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The map label for this gene is atzB [H]

Identifier: 17546838

GI number: 17546838

Start: 2295684

End: 2297108

Strand: Direct

Name: atzB [H]

Synonym: RSc2119

Alternate gene names: 17546838

Gene position: 2295684-2297108 (Clockwise)

Preceding gene: 17546837

Following gene: 17546839

Centisome position: 61.77

GC content: 72.56

Gene sequence:

>1425_bases
ATGACCACCCACCGCACCAGCTCCGACCCGCTCCTGATCGCCCGCCACGCCGACGTGCTGGTCACCATGGACGCGCAGCG
CCGCGAGATCGCCGACGGCGCGCTGGTGGCGCGCTGCGGCGTGATCGAGTGGGTCGGCGCCACCGCCGACCTGCCCGTGC
CCTACCGCGACGCGATCGGCCGCCCCAACGTGCGCGTGCTGGAACTGCGCGACCACGTGGTCACGCCCGGCCTGGTCAAC
ACGCACCACCACATGGCCCAGAGCCTGACGCGCGCCCTGCCCGCCGCGCAGGATGCCGAGCTGTTCGGCTGGCTCACCCA
CCTGTATCCGGTGTGGGCGGGCCTGACGCCGGAGATGGTGCGCGTGTCGACGCTCACCGCGATGGCCGAGCTGATGCTGT
CGGGCTGCACGACTTCGAGCGATCACCTGTATCTGTATCCCAACGGCTGCCGGCTCGACGATGCGATCGAGGCCGCGCGG
CAGATCGGCATGCGCTTTCACGCCGCGCGCGGCAGCATGAGCGTTGGCCGCAGCCAGGGCGGGCTGCCGCCGGACCGCGT
GGTCGAGGGCGAGCCCGCCATCCTGCGCGAAACCCAGCGCCTGATCGAGACCTGGCACGACGCCGACCGCCATGCGATGC
TGCGCATCGTCGTGGCGCCCTGCTCGCCGTTCTCGGTGTCGCGCGACCTGATGCGCGAATCGGCGCGGCTGGCGCGCAGC
TACGGCGTGTCGATGCACACCCACCTGGCCGAGAACGACAGCGACATCGCCTACTCGCGCGAGCGGTTCGGCATGACGCC
CGCCGAATACGCTGAAGACCTCGGCTGGGTCGGCCACGACGTCTGGCATGCGCACTGCGTCAAGCTGGACGCGCACGGCA
TCGAGCTGTTCGCGCGCACCGGCACCGGGGTGGCCCACTGCCCGTGCTCGAACATGCGGCTCGCCTCGGGCATCGCGCCC
GTGCGCGCCATGCGCGATGCCGGGGCGCCGGTCGGCCTGGGGGTGGACGGCAGCGCGTCGAACGACGGCGCCCACATGCT
CGGCGAGGCGCGCCAGGCGATGCTGCTGGCGCGCGTCGGTTTCGGCCCGGCGGCGATGGGCGCGCGCGAGGCGCTGGAGA
TCGCCACGCTGGGCGGCGCCTGCGTGCTCAACCGCGACGACATCGGCGCGCTCGCGCCCGGCATGTCGGCCGACTTTGTC
AGCTTCGACCGCCGCCAGGTCGGCTTTGCCGGCGCGGACCACGACCCGGTCGCGGCGCTGGTGTTCTGCGCGCCGTCCGG
CGTGTCGCACAGCGTGATCAACGGGCGCGTGGTGGTCGACAACCGTCGCCTGGTCACGCTGGAGCTCGGCGCCCATCTGA
GCGTTCACCGCAAGCTTGCGCTGGAGCTGGCGCAGACCGCCCGGGCCGTTCCGGCCTCCGCATGA

Upstream 100 bases:

>100_bases
CTGGTGGCGGTGATCCTGAACCTGTACTACAACGGCATGCAGCCGGCCGAGCACGCCATGCGCGCGGCCGCGGCCACCAC
GCACAGCGCGGAGTGAGCGC

Downstream 100 bases:

