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The map label for this gene is nuoL [H]

Identifier: 17546770

GI number: 17546770

Start: 2224170

End: 2226230

Strand: Reverse

Name: nuoL [H]

Synonym: RSc2051

Alternate gene names: 17546770

Gene position: 2226230-2224170 (Counterclockwise)

Preceding gene: 17546771

Following gene: 17546769

Centisome position: 59.9

GC content: 63.61

Gene sequence:

>2061_bases
ATGGCTACCACGCTCAATCCCAACCTGCTGCTGGCGATCCCGCTCGCGCCGCTGGCCGGCGCGGCGATCGCCGGGCTGTT
CGGCACCAAGTTCTTCGGCGAGAAGATCGGCCGCGCGGCGTCCCACAGCGTCACCATCCTCGGTGTTGCGATCGCCTTCA
TCCTGTCGGCGCTGGTGCTGTTCGACGTGATGGGCGGCGCCGGTTACAACGGCACCGTCTATGAATGGATGGCGGTCGGC
TCGCTGAAGATGGAAGTCGGCTTCCTCATCGATTCGCTGACCGCGATGATGATGTGCGTGGTGACCTTCGTCTCGCTGAT
GGTGCACATCTACACCATCGGCTACATGCAGGAAGACCCGGGCTACAACCGCTTCTTCGCGTACATCTCGCTGTTCACCT
TCTCGATGCTGATGCTCGTGATGAGCAACAACTTCCTGCAGCTGTTCTTCGGCTGGGAAGCGGTGGGTCTGGTGTCGTAT
CTGCTGATCGGCTTCTGGTTCAAGCGCCCGACGGCCATCTACGCCAACATGAAGGCGTTCCTGGTCAACCGCGTGGGTGA
CTTCGGCTTCGTGCTCGGCATCGGCCTGCTGCTGGCCTATGCCGGCAGCCTGAGCTACGCCGATGTGTTCGCGGCACGCG
AGAAGCTCGCCGTCATCGGCTTCCCCGGCACCGACTGGCAGATGCTGACGGTTGCCTGCATTTGCCTGTTCATCGGCGCG
ATGGGCAAGTCCGCGCAGTTCCCGCTGCACGTGTGGCTGCCCGACTCGATGGAAGGCCCGACCCCGATTTCCGCGCTGAT
CCACGCGGCCACCATGGTGACGGCCGGCATCTTCATGGTCGCGCGCATGTCGCCGCTGTTCGAGCTGTCGGACACCGCTC
TGTCGGTGGTGCTGGTGATCGGCGCCATCACCGCGCTGTTCATGGGCTTCCTCGGCATCATCCAGACCGACATCAAGCGC
GTGGTGGCGTATTCGACACTGTCGCAGCTCGGTTACATGACGGTGGCGCTGGGCGCGTCCGCCTACCAGGTGGCCGTGTT
CCACCTGATGACCCACGCGTTCTTCAAGGCGCTGCTGTTCCTGGGCGCGGGCTCGGTCATCATCGGCATGCACCACGACC
AGGACATGCGCAACATGGGCGGCCTGCGCAAGTACATGCCGATCACGTGGCTGACGTCGCTGGTGGGTTCGCTGGCGCTG
ATCGGCACGCCGTTCTTCTCGGGCTTCTATTCGAAGGATTCGATCATCGAGGCGGTGCGCGAGTCGCACCTGCCGGGCGC
GGGCTTCGCCTACTGGGCGGTGCTGGCCGGTGTGTTCGTGACCGCGTTCTATTCGTTCCGGATGTACTTCCTGGTGTTCC
ACGGCGAAGAGCGCTTCGGCAAGGAAGACTCGCATCACGAGGGCAACCACGTGGACGAGGAAGAGACCGCCGACCACCAC
CACGGCCTGGCGCCGGGCCAGAAGCCGCACGAGTCGCCGTGGGTGGTGACGGTGCCCCTGGTGCTGCTGGCGATTCCGTC
GGTCGTCGTCGGCGCGATGGCGATCCAGCCGATGCTGTTCGGCGAGTTCTTCAAGCACGGCGTGGTCTTCACCGATGTCA
TCTTCAACGCCGAGCACCACGAGGCAATGAAGGTGCTGGCCGAGGATTTCCACGGCTGGGTCGGGATGGCGCTGCACGGC
TTCACGTCGGCTCCGTTCATCCTGCTGGTGTCCGGCGTGGTGCTGTCGTGGTTCTTCTACCTGAAGCGCCCGGACATTCC
GGCCGCGATCGCCAAGCGTTTCTCCGGCCTCCACACGCTGCTGGACAACAAGTACTACATGGACAAGATCAACGAGATCG
TCTTCGCCAACGGTGCGGTCAAGTTCGGCCGCGGCCTGTGGAAGGGCGGCGATCAGGGCGTGATCGATGGCGTGGTCGTC
AACGGCAGCGCGCGTCTGGTGGGGTGGTTCGCCAGCGTGGTGCGCCTGCTCCAGTCCGGCTACATCTATGACTATGCGTT
CGCGATGATCGTCGGCACCGTGCTGCTGCTGACGTACTTCGTGTTCCTGGCGGGCAAATAA

Upstream 100 bases:

>100_bases
CGCCATCCTGGTGGTGCTGTTCCGTAACCTGGACACCATCAACGTTGACGATCTGGACAGCCTCAAGGGCTGATCGCCGC
ATCCACACATAAGAAGCTCC

Downstream 100 bases:

>100_bases
GGGATAACGAAAAATGGTTCTGTCTTTTGCGATCTGGCTGCCGATCTTTTTTGGCGTGCTGGTGCTGGCTTCGGGCTCAG
ACCGCAATCCCGGCTATGTC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 686; Mature: 685

Protein sequence:

>686_residues
MATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGEKIGRAASHSVTILGVAIAFILSALVLFDVMGGAGYNGTVYEWMAVG
SLKMEVGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMQEDPGYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSY
LLIGFWFKRPTAIYANMKAFLVNRVGDFGFVLGIGLLLAYAGSLSYADVFAAREKLAVIGFPGTDWQMLTVACICLFIGA
MGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALSVVLVIGAITALFMGFLGIIQTDIKR
VVAYSTLSQLGYMTVALGASAYQVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWLTSLVGSLAL
IGTPFFSGFYSKDSIIEAVRESHLPGAGFAYWAVLAGVFVTAFYSFRMYFLVFHGEERFGKEDSHHEGNHVDEEETADHH
HGLAPGQKPHESPWVVTVPLVLLAIPSVVVGAMAIQPMLFGEFFKHGVVFTDVIFNAEHHEAMKVLAEDFHGWVGMALHG
FTSAPFILLVSGVVLSWFFYLKRPDIPAAIAKRFSGLHTLLDNKYYMDKINEIVFANGAVKFGRGLWKGGDQGVIDGVVV
NGSARLVGWFASVVRLLQSGYIYDYAFAMIVGTVLLLTYFVFLAGK

Sequences:

>Translated_686_residues
MATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGEKIGRAASHSVTILGVAIAFILSALVLFDVMGGAGYNGTVYEWMAVG
SLKMEVGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMQEDPGYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSY
LLIGFWFKRPTAIYANMKAFLVNRVGDFGFVLGIGLLLAYAGSLSYADVFAAREKLAVIGFPGTDWQMLTVACICLFIGA
MGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALSVVLVIGAITALFMGFLGIIQTDIKR
VVAYSTLSQLGYMTVALGASAYQVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWLTSLVGSLAL
IGTPFFSGFYSKDSIIEAVRESHLPGAGFAYWAVLAGVFVTAFYSFRMYFLVFHGEERFGKEDSHHEGNHVDEEETADHH
HGLAPGQKPHESPWVVTVPLVLLAIPSVVVGAMAIQPMLFGEFFKHGVVFTDVIFNAEHHEAMKVLAEDFHGWVGMALHG
FTSAPFILLVSGVVLSWFFYLKRPDIPAAIAKRFSGLHTLLDNKYYMDKINEIVFANGAVKFGRGLWKGGDQGVIDGVVV
NGSARLVGWFASVVRLLQSGYIYDYAFAMIVGTVLLLTYFVFLAGK
>Mature_685_residues
ATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGEKIGRAASHSVTILGVAIAFILSALVLFDVMGGAGYNGTVYEWMAVGS
LKMEVGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMQEDPGYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYL
LIGFWFKRPTAIYANMKAFLVNRVGDFGFVLGIGLLLAYAGSLSYADVFAAREKLAVIGFPGTDWQMLTVACICLFIGAM
GKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALSVVLVIGAITALFMGFLGIIQTDIKRV
VAYSTLSQLGYMTVALGASAYQVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWLTSLVGSLALI
GTPFFSGFYSKDSIIEAVRESHLPGAGFAYWAVLAGVFVTAFYSFRMYFLVFHGEERFGKEDSHHEGNHVDEEETADHHH
GLAPGQKPHESPWVVTVPLVLLAIPSVVVGAMAIQPMLFGEFFKHGVVFTDVIFNAEHHEAMKVLAEDFHGWVGMALHGF
TSAPFILLVSGVVLSWFFYLKRPDIPAAIAKRFSGLHTLLDNKYYMDKINEIVFANGAVKFGRGLWKGGDQGVIDGVVVN
GSARLVGWFASVVRLLQSGYIYDYAFAMIVGTVLLLTYFVFLAGK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=396, Percent_Identity=40.6565656565657, Blast_Score=302, Evalue=7e-82,
Organism=Escherichia coli, GI1788614, Length=489, Percent_Identity=42.3312883435583, Blast_Score=353, Evalue=3e-98,
Organism=Escherichia coli, GI1788829, Length=339, Percent_Identity=30.9734513274336, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788831, Length=354, Percent_Identity=29.0960451977401, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1788827, Length=416, Percent_Identity=30.2884615384615, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI145693160, Length=368, Percent_Identity=27.1739130434783, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1788613, Length=272, Percent_Identity=28.3088235294118, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI2367154, Length=136, Percent_Identity=33.8235294117647, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 74931; Mature: 74800

