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The map label for this gene is glxR [H]

Identifier: 17547148

GI number: 17547148

Start: 2633842

End: 2634738

Strand: Direct

Name: glxR [H]

Synonym: RSc2429

Alternate gene names: 17547148

Gene position: 2633842-2634738 (Clockwise)

Preceding gene: 17547147

Following gene: 17547149

Centisome position: 70.87

GC content: 70.9

Gene sequence:

>897_bases
ATGACACGCATCGCCTTCATCGGCCTCGGCAACATGGGGTCGCCGATGGTCCAACATCTCATCGCGGCCGGCCATGCCGT
GCGCGCCTACGTGCGCCGTCCCGAAGCCGCCGAGCACGCCCGTGCCCTGGGCGCCGAGCCATGCGCCTCCCCCGCCGACG
CCGCGCGCGACGCCGAAGCCATCTTCACCAACGTCACCTCCACGGCCGACGTGGAGGCTGTGCTGCTGGGGCCGGACGGC
GTCATCCACGGCGCGCCCCGTGGCAAACCCGGCGGCGCGGTATGCATCGACCACAGCACGATCTCCGCGGTGGCCACGCG
CCGCATTGCGGCCGAACTGGAAGCGGCCGGGCTCGACTTCCTGGACGCCCCGGTGTCGGGCGGCACCCTGGGCGCGCAGA
AGGCCACGCTGTCGATCATGGTCGGCGGCAAGGCCGAAGTGCTCGAGCGTGCGCGCCCCCTGCTGCAGCTGCTGGGCACC
ACCATCACGCACATCGGCGGCCACGGCGCGGGCCAGGTCGCCAAGGCATGCAACCAGATCGTGCAGGTGATCAACATCCA
GGGCATCGCCGAGGCCATGCTGTTCGCGCGCGCCCAGGGCACCGATCCGTCGCGCGTGCTGGCGGCCATCGGCCCGGGCT
TCGCGGGCAGCCGCATGCTGGACATGATGGGACCGAAGATGGCCGAGCGGAACTTCGCCGCCGGCATCGAGGCCCGCCTG
CACGACAAGGACTTCGGCCTGGTGCGCGACATCGCCCGCGAGCTCGGCCTGAAAATGCCGGCGATGGAGCTGGTGGCTTC
GCAGCTCGATGCGCTCGTCGACAGCGGATGGGGCTACGACGATACGTCGTCGCTGCTGCGCGTGCTGGAAGCACAAAACG
GCCGGGCGCCGTCCTGA

Upstream 100 bases:

>100_bases
GCCCGCGATCACCAGGGCTTCGACCAGCGCTCGCGCGTGATGGGCATCATCCGGGACGGACGCTTCGCCTACGCGGGCCC
ACGCTGACGGGAGACTTGCC

Downstream 100 bases:

>100_bases
CCCGCGGGCCGGAAGGCAGCCGCCTTGTCCGGGGCGCCGCGTTTCTGGCATAATTGCCGGCTCATTCGCACCCTGCCCGG
GTGGTGAAACAGGTAGACGC

Product: oxidoreductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTRIAFIGLGNMGSPMVQHLIAAGHAVRAYVRRPEAAEHARALGAEPCASPADAARDAEAIFTNVTSTADVEAVLLGPDG
VIHGAPRGKPGGAVCIDHSTISAVATRRIAAELEAAGLDFLDAPVSGGTLGAQKATLSIMVGGKAEVLERARPLLQLLGT
TITHIGGHGAGQVAKACNQIVQVINIQGIAEAMLFARAQGTDPSRVLAAIGPGFAGSRMLDMMGPKMAERNFAAGIEARL
HDKDFGLVRDIARELGLKMPAMELVASQLDALVDSGWGYDDTSSLLRVLEAQNGRAPS

Sequences:

>Translated_298_residues
MTRIAFIGLGNMGSPMVQHLIAAGHAVRAYVRRPEAAEHARALGAEPCASPADAARDAEAIFTNVTSTADVEAVLLGPDG
VIHGAPRGKPGGAVCIDHSTISAVATRRIAAELEAAGLDFLDAPVSGGTLGAQKATLSIMVGGKAEVLERARPLLQLLGT
TITHIGGHGAGQVAKACNQIVQVINIQGIAEAMLFARAQGTDPSRVLAAIGPGFAGSRMLDMMGPKMAERNFAAGIEARL
HDKDFGLVRDIARELGLKMPAMELVASQLDALVDSGWGYDDTSSLLRVLEAQNGRAPS
>Mature_297_residues
TRIAFIGLGNMGSPMVQHLIAAGHAVRAYVRRPEAAEHARALGAEPCASPADAARDAEAIFTNVTSTADVEAVLLGPDGV
IHGAPRGKPGGAVCIDHSTISAVATRRIAAELEAAGLDFLDAPVSGGTLGAQKATLSIMVGGKAEVLERARPLLQLLGTT
ITHIGGHGAGQVAKACNQIVQVINIQGIAEAMLFARAQGTDPSRVLAAIGPGFAGSRMLDMMGPKMAERNFAAGIEARLH
DKDFGLVRDIARELGLKMPAMELVASQLDALVDSGWGYDDTSSLLRVLEAQNGRAPS

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=299, Percent_Identity=31.1036789297659, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI40556376, Length=250, Percent_Identity=28, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786719, Length=288, Percent_Identity=39.9305555555556, Blast_Score=205, Evalue=2e-54,
Organism=Escherichia coli, GI145693186, Length=283, Percent_Identity=38.1625441696113, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1790315, Length=298, Percent_Identity=33.5570469798658, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=28.6689419795222, Blast_Score=85, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17557316, Length=304, Percent_Identity=31.5789473684211, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24655230, Length=299, Percent_Identity=31.438127090301, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI19922568, Length=299, Percent_Identity=31.438127090301, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28574115, Length=286, Percent_Identity=24.4755244755245, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30822; Mature: 30691

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIAFIGLGNMGSPMVQHLIAAGHAVRAYVRRPEAAEHARALGAEPCASPADAARDAEA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHH
IFTNVTSTADVEAVLLGPDGVIHGAPRGKPGGAVCIDHSTISAVATRRIAAELEAAGLDF
HHHHCCCCCCCEEEEECCCCEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCH
LDAPVSGGTLGAQKATLSIMVGGKAEVLERARPLLQLLGTTITHIGGHGAGQVAKACNQI
HCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VQVINIQGIAEAMLFARAQGTDPSRVLAAIGPGFAGSRMLDMMGPKMAERNFAAGIEARL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCHHEE
HDKDFGLVRDIARELGLKMPAMELVASQLDALVDSGWGYDDTSSLLRVLEAQNGRAPS
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TRIAFIGLGNMGSPMVQHLIAAGHAVRAYVRRPEAAEHARALGAEPCASPADAARDAEA
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHH
IFTNVTSTADVEAVLLGPDGVIHGAPRGKPGGAVCIDHSTISAVATRRIAAELEAAGLDF
HHHHCCCCCCCEEEEECCCCEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCH
LDAPVSGGTLGAQKATLSIMVGGKAEVLERARPLLQLLGTTITHIGGHGAGQVAKACNQI
HCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VQVINIQGIAEAMLFARAQGTDPSRVLAAIGPGFAGSRMLDMMGPKMAERNFAAGIEARL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCHHEE
HDKDFGLVRDIARELGLKMPAMELVASQLDALVDSGWGYDDTSSLLRVLEAQNGRAPS
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]