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The map label for this gene is yggV [C]

Identifier: 17546879

GI number: 17546879

Start: 2342984

End: 2343589

Strand: Direct

Name: yggV [C]

Synonym: RSc2160

Alternate gene names: 17546879

Gene position: 2342984-2343589 (Clockwise)

Preceding gene: 17546878

Following gene: 17546880

Centisome position: 63.04

GC content: 71.78

Gene sequence:

>606_bases
GTGCGCAGGATCGTCCTGGCCTCCAACAACCCCGGCAAGCTGGCGGAGTTCAATGCGCTGCTGGCCCCGCTCGGCCTGGA
TGTCGCGCCGCAGGGCGAGCTGGGCATTCCCGAGGCGGAAGAGCCGCACGCGACCTTCGTCGAAAACGCCCTGGCCAAGG
CACGGCACGCCAGCCGCCTGGCCGGCCTGCCCGCGCTGGCGGACGACTCCGGCATCTGCGCGCACGCACTGGGCGGCGCG
CCGGGCGTGTATTCGGCCCGCTATGCGCAACTGGCCGGCGGGCCGAAGTCCGACGCCGCCAACAACGCGCGCCTGGTGCG
CGAACTGGCCGGACACGCCGATCGCGGCGCACACTATGTCTGCGTGCTGGTCTACGTGCGCCACGCGGACGATCCGCAGC
CGATCATCGCCGAAGGCAGCTGGTTCGGCGAAGTGATCGACGCGCCGCGCGGCGACGGCGGCTTCGGCTACGACCCGCAC
TTCCTGCTGCCCGCGCTCGGCAAGACGGCCGCCGAGCTGTCCAAGGCCGAGAAGAATGCCGTCAGCCACCGCGCGCAAGC
GCTCGCGCAGCTGGTCGAGCGGCTGCGCCTGTTCGAGAACGCCTGA

Upstream 100 bases:

>100_bases
CGCGCACCGAGATGGACGCGCTGCTGGGCCTGGCCGACCACGGCATCCGCACGCTGATCGGCCTGCAGAAGCAGGCGCTC
GGCCTGTGAGCGGAGCGGAC

Downstream 100 bases:

>100_bases
CGCTTCATGATTCCGATCCACCCCGTGGGCGGGAGCCAGACGCCCGCTTCTTCCACCGCCGCAGCCGGGACCGGCGATGC
CGTCACGTCGGTCTTCCTGC

Product: deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MRRIVLASNNPGKLAEFNALLAPLGLDVAPQGELGIPEAEEPHATFVENALAKARHASRLAGLPALADDSGICAHALGGA
PGVYSARYAQLAGGPKSDAANNARLVRELAGHADRGAHYVCVLVYVRHADDPQPIIAEGSWFGEVIDAPRGDGGFGYDPH
FLLPALGKTAAELSKAEKNAVSHRAQALAQLVERLRLFENA

Sequences:

>Translated_201_residues
MRRIVLASNNPGKLAEFNALLAPLGLDVAPQGELGIPEAEEPHATFVENALAKARHASRLAGLPALADDSGICAHALGGA
PGVYSARYAQLAGGPKSDAANNARLVRELAGHADRGAHYVCVLVYVRHADDPQPIIAEGSWFGEVIDAPRGDGGFGYDPH
FLLPALGKTAAELSKAEKNAVSHRAQALAQLVERLRLFENA
>Mature_201_residues
MRRIVLASNNPGKLAEFNALLAPLGLDVAPQGELGIPEAEEPHATFVENALAKARHASRLAGLPALADDSGICAHALGGA
PGVYSARYAQLAGGPKSDAANNARLVRELAGHADRGAHYVCVLVYVRHADDPQPIIAEGSWFGEVIDAPRGDGGFGYDPH
FLLPALGKTAAELSKAEKNAVSHRAQALAQLVERLRLFENA

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family

Homologues:

Organism=Homo sapiens, GI15626999, Length=194, Percent_Identity=32.9896907216495, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI31657144, Length=147, Percent_Identity=36.0544217687075, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1789324, Length=198, Percent_Identity=50.5050505050505, Blast_Score=204, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17556833, Length=199, Percent_Identity=32.1608040201005, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19920712, Length=188, Percent_Identity=33.5106382978723, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPA_RALSO (Q8XXF4)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520281.1
- ProteinModelPortal:   Q8XXF4
- SMR:   Q8XXF4
- GeneID:   1221003
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2160
- NMPDR:   fig|267608.1.peg.2160
- HOGENOM:   HBG697237
- OMA:   VYTADWA
- ProtClustDB:   PRK00120
- BioCyc:   RSOL267608:RSC2160-MONOMER
- BRENDA:   3.6.1.15
- HAMAP:   MF_01405
- InterPro:   IPR002637
- InterPro:   IPR020922
- PANTHER:   PTHR11067
- TIGRFAMs:   TIGR00042

Pfam domain/function: PF01725 Ham1p_like

EC number: =3.6.1.15

Molecular weight: Translated: 21108; Mature: 21108

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIVLASNNPGKLAEFNALLAPLGLDVAPQGELGIPEAEEPHATFVENALAKARHASRL
CCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AGLPALADDSGICAHALGGAPGVYSARYAQLAGGPKSDAANNARLVRELAGHADRGAHYV
HCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEE
CVLVYVRHADDPQPIIAEGSWFGEVIDAPRGDGGFGYDPHFLLPALGKTAAELSKAEKNA
EEEEEECCCCCCCCEEECCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VSHRAQALAQLVERLRLFENA
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRRIVLASNNPGKLAEFNALLAPLGLDVAPQGELGIPEAEEPHATFVENALAKARHASRL
CCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AGLPALADDSGICAHALGGAPGVYSARYAQLAGGPKSDAANNARLVRELAGHADRGAHYV
HCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEE
CVLVYVRHADDPQPIIAEGSWFGEVIDAPRGDGGFGYDPHFLLPALGKTAAELSKAEKNA
EEEEEECCCCCCCCEEECCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VSHRAQALAQLVERLRLFENA
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852