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The map label for this gene is ybdL [H]

Identifier: 17546730

GI number: 17546730

Start: 2189763

End: 2190962

Strand: Direct

Name: ybdL [H]

Synonym: RSc2011

Alternate gene names: 17546730

Gene position: 2189763-2190962 (Clockwise)

Preceding gene: 17546729

Following gene: 17546732

Centisome position: 58.92

GC content: 69.25

Gene sequence:

>1200_bases
ATGACCACTGCTTCCGCTGCCCGGCCCGCCCCGTCCGCTGACACGCTCGCGCCCATCGCCCCGCCACCGTCGCGGCTGCC
GAAGGTCGGGACCACCATCTTCACCGTGATGTCGGCGCTGGCCGCGGAGAAGCAGGCCGTCAACCTGGGCCAGGGCTTTC
CGGATTTCGATTGCGACCCGCGCATCGTCGACGCCGTGTCGGATGCCATGCGCGCCGGCTTCAACCAGTACCCGCCGATG
ACCGGCGTGCCGGCGCTGCGCCAGGCGATCGCCGCCAAGATCGCCACGCTGTACGGCCACGCCTACGACGCCGAGCGCGA
GATCACCGTCACCGCGGGCGCCACGCAGGCGCTGCTGACGGCGGTGCTGTGCTGCGTGCATCCGGGCGACGAGGTGATCG
TCTTCGAGCCGACCTACGACAGCTACCTGCCGTCGATCGAGCTGGCCGGCGGCAAGGCGGTGCCGATCACGCTGGAGGCG
CCCGACTACCGCATTCCGTTCGACAAGCTGGCCGCCGCCATCACGCCGCGCACGCGCCTGATCATGCTCAACACGCCGCA
CAACCCGACCGGCACGGTCTGGCACGCGGACGACATGCGCAGGCTGGCCGAGATCGTCGCGCCGACCGATGTGCTGCTGC
TCTCCGACGAGGTCTACGAGCACATGGTCTACGACGGCGTGCCGCATGCGTCGGTGTCGCGCATCCCGGAGCTGGCGCGG
CGCGCCTTCGTGGTGTCGAGCTTCGGCAAGACGTATCACGTGACGGGCTGGAAGGTCGGCTACGTGGCCGCGCCCGCCGC
GCTGTCGGCGGAATTCCGCAAGGTGCACCAGTTCAACGTGTTCACCGTCAACACGCCGGTGCAGCACGGGCTGGCCGCCT
ACATGGCCGACCCGCGCCCATACCTGGAGCTGCCCGCGTTCTACCAGCACAAGCGCGACCTGTTCCGCGCGGGGCTGGAG
CACACCCGCTTCAAGCTGCTGCCGTGCCAGGGCACCTACTTCCAGTGCGTGGACTACAGCGCCCTCTCCGACCTGCCCGA
GGCCGCGTTCGCCAAATGGCTCACCAGCGAGATCGGCGTGGCGGCGATCCCGGTGTCGGCGTTCTATTCGCAGCCGCACG
AATCGGGCGTGGTGCGGTTCTGCTTCGCCAAGAAGGACGAGACGCTCCGGCTCGCGCTGGAGCGCCTGTCCAGGCTGTAA

Upstream 100 bases:

>100_bases
TGGCGGTGGTGCCGCCCGGACAGTTCATCGCCGAGATCCGGCTGGACGCCGCGCCCATCGCTTAGACCGTCTTCGCTTGC
GCTCCCCTATCGCCCTCGCC

Downstream 100 bases:

>100_bases
GCCCGCCGGGCGTTACTGGCGCTTGCCGGCGTAGTACGCGAGCATCTGCTCGGTGTTCACCTTGCGCTCGGCGTTCACGC
GCTGCACGTTGGGCATCTCG

Product: aminotransferase

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTTASAARPAPSADTLAPIAPPPSRLPKVGTTIFTVMSALAAEKQAVNLGQGFPDFDCDPRIVDAVSDAMRAGFNQYPPM
TGVPALRQAIAAKIATLYGHAYDAEREITVTAGATQALLTAVLCCVHPGDEVIVFEPTYDSYLPSIELAGGKAVPITLEA
PDYRIPFDKLAAAITPRTRLIMLNTPHNPTGTVWHADDMRRLAEIVAPTDVLLLSDEVYEHMVYDGVPHASVSRIPELAR
RAFVVSSFGKTYHVTGWKVGYVAAPAALSAEFRKVHQFNVFTVNTPVQHGLAAYMADPRPYLELPAFYQHKRDLFRAGLE
HTRFKLLPCQGTYFQCVDYSALSDLPEAAFAKWLTSEIGVAAIPVSAFYSQPHESGVVRFCFAKKDETLRLALERLSRL

Sequences:

>Translated_399_residues
MTTASAARPAPSADTLAPIAPPPSRLPKVGTTIFTVMSALAAEKQAVNLGQGFPDFDCDPRIVDAVSDAMRAGFNQYPPM
TGVPALRQAIAAKIATLYGHAYDAEREITVTAGATQALLTAVLCCVHPGDEVIVFEPTYDSYLPSIELAGGKAVPITLEA
PDYRIPFDKLAAAITPRTRLIMLNTPHNPTGTVWHADDMRRLAEIVAPTDVLLLSDEVYEHMVYDGVPHASVSRIPELAR
RAFVVSSFGKTYHVTGWKVGYVAAPAALSAEFRKVHQFNVFTVNTPVQHGLAAYMADPRPYLELPAFYQHKRDLFRAGLE
HTRFKLLPCQGTYFQCVDYSALSDLPEAAFAKWLTSEIGVAAIPVSAFYSQPHESGVVRFCFAKKDETLRLALERLSRL
>Mature_398_residues
TTASAARPAPSADTLAPIAPPPSRLPKVGTTIFTVMSALAAEKQAVNLGQGFPDFDCDPRIVDAVSDAMRAGFNQYPPMT
GVPALRQAIAAKIATLYGHAYDAEREITVTAGATQALLTAVLCCVHPGDEVIVFEPTYDSYLPSIELAGGKAVPITLEAP
DYRIPFDKLAAAITPRTRLIMLNTPHNPTGTVWHADDMRRLAEIVAPTDVLLLSDEVYEHMVYDGVPHASVSRIPELARR
AFVVSSFGKTYHVTGWKVGYVAAPAALSAEFRKVHQFNVFTVNTPVQHGLAAYMADPRPYLELPAFYQHKRDLFRAGLEH
TRFKLLPCQGTYFQCVDYSALSDLPEAAFAKWLTSEIGVAAIPVSAFYSQPHESGVVRFCFAKKDETLRLALERLSRL

Specific function: Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine [H]

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=409, Percent_Identity=35.2078239608802, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI169881279, Length=409, Percent_Identity=35.2078239608802, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI56713254, Length=401, Percent_Identity=34.6633416458853, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI56713256, Length=401, Percent_Identity=34.6633416458853, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI169881281, Length=407, Percent_Identity=30.7125307125307, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI4507369, Length=219, Percent_Identity=26.027397260274, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786816, Length=379, Percent_Identity=53.0343007915567, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1788722, Length=388, Percent_Identity=25.7731958762887, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1788627, Length=253, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787909, Length=206, Percent_Identity=27.1844660194175, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1787710, Length=424, Percent_Identity=25.2358490566038, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71994472, Length=413, Percent_Identity=33.6561743341404, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71994476, Length=413, Percent_Identity=33.6561743341404, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17567369, Length=399, Percent_Identity=32.3308270676692, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17567663, Length=360, Percent_Identity=23.0555555555556, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322401, Length=395, Percent_Identity=32.9113924050633, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28573069, Length=409, Percent_Identity=34.718826405868, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24646114, Length=409, Percent_Identity=34.718826405868, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI28573067, Length=409, Percent_Identity=34.718826405868, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI28573065, Length=409, Percent_Identity=34.718826405868, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI18859735, Length=217, Percent_Identity=26.2672811059908, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.1

Molecular weight: Translated: 43575; Mature: 43444

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTASAARPAPSADTLAPIAPPPSRLPKVGTTIFTVMSALAAEKQAVNLGQGFPDFDCDP
CCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
RIVDAVSDAMRAGFNQYPPMTGVPALRQAIAAKIATLYGHAYDAEREITVTAGATQALLT
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
AVLCCVHPGDEVIVFEPTYDSYLPSIELAGGKAVPITLEAPDYRIPFDKLAAAITPRTRL
HHHHHCCCCCEEEEECCCHHHHCCCEEECCCCEEEEEECCCCCCCCHHHHHHHCCCCEEE
IMLNTPHNPTGTVWHADDMRRLAEIVAPTDVLLLSDEVYEHMVYDGVPHASVSRIPELAR
EEEECCCCCCCCEEEHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCCHHHHHHHHHHH
RAFVVSSFGKTYHVTGWKVGYVAAPAALSAEFRKVHQFNVFTVNTPVQHGLAAYMADPRP
HHHHHHHCCCEEEECCEEEEEEECCHHHHHHHHHHHEEEEEEECCCHHHHHHHHHCCCCC
YLELPAFYQHKRDLFRAGLEHTRFKLLPCQGTYFQCVDYSALSDLPEAAFAKWLTSEIGV
CCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCHHHHCCHHHHHHHHHHHHCCE
AAIPVSAFYSQPHESGVVRFCFAKKDETLRLALERLSRL
EEEEHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TTASAARPAPSADTLAPIAPPPSRLPKVGTTIFTVMSALAAEKQAVNLGQGFPDFDCDP
CCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
RIVDAVSDAMRAGFNQYPPMTGVPALRQAIAAKIATLYGHAYDAEREITVTAGATQALLT
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
AVLCCVHPGDEVIVFEPTYDSYLPSIELAGGKAVPITLEAPDYRIPFDKLAAAITPRTRL
HHHHHCCCCCEEEEECCCHHHHCCCEEECCCCEEEEEECCCCCCCCHHHHHHHCCCCEEE
IMLNTPHNPTGTVWHADDMRRLAEIVAPTDVLLLSDEVYEHMVYDGVPHASVSRIPELAR
EEEECCCCCCCCEEEHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCCHHHHHHHHHHH
RAFVVSSFGKTYHVTGWKVGYVAAPAALSAEFRKVHQFNVFTVNTPVQHGLAAYMADPRP
HHHHHHHCCCEEEECCEEEEEEECCHHHHHHHHHHHEEEEEEECCCHHHHHHHHHCCCCC
YLELPAFYQHKRDLFRAGLEHTRFKLLPCQGTYFQCVDYSALSDLPEAAFAKWLTSEIGV
CCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCHHHHCCHHHHHHHHHHHHCCE
AAIPVSAFYSQPHESGVVRFCFAKKDETLRLALERLSRL
EEEEHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]