTGCTCAAGCCGCTGTCGTCGGGCATCGTGATCGGCAGCGGCGGACCGTTCGGCG
CGGAAGGTCCGATCATCATGACCGGCGGCGCGATCGGCTCGCTGCTCGCGCAGTGCTTCCGGCTGACCGCCGCCGAGCGC
AAGACGCTGCTGGTGGCGGGCGCCACCGCCGGCATGACTGCCGTGTTCGGCACCCCGGTGGCCGCGGTGCTGCTGGCGGT
GGAACTGCTGCTGTTCGAATGGCGCCCGCGCAGCATGCTGCCGGTGGCGGTGGCGTGCGCGGTGGCCGGCTTCCTGCGCG
TGCTGGTGCTGGAACCGGGCCCGCTCTTTCCGCTGGCGACCGCCCCGGCAACGCTGCCGGCGCTAGGCTCGTGCGTGATC
GCGGGGCTGCTGTGCGGGGCACTGTCGCGTTCGCTGTCGACCGCGCTCTACAAAACCGAAGACCTGTTCGGCCGCCTGCC
GATCCACTGGATGTGGTGGCCCGCCCTCGGCGGGCTGGCCATCGGCATCGGCGGCTATTTCGAACCGCGCGCGCTGGGCG
TGGGCTACGACGTCATCGGCGATCTGCTGCACAACCACCTGGCCATCCGCATCGCGCTCGCGCTGCTGGTGGTCAAGGCG
CTGATCTGGGTGATCGCGCTGGGCTCGGGCACGTCCGGCGGCGTCCTTGCGCCGCTGCTGATGATGGGCGCGGGCCTGGG
CGTGCTGCTCGGCCCCGTCCTGCCAGGCGGCGACCCAGGGCTGTGGCCGCTGGTGTGCATGGCCGCCACGCTGGCCGGTG
TGCTGGGCGCGCCGCTCACCGCCATCGTGTTCGCCTTCGGGCTCACGCACGACATCAACGCCATCCTGCCGGCGCTGCTG
GCGGTGTCGGTCGCGTACGGTTTTGTGGTGCTGACCATGCCGCGCTCGATCATGACCGAGAAGATCGCGCGGCGCGGGTT
CCACATCTATCGCGAATACGCGGTGGATCCGCTGGAGCGCCACGCCGTCGACGAGGTGATGACGCGCACCGTGCAGACCA
TCGATGCGCAAGCCTTCGTGGCCGGCATCCTGGCCGAGCGCTTCGGCCCGACGCAGGCGCACCGCGCGTTTCCGGTGGTG
CGCAACGGCGCGCTGATTGGCATGCTGGACCGCGACGCCCTGCTCGCCGGCCACGCGCGCGGCGCGGCCATGATCGCCGA
CCTGTTCGGCGCCAACGCGCCGGTGATGGCGCTGCCCGGCGAGACCTGCCGCATCGTCGCCACGCGCCTGGCCGTGCACG
GACTGGAGCGGCTGCCGGTCGTGGCCGATGCGCAATCGCGCCGGCTGGTGGGCATTGTCTCGCGCAGCGACCTGGTCAAG
CCGTCGGTGGCGTTCTTCGATGAGGAGCAGCGCCGCGAGCGGTTCCGGCGCGCGCCGCTGGCAGGCGCCCGCGTGCAGCT
CGAACTGCGGCGCAGGCGCGCACGCCGTACGCCGAACTGA

Upstream 100 bases:

>100_bases
GAACGCTGCGTCGGCCAGTTGGCGGCGCTGCACCAGAGCGAGCTGAGCGCCTTCAAGCGCGCCTTCCGCCTGCCCGATTT
CGAAGCCTAGGAGCCGCCCC

Downstream 100 bases:

>100_bases
GCGGCCGGCTTGCGCGTAAAGGCATCGGCGCCGCGCTCCTAACCCGCCGCGTGCCGGTTCCGCCCGCTTTCCTTGGCGCG
GTAGAGCGCCAGGTCGGCGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MQTHVLRRDFATDTTLFRTVALAAVIAALATVAAAVLLGLIRFFTNLFFFQTLSFADHSPAGNTLGLWVIAVPVIGGLIV
GLMARFGSDKIRGHGIPEAIEAILFGKSRMSPRVAVLKPLSSGIVIGSGGPFGAEGPIIMTGGAIGSLLAQCFRLTAAER
KTLLVAGATAGMTAVFGTPVAAVLLAVELLLFEWRPRSMLPVAVACAVAGFLRVLVLEPGPLFPLATAPATLPALGSCVI
AGLLCGALSRSLSTALYKTEDLFGRLPIHWMWWPALGGLAIGIGGYFEPRALGVGYDVIGDLLHNHLAIRIALALLVVKA
LIWVIALGSGTSGGVLAPLLMMGAGLGVLLGPVLPGGDPGLWPLVCMAATLAGVLGAPLTAIVFAFGLTHDINAILPALL
AVSVAYGFVVLTMPRSIMTEKIARRGFHIYREYAVDPLERHAVDEVMTRTVQTIDAQAFVAGILAERFGPTQAHRAFPVV
RNGALIGMLDRDALLAGHARGAAMIADLFGANAPVMALPGETCRIVATRLAVHGLERLPVVADAQSRRLVGIVSRSDLVK
PSVAFFDEEQRRERFRRAPLAGARVQLELRRRRARRTPN

Sequences:

>Translated_599_residues
MQTHVLRRDFATDTTLFRTVALAAVIAALATVAAAVLLGLIRFFTNLFFFQTLSFADHSPAGNTLGLWVIAVPVIGGLIV
GLMARFGSDKIRGHGIPEAIEAILFGKSRMSPRVAVLKPLSSGIVIGSGGPFGAEGPIIMTGGAIGSLLAQCFRLTAAER
KTLLVAGATAGMTAVFGTPVAAVLLAVELLLFEWRPRSMLPVAVACAVAGFLRVLVLEPGPLFPLATAPATLPALGSCVI
AGLLCGALSRSLSTALYKTEDLFGRLPIHWMWWPALGGLAIGIGGYFEPRALGVGYDVIGDLLHNHLAIRIALALLVVKA
LIWVIALGSGTSGGVLAPLLMMGAGLGVLLGPVLPGGDPGLWPLVCMAATLAGVLGAPLTAIVFAFGLTHDINAILPALL
AVSVAYGFVVLTMPRSIMTEKIARRGFHIYREYAVDPLERHAVDEVMTRTVQTIDAQAFVAGILAERFGPTQAHRAFPVV
RNGALIGMLDRDALLAGHARGAAMIADLFGANAPVMALPGETCRIVATRLAVHGLERLPVVADAQSRRLVGIVSRSDLVK
PSVAFFDEEQRRERFRRAPLAGARVQLELRRRRARRTPN
>Mature_599_residues
MQTHVLRRDFATDTTLFRTVALAAVIAALATVAAAVLLGLIRFFTNLFFFQTLSFADHSPAGNTLGLWVIAVPVIGGLIV
GLMARFGSDKIRGHGIPEAIEAILFGKSRMSPRVAVLKPLSSGIVIGSGGPFGAEGPIIMTGGAIGSLLAQCFRLTAAER
KTLLVAGATAGMTAVFGTPVAAVLLAVELLLFEWRPRSMLPVAVACAVAGFLRVLVLEPGPLFPLATAPATLPALGSCVI
AGLLCGALSRSLSTALYKTEDLFGRLPIHWMWWPALGGLAIGIGGYFEPRALGVGYDVIGDLLHNHLAIRIALALLVVKA
LIWVIALGSGTSGGVLAPLLMMGAGLGVLLGPVLPGGDPGLWPLVCMAATLAGVLGAPLTAIVFAFGLTHDINAILPALL
AVSVAYGFVVLTMPRSIMTEKIARRGFHIYREYAVDPLERHAVDEVMTRTVQTIDAQAFVAGILAERFGPTQAHRAFPVV
RNGALIGMLDRDALLAGHARGAAMIADLFGANAPVMALPGETCRIVATRLAVHGLERLPVVADAQSRRLVGIVSRSDLVK
PSVAFFDEEQRRERFRRAPLAGARVQLELRRRRARRTPN

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=347, Percent_Identity=29.1066282420749, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786350, Length=407, Percent_Identity=26.7813267813268, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 63180; Mature: 63180

Theoretical pI: Translated: 10.70; Mature: 10.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTHVLRRDFATDTTLFRTVALAAVIAALATVAAAVLLGLIRFFTNLFFFQTLSFADHSP
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGNTLGLWVIAVPVIGGLIVGLMARFGSDKIRGHGIPEAIEAILFGKSRMSPRVAVLKPL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCHHEEEEC
SSGIVIGSGGPFGAEGPIIMTGGAIGSLLAQCFRLTAAERKTLLVAGATAGMTAVFGTPV
CCCEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCHH
AAVLLAVELLLFEWRPRSMLPVAVACAVAGFLRVLVLEPGPLFPLATAPATLPALGSCVI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
AGLLCGALSRSLSTALYKTEDLFGRLPIHWMWWPALGGLAIGIGGYFEPRALGVGYDVIG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCEEEECCCCCCCCCCCCCHHHHH
DLLHNHLAIRIALALLVVKALIWVIALGSGTSGGVLAPLLMMGAGLGVLLGPVLPGGDPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHCCCCCCCCC
LWPLVCMAATLAGVLGAPLTAIVFAFGLTHDINAILPALLAVSVAYGFVVLTMPRSIMTE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
KIARRGFHIYREYAVDPLERHAVDEVMTRTVQTIDAQAFVAGILAERFGPTQAHRAFPVV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEE
RNGALIGMLDRDALLAGHARGAAMIADLFGANAPVMALPGETCRIVATRLAVHGLERLPV
ECCCEEEEECCHHHHHCCCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHCCE
VADAQSRRLVGIVSRSDLVKPSVAFFDEEQRRERFRRAPLAGARVQLELRRRRARRTPN
EECCCCCCEEEEECCCCCCCCHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQTHVLRRDFATDTTLFRTVALAAVIAALATVAAAVLLGLIRFFTNLFFFQTLSFADHSP
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGNTLGLWVIAVPVIGGLIVGLMARFGSDKIRGHGIPEAIEAILFGKSRMSPRVAVLKPL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCHHEEEEC
SSGIVIGSGGPFGAEGPIIMTGGAIGSLLAQCFRLTAAERKTLLVAGATAGMTAVFGTPV
CCCEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCHH
AAVLLAVELLLFEWRPRSMLPVAVACAVAGFLRVLVLEPGPLFPLATAPATLPALGSCVI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
AGLLCGALSRSLSTALYKTEDLFGRLPIHWMWWPALGGLAIGIGGYFEPRALGVGYDVIG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCEEEECCCCCCCCCCCCCHHHHH
DLLHNHLAIRIALALLVVKALIWVIALGSGTSGGVLAPLLMMGAGLGVLLGPVLPGGDPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHCCCCCCCCC
LWPLVCMAATLAGVLGAPLTAIVFAFGLTHDINAILPALLAVSVAYGFVVLTMPRSIMTE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
KIARRGFHIYREYAVDPLERHAVDEVMTRTVQTIDAQAFVAGILAERFGPTQAHRAFPVV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEE
RNGALIGMLDRDALLAGHARGAAMIADLFGANAPVMALPGETCRIVATRLAVHGLERLPV
ECCCEEEEECCHHHHHCCCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHCCE
VADAQSRRLVGIVSRSDLVKPSVAFFDEEQRRERFRRAPLAGARVQLELRRRRARRTPN
EECCCCCCEEEEECCCCCCCCHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA