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The map label for this gene is hemC

Identifier: 17547076

GI number: 17547076

Start: 2556982

End: 2557986

Strand: Reverse

Name: hemC

Synonym: RSc2357

Alternate gene names: 17547076

Gene position: 2557986-2556982 (Counterclockwise)

Preceding gene: 17547078

Following gene: 17547075

Centisome position: 68.83

GC content: 72.44

Gene sequence:

>1005_bases
ATGTCTTCAAACGCCCGTCCGACCTCCGTCGAATCCCCTCTGGCAGCCCAGGCGCCGACCAAGCTGGTCATCGCCTCGCG
CGAAAGCCGGCTCGCCATGTGGCAGGCCGAATACGTGCGTGCTGCGTTGCAAAAATACTATCCCGCGTGCGACGTGTCCA
TCCTGGGCATGACTACGCGCGGTGACCAGATTCTCGACCGCTCGCTCGCCAAGGTGGGCGGCAAGGGCCTGTTCGTGAAG
GAGCTCGAGGTCGCGCTCGCCGAGGGCCGCGCCGACCTCGCCGTCCACTCGCTCAAGGACGTGCCGATGGAGCTGCCGCC
GGGCTTCGTGCTGTCGGCCATCCTCGAGCGCGAGGATCCGCGTGATGCCTTTGTCTCCAATGATTACGCCGATCTCGCCG
CGCTGCCCGCGGGCGCGGTGGTGGGCACCTCCAGCCTGCGCCGCGAGGCGTCGCTGCGGGCGCGCTTTCCGCACCTGGTC
ATCCAGCCGCTGCGCGGCAATCTCGACACACGGCTGTCCAAGCTCGACCGCGGCGATTACGCGGCCATCATCCTCGCGGC
CGCCGGGCTCAAGCGGCTGGGGCTGTCCGAGCGCATCCGCGCCGTCATCGCGCCCGAAACGTCCCTGCCGGCGGCGGGGC
AGGGCGCGCTCGGCATCGAGAGCCGCGTCGATCGCCACGACGTGCAGGCCTGGCTCGCGCCGCTGCATCACGCGCCCACG
GCGCTGGCCGTGACCGCCGAGCGCGCGGTGTCGCGCCAGCTGGGCGGCTCGTGCCAGGTGCCGCTGGCCGCGTTCGCGCA
ATGGACCGATGCCGGCGCGCTGCGCCTGCGCGCCTTCGTCGCTTCGCCGGACGGCCGCCGCAAGCTTGCCGCCGAAGCCG
AGGCCACGCCCGCCACACCGGCCGAGGCCGAGGCCCTGGGCGCCCGCGTCGCGCAGCAGATGCTGGACGGCGGCGCACAC
GACATCCTCGCCACGCTGGGCGCCGACGCGCCGCCCGCCACCTGA

Upstream 100 bases:

>100_bases
CCTGGTTGGATGGGTCAAGTGCCGGATCGGTCTTCTTTTCTGCATCACTTCCACGGGATGGCCGCCCTGTGGCGAAAAAG
CTGCGTGCTACCATTGCCGC

Downstream 100 bases:

>100_bases
CCTCCCGGCCCGCCATGGACGACCGCTCGCCTTCTCCATCCAGCGTGCCGCCCGACGCTCTCCCGCATCCTTCCGCGCCC
GTCGTCATCGTCACGCGGCC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSSNARPTSVESPLAAQAPTKLVIASRESRLAMWQAEYVRAALQKYYPACDVSILGMTTRGDQILDRSLAKVGGKGLFVK
ELEVALAEGRADLAVHSLKDVPMELPPGFVLSAILEREDPRDAFVSNDYADLAALPAGAVVGTSSLRREASLRARFPHLV
IQPLRGNLDTRLSKLDRGDYAAIILAAAGLKRLGLSERIRAVIAPETSLPAAGQGALGIESRVDRHDVQAWLAPLHHAPT
ALAVTAERAVSRQLGGSCQVPLAAFAQWTDAGALRLRAFVASPDGRRKLAAEAEATPATPAEAEALGARVAQQMLDGGAH
DILATLGADAPPAT

Sequences:

>Translated_334_residues
MSSNARPTSVESPLAAQAPTKLVIASRESRLAMWQAEYVRAALQKYYPACDVSILGMTTRGDQILDRSLAKVGGKGLFVK
ELEVALAEGRADLAVHSLKDVPMELPPGFVLSAILEREDPRDAFVSNDYADLAALPAGAVVGTSSLRREASLRARFPHLV
IQPLRGNLDTRLSKLDRGDYAAIILAAAGLKRLGLSERIRAVIAPETSLPAAGQGALGIESRVDRHDVQAWLAPLHHAPT
ALAVTAERAVSRQLGGSCQVPLAAFAQWTDAGALRLRAFVASPDGRRKLAAEAEATPATPAEAEALGARVAQQMLDGGAH
DILATLGADAPPAT
>Mature_333_residues
SSNARPTSVESPLAAQAPTKLVIASRESRLAMWQAEYVRAALQKYYPACDVSILGMTTRGDQILDRSLAKVGGKGLFVKE
LEVALAEGRADLAVHSLKDVPMELPPGFVLSAILEREDPRDAFVSNDYADLAALPAGAVVGTSSLRREASLRARFPHLVI
QPLRGNLDTRLSKLDRGDYAAIILAAAGLKRLGLSERIRAVIAPETSLPAAGQGALGIESRVDRHDVQAWLAPLHHAPTA
LAVTAERAVSRQLGGSCQVPLAAFAQWTDAGALRLRAFVASPDGRRKLAAEAEATPATPAEAEALGARVAQQMLDGGAHD
ILATLGADAPPAT

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI66933009, Length=285, Percent_Identity=45.9649122807018, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI20149500, Length=285, Percent_Identity=45.9649122807018, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI48994974, Length=311, Percent_Identity=57.556270096463, Blast_Score=335, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6319996, Length=323, Percent_Identity=38.390092879257, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI20130425, Length=295, Percent_Identity=41.3559322033898, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_RALSO (Q8XWW3)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520478.1
- ProteinModelPortal:   Q8XWW3
- SMR:   Q8XWW3
- GeneID:   1221203
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2357
- NMPDR:   fig|267608.1.peg.2357
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- ProtClustDB:   PRK00072
- BioCyc:   RSOL267608:RSC2357-MONOMER
- BRENDA:   2.5.1.61
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 35188; Mature: 35056

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNARPTSVESPLAAQAPTKLVIASRESRLAMWQAEYVRAALQKYYPACDVSILGMTTR
CCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
GDQILDRSLAKVGGKGLFVKELEVALAEGRADLAVHSLKDVPMELPPGFVLSAILEREDP
CHHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCC
RDAFVSNDYADLAALPAGAVVGTSSLRREASLRARFPHLVIQPLRGNLDTRLSKLDRGDY
CHHHHCCCHHHHHHCCCCHHHCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHCCCCCH
AAIILAAAGLKRLGLSERIRAVIAPETSLPAAGQGALGIESRVDRHDVQAWLAPLHHAPT
HHHHHHHHHHHHCCHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
ALAVTAERAVSRQLGGSCQVPLAAFAQWTDAGALRLRAFVASPDGRRKLAAEAEATPATP
CEEHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEEECCCCCHHHHHCCCCCCCCC
AEAEALGARVAQQMLDGGAHDILATLGADAPPAT
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSNARPTSVESPLAAQAPTKLVIASRESRLAMWQAEYVRAALQKYYPACDVSILGMTTR
CCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
GDQILDRSLAKVGGKGLFVKELEVALAEGRADLAVHSLKDVPMELPPGFVLSAILEREDP
CHHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCC
RDAFVSNDYADLAALPAGAVVGTSSLRREASLRARFPHLVIQPLRGNLDTRLSKLDRGDY
CHHHHCCCHHHHHHCCCCHHHCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHCCCCCH
AAIILAAAGLKRLGLSERIRAVIAPETSLPAAGQGALGIESRVDRHDVQAWLAPLHHAPT
HHHHHHHHHHHHCCHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
ALAVTAERAVSRQLGGSCQVPLAAFAQWTDAGALRLRAFVASPDGRRKLAAEAEATPATP
CEEHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEEECCCCCHHHHHCCCCCCCCC
AEAEALGARVAQQMLDGGAHDILATLGADAPPAT
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852