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The map label for this gene is paaH2 [H]

Identifier: 17546732

GI number: 17546732

Start: 2191733

End: 2193241

Strand: Direct

Name: paaH2 [H]

Synonym: RSc2013

Alternate gene names: 17546732

Gene position: 2191733-2193241 (Clockwise)

Preceding gene: 17546730

Following gene: 17546733

Centisome position: 58.97

GC content: 73.56

Gene sequence:

>1509_bases
ATGAATGCGATCGGGATCGTGGGTACCGGCGCCATGGGGCGCGGCATTGCGCAGATCGCGGCCCAGGCCGGCCTGCGCGT
CAGGCTGTTCGACGCCAGCCCACAGGCCGTGGAGGCGGCCCGCGCCGCGCTGGCCGATACGCTCGCCAGGCTGGCGGCCA
AGGGCCGGCTCACCGCCGACCAGGCCGACGCCGCCCTCGCGCGCCTGATGCCGGCCGCCGCCCTCGCCGAGCTGGCCGAC
TGCGACCTCGTGGTCGAGGCCATCGTCGAGAACCTGGAGGCCAAGCGCGATCTGTTCCGCCAGCTCGAGGCCATCGTGGG
GCCGGAGACGATCCTCGCCTCCAACACCTCGTCGCTGTCGATCACGGCGATTGCCGCCGCGTGCCGGCGGCCCGAGCGCG
TGGCTGGCTTCCATTTCTTCAACCCGGTGCCGCTGATGAAGGTGGTCGAGGTGATCGCGGGCCTGCGCAGCGCCCCCGCC
GCCTGCGATGCCCTGGCCGCCCTGGCCGGGCGCATGGGCCACGCCGCCGTGCGCTGCACCGACATGCCGGGCTTCATCGT
CAACCACGCGGGGCGCGGCATGAACACCGAGGGCCTGCGCGTGGTTCAGGAAGGCGTGACCGCCTTTGCCGACGTGGATG
CGGTGATGCGCGAGCAGGCCGGCTTCCGCATGGGCCCGTTCGAGCTGATGGACCTGACCGGGCTGGATGTGTCGCATCCG
GTGATGGAGTCGATCTACCGGCAGTTCTATGACGAGCCGCGCTACCGGCCGTCGCGGATCACCGCCGTGCGGCTGGCCGG
CGGCCTGCTCGGCCGCAAGACCGGCGAAGGCTTCTACCGCTACGCCGACGGCCAGAAGCCGGTGCCGCCGGAAGCGGCCG
CGCCCGCCGCGCGGCCGAAGTCGGTGTGGGTCAGCCGCGCGCACGCGGCCGGCCACACCGCCGCGCAGCGCCTGCTGCTG
GACCTGTGTGTCACACCCGAGGACGGCGCCTGGCCCTCGGCCGAAGCGCTCATCGTGGTGACGCCGCGCGGGCTCGACGC
CACGGCCGCCGCGGTGGCCGAAGGCCTGGACGGCCGCCGCACCGTCGCGCTCGATACGCTCTATCCGTTCGCCGCCACCC
GGCGCCGCACGCTGATGACCACGCCCGCCACCGACCCCGCCCACCGCGACGCCGCGCACGGCCTGTTCGCCGCCGACGGC
GTGCCGGTGACGGTGATCCGCGACTCGGGCGGCTTCGTGGCGCAGCGCATCGTCGCGTGCATCGTCAACATCGCATGCGA
CATCGCGCAGCAGCGCATTGCCACGCCGGCCGACATCGACCTGGCCGTCACGCTGGGCCTGGGCTACCCGCAGGGGCCGC
TGGCGTTGGGCGACACGCTCGGCGCGGGCGCGGTGCTCGAAGTGCTGCAGAATCTCACCACGCTGTACGGCGACCCGCGC
TATCGCCCAAGCCCATGGCTGCTGCGCCGCGCGCGCCTGGGCCTGTCGCTGCTGACGCCGGACGCCTGA

Upstream 100 bases:

>100_bases
GGCCATCTCCTGGTGGTATGACTGCGGTTCGGGTCTGTGCGGATGAAAAAATCGCACGCTCGTGCTATTTTAACCGGACT
TCCTTCACGGCAGATTTTGC

Downstream 100 bases:

>100_bases
TCCGCCCCCCCTTCCTCCGAGGCCATCGCCATGACCGCGCAACTGCTCTCCCGACGCACCGGCTCCACGCTGGTGCTGAC
GCTCTCCAACCCCGACGCGC

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MNAIGIVGTGAMGRGIAQIAAQAGLRVRLFDASPQAVEAARAALADTLARLAAKGRLTADQADAALARLMPAAALAELAD
CDLVVEAIVENLEAKRDLFRQLEAIVGPETILASNTSSLSITAIAAACRRPERVAGFHFFNPVPLMKVVEVIAGLRSAPA
ACDALAALAGRMGHAAVRCTDMPGFIVNHAGRGMNTEGLRVVQEGVTAFADVDAVMREQAGFRMGPFELMDLTGLDVSHP
VMESIYRQFYDEPRYRPSRITAVRLAGGLLGRKTGEGFYRYADGQKPVPPEAAAPAARPKSVWVSRAHAAGHTAAQRLLL
DLCVTPEDGAWPSAEALIVVTPRGLDATAAAVAEGLDGRRTVALDTLYPFAATRRRTLMTTPATDPAHRDAAHGLFAADG
VPVTVIRDSGGFVAQRIVACIVNIACDIAQQRIATPADIDLAVTLGLGYPQGPLALGDTLGAGAVLEVLQNLTTLYGDPR
YRPSPWLLRRARLGLSLLTPDA

Sequences:

>Translated_502_residues
MNAIGIVGTGAMGRGIAQIAAQAGLRVRLFDASPQAVEAARAALADTLARLAAKGRLTADQADAALARLMPAAALAELAD
CDLVVEAIVENLEAKRDLFRQLEAIVGPETILASNTSSLSITAIAAACRRPERVAGFHFFNPVPLMKVVEVIAGLRSAPA
ACDALAALAGRMGHAAVRCTDMPGFIVNHAGRGMNTEGLRVVQEGVTAFADVDAVMREQAGFRMGPFELMDLTGLDVSHP
VMESIYRQFYDEPRYRPSRITAVRLAGGLLGRKTGEGFYRYADGQKPVPPEAAAPAARPKSVWVSRAHAAGHTAAQRLLL
DLCVTPEDGAWPSAEALIVVTPRGLDATAAAVAEGLDGRRTVALDTLYPFAATRRRTLMTTPATDPAHRDAAHGLFAADG
VPVTVIRDSGGFVAQRIVACIVNIACDIAQQRIATPADIDLAVTLGLGYPQGPLALGDTLGAGAVLEVLQNLTTLYGDPR
YRPSPWLLRRARLGLSLLTPDA
>Mature_502_residues
MNAIGIVGTGAMGRGIAQIAAQAGLRVRLFDASPQAVEAARAALADTLARLAAKGRLTADQADAALARLMPAAALAELAD
CDLVVEAIVENLEAKRDLFRQLEAIVGPETILASNTSSLSITAIAAACRRPERVAGFHFFNPVPLMKVVEVIAGLRSAPA
ACDALAALAGRMGHAAVRCTDMPGFIVNHAGRGMNTEGLRVVQEGVTAFADVDAVMREQAGFRMGPFELMDLTGLDVSHP
VMESIYRQFYDEPRYRPSRITAVRLAGGLLGRKTGEGFYRYADGQKPVPPEAAAPAARPKSVWVSRAHAAGHTAAQRLLL
DLCVTPEDGAWPSAEALIVVTPRGLDATAAAVAEGLDGRRTVALDTLYPFAATRRRTLMTTPATDPAHRDAAHGLFAADG
VPVTVIRDSGGFVAQRIVACIVNIACDIAQQRIATPADIDLAVTLGLGYPQGPLALGDTLGAGAVLEVLQNLTTLYGDPR
YRPSPWLLRRARLGLSLLTPDA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=286, Percent_Identity=38.1118881118881, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI296179427, Length=303, Percent_Identity=36.963696369637, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI20127408, Length=286, Percent_Identity=32.5174825174825, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI261878539, Length=295, Percent_Identity=31.864406779661, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=32.0819112627986, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI115430219, Length=237, Percent_Identity=28.2700421940928, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1787661, Length=495, Percent_Identity=38.1818181818182, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1790281, Length=275, Percent_Identity=31.6363636363636, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1788682, Length=270, Percent_Identity=34.0740740740741, Blast_Score=135, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=38.0622837370242, Blast_Score=208, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17553560, Length=283, Percent_Identity=35.6890459363958, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17508951, Length=286, Percent_Identity=33.9160839160839, Blast_Score=167, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25144276, Length=286, Percent_Identity=33.9160839160839, Blast_Score=167, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17508953, Length=286, Percent_Identity=33.9160839160839, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17563036, Length=291, Percent_Identity=32.9896907216495, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17558304, Length=305, Percent_Identity=33.7704918032787, Blast_Score=155, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71985923, Length=288, Percent_Identity=29.1666666666667, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71985930, Length=290, Percent_Identity=28.9655172413793, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24583077, Length=288, Percent_Identity=30.2083333333333, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24583079, Length=288, Percent_Identity=30.2083333333333, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI19921000, Length=288, Percent_Identity=30.2083333333333, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI45549573, Length=239, Percent_Identity=32.2175732217573, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20129993, Length=225, Percent_Identity=28, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 52835; Mature: 52835

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAIGIVGTGAMGRGIAQIAAQAGLRVRLFDASPQAVEAARAALADTLARLAAKGRLTAD
CCCCEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
QADAALARLMPAAALAELADCDLVVEAIVENLEAKRDLFRQLEAIVGPETILASNTSSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEE
ITAIAAACRRPERVAGFHFFNPVPLMKVVEVIAGLRSAPAACDALAALAGRMGHAAVRCT
HHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEE
DMPGFIVNHAGRGMNTEGLRVVQEGVTAFADVDAVMREQAGFRMGPFELMDLTGLDVSHP
CCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCHH
VMESIYRQFYDEPRYRPSRITAVRLAGGLLGRKTGEGFYRYADGQKPVPPEAAAPAARPK
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCH
SVWVSRAHAAGHTAAQRLLLDLCVTPEDGAWPSAEALIVVTPRGLDATAAAVAEGLDGRR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCE
TVALDTLYPFAATRRRTLMTTPATDPAHRDAAHGLFAADGVPVTVIRDSGGFVAQRIVAC
EEEEHHHHHHHHHCCCEEEECCCCCCCHHHHHCCCEECCCCEEEEEECCCCHHHHHHHHH
IVNIACDIAQQRIATPADIDLAVTLGLGYPQGPLALGDTLGAGAVLEVLQNLTTLYGDPR
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
YRPSPWLLRRARLGLSLLTPDA
CCCCHHHHHHHHCCCEECCCCC
>Mature Secondary Structure
MNAIGIVGTGAMGRGIAQIAAQAGLRVRLFDASPQAVEAARAALADTLARLAAKGRLTAD
CCCCEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
QADAALARLMPAAALAELADCDLVVEAIVENLEAKRDLFRQLEAIVGPETILASNTSSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEE
ITAIAAACRRPERVAGFHFFNPVPLMKVVEVIAGLRSAPAACDALAALAGRMGHAAVRCT
HHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEE
DMPGFIVNHAGRGMNTEGLRVVQEGVTAFADVDAVMREQAGFRMGPFELMDLTGLDVSHP
CCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCHH
VMESIYRQFYDEPRYRPSRITAVRLAGGLLGRKTGEGFYRYADGQKPVPPEAAAPAARPK
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCH
SVWVSRAHAAGHTAAQRLLLDLCVTPEDGAWPSAEALIVVTPRGLDATAAAVAEGLDGRR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCE
TVALDTLYPFAATRRRTLMTTPATDPAHRDAAHGLFAADGVPVTVIRDSGGFVAQRIVAC
EEEEHHHHHHHHHCCCEEEECCCCCCCHHHHHCCCEECCCCEEEEEECCCCHHHHHHHHH
IVNIACDIAQQRIATPADIDLAVTLGLGYPQGPLALGDTLGAGAVLEVLQNLTTLYGDPR
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
YRPSPWLLRRARLGLSLLTPDA
CCCCHHHHHHHHCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]