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The map label for this gene is lpxD [H]

Identifier: 17546133

GI number: 17546133

Start: 1514575

End: 1515645

Strand: Direct

Name: lpxD [H]

Synonym: RSc1414

Alternate gene names: 17546133

Gene position: 1514575-1515645 (Clockwise)

Preceding gene: 17546132

Following gene: 17546134

Centisome position: 40.75

GC content: 67.97

Gene sequence:

>1071_bases
ATGTCGTTTTCGCTTGATGAACTCGCCGCGTCGCTCGGCGCGACCGTCCAGGGCGATGCCGGCCTGATCGTCAAGTCGAT
CGCGCCGCTGGATCAGGCCGGCGCCGATCAGCTCGCCTTCCTTTCCAATCCGCTGTACCTCAACCAGGCCGTGACCTCCG
GCGCCGGCGCGATCATCGTATCGCCCCGCGACCTGGAGACGCTCACGGCCGAGGGCCATGCGGCGGGCCGCAACTGGCTC
GTGGCCGCCAACCCGTATGCGGCCTTCGCACGCATTGCCCAGCGCTTCGCCGCGCTGGGCGCGCGGCCGGCGGCGGCCGG
CATCCACCCCAGCGCCAGCGTGGGCGAGGGGGCCGTCGTGCCGGCGTCGTGCTCGATTGGCCCGAACGTCACGATCGAAG
CCGGCGCGGTGCTGGGCGAGCGCGTGCGGATCGCGGGCAACAGCTTTATCGGCGCGGACGCGCAGGTCGGCGACGACACG
CTGCTCTACGCCAATGTCTCGATCTATCACGGCTGCGTGGTCGGCGCGCGCTGCATTCTGCATAGCGGCGTGGTGATCGG
CGCGGACGGCTTCGGCTTCGCGCCCGATTTCGGCCCGCAGGGCGGCGAGTGGGTGAAGATTCCCCAGACCGGCCGGGCGA
TCGTCGGCGACGACGTGGAGATCGGCGCCAACACCGCCATCGACCGCGGCGCCATGGCCGATACCGTGGTCGAGCAGGGT
TGCAAGATCGACAACCAGGTGCAGATCGCGCACAACGTGCACGTGGGGGCGTACACCGTCATCGCGGGTTGTGCGGCCAT
CTCGGGTAGCACCAAGATCGGGCGCTACTGCATCATCGGCGGCGCGGCCAATTTCGCGGGCCACCTGACCATCGCCGATC
GCGTGACCGTTTCGGGCGGCACGTCGATCACCAAGTCCATTCCCAAGCCTGGCCACTTCACCAGCGTCTTCCCGTTCATG
CCCCACGCGGATTGGGAACGTAACGCGGCCATCCTCCGTGGCCTGACGCGCATGCGCGAACGGTTGCAACAACTGGAACA
GCAGGTCAAGCATCTGCAGCAATCATCATGA

Upstream 100 bases:

>100_bases
ATCGTGCAGGAGGCGGTGTACGTGAACCCGCGCATCGACATCACCGACGAAGTGCTCAAGGCACTGAACGCCTCGCAATC
GGCGAAATGAGGGTGCCCCG

Downstream 100 bases:

>100_bases
CCGAACCCTCTGCCGCGACGACGAGCCTCGTCAGCGATTTCAACATCAAGAAGATTCTCGAACTGCTGCCGCACCGCTAT
CCGATGCTGCTGGTCGATCG

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSFSLDELAASLGATVQGDAGLIVKSIAPLDQAGADQLAFLSNPLYLNQAVTSGAGAIIVSPRDLETLTAEGHAAGRNWL
VAANPYAAFARIAQRFAALGARPAAAGIHPSASVGEGAVVPASCSIGPNVTIEAGAVLGERVRIAGNSFIGADAQVGDDT
LLYANVSIYHGCVVGARCILHSGVVIGADGFGFAPDFGPQGGEWVKIPQTGRAIVGDDVEIGANTAIDRGAMADTVVEQG
CKIDNQVQIAHNVHVGAYTVIAGCAAISGSTKIGRYCIIGGAANFAGHLTIADRVTVSGGTSITKSIPKPGHFTSVFPFM
PHADWERNAAILRGLTRMRERLQQLEQQVKHLQQSS

Sequences:

>Translated_356_residues
MSFSLDELAASLGATVQGDAGLIVKSIAPLDQAGADQLAFLSNPLYLNQAVTSGAGAIIVSPRDLETLTAEGHAAGRNWL
VAANPYAAFARIAQRFAALGARPAAAGIHPSASVGEGAVVPASCSIGPNVTIEAGAVLGERVRIAGNSFIGADAQVGDDT
LLYANVSIYHGCVVGARCILHSGVVIGADGFGFAPDFGPQGGEWVKIPQTGRAIVGDDVEIGANTAIDRGAMADTVVEQG
CKIDNQVQIAHNVHVGAYTVIAGCAAISGSTKIGRYCIIGGAANFAGHLTIADRVTVSGGTSITKSIPKPGHFTSVFPFM
PHADWERNAAILRGLTRMRERLQQLEQQVKHLQQSS
>Mature_355_residues
SFSLDELAASLGATVQGDAGLIVKSIAPLDQAGADQLAFLSNPLYLNQAVTSGAGAIIVSPRDLETLTAEGHAAGRNWLV
AANPYAAFARIAQRFAALGARPAAAGIHPSASVGEGAVVPASCSIGPNVTIEAGAVLGERVRIAGNSFIGADAQVGDDTL
LYANVSIYHGCVVGARCILHSGVVIGADGFGFAPDFGPQGGEWVKIPQTGRAIVGDDVEIGANTAIDRGAMADTVVEQGC
KIDNQVQIAHNVHVGAYTVIAGCAAISGSTKIGRYCIIGGAANFAGHLTIADRVTVSGGTSITKSIPKPGHFTSVFPFMP
HADWERNAAILRGLTRMRERLQQLEQQVKHLQQSS

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=351, Percent_Identity=41.025641025641, Blast_Score=266, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36642; Mature: 36511

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSLDELAASLGATVQGDAGLIVKSIAPLDQAGADQLAFLSNPLYLNQAVTSGAGAIIV
CCCCHHHHHHHHCCEECCCCCEEEEHHCCCCCCCCCHHHHHCCCEEEEHHHCCCCCEEEE
SPRDLETLTAEGHAAGRNWLVAANPYAAFARIAQRFAALGARPAAAGIHPSASVGEGAVV
CCCCCCEEECCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
PASCSIGPNVTIEAGAVLGERVRIAGNSFIGADAQVGDDTLLYANVSIYHGCVVGARCIL
ECCCCCCCCEEEECCCCCCCEEEEECCCEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHH
HSGVVIGADGFGFAPDFGPQGGEWVKIPQTGRAIVGDDVEIGANTAIDRGAMADTVVEQG
HCCEEEECCCCCCCCCCCCCCCCEEECCCCCCEEECCCEEECCCCCCCCCHHHHHHHHCC
CKIDNQVQIAHNVHVGAYTVIAGCAAISGSTKIGRYCIIGGAANFAGHLTIADRVTVSGG
CCCCCEEEEEEEEECHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEEEEEEECCC
TSITKSIPKPGHFTSVFPFMPHADWERNAAILRGLTRMRERLQQLEQQVKHLQQSS
CHHHHCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFSLDELAASLGATVQGDAGLIVKSIAPLDQAGADQLAFLSNPLYLNQAVTSGAGAIIV
CCCHHHHHHHHCCEECCCCCEEEEHHCCCCCCCCCHHHHHCCCEEEEHHHCCCCCEEEE
SPRDLETLTAEGHAAGRNWLVAANPYAAFARIAQRFAALGARPAAAGIHPSASVGEGAVV
CCCCCCEEECCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
PASCSIGPNVTIEAGAVLGERVRIAGNSFIGADAQVGDDTLLYANVSIYHGCVVGARCIL
ECCCCCCCCEEEECCCCCCCEEEEECCCEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHH
HSGVVIGADGFGFAPDFGPQGGEWVKIPQTGRAIVGDDVEIGANTAIDRGAMADTVVEQG
HCCEEEECCCCCCCCCCCCCCCCEEECCCCCCEEECCCEEECCCCCCCCCHHHHHHHHCC
CKIDNQVQIAHNVHVGAYTVIAGCAAISGSTKIGRYCIIGGAANFAGHLTIADRVTVSGG
CCCCCEEEEEEEEECHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEEEEEEECCC
TSITKSIPKPGHFTSVFPFMPHADWERNAAILRGLTRMRERLQQLEQQVKHLQQSS
CHHHHCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA