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The map label for this gene is moeA2 [H]

Identifier: 17546049

GI number: 17546049

Start: 1416037

End: 1417296

Strand: Direct

Name: moeA2 [H]

Synonym: RSc1330

Alternate gene names: 17546049

Gene position: 1416037-1417296 (Clockwise)

Preceding gene: 17546048

Following gene: 17546050

Centisome position: 38.1

GC content: 71.35

Gene sequence:

>1260_bases
ATGTCCGCCAACGATGCTCCCGCCGTCAAACCGTCCCTGCTGACGCTCGAGGCGGCGCTGTTGCAACTGCTCGCCGCCGC
GCGGGGCCTGACCGAGACCGAAACGGTACCGACGCTGCACGCCAACGGCCGCGTGCTGGCCCAGGCCGTGCGCAGCGGCC
TGAACGTGCCGCCGGCCGACAACACGCAGATGGATGGCTACGCCGTGCGCGCGGCCGATATCACCGCGCCGGGCACGCGC
CTGAAGGTGGCGCAGCGCATTCCCGCCGGCCAGGTCGGCCGGCCGCTCCAGGCCGGCGAGGCGGCGCGCATCTTCACCGG
CGCGCTGATCCCGCCGGGCGCCGATGCGGTGGTCATGCAGGAGCAGTGCAAGCCCGATCCCGATACCGGCACCGTCGTCA
TCGACCACGTGCCGGAGGCGGGTGAATGGATTCGCCGCGCCGGCGAGGACATCACCGCCGGCGCCGAGATCCTTCCGCGC
GGCACGCGCCTGGGGGCGCAGCAGCTCGGGCTGGCGGCGTCGGTCGGCTGCGCGGGCCTGCAGGTGGTGCGCCGTCCGCG
CGTGGCGGTGTTCTTTACCGGCGATGAGCTTGCCATGCCGGGGGAGCCGCTCAAGCCGGGCGCCATCTACAACTCCAACC
GCTTCACGCTGCGCGCGCTGCTGGAAAACCTCGGCTGCGAGATCACCGATTTCGGCATCGTGCCCGATACGCTGCAGGCC
ACGCGCGACACCCTGCGCGAGGCCGCCGAGGCGCACGACCTCATCATCACGTCGGGCGGCGTGTCGGTGGGCGAGGAAGA
CCACATCAAGCCGGCGGTGGAGGCCGAGGGGCGCCTGAACCTGTGGCAGATCGCCATCAAGCCGGGCAAGCCGCTGGCCT
TCGGCGAGGTGCGCAGGCCACAGGGCATGGCGGGCGGGCCGGCGGCCTTCTTCATCGGCCTGCCGGGCAACCCGGTCTCG
AGCTTCGTCACCTTCCTGCTGTTCGTGCGGCCGTTCATCCTGCGCTTGCTGGGTGTGGACGACGTGACGCCGAAGCGCAT
CCCGATGCGGGCCGