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The map label for this gene is hemF [H]

Identifier: 17546911

GI number: 17546911

Start: 2374827

End: 2375735

Strand: Direct

Name: hemF [H]

Synonym: RSc2192

Alternate gene names: 17546911

Gene position: 2374827-2375735 (Clockwise)

Preceding gene: 17546910

Following gene: 17546912

Centisome position: 63.9

GC content: 69.64

Gene sequence:

>909_bases
ATGGATACCCAAGCCGTCCGAGCCTACCTGCTGGATCTGCAGGACCGCATCACCACCGCCGTCGGCACGCTCGACGGCGG
CACGTTCGTCACCGACACGTGGGACAAGCCGCCCACCGAACGCCTGCGCGGCAGCGGCCGCACCTGCATCCTGGAGAACG
GCGCCGTGCTGGAGCGCGGCGGCGTGGGCTTCTCGCACGTGATGGGCGACACCCTGCCGCCGTCGGCCACGGCCAACCGG
CCCGAGCTGGCCGGGCGCGGCTTCGAAGCGATGGGCGTGTCGCTGGTGTTCCACCCGCGCAACCCGTACGCGCCGACCGT
GCACATGAACGTGCGCTGCTTCGTCGCGCAGCGGCCCGACGCCGAGCCGGTCTGGTGGTTCGGCGGCGGCATGGACCTGA
CCCCCTACTACGGCTTCGCGGAAGACGCCGCGCATTTCCACCGCACCTGCAAGCAGGCGCTGGAGCCGTTCGGTGAAGAG
CTCTACCCGCGCTTCAAGCAGTGGTGCGACGACTACTTTTACCTGAAGCACCGCAAGGAAGCGCGCGGCGTCGGCGGCAT
CTTCTTCGACGATTTCGCCGAGCTCGGCTTCGAGCGCAGCTTCGAGATGATGCGCGCGGTCGGCGACGCGCTGCTGCCGG
CCTGGCTGCCGATCGCCGAGCAGCGCCACGCCACGCCGTACGGCGAGCGCGAGCGCGCGTTCCAGGCCTATCGCCGCGGC
CGCTATGTCGAATTCAACCTGGTGTTCGACCGCGGCACGCTGTTCGGCCTGCAGAGCGGTGGGCGAACCGAGTCGATCCT
GATGTCGATGCCGCCCGTGGCCAACTGGCGCTACGACTGGCAGCCGGAGCCGGGCTCGCCGGAAGCGGCGCTCTACACCG
ACTTCCTGCCGGCGCGCGATTGGGTATGA

Upstream 100 bases:

>100_bases
GCCGTCACCCAGGGTGATCCCCCGGCTTGCCCGGGCGGCGCGCCCGCTACAATGGTGACAACCGTATGACTGGGCCGCCG
CAGCGGCCCCTCCCGACCCG

Downstream 100 bases:

>100_bases
CGCCTCCCGATCTTGGCCGCCCCTATCGCCTGGGCCTGCTGGGCGGTACCTTCGACCCGCCGCACGTCGGCCATCTCGCC
CTGGCCGAACTGTGCATCGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MDTQAVRAYLLDLQDRITTAVGTLDGGTFVTDTWDKPPTERLRGSGRTCILENGAVLERGGVGFSHVMGDTLPPSATANR
PELAGRGFEAMGVSLVFHPRNPYAPTVHMNVRCFVAQRPDAEPVWWFGGGMDLTPYYGFAEDAAHFHRTCKQALEPFGEE
LYPRFKQWCDDYFYLKHRKEARGVGGIFFDDFAELGFERSFEMMRAVGDALLPAWLPIAEQRHATPYGERERAFQAYRRG
RYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYDWQPEPGSPEAALYTDFLPARDWV

Sequences:

>Translated_302_residues
MDTQAVRAYLLDLQDRITTAVGTLDGGTFVTDTWDKPPTERLRGSGRTCILENGAVLERGGVGFSHVMGDTLPPSATANR
PELAGRGFEAMGVSLVFHPRNPYAPTVHMNVRCFVAQRPDAEPVWWFGGGMDLTPYYGFAEDAAHFHRTCKQALEPFGEE
LYPRFKQWCDDYFYLKHRKEARGVGGIFFDDFAELGFERSFEMMRAVGDALLPAWLPIAEQRHATPYGERERAFQAYRRG
RYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYDWQPEPGSPEAALYTDFLPARDWV
>Mature_302_residues
MDTQAVRAYLLDLQDRITTAVGTLDGGTFVTDTWDKPPTERLRGSGRTCILENGAVLERGGVGFSHVMGDTLPPSATANR
PELAGRGFEAMGVSLVFHPRNPYAPTVHMNVRCFVAQRPDAEPVWWFGGGMDLTPYYGFAEDAAHFHRTCKQALEPFGEE
LYPRFKQWCDDYFYLKHRKEARGVGGIFFDDFAELGFERSFEMMRAVGDALLPAWLPIAEQRHATPYGERERAFQAYRRG
RYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYDWQPEPGSPEAALYTDFLPARDWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=306, Percent_Identity=43.1372549019608, Blast_Score=257, Evalue=1e-68,
Organism=Escherichia coli, GI1788777, Length=301, Percent_Identity=62.1262458471761, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6320249, Length=317, Percent_Identity=43.5331230283912, Blast_Score=259, Evalue=5e-70,
Organism=Drosophila melanogaster, GI17864388, Length=303, Percent_Identity=44.5544554455446, Blast_Score=261, Evalue=6e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34212; Mature: 34212

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTQAVRAYLLDLQDRITTAVGTLDGGTFVTDTWDKPPTERLRGSGRTCILENGAVLERG
CCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHCCCCCEEEEECCCEEECC
GVGFSHVMGDTLPPSATANRPELAGRGFEAMGVSLVFHPRNPYAPTVHMNVRCFVAQRPD
CCCHHHHHCCCCCCCCCCCCCHHCCCCCHHCCEEEEEECCCCCCCEEEEEEEEEEECCCC
AEPVWWFGGGMDLTPYYGFAEDAAHFHRTCKQALEPFGEELYPRFKQWCDDYFYLKHRKE
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARGVGGIFFDDFAELGFERSFEMMRAVGDALLPAWLPIAEQRHATPYGERERAFQAYRRG
HCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCC
RYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYDWQPEPGSPEAALYTDFLPARD
CEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCEECCCCCCCCCCCEEEECCCCCCC
WV
CC
>Mature Secondary Structure
MDTQAVRAYLLDLQDRITTAVGTLDGGTFVTDTWDKPPTERLRGSGRTCILENGAVLERG
CCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHCCCCCEEEEECCCEEECC
GVGFSHVMGDTLPPSATANRPELAGRGFEAMGVSLVFHPRNPYAPTVHMNVRCFVAQRPD
CCCHHHHHCCCCCCCCCCCCCHHCCCCCHHCCEEEEEECCCCCCCEEEEEEEEEEECCCC
AEPVWWFGGGMDLTPYYGFAEDAAHFHRTCKQALEPFGEELYPRFKQWCDDYFYLKHRKE
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARGVGGIFFDDFAELGFERSFEMMRAVGDALLPAWLPIAEQRHATPYGERERAFQAYRRG
HCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCC
RYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYDWQPEPGSPEAALYTDFLPARD
CEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCEECCCCCCCCCCCEEEECCCCCCC
WV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA