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The map label for this gene is aceA [H]

Identifier: 17546077

GI number: 17546077

Start: 1447965

End: 1449296

Strand: Direct

Name: aceA [H]

Synonym: RSc1358

Alternate gene names: 17546077

Gene position: 1447965-1449296 (Clockwise)

Preceding gene: 17546076

Following gene: 17546081

Centisome position: 38.96

GC content: 65.32

Gene sequence:

>1332_bases
ATGGATCGATCACACAAGGAGAGAGTCATGTCGCGCGAACCCGAAGTGAAGGCGCTGCAGCAAGAGTGGGACACCAACCC
GCGCTGGAAAGGCATCAAGCGCGGCTACACCGCGCAAGACGTGGTGCGCCTGCGCGGCTCGCTGCAGATCGAGCACACCC
TGGCCCGCCGCGGTGCCGAAAAGCTGTGGACCCTGATGAACAGTGAGCCGTTCGTCAACGCGCTGGGCGCGCTGACGGGC
AACCAGGCCATGCAGCAGGTCAAGGCCGGCCTGAAGGCCATCTACCTGTCGGGCTGGCAGGTGGCGGGCGACGCCAACAG
CAACGGCGAGATGTATCCCGACCAGTCGCTGTACTCGGTGGACTCGGTGCCCAAGGTGGTCAAGCGCATCAACAATACGT
TCCAGCGCGCCGACCAGATCCAATGGTCGGAAGGCAAGGACGATGTCGACTTCTTCGCCCCGATCGTGGCCGATGCCGAG
GCCGGCTTCGGCGGCGTGCTGAATGCGTTCGAGCTGATGAAGGCGATGATCGAGGCGGGCGCCGCCGGCGTGCACTTCGA
AGACCAGCTGGCCGCCGTCAAGAAATGCGGCCACATGGGCGGCAAGGTGCTGGTGCCGACACGCGAGGCGGTGTCCAAGC
TGGTGGCCGCGCGCCTGGCCGCCGATGTGATGGGCGTGCCGACCGTGCTGATCGCCCGCACCGACGCCGAGGCCGCCGAC
CTGCTGACCGCCGACGTGGACGACAACGACCGTCCGTTCTGCACCGGCGAGCGCACCGTGGAAGGCTTCTACCGCACCAA
GCCGGGCCTGCAGCAGGCCATCGCGCGCGGCCTGGCTTACGCCGACTACGCCGACCTGGTGTGGTGCGAAACCGGCAAGC
CGGACCTGGAGTACGCCAAGAAGTTTGCCGAGGCCATCCACGCCAAGTTCCCCGGCAAGATGCTGGCCTACAACTGCTCG
CCGTCGTTCAACTGGAAGAAGAACCTGGACGACGCCACCATCGCCAAGTTCCAGAAGGAGCTGGGCGCGATGGGCTACAA
GTTCCAGTTCATCACGCTGGCCGGCTTCCATGCCCTGAACTACTCGATGTTCAACCTGGCCCACGGCTATGCCCGCAACC
AGATGAGCGCCTTCGTCGAGCTGCAGGAAGCCGAATTCGCGGCGGCCGAGAAGGGCTTCACCGCGGTCAAGCACCAGCGC
GAAGTCGGCACCGGCTACTTCGATGCCGTGACGCAGACCATCGAGCGCGACGCGTCCACCACGGCGCTCAAGGGCTCGAC
CGAGGACGAGCAGTTCTTCGAAGAAAAGGCGCACGCCAAGAAGGTCGCCTGA

Upstream 100 bases:

>100_bases
CACTCTTATATAAGACATATGACCTGAGCTGCTCGGATGCCCCCTGCAAGGCGTGGGCGGTTCAAGGCGTAGAGCGCATT
ACCCCGGTTTTTATTGTTTG

Downstream 100 bases:

>100_bases
GGTGCCGCCGCATCCGGCACCCAGGACACCGGGGCCGGCGCCCTGACCACGCGCCGGCCGCTCAAAACCGCTCCCCCCGG
CGCGGTTTTTTTATGCCCGG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MDRSHKERVMSREPEVKALQQEWDTNPRWKGIKRGYTAQDVVRLRGSLQIEHTLARRGAEKLWTLMNSEPFVNALGALTG
NQAMQQVKAGLKAIYLSGWQVAGDANSNGEMYPDQSLYSVDSVPKVVKRINNTFQRADQIQWSEGKDDVDFFAPIVADAE
AGFGGVLNAFELMKAMIEAGAAGVHFEDQLAAVKKCGHMGGKVLVPTREAVSKLVAARLAADVMGVPTVLIARTDAEAAD
LLTADVDDNDRPFCTGERTVEGFYRTKPGLQQAIARGLAYADYADLVWCETGKPDLEYAKKFAEAIHAKFPGKMLAYNCS
PSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARNQMSAFVELQEAEFAAAEKGFTAVKHQR
EVGTGYFDAVTQTIERDASTTALKGSTEDEQFFEEKAHAKKVA

Sequences:

>Translated_443_residues
MDRSHKERVMSREPEVKALQQEWDTNPRWKGIKRGYTAQDVVRLRGSLQIEHTLARRGAEKLWTLMNSEPFVNALGALTG
NQAMQQVKAGLKAIYLSGWQVAGDANSNGEMYPDQSLYSVDSVPKVVKRINNTFQRADQIQWSEGKDDVDFFAPIVADAE
AGFGGVLNAFELMKAMIEAGAAGVHFEDQLAAVKKCGHMGGKVLVPTREAVSKLVAARLAADVMGVPTVLIARTDAEAAD
LLTADVDDNDRPFCTGERTVEGFYRTKPGLQQAIARGLAYADYADLVWCETGKPDLEYAKKFAEAIHAKFPGKMLAYNCS
PSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARNQMSAFVELQEAEFAAAEKGFTAVKHQR
EVGTGYFDAVTQTIERDASTTALKGSTEDEQFFEEKAHAKKVA
>Mature_443_residues
MDRSHKERVMSREPEVKALQQEWDTNPRWKGIKRGYTAQDVVRLRGSLQIEHTLARRGAEKLWTLMNSEPFVNALGALTG
NQAMQQVKAGLKAIYLSGWQVAGDANSNGEMYPDQSLYSVDSVPKVVKRINNTFQRADQIQWSEGKDDVDFFAPIVADAE
AGFGGVLNAFELMKAMIEAGAAGVHFEDQLAAVKKCGHMGGKVLVPTREAVSKLVAARLAADVMGVPTVLIARTDAEAAD
LLTADVDDNDRPFCTGERTVEGFYRTKPGLQQAIARGLAYADYADLVWCETGKPDLEYAKKFAEAIHAKFPGKMLAYNCS
PSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARNQMSAFVELQEAEFAAAEKGFTAVKHQR
EVGTGYFDAVTQTIERDASTTALKGSTEDEQFFEEKAHAKKVA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=433, Percent_Identity=67.4364896073903, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI1786525, Length=261, Percent_Identity=28.735632183908, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71982926, Length=413, Percent_Identity=62.953995157385, Blast_Score=536, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17561814, Length=413, Percent_Identity=62.953995157385, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6320908, Length=289, Percent_Identity=35.6401384083045, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6325263, Length=266, Percent_Identity=36.0902255639098, Blast_Score=154, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 48897; Mature: 48897

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRSHKERVMSREPEVKALQQEWDTNPRWKGIKRGYTAQDVVRLRGSLQIEHTLARRGAE
CCCCHHHHHHCCCCHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHHH
KLWTLMNSEPFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANSNGEMYPDQSLYSV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCHHHH
DSVPKVVKRINNTFQRADQIQWSEGKDDVDFFAPIVADAEAGFGGVLNAFELMKAMIEAG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
AAGVHFEDQLAAVKKCGHMGGKVLVPTREAVSKLVAARLAADVMGVPTVLIARTDAEAAD
CCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHH
LLTADVDDNDRPFCTGERTVEGFYRTKPGLQQAIARGLAYADYADLVWCETGKPDLEYAK
HEEECCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCHHCEEEECCCCCCHHHHH
KFAEAIHAKFPGKMLAYNCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALN
HHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHHHHHHH
YSMFNLAHGYARNQMSAFVELQEAEFAAAEKGFTAVKHQREVGTGYFDAVTQTIERDAST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCC
TALKGSTEDEQFFEEKAHAKKVA
CEECCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDRSHKERVMSREPEVKALQQEWDTNPRWKGIKRGYTAQDVVRLRGSLQIEHTLARRGAE
CCCCHHHHHHCCCCHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHHH
KLWTLMNSEPFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANSNGEMYPDQSLYSV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCHHHH
DSVPKVVKRINNTFQRADQIQWSEGKDDVDFFAPIVADAEAGFGGVLNAFELMKAMIEAG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
AAGVHFEDQLAAVKKCGHMGGKVLVPTREAVSKLVAARLAADVMGVPTVLIARTDAEAAD
CCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHH
LLTADVDDNDRPFCTGERTVEGFYRTKPGLQQAIARGLAYADYADLVWCETGKPDLEYAK
HEEECCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCHHCEEEECCCCCCHHHHH
KFAEAIHAKFPGKMLAYNCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALN
HHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHHHHHHH
YSMFNLAHGYARNQMSAFVELQEAEFAAAEKGFTAVKHQREVGTGYFDAVTQTIERDAST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCC
TALKGSTEDEQFFEEKAHAKKVA
CEECCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]