>100_bases
CCTCTCCTCGAACGACAGCCATGACCCACAAGAACTATCCGCGCGATCTCATCGGTTACGGCAAGACCCCGCCCGACCCC
AAATGGCCCGGCGGCGCGCG

Product: hydroxydechloroatrazine ethylaminohydrolase

Products: NA

Alternate protein names: Hydroxyatrazine hydrolase [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MTTHRTSSDPLLIARHADVLVTMDAQRREIADGALVARCGVIEWVGATADLPVPYRDAIGRPNVRVLELRDHVVTPGLVN
THHHMAQSLTRALPAAQDAELFGWLTHLYPVWAGLTPEMVRVSTLTAMAELMLSGCTTSSDHLYLYPNGCRLDDAIEAAR
QIGMRFHAARGSMSVGRSQGGLPPDRVVEGEPAILRETQRLIETWHDADRHAMLRIVVAPCSPFSVSRDLMRESARLARS
YGVSMHTHLAENDSDIAYSRERFGMTPAEYAEDLGWVGHDVWHAHCVKLDAHGIELFARTGTGVAHCPCSNMRLASGIAP
VRAMRDAGAPVGLGVDGSASNDGAHMLGEARQAMLLARVGFGPAAMGAREALEIATLGGACVLNRDDIGALAPGMSADFV
SFDRRQVGFAGADHDPVAALVFCAPSGVSHSVINGRVVVDNRRLVTLELGAHLSVHRKLALELAQTARAVPASA

Sequences:

>Translated_474_residues
MTTHRTSSDPLLIARHADVLVTMDAQRREIADGALVARCGVIEWVGATADLPVPYRDAIGRPNVRVLELRDHVVTPGLVN
THHHMAQSLTRALPAAQDAELFGWLTHLYPVWAGLTPEMVRVSTLTAMAELMLSGCTTSSDHLYLYPNGCRLDDAIEAAR
QIGMRFHAARGSMSVGRSQGGLPPDRVVEGEPAILRETQRLIETWHDADRHAMLRIVVAPCSPFSVSRDLMRESARLARS
YGVSMHTHLAENDSDIAYSRERFGMTPAEYAEDLGWVGHDVWHAHCVKLDAHGIELFARTGTGVAHCPCSNMRLASGIAP
VRAMRDAGAPVGLGVDGSASNDGAHMLGEARQAMLLARVGFGPAAMGAREALEIATLGGACVLNRDDIGALAPGMSADFV
SFDRRQVGFAGADHDPVAALVFCAPSGVSHSVINGRVVVDNRRLVTLELGAHLSVHRKLALELAQTARAVPASA
>Mature_473_residues
TTHRTSSDPLLIARHADVLVTMDAQRREIADGALVARCGVIEWVGATADLPVPYRDAIGRPNVRVLELRDHVVTPGLVNT
HHHMAQSLTRALPAAQDAELFGWLTHLYPVWAGLTPEMVRVSTLTAMAELMLSGCTTSSDHLYLYPNGCRLDDAIEAARQ
IGMRFHAARGSMSVGRSQGGLPPDRVVEGEPAILRETQRLIETWHDADRHAMLRIVVAPCSPFSVSRDLMRESARLARSY
GVSMHTHLAENDSDIAYSRERFGMTPAEYAEDLGWVGHDVWHAHCVKLDAHGIELFARTGTGVAHCPCSNMRLASGIAPV
RAMRDAGAPVGLGVDGSASNDGAHMLGEARQAMLLARVGFGPAAMGAREALEIATLGGACVLNRDDIGALAPGMSADFVS
FDRRQVGFAGADHDPVAALVFCAPSGVSHSVINGRVVVDNRRLVTLELGAHLSVHRKLALELAQTARAVPASA

Specific function: Catalyzes the deamination reaction of hydroxyatrazine to N-isopropylammelide (dihydroxy-isopropyl-atrazine). The enzyme is also capable of catalyzing some dechlorinating reactions [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=347, Percent_Identity=23.0547550432277, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789249, Length=431, Percent_Identity=28.3062645011601, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI87082177, Length=416, Percent_Identity=23.7980769230769, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319963, Length=353, Percent_Identity=25.4957507082153, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24643849, Length=346, Percent_Identity=25.7225433526012, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.99.3 [H]

Molecular weight: Translated: 50849; Mature: 50717

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHRTSSDPLLIARHADVLVTMDAQRREIADGALVARCGVIEWVGATADLPVPYRDAIG
CCCCCCCCCCEEEEECCCEEEEECCHHHHHHCCHHHHHCCHHEECCCCCCCCCCHHHHCC
RPNVRVLELRDHVVTPGLVNTHHHMAQSLTRALPAAQDAELFGWLTHLYPVWAGLTPEMV
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHH
RVSTLTAMAELMLSGCTTSSDHLYLYPNGCRLDDAIEAARQIGMRFHAARGSMSVGRSQG
HHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCCC
GLPPDRVVEGEPAILRETQRLIETWHDADRHAMLRIVVAPCSPFSVSRDLMRESARLARS
CCCHHHEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHH
YGVSMHTHLAENDSDIAYSRERFGMTPAEYAEDLGWVGHDVWHAHCVKLDAHGIELFART
HCCEEEEEECCCCCCHHCCHHHCCCCHHHHHHHHCCCCHHHHEEEEEEEECCCEEEEEEC
GTGVAHCPCSNMRLASGIAPVRAMRDAGAPVGLGVDGSASNDGAHMLGEARQAMLLARVG
CCCEEECCCCCCCHHCCCHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
FGPAAMGAREALEIATLGGACVLNRDDIGALAPGMSADFVSFDRRQVGFAGADHDPVAAL
CCHHHCCHHHHHHHEECCCEEEECCCCCCCCCCCCCCHHHHCCCHHCCCCCCCCCCEEEE
VFCAPSGVSHSVINGRVVVDNRRLVTLELGAHLSVHRKLALELAQTARAVPASA
EEECCCCCCCCEECCEEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTHRTSSDPLLIARHADVLVTMDAQRREIADGALVARCGVIEWVGATADLPVPYRDAIG
CCCCCCCCCEEEEECCCEEEEECCHHHHHHCCHHHHHCCHHEECCCCCCCCCCHHHHCC
RPNVRVLELRDHVVTPGLVNTHHHMAQSLTRALPAAQDAELFGWLTHLYPVWAGLTPEMV
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHH
RVSTLTAMAELMLSGCTTSSDHLYLYPNGCRLDDAIEAARQIGMRFHAARGSMSVGRSQG
HHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCCC
GLPPDRVVEGEPAILRETQRLIETWHDADRHAMLRIVVAPCSPFSVSRDLMRESARLARS
CCCHHHEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHH
YGVSMHTHLAENDSDIAYSRERFGMTPAEYAEDLGWVGHDVWHAHCVKLDAHGIELFART
HCCEEEEEECCCCCCHHCCHHHCCCCHHHHHHHHCCCCHHHHEEEEEEEECCCEEEEEEC
GTGVAHCPCSNMRLASGIAPVRAMRDAGAPVGLGVDGSASNDGAHMLGEARQAMLLARVG
CCCEEECCCCCCCHHCCCHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
FGPAAMGAREALEIATLGGACVLNRDDIGALAPGMSADFVSFDRRQVGFAGADHDPVAAL
CCHHHCCHHHHHHHEECCCEEEECCCCCCCCCCCCCCHHHHCCCHHCCCCCCCCCCEEEE
VFCAPSGVSHSVINGRVVVDNRRLVTLELGAHLSVHRKLALELAQTARAVPASA
EEECCCCCCCCEECCEEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9055410 [H]