Click here to switch to the map view.

The map label for this gene is mltD [H]

Identifier: 17546235

GI number: 17546235

Start: 1617229

End: 1618584

Strand: Direct

Name: mltD [H]

Synonym: RSc1516

Alternate gene names: 17546235

Gene position: 1617229-1618584 (Clockwise)

Preceding gene: 17546234

Following gene: 17546236

Centisome position: 43.52

GC content: 67.48

Gene sequence:

>1356_bases
GTGCGACTTCTCGCGGCATCTGTGTTCAGTCTGCTTCTGGCAGCCTGTGCCACGGGCCCCGCTCCGAATGCCGACACCGC
CAGCACAAGCGCCGTTTCCTCCACGTCCGGCAAAGATGCGCCGGTCGTTAATGTCGATCAGCAGCCCGTGGCCTCCCTCA
AGGGGCCGGCCAAGGACCTGTGGGCGCGCATCCGCCAAGGTTTCTCCATGCCCGACCTGCAGAGTTCGGCCGTGGACGAC
CGCGCCGACTGGTATGCCCAGCGCCCCGAGGCGTTCCGCCGCATGGTGGACCGCTCCAACCGCTACCTGTATCACATCGT
CGAGGAACTCGAACGGCGCAACATGCCCACCGAACTGGCCCTGCTGCCGTTCGTGGAGAGCGCGTTCAACCCGCAGGCGG
TCTCCAGCGCCAAGGCGGCCGGTATGTGGCAGTTCATCCCGAGCACCGGCAAGACCTACAACCTCCGGCAAAACGTTTTC
CAGGACGAGCGCCGCGACGTGCTGGCCTCGACCGATGCCGCGCTGGACTACCTGTCCAAGCTGCACGACCAGTTCGGCGA
CTGGCAACTGGCGCTGGCCGCCTACAACTGGGGCGAGGGCGCGGTGGCGCGGGCGATCGCGCGCAACCAGGCGGCCGGGC
TGTCGGCCGACTACCTCAACCTGAACATGCCCGCCGAGACGCGCATGTACGTGCCCAAGCTCCAGGCGATCAAGAACATC
ATCACCAGCCCGGAGCGCTATGGCATCACGTTGCCGGACATCCCCAACCACCCGTACTTCGTCACCGTCACCACCTCGCG
CGACATCGACGTGACGCTGGCGGCGCGGCTGGCCAACCTGCCGATCGACGAGTTCAAGGCGCTGAATCCGTCGTTCAACC
GGCCGGTCATCCTGGGCGCGTCCAACCCGCAAATCCTGCTGCCGTACGACAACGCCGAGACATTCCAGTACAACCTCAAC
ACCTATCGCGGCGGGCTGTCGAGCTGGACTGCCGTTACGGTCGGCAACCGCGAGCGCGTCGAGGCGCTGGCCGCGCGGCT
CAAGGTCGATCCGGACACCATCCGCGAGATCAACCGCATTCCCAAGGGCATGCGCCTGAAGGCCGGCTCCACCGTGGTGG
TGCCGCGCGCCGAGGATGCCAAGGAGGACGCCCCCGACATCAGCCCCGAGCTGGCCGAGAACGCCACCATGACGGTCGAG
CCCGACGTGCCCGACCTGCGCCGCGTGGTGGTGCGCGCCGGCAGGCGGGATACGCTGGCGGGCCTGTCGCACCGCTATGG
CGTGTCGGTGGCGCACTGCGCGCGTGGAACCAGCTGTCCGGAGACGCGATCCCGAAGGGGCGCAACGTGGTCCTGA

Upstream 100 bases:

>100_bases
ACGGTCCCATGCCGGGTGAAAGCGGGTTGACGCGGCGGAATGCCTTCCATACCATCGGGGGCAATTTTTGGTACCAACCC
CTCAGAACTTGATGCGATCC

Downstream 100 bases:

>100_bases
TGCTGCCGCAGGCGCGCTCGGGCGCTCAGGTGCGCGCGGTGCGGGTCTCGGCGATGTCGCGTCCTGTGGCATCGGCGGTG
CGGGTGCCGGTGGCGAAGGT

Product: membrane-bound lytic murein transglycosylase-like lipoprotein

Products: 1,6-Anhydrobond In The Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase D; Regulatory protein dniR [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MRLLAASVFSLLLAACATGPAPNADTASTSAVSSTSGKDAPVVNVDQQPVASLKGPAKDLWARIRQGFSMPDLQSSAVDD
RADWYAQRPEAFRRMVDRSNRYLYHIVEELERRNMPTELALLPFVESAFNPQAVSSAKAAGMWQFIPSTGKTYNLRQNVF
QDERRDVLASTDAALDYLSKLHDQFGDWQLALAAYNWGEGAVARAIARNQAAGLSADYLNLNMPAETRMYVPKLQAIKNI
ITSPERYGITLPDIPNHPYFVTVTTSRDIDVTLAARLANLPIDEFKALNPSFNRPVILGASNPQILLPYDNAETFQYNLN
TYRGGLSSWTAVTVGNRERVEALAARLKVDPDTIREINRIPKGMRLKAGSTVVVPRAEDAKEDAPDISPELAENATMTVE
PDVPDLRRVVVRAGRRDTLAGLSHRYGVSVAHCARGTSCPETRSRRGATWS

Sequences:

>Translated_451_residues
MRLLAASVFSLLLAACATGPAPNADTASTSAVSSTSGKDAPVVNVDQQPVASLKGPAKDLWARIRQGFSMPDLQSSAVDD
RADWYAQRPEAFRRMVDRSNRYLYHIVEELERRNMPTELALLPFVESAFNPQAVSSAKAAGMWQFIPSTGKTYNLRQNVF
QDERRDVLASTDAALDYLSKLHDQFGDWQLALAAYNWGEGAVARAIARNQAAGLSADYLNLNMPAETRMYVPKLQAIKNI
ITSPERYGITLPDIPNHPYFVTVTTSRDIDVTLAARLANLPIDEFKALNPSFNRPVILGASNPQILLPYDNAETFQYNLN
TYRGGLSSWTAVTVGNRERVEALAARLKVDPDTIREINRIPKGMRLKAGSTVVVPRAEDAKEDAPDISPELAENATMTVE
PDVPDLRRVVVRAGRRDTLAGLSHRYGVSVAHCARGTSCPETRSRRGATWS
>Mature_451_residues
MRLLAASVFSLLLAACATGPAPNADTASTSAVSSTSGKDAPVVNVDQQPVASLKGPAKDLWARIRQGFSMPDLQSSAVDD
RADWYAQRPEAFRRMVDRSNRYLYHIVEELERRNMPTELALLPFVESAFNPQAVSSAKAAGMWQFIPSTGKTYNLRQNVF
QDERRDVLASTDAALDYLSKLHDQFGDWQLALAAYNWGEGAVARAIARNQAAGLSADYLNLNMPAETRMYVPKLQAIKNI
ITSPERYGITLPDIPNHPYFVTVTTSRDIDVTLAARLANLPIDEFKALNPSFNRPVILGASNPQILLPYDNAETFQYNLN
TYRGGLSSWTAVTVGNRERVEALAARLKVDPDTIREINRIPKGMRLKAGSTVVVPRAEDAKEDAPDISPELAENATMTVE
PDVPDLRRVVVRAGRRDTLAGLSHRYGVSVAHCARGTSCPETRSRRGATWS

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 LysM repeats [H]

Homologues:

Organism=Escherichia coli, GI1786405, Length=396, Percent_Identity=32.8282828282828, Blast_Score=211, Evalue=8e-56,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR010511
- InterPro:   IPR018392
- InterPro:   IPR002482
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01476 LysM; PF06474 MLTD_N; PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 49615; Mature: 49615

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLAASVFSLLLAACATGPAPNADTASTSAVSSTSGKDAPVVNVDQQPVASLKGPAKDL
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCEEECCCCHHHHHCCCHHHH
WARIRQGFSMPDLQSSAVDDRADWYAQRPEAFRRMVDRSNRYLYHIVEELERRNMPTELA
HHHHHCCCCCCCCCHHHCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
LLPFVESAFNPQAVSSAKAAGMWQFIPSTGKTYNLRQNVFQDERRDVLASTDAALDYLSK
HHHHHHHCCCCHHHHHHHHCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHDQFGDWQLALAAYNWGEGAVARAIARNQAAGLSADYLNLNMPAETRMYVPKLQAIKNI
HHHHCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
ITSPERYGITLPDIPNHPYFVTVTTSRDIDVTLAARLANLPIDEFKALNPSFNRPVILGA
HCCCHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHCCCCCCCCCEEEEC
SNPQILLPYDNAETFQYNLNTYRGGLSSWTAVTVGNRERVEALAARLKVDPDTIREINRI
CCCEEEEECCCCCEEEEECHHHCCCCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHC
PKGMRLKAGSTVVVPRAEDAKEDAPDISPELAENATMTVEPDVPDLRRVVVRAGRRDTLA
CCCCEEECCCEEEEECCCCCCCCCCCCCHHHHCCCEEEECCCCHHHHHHHHHCCCCHHHH
GLSHRYGVSVAHCARGTSCPETRSRRGATWS
HHHHHCCCCHHHHHCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MRLLAASVFSLLLAACATGPAPNADTASTSAVSSTSGKDAPVVNVDQQPVASLKGPAKDL
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCEEECCCCHHHHHCCCHHHH
WARIRQGFSMPDLQSSAVDDRADWYAQRPEAFRRMVDRSNRYLYHIVEELERRNMPTELA
HHHHHCCCCCCCCCHHHCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
LLPFVESAFNPQAVSSAKAAGMWQFIPSTGKTYNLRQNVFQDERRDVLASTDAALDYLSK
HHHHHHHCCCCHHHHHHHHCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHDQFGDWQLALAAYNWGEGAVARAIARNQAAGLSADYLNLNMPAETRMYVPKLQAIKNI
HHHHCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
ITSPERYGITLPDIPNHPYFVTVTTSRDIDVTLAARLANLPIDEFKALNPSFNRPVILGA
HCCCHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHCCCCCCCCCEEEEC
SNPQILLPYDNAETFQYNLNTYRGGLSSWTAVTVGNRERVEALAARLKVDPDTIREINRI
CCCEEEEECCCCCEEEEECHHHCCCCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHC
PKGMRLKAGSTVVVPRAEDAKEDAPDISPELAENATMTVEPDVPDLRRVVVRAGRRDTLA
CCCCEEECCCEEEEECCCCCCCCCCCCCHHHHCCCEEEECCCCHHHHHHHHHCCCCHHHH
GLSHRYGVSVAHCARGTSCPETRSRRGATWS
HHHHHCCCCHHHHHCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]