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGEKIGRAASHSVTILGVAIAFILSALVL
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHH
FDVMGGAGYNGTVYEWMAVGSLKMEVGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMQEDP
HHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCC
GYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWFKRPTAIYANMKAF
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LVNRVGDFGFVLGIGLLLAYAGSLSYADVFAAREKLAVIGFPGTDWQMLTVACICLFIGA
HHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHC
MGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALSVVLVI
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
GAITALFMGFLGIIQTDIKRVVAYSTLSQLGYMTVALGASAYQVAVFHLMTHAFFKALLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGAGSVIIGMHHDQDMRNMGGLRKYMPITWLTSLVGSLALIGTPFFSGFYSKDSIIEAVR
HCCCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHH
ESHLPGAGFAYWAVLAGVFVTAFYSFRMYFLVFHGEERFGKEDSHHEGNHVDEEETADHH
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHCCCCCCCCCCCCCCCHHCCHHH
HGLAPGQKPHESPWVVTVPLVLLAIPSVVVGAMAIQPMLFGEFFKHGVVFTDVIFNAEHH
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHH
EAMKVLAEDFHGWVGMALHGFTSAPFILLVSGVVLSWFFYLKRPDIPAAIAKRFSGLHTL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LDNKYYMDKINEIVFANGAVKFGRGLWKGGDQGVIDGVVVNGSARLVGWFASVVRLLQSG
HCCCHHHHHHHHHHEECCCHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCC
YIYDYAFAMIVGTVLLLTYFVFLAGK
CHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGEKIGRAASHSVTILGVAIAFILSALVL
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHH
FDVMGGAGYNGTVYEWMAVGSLKMEVGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMQEDP
HHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCC
GYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWFKRPTAIYANMKAF
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LVNRVGDFGFVLGIGLLLAYAGSLSYADVFAAREKLAVIGFPGTDWQMLTVACICLFIGA
HHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHC
MGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALSVVLVI
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
GAITALFMGFLGIIQTDIKRVVAYSTLSQLGYMTVALGASAYQVAVFHLMTHAFFKALLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGAGSVIIGMHHDQDMRNMGGLRKYMPITWLTSLVGSLALIGTPFFSGFYSKDSIIEAVR
HCCCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHH
ESHLPGAGFAYWAVLAGVFVTAFYSFRMYFLVFHGEERFGKEDSHHEGNHVDEEETADHH
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHCCCCCCCCCCCCCCCHHCCHHH
HGLAPGQKPHESPWVVTVPLVLLAIPSVVVGAMAIQPMLFGEFFKHGVVFTDVIFNAEHH
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHH
EAMKVLAEDFHGWVGMALHGFTSAPFILLVSGVVLSWFFYLKRPDIPAAIAKRFSGLHTL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LDNKYYMDKINEIVFANGAVKFGRGLWKGGDQGVIDGVVVNGSARLVGWFASVVRLLQSG
HCCCHHHHHHHHHHEECCCHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCC
YIYDYAFAMIVGTVLLLTYFVFLAGK
CHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]