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The map label for this gene is yngJ [H]

Identifier: 17546763

GI number: 17546763

Start: 2217160

End: 2218290

Strand: Reverse

Name: yngJ [H]

Synonym: RSc2044

Alternate gene names: 17546763

Gene position: 2218290-2217160 (Counterclockwise)

Preceding gene: 17546764

Following gene: 17546762

Centisome position: 59.69

GC content: 69.94

Gene sequence:

>1131_bases
ATGGATTTCTCGTTCACCGACGAACAGAAGCAGCTGGCGGATGCGGTACGCCGCTTCATCGACAAGGATTACGGCTTCGA
AGCGCGCAACAAGGTCGTCTACTCGCCCGCGGGCGTGTCGCAGGCGCATTGGGACGCCCTGGCCGAGCTGGGCTTGACCG
CGCTGCCGGTGCCGCAAGCGCAGGGCGGCTTCGATGGCAGCGCGATGGACCTGCTGGTGGTGATGCAGGAACTGGGGCGC
GGCCTGGTGGTGGAGCCCTATGCGGCCACCGTGCTGGGCATGCAGGCACTCAAGCTGGCGGGCGGCCAGGAGGCGCTGCT
GGAGCCGGTGGCGGGCGGCGCGCTGAAGCTGGCGGCGGCCTTTGGCGAGCCGCAGTCGCGCTATGAGTTGTTCAACGTGA
CCACGCGCGCGGCGCGGCAGGGCGGCGGCTGGACGCTGTCGGGCGCCAAGGCCGTGGTGGTGCACGGCGGGCAGGCCGAC
AAGCTGGTCGTGTCGGCGCGCACGGGCGGCGAGGCGCGCGACACATCGGGCCTGTCGCTGTTCCTGGTCGATCGCGAGGC
CGCGGGCGTGACGGTCAAGGACTACCGCACCATCGATAACCTGCGCGCGGCCGACGTCCGCTTCGACAATGCGCCGGCTA
CGCTGCTCGGCCAGGCCGGCGAGGCGTGGGAGATCATCGATGCGGTGGCGGATCTCGGCTGCGTGCTGCTGTGCGCCGAG
GCGATCGGCCTGATCGATGCGCTGAACGCCGCCACGCTGGAATACACCAAGACGCGCCAGCAGTTCGGCGTGCCGATCGC
GCGCTTCCAGGCGCTGCAGCACCGCATGGTCGACATGTTCATCCATGCGGAGCAGGCGCGCTCGATCACCTATCTCGCGG
CGGCGCATTTCGAAGACGGCGATGCCGAGGCGCGCCGCCGCTACGTGTCGGCCGCCAAGGCGCGCGTCGGCCAGGCGGCC
CGCGAAGTGGGGCAGGAGGCGGTGCAGCTGCACGGCGGCATGGGCGTGACCAATGAGCTGCCCGCCGCGCACATGTTCAA
GCGGCTGACGATGATCAACACCACGCTCGGCGATGTCGATCACCATCTGGCGCGCTTTGCGTCGCGGCCGGGCTTCCGTG
ACGCCGCGTGA

Upstream 100 bases:

>100_bases
TCGCAAGACCTCGATCTACGGCGGGTCGAACGAGATCCAGCGCAACATCATCAGCCAGATGATCCTCGGCGTCTGACCAG
AACGAACAGCGGAGACAACC

Downstream 100 bases:

>100_bases
TGCCACCCGGCGCGCCCCGCGCAGCCGCGGGGCGCTGTTTTTTTGAGCGGCCGCGCCCGCGCAGCGGAGGCGGCGATGGA
GGAGACGCCATGACGGAAGC

Product: acyl-CoA dehydrogenase oxidoreductase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MDFSFTDEQKQLADAVRRFIDKDYGFEARNKVVYSPAGVSQAHWDALAELGLTALPVPQAQGGFDGSAMDLLVVMQELGR
GLVVEPYAATVLGMQALKLAGGQEALLEPVAGGALKLAAAFGEPQSRYELFNVTTRAARQGGGWTLSGAKAVVVHGGQAD
KLVVSARTGGEARDTSGLSLFLVDREAAGVTVKDYRTIDNLRAADVRFDNAPATLLGQAGEAWEIIDAVADLGCVLLCAE
AIGLIDALNAATLEYTKTRQQFGVPIARFQALQHRMVDMFIHAEQARSITYLAAAHFEDGDAEARRRYVSAAKARVGQAA
REVGQEAVQLHGGMGVTNELPAAHMFKRLTMINTTLGDVDHHLARFASRPGFRDAA

Sequences:

>Translated_376_residues
MDFSFTDEQKQLADAVRRFIDKDYGFEARNKVVYSPAGVSQAHWDALAELGLTALPVPQAQGGFDGSAMDLLVVMQELGR
GLVVEPYAATVLGMQALKLAGGQEALLEPVAGGALKLAAAFGEPQSRYELFNVTTRAARQGGGWTLSGAKAVVVHGGQAD
KLVVSARTGGEARDTSGLSLFLVDREAAGVTVKDYRTIDNLRAADVRFDNAPATLLGQAGEAWEIIDAVADLGCVLLCAE
AIGLIDALNAATLEYTKTRQQFGVPIARFQALQHRMVDMFIHAEQARSITYLAAAHFEDGDAEARRRYVSAAKARVGQAA
REVGQEAVQLHGGMGVTNELPAAHMFKRLTMINTTLGDVDHHLARFASRPGFRDAA
>Mature_376_residues
MDFSFTDEQKQLADAVRRFIDKDYGFEARNKVVYSPAGVSQAHWDALAELGLTALPVPQAQGGFDGSAMDLLVVMQELGR
GLVVEPYAATVLGMQALKLAGGQEALLEPVAGGALKLAAAFGEPQSRYELFNVTTRAARQGGGWTLSGAKAVVVHGGQAD
KLVVSARTGGEARDTSGLSLFLVDREAAGVTVKDYRTIDNLRAADVRFDNAPATLLGQAGEAWEIIDAVADLGCVLLCAE
AIGLIDALNAATLEYTKTRQQFGVPIARFQALQHRMVDMFIHAEQARSITYLAAAHFEDGDAEARRRYVSAAKARVGQAA
REVGQEAVQLHGGMGVTNELPAAHMFKRLTMINTTLGDVDHHLARFASRPGFRDAA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=318, Percent_Identity=27.6729559748428, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI226958412, Length=358, Percent_Identity=24.0223463687151, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI226958414, Length=322, Percent_Identity=25.1552795031056, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI21361497, Length=378, Percent_Identity=25.1322751322751, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4557235, Length=375, Percent_Identity=25.0666666666667, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI76496475, Length=375, Percent_Identity=25.0666666666667, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4501859, Length=358, Percent_Identity=24.0223463687151, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI4557231, Length=364, Percent_Identity=24.7252747252747, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI187960098, Length=364, Percent_Identity=24.7252747252747, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501857, Length=359, Percent_Identity=25.3481894150418, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI7656849, Length=299, Percent_Identity=25.0836120401338, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786223, Length=351, Percent_Identity=25.6410256410256, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87081958, Length=348, Percent_Identity=21.8390804597701, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=359, Percent_Identity=24.7910863509749, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17506239, Length=357, Percent_Identity=27.1708683473389, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17508101, Length=361, Percent_Identity=26.0387811634349, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17534899, Length=367, Percent_Identity=26.158038147139, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71985184, Length=358, Percent_Identity=28.2122905027933, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17569725, Length=367, Percent_Identity=25.8855585831063, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17570075, Length=364, Percent_Identity=24.1758241758242, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985192, Length=322, Percent_Identity=27.9503105590062, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71990804, Length=267, Percent_Identity=22.4719101123595, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32563615, Length=240, Percent_Identity=25.8333333333333, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24660351, Length=368, Percent_Identity=27.7173913043478, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI21355753, Length=360, Percent_Identity=25, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI21356377, Length=320, Percent_Identity=25, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24666513, Length=384, Percent_Identity=23.9583333333333, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24646207, Length=370, Percent_Identity=24.5945945945946, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281363737, Length=359, Percent_Identity=25.0696378830084, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40195; Mature: 40195

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSFTDEQKQLADAVRRFIDKDYGFEARNKVVYSPAGVSQAHWDALAELGLTALPVPQA
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCC
QGGFDGSAMDLLVVMQELGRGLVVEPYAATVLGMQALKLAGGQEALLEPVAGGALKLAAA
CCCCCCHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEHHH
FGEPQSRYELFNVTTRAARQGGGWTLSGAKAVVVHGGQADKLVVSARTGGEARDTSGLSL
HCCCHHHHHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCEEEEEECCCCCCCCCCCCEE
FLVDREAAGVTVKDYRTIDNLRAADVRFDNAPATLLGQAGEAWEIIDAVADLGCVLLCAE
EEEECCCCCCCHHHHHHHHCCCHHCEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHH
AIGLIDALNAATLEYTKTRQQFGVPIARFQALQHRMVDMFIHAEQARSITYLAAAHFEDG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
DAEARRRYVSAAKARVGQAAREVGQEAVQLHGGMGVTNELPAAHMFKRLTMINTTLGDVD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
HHLARFASRPGFRDAA
HHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDFSFTDEQKQLADAVRRFIDKDYGFEARNKVVYSPAGVSQAHWDALAELGLTALPVPQA
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCC
QGGFDGSAMDLLVVMQELGRGLVVEPYAATVLGMQALKLAGGQEALLEPVAGGALKLAAA
CCCCCCHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEHHH
FGEPQSRYELFNVTTRAARQGGGWTLSGAKAVVVHGGQADKLVVSARTGGEARDTSGLSL
HCCCHHHHHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCEEEEEECCCCCCCCCCCCEE
FLVDREAAGVTVKDYRTIDNLRAADVRFDNAPATLLGQAGEAWEIIDAVADLGCVLLCAE
EEEECCCCCCCHHHHHHHHCCCHHCEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHH
AIGLIDALNAATLEYTKTRQQFGVPIARFQALQHRMVDMFIHAEQARSITYLAAAHFEDG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
DAEARRRYVSAAKARVGQAAREVGQEAVQLHGGMGVTNELPAAHMFKRLTMINTTLGDVD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
HHLARFASRPGFRDAA
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]