Click here to switch to the map view.

The map label for this gene is cyoB2 [H]

Identifier: 17546578

GI number: 17546578

Start: 2042643

End: 2044619

Strand: Direct

Name: cyoB2 [H]

Synonym: RSc1859

Alternate gene names: 17546578

Gene position: 2042643-2044619 (Clockwise)

Preceding gene: 17546577

Following gene: 17546579

Centisome position: 54.96

GC content: 63.73

Gene sequence:

>1977_bases
ATGTTCGGAAAACTCAACCTCAATGCCGTCCCGCTCCATGAGCCGATCATCATGGGAACGCTGGCGGCCGTGCTGGTCCT
CGGCGCGGCGCTGATCGGCGCCATCACGTACTTCGGCAGATGGAAGCCCTTGTGGACGGAGTGGATCTGCTCGGTCGACC
ACAAGAAGATCGGCGTGATGTACATCGTGCTGGCGCTGGTGATGCTGCTGCGCGGCTTTGCCGACGCCATCATGATGCGC
GTCCAGCAGGCGATCGCCTACGGCGATGCCGCGGGCTATCTGCCGCCGCATCACTACGACCAGATCTTCACCGCCCACGG
CGTGATCATGATCTTCTTCGTCGCCACGCCGCTGGTGCTCGGCCTGATGAACGTGATCGTTCCGCTGCAGATCGGCGCGC
GCGACGTGGCCTTCCCGTTCGTCAACTCGCTGAGCTTCTGGCTTTCGGCCATGGGCGCGGTGCTGGTCATGCTGTCCATG
TTCGTCGGCGATTTCGCGGCCACGGGCTGGGTTGCCTACCCGCCGCTATCGGAGCTCGGGTACAGCCCGACGCCCGGCGT
CGACTACTACATCTGGTCGCTGCAGATCTCCGGCCTCGGCACGACGCTGACGGGCATCAACTTCATCGTCACGATCCTGC
GCATGCGTGCTCCCGGCATGAACCTGATGAAGATGCCGGTGTTCACCTGGACCGCGCTGATCACCAACATCCTGATCGTC
GCCATCTTTCCCGTCCTGACCGCGACGCTCGCGCTGCTCACCGCCGACCGCTACCTCGGCATGCACTTCTTCACCAACGA
GCTCGGCGGCAACGCGATGATGTACGTGAACCTGATCTGGGTGTGGGGCCACCCCGAGGTCTACGTGCTGATCCTGCCGG
CGTTCGGTGCGTTCTCCGAGATCATCGCCACCTTCTCCCGCAAGCCCCTGTTCGGCTACAAGTCGATGGTGTACGCCACC
TCCTCGATCGGCGTGCTGTCGTTCTTTGTCTGGCTGCACCACTTCTTCACCATGGGATCGGGAGCCAACGTCAATGCCTT
TTTCGGGATCATGACGTCGATCATTTCGATCCCCACCGGGGTCAAGCTGTTCAACTGGCTGTTCACCATGTACCGGGGCC
GGATCCGCTTCCATTCGTCGACCCTGTGGACCATCGGCTTCATGGTCACGTTCGCCGTCGGCGGCATGACCGGCGTGCTG
CTGGCCGTTCCGGGCGCCGACTTCGTGCTGCACAACAGCCTGTTCCTGGTGGCCCACTTCCACAACGTCATCATCGGCGG
CGTGCTCTTCGGCTGCCTGGCCGCGATCAGCTTCTGGTTCCCGAAGGTGTTCGGCTTCAAGCTCAACGAGTTCTGGGGCA
AGGTGTCGTTCTGGTGCTGGCTGAGCGGCTTCTTCCTGGCCTTCATGCCGCTCTATGTGCTCGGCTTCAAGGGCATGACC
CGCCGGATGAACCACTACGCCAACGTCGACTGGCATCCGTACCTGGTGGTGGCGCTGGTCGGGGCGTGCGTCATCGGCGC
CGGGATCGTGGCCATGCTGATCCAGCTGGGCATCAGCATCCGCGACCGCAAGACGCATCCGGACCTCACCGGCGACCCGT
GGGACGGCCGCAGTCTCGAATGGTCGACCGCTTCGCCGGCGCCGTTCTACAACTTCGCCCACATTCCGCACATCACCTCG
CTCGAGCAGCACTGGGAAGACAAGGAAACCCGCCGGGCGTGGCGGCAGCCGGCCCACTACGAAGACATCCACATGCCGCG
CAATACGTCGGCGGGGTTCGTGGTGTCGGCCTTCGGCCTGCTGCTGTGCTTCGCGCTGGTCTGGCACATGTGGCCGGTCG
CCGTCGCCGGCCTGCTCGGTGCGGTGGCCACCTTCATTCTCCGCAGCTATGACCGCGATGTGGACTACTACGTGAGCGCG
GCGGAAGTCGAGCGGATCGAACGCGCGCGCTACGCGCAATTGCAGGACGCGGCCTGA

Upstream 100 bases:

>100_bases
GCTGGCCAACGGCCAGGTCTGCCGCGCAGACGGGCCCGAGTCCCTGCAGGCCTTCCAGCCCATCCCGTCCGCGTCCATCG
GGCGCGTGGAGCAATAAGCC

Downstream 100 bases:

>100_bases
CCATGACACACACCCTTTCCCCGACCCTGGATCCCACGGCGCCCGAGGCGGCGCACCCGCACCCGCATCACGACACCGGG
TTCAACACGACGCTGGGCTT

Product: transmembrane cytochrome O ubiquinol oxidase subunit I

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MFGKLNLNAVPLHEPIIMGTLAAVLVLGAALIGAITYFGRWKPLWTEWICSVDHKKIGVMYIVLALVMLLRGFADAIMMR
VQQAIAYGDAAGYLPPHHYDQIFTAHGVIMIFFVATPLVLGLMNVIVPLQIGARDVAFPFVNSLSFWLSAMGAVLVMLSM
FVGDFAATGWVAYPPLSELGYSPTPGVDYYIWSLQISGLGTTLTGINFIVTILRMRAPGMNLMKMPVFTWTALITNILIV
AIFPVLTATLALLTADRYLGMHFFTNELGGNAMMYVNLIWVWGHPEVYVLILPAFGAFSEIIATFSRKPLFGYKSMVYAT
SSIGVLSFFVWLHHFFTMGSGANVNAFFGIMTSIISIPTGVKLFNWLFTMYRGRIRFHSSTLWTIGFMVTFAVGGMTGVL
LAVPGADFVLHNSLFLVAHFHNVIIGGVLFGCLAAISFWFPKVFGFKLNEFWGKVSFWCWLSGFFLAFMPLYVLGFKGMT
RRMNHYANVDWHPYLVVALVGACVIGAGIVAMLIQLGISIRDRKTHPDLTGDPWDGRSLEWSTASPAPFYNFAHIPHITS
LEQHWEDKETRRAWRQPAHYEDIHMPRNTSAGFVVSAFGLLLCFALVWHMWPVAVAGLLGAVATFILRSYDRDVDYYVSA
AEVERIERARYAQLQDAA

Sequences:

>Translated_658_residues
MFGKLNLNAVPLHEPIIMGTLAAVLVLGAALIGAITYFGRWKPLWTEWICSVDHKKIGVMYIVLALVMLLRGFADAIMMR
VQQAIAYGDAAGYLPPHHYDQIFTAHGVIMIFFVATPLVLGLMNVIVPLQIGARDVAFPFVNSLSFWLSAMGAVLVMLSM
FVGDFAATGWVAYPPLSELGYSPTPGVDYYIWSLQISGLGTTLTGINFIVTILRMRAPGMNLMKMPVFTWTALITNILIV
AIFPVLTATLALLTADRYLGMHFFTNELGGNAMMYVNLIWVWGHPEVYVLILPAFGAFSEIIATFSRKPLFGYKSMVYAT
SSIGVLSFFVWLHHFFTMGSGANVNAFFGIMTSIISIPTGVKLFNWLFTMYRGRIRFHSSTLWTIGFMVTFAVGGMTGVL
LAVPGADFVLHNSLFLVAHFHNVIIGGVLFGCLAAISFWFPKVFGFKLNEFWGKVSFWCWLSGFFLAFMPLYVLGFKGMT
RRMNHYANVDWHPYLVVALVGACVIGAGIVAMLIQLGISIRDRKTHPDLTGDPWDGRSLEWSTASPAPFYNFAHIPHITS
LEQHWEDKETRRAWRQPAHYEDIHMPRNTSAGFVVSAFGLLLCFALVWHMWPVAVAGLLGAVATFILRSYDRDVDYYVSA
AEVERIERARYAQLQDAA
>Mature_658_residues
MFGKLNLNAVPLHEPIIMGTLAAVLVLGAALIGAITYFGRWKPLWTEWICSVDHKKIGVMYIVLALVMLLRGFADAIMMR
VQQAIAYGDAAGYLPPHHYDQIFTAHGVIMIFFVATPLVLGLMNVIVPLQIGARDVAFPFVNSLSFWLSAMGAVLVMLSM
FVGDFAATGWVAYPPLSELGYSPTPGVDYYIWSLQISGLGTTLTGINFIVTILRMRAPGMNLMKMPVFTWTALITNILIV
AIFPVLTATLALLTADRYLGMHFFTNELGGNAMMYVNLIWVWGHPEVYVLILPAFGAFSEIIATFSRKPLFGYKSMVYAT
SSIGVLSFFVWLHHFFTMGSGANVNAFFGIMTSIISIPTGVKLFNWLFTMYRGRIRFHSSTLWTIGFMVTFAVGGMTGVL
LAVPGADFVLHNSLFLVAHFHNVIIGGVLFGCLAAISFWFPKVFGFKLNEFWGKVSFWCWLSGFFLAFMPLYVLGFKGMT
RRMNHYANVDWHPYLVVALVGACVIGAGIVAMLIQLGISIRDRKTHPDLTGDPWDGRSLEWSTASPAPFYNFAHIPHITS
LEQHWEDKETRRAWRQPAHYEDIHMPRNTSAGFVVSAFGLLLCFALVWHMWPVAVAGLLGAVATFILRSYDRDVDYYVSA
AEVERIERARYAQLQDAA

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=516, Percent_Identity=37.2093023255814, Blast_Score=317, Evalue=2e-86,
Organism=Escherichia coli, GI1786634, Length=658, Percent_Identity=66.5653495440729, Blast_Score=941, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=447, Percent_Identity=40.2684563758389, Blast_Score=330, Evalue=4e-91,
Organism=Saccharomyces cerevisiae, GI6226524, Length=326, Percent_Identity=42.3312883435583, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6226523, Length=246, Percent_Identity=35.3658536585366, Blast_Score=139, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 73347; Mature: 73347

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGKLNLNAVPLHEPIIMGTLAAVLVLGAALIGAITYFGRWKPLWTEWICSVDHKKIGVM
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHH
YIVLALVMLLRGFADAIMMRVQQAIAYGDAAGYLPPHHYDQIFTAHGVIMIFFVATPLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLMNVIVPLQIGARDVAFPFVNSLSFWLSAMGAVLVMLSMFVGDFAATGWVAYPPLSELG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHCC
YSPTPGVDYYIWSLQISGLGTTLTGINFIVTILRMRAPGMNLMKMPVFTWTALITNILIV
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AIFPVLTATLALLTADRYLGMHFFTNELGGNAMMYVNLIWVWGHPEVYVLILPAFGAFSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCEEEEEEECHHHHHH
IIATFSRKPLFGYKSMVYATSSIGVLSFFVWLHHFFTMGSGANVNAFFGIMTSIISIPTG
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCH
VKLFNWLFTMYRGRIRFHSSTLWTIGFMVTFAVGGMTGVLLAVPGADFVLHNSLFLVAHF
HHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCHHEEEEECCCCCCHHHCHHHHHHHH
HNVIIGGVLFGCLAAISFWFPKVFGFKLNEFWGKVSFWCWLSGFFLAFMPLYVLGFKGMT
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RRMNHYANVDWHPYLVVALVGACVIGAGIVAMLIQLGISIRDRKTHPDLTGDPWDGRSLE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCC
WSTASPAPFYNFAHIPHITSLEQHWEDKETRRAWRQPAHYEDIHMPRNTSAGFVVSAFGL
CCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
LLCFALVWHMWPVAVAGLLGAVATFILRSYDRDVDYYVSAAEVERIERARYAQLQDAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFGKLNLNAVPLHEPIIMGTLAAVLVLGAALIGAITYFGRWKPLWTEWICSVDHKKIGVM
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHH
YIVLALVMLLRGFADAIMMRVQQAIAYGDAAGYLPPHHYDQIFTAHGVIMIFFVATPLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLMNVIVPLQIGARDVAFPFVNSLSFWLSAMGAVLVMLSMFVGDFAATGWVAYPPLSELG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHCC
YSPTPGVDYYIWSLQISGLGTTLTGINFIVTILRMRAPGMNLMKMPVFTWTALITNILIV
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AIFPVLTATLALLTADRYLGMHFFTNELGGNAMMYVNLIWVWGHPEVYVLILPAFGAFSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCEEEEEEECHHHHHH
IIATFSRKPLFGYKSMVYATSSIGVLSFFVWLHHFFTMGSGANVNAFFGIMTSIISIPTG
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCH
VKLFNWLFTMYRGRIRFHSSTLWTIGFMVTFAVGGMTGVLLAVPGADFVLHNSLFLVAHF
HHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCHHEEEEECCCCCCHHHCHHHHHHHH
HNVIIGGVLFGCLAAISFWFPKVFGFKLNEFWGKVSFWCWLSGFFLAFMPLYVLGFKGMT
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RRMNHYANVDWHPYLVVALVGACVIGAGIVAMLIQLGISIRDRKTHPDLTGDPWDGRSLE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCC
WSTASPAPFYNFAHIPHITSLEQHWEDKETRRAWRQPAHYEDIHMPRNTSAGFVVSAFGL
CCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
LLCFALVWHMWPVAVAGLLGAVATFILRSYDRDVDYYVSAAEVERIERARYAQLQDAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]