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The map label for this gene is uppS

Identifier: 17546127

GI number: 17546127

Start: 1507323

End: 1508099

Strand: Direct

Name: uppS

Synonym: RSc1408

Alternate gene names: 17546127

Gene position: 1507323-1508099 (Clockwise)

Preceding gene: 17546126

Following gene: 17546128

Centisome position: 40.56

GC content: 65.51

Gene sequence:

>777_bases
ATGCATATCAGCTCGACACTGGCGGTGCCTGACACCGCCGATACGCCACACCACGTTGCCATCATCATGGATGGCAATGG
CCGCTGGGCCACCGAACGCCACCTCCCGCGCATGGCAGGGCACAGTCGTGGCCTCGATGCCGTGCGTGCCGCGGTCCAGG
CCGCAGACCACCGTGGCGTGCGCTACCTGACGCTGTTCGCGTTCAGTTCGGAGAACTGGCGCCGTCCGGCCGAGGAAATC
TCCTTCCTGATGAAGCTGTTCATGACGGCTCTGCGGCGCGAGGTGAGCAAGCTGAATGACAGCGGCATCCGCCTGCGCGT
GGTGGGTGACCTGAGTGCGTTCAGTCCGCGTATCCAGCTGATGATCCGCGAGGCGGAAGCCAAGACGGCGACCAACCCCG
GGCTCACTGTCACCATCGCCGCCAACTACGGCGGCCGCTGGGACATCCTGCAGGCCATGCGCGCGCTGGTGGCCGATCAG
CCCGACATCGCGCCCGAAGCCATCACCGAAGAGGCGCTGTCGCCGTATATGGCGCTGGCGTATGCGTCGGAGCCGGACCT
GTTCATCCGCACCGGCGGCGAGCAGCGCATCAGCAATTTCATGCTGTGGCAGCTCGCCTATTCCGAGCTCTACTTCACCG
AACGCTACTGGCCCGATTTCGACGCTGCGGAGATGGATCGCGCCTTTGCCTGGTATCGCAACCGCGAGCGGCGCTTTGGC
CGTACCAGCGCGCAGCTGGAACCCGGTACTGCCCCCGCACTGTCGGCTGGAGCCTGA

Upstream 100 bases:

>100_bases
GGTGGACAAGCTTGTCGCCGAAAAGGACAAGGAAATCATGACGGTTTGAGGCCGTCTCCCACCTGCCGGCGCATTGTGTG
TCGGCCATGGGAACCCATTC

Downstream 100 bases:

>100_bases
CGCATGCTGCTGACTCGCGTGATCACCGCTGTCTGCCTGCTGATTGTCATCCTGCCGATCCTGTTGTTCGCTCCGCCCGC
CGGCCTGACCGGGCTGGTGA

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MHISSTLAVPDTADTPHHVAIIMDGNGRWATERHLPRMAGHSRGLDAVRAAVQAADHRGVRYLTLFAFSSENWRRPAEEI
SFLMKLFMTALRREVSKLNDSGIRLRVVGDLSAFSPRIQLMIREAEAKTATNPGLTVTIAANYGGRWDILQAMRALVADQ
PDIAPEAITEEALSPYMALAYASEPDLFIRTGGEQRISNFMLWQLAYSELYFTERYWPDFDAAEMDRAFAWYRNRERRFG
RTSAQLEPGTAPALSAGA

Sequences:

>Translated_258_residues
MHISSTLAVPDTADTPHHVAIIMDGNGRWATERHLPRMAGHSRGLDAVRAAVQAADHRGVRYLTLFAFSSENWRRPAEEI
SFLMKLFMTALRREVSKLNDSGIRLRVVGDLSAFSPRIQLMIREAEAKTATNPGLTVTIAANYGGRWDILQAMRALVADQ
PDIAPEAITEEALSPYMALAYASEPDLFIRTGGEQRISNFMLWQLAYSELYFTERYWPDFDAAEMDRAFAWYRNRERRFG
RTSAQLEPGTAPALSAGA
>Mature_258_residues
MHISSTLAVPDTADTPHHVAIIMDGNGRWATERHLPRMAGHSRGLDAVRAAVQAADHRGVRYLTLFAFSSENWRRPAEEI
SFLMKLFMTALRREVSKLNDSGIRLRVVGDLSAFSPRIQLMIREAEAKTATNPGLTVTIAANYGGRWDILQAMRALVADQ
PDIAPEAITEEALSPYMALAYASEPDLFIRTGGEQRISNFMLWQLAYSELYFTERYWPDFDAAEMDRAFAWYRNRERRFG
RTSAQLEPGTAPALSAGA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=210, Percent_Identity=32.8571428571429, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI45580738, Length=210, Percent_Identity=32.8571428571429, Blast_Score=125, Evalue=3e-29,
Organism=Escherichia coli, GI1786371, Length=257, Percent_Identity=50.9727626459144, Blast_Score=251, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71993029, Length=229, Percent_Identity=31.8777292576419, Blast_Score=126, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=218, Percent_Identity=33.0275229357798, Blast_Score=122, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=31.4814814814815, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18857969, Length=207, Percent_Identity=37.1980676328502, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_RALSO (Q8XZI7)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519529.1
- ProteinModelPortal:   Q8XZI7
- SMR:   Q8XZI7
- GeneID:   1220232
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1408
- NMPDR:   fig|267608.1.peg.1408
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   CLSK896966
- BioCyc:   RSOL267608:RSC1408-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28936; Mature: 28936

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 24-24

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHISSTLAVPDTADTPHHVAIIMDGNGRWATERHLPRMAGHSRGLDAVRAAVQAADHRGV
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHCHHHHCCCCCHHHHHHHHHHHHCCCC
RYLTLFAFSSENWRRPAEEISFLMKLFMTALRREVSKLNDSGIRLRVVGDLSAFSPRIQL
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEE
MIREAEAKTATNPGLTVTIAANYGGRWDILQAMRALVADQPDIAPEAITEEALSPYMALA
EEEHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCHHEEEE
YASEPDLFIRTGGEQRISNFMLWQLAYSELYFTERYWPDFDAAEMDRAFAWYRNRERRFG
ECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
RTSAQLEPGTAPALSAGA
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHISSTLAVPDTADTPHHVAIIMDGNGRWATERHLPRMAGHSRGLDAVRAAVQAADHRGV
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHCHHHHCCCCCHHHHHHHHHHHHCCCC
RYLTLFAFSSENWRRPAEEISFLMKLFMTALRREVSKLNDSGIRLRVVGDLSAFSPRIQL
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEE
MIREAEAKTATNPGLTVTIAANYGGRWDILQAMRALVADQPDIAPEAITEEALSPYMALA
EEEHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCHHEEEE
YASEPDLFIRTGGEQRISNFMLWQLAYSELYFTERYWPDFDAAEMDRAFAWYRNRERRFG
ECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
RTSAQLEPGTAPALSAGA
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852