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The map label for this gene is folC [H]

Identifier: 17546698

GI number: 17546698

Start: 2153414

End: 2154712

Strand: Reverse

Name: folC [H]

Synonym: RSc1979

Alternate gene names: 17546698

Gene position: 2154712-2153414 (Counterclockwise)

Preceding gene: 17546699

Following gene: 17546697

Centisome position: 57.98

GC content: 68.21

Gene sequence:

>1299_bases
ATGCATTGTTTCGATAACCTGCCGGACTGGCTGGCCCATCTGGAAACCGCGCACCCCGTCGGCATCGACATGGGGCTCGA
GCGCATCAGCCGCGTGCGCGACGCGCTGGCGCTCAAGCTCGATCCGGTCGTCTTCACCGTGGGCGGCACCAACGGCAAGG
GCTCGACCTGCGCGATGCTGGAGGCCATCCTGATGGCGGCTGGCTACAAGGTCGGCTGCCACACATCGCCGCACCTGATC
GACTTCAACGAGCGCGCCCGCGTCAATGGCGAGATCGCCACCGACGCGATGCTGCTGCCGCATTTCGAGGCGGTCGAGCG
CGCCCGCTGCAGCTTCGCCGAGCCCGTCAGCCTGACGTACTTCGAGTTCACCACGCTGGCGATCATGCATCTGTTTGCCG
GGGCGGGGCTGGATGCGGTGATCCTGGAGGTGGGGCTGGGCGGCCGGCTGGATGCGGTCAATATCATCGATCCCGACTGT
GCCGTCGTCACCAGTGTCGATCTCGACCACATGGCCTACCTGGGCGACACGCGCGAGGCGATCGGCTTCGAGAAGGCCGG
CATCTTCCGGCCGGGCGTGCCGGCGGTGTGCTCCGACCCGGTGCCGCCGGTCTCGCTGGTCCGGCACGCCGAGGCCATCG
GCGCGGACCTGTGGCTGATCGGCCGCGATTTCAACTTCCAGGGCGATAAGCAGCAGTGGGGCTGGAGCGGGCGGGGCCGG
CGCTGGTCGTCGCTGGGCTATCCGGCGCTGCGCGGGGCCAACCAGCTGCTGAATGCGTCGGCGGCGCTGGCTGCGCTGGA
CTCGGTGCGCGACCGGCTGGCGATCACCGCGCAGGACGTGCGCGTCGGGCTATCGCGCGTGGCGCTGCCGGGACGCTTCC
AGGTGATGCCGGGCCGACCGGCGGTGATCCTGGATGTGGCCCACAATCCGCATGCCGCGGCGGCCCTGGGCCAGAATCTC
GAGAACATGGGTTTCTTCCGCTACACCTACGCGGTGTTCGGCGCCATGCAGGACAAGGACATCGCGGGCGTGCTGGGCCA
TCTGCTCGACAAGGTCGATCACTGGTGCCTGACCGATCTGCCGACGCCGCGCGCGGCGAGCGCGGCACAACTCGAGCAAG
CCTTGGCGGATGCAGGCTTCAGCCCGGGCAAGGAGGCCAGCGTCGCAACCTATGGCGATCCCGCCACCGCCTATCGCAAC
GCCATGGAGCGGGCGACCGAGGATGATAGAATCGTCGTCTTCGGATCGTTCTTCACCGTTGCCGGTGTGCTGGCGGAGCG
CAAGACCCGCGCGCACTAA

Upstream 100 bases:

>100_bases
GGCCGACGCGCTGGCCTGATGTCCCGCACCCTGTGAACTGAAGCGCGGGCGAGAGTCCGCGCTTCTTCTTTTTGCGCGAT
CCGATCGCACACCGCACCGC

Downstream 100 bases:

>100_bases
CGAAGACCAGGCAGCGCCGGGCGATCCGGTGCCGGTGCTGCAGCCCCTCGTTTCGCATCGTCAGAGAGCCAACCCGGGCG
CAATCCATGGGACTGTTTTC

Product: bifunctional folylpolyglutamate synthase/dihydrofolate synthase

Products: NA

Alternate protein names: Folylpolyglutamate synthase; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase; Dihydrofolate synthase [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MHCFDNLPDWLAHLETAHPVGIDMGLERISRVRDALALKLDPVVFTVGGTNGKGSTCAMLEAILMAAGYKVGCHTSPHLI
DFNERARVNGEIATDAMLLPHFEAVERARCSFAEPVSLTYFEFTTLAIMHLFAGAGLDAVILEVGLGGRLDAVNIIDPDC
AVVTSVDLDHMAYLGDTREAIGFEKAGIFRPGVPAVCSDPVPPVSLVRHAEAIGADLWLIGRDFNFQGDKQQWGWSGRGR
RWSSLGYPALRGANQLLNASAALAALDSVRDRLAITAQDVRVGLSRVALPGRFQVMPGRPAVILDVAHNPHAAAALGQNL
ENMGFFRYTYAVFGAMQDKDIAGVLGHLLDKVDHWCLTDLPTPRAASAAQLEQALADAGFSPGKEASVATYGDPATAYRN
AMERATEDDRIVVFGSFFTVAGVLAERKTRAH

Sequences:

>Translated_432_residues
MHCFDNLPDWLAHLETAHPVGIDMGLERISRVRDALALKLDPVVFTVGGTNGKGSTCAMLEAILMAAGYKVGCHTSPHLI
DFNERARVNGEIATDAMLLPHFEAVERARCSFAEPVSLTYFEFTTLAIMHLFAGAGLDAVILEVGLGGRLDAVNIIDPDC
AVVTSVDLDHMAYLGDTREAIGFEKAGIFRPGVPAVCSDPVPPVSLVRHAEAIGADLWLIGRDFNFQGDKQQWGWSGRGR
RWSSLGYPALRGANQLLNASAALAALDSVRDRLAITAQDVRVGLSRVALPGRFQVMPGRPAVILDVAHNPHAAAALGQNL
ENMGFFRYTYAVFGAMQDKDIAGVLGHLLDKVDHWCLTDLPTPRAASAAQLEQALADAGFSPGKEASVATYGDPATAYRN
AMERATEDDRIVVFGSFFTVAGVLAERKTRAH
>Mature_432_residues
MHCFDNLPDWLAHLETAHPVGIDMGLERISRVRDALALKLDPVVFTVGGTNGKGSTCAMLEAILMAAGYKVGCHTSPHLI
DFNERARVNGEIATDAMLLPHFEAVERARCSFAEPVSLTYFEFTTLAIMHLFAGAGLDAVILEVGLGGRLDAVNIIDPDC
AVVTSVDLDHMAYLGDTREAIGFEKAGIFRPGVPAVCSDPVPPVSLVRHAEAIGADLWLIGRDFNFQGDKQQWGWSGRGR
RWSSLGYPALRGANQLLNASAALAALDSVRDRLAITAQDVRVGLSRVALPGRFQVMPGRPAVILDVAHNPHAAAALGQNL
ENMGFFRYTYAVFGAMQDKDIAGVLGHLLDKVDHWCLTDLPTPRAASAAQLEQALADAGFSPGKEASVATYGDPATAYRN
AMERATEDDRIVVFGSFFTVAGVLAERKTRAH

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932990, Length=296, Percent_Identity=33.445945945946, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI66932984, Length=334, Percent_Identity=32.3353293413174, Blast_Score=125, Evalue=5e-29,
Organism=Escherichia coli, GI1788654, Length=419, Percent_Identity=43.6754176610979, Blast_Score=299, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17553150, Length=434, Percent_Identity=26.7281105990783, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71984923, Length=434, Percent_Identity=26.7281105990783, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17553148, Length=434, Percent_Identity=26.7281105990783, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323760, Length=433, Percent_Identity=26.7898383371824, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324815, Length=287, Percent_Identity=31.7073170731707, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24641571, Length=152, Percent_Identity=37.5, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24581568, Length=155, Percent_Identity=34.8387096774194, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17; =6.3.2.12 [H]

Molecular weight: Translated: 46457; Mature: 46457

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHCFDNLPDWLAHLETAHPVGIDMGLERISRVRDALALKLDPVVFTVGGTNGKGSTCAML
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEECCEEEEECCCCCCCHHHHHH
EAILMAAGYKVGCHTSPHLIDFNERARVNGEIATDAMLLPHFEAVERARCSFAEPVSLTY
HHHHHHCCCEECCCCCCCEEECCCCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCEEEH
FEFTTLAIMHLFAGAGLDAVILEVGLGGRLDAVNIIDPDCAVVTSVDLDHMAYLGDTREA
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCEEEEECCHHHHHHHCCCHHH
IGFEKAGIFRPGVPAVCSDPVPPVSLVRHAEAIGADLWLIGRDFNFQGDKQQWGWSGRGR
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCC
RWSSLGYPALRGANQLLNASAALAALDSVRDRLAITAQDVRVGLSRVALPGRFQVMPGRP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHCCCCCEEECCCCC
AVILDVAHNPHAAAALGQNLENMGFFRYTYAVFGAMQDKDIAGVLGHLLDKVDHWCLTDL
EEEEEECCCCHHHHHHHCCHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCC
PTPRAASAAQLEQALADAGFSPGKEASVATYGDPATAYRNAMERATEDDRIVVFGSFFTV
CCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEEECHHHH
AGVLAERKTRAH
HHHHHHHHHCCC
>Mature Secondary Structure
MHCFDNLPDWLAHLETAHPVGIDMGLERISRVRDALALKLDPVVFTVGGTNGKGSTCAML
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEECCEEEEECCCCCCCHHHHHH
EAILMAAGYKVGCHTSPHLIDFNERARVNGEIATDAMLLPHFEAVERARCSFAEPVSLTY
HHHHHHCCCEECCCCCCCEEECCCCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCEEEH
FEFTTLAIMHLFAGAGLDAVILEVGLGGRLDAVNIIDPDCAVVTSVDLDHMAYLGDTREA
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCEEEEECCHHHHHHHCCCHHH
IGFEKAGIFRPGVPAVCSDPVPPVSLVRHAEAIGADLWLIGRDFNFQGDKQQWGWSGRGR
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCC
RWSSLGYPALRGANQLLNASAALAALDSVRDRLAITAQDVRVGLSRVALPGRFQVMPGRP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHCCCCCEEECCCCC
AVILDVAHNPHAAAALGQNLENMGFFRYTYAVFGAMQDKDIAGVLGHLLDKVDHWCLTDL
EEEEEECCCCHHHHHHHCCHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCC
PTPRAASAAQLEQALADAGFSPGKEASVATYGDPATAYRNAMERATEDDRIVVFGSFFTV
CCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEEECHHHH
AGVLAERKTRAH
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3040739; 3040734; 9205837; 9278503; 1989505 [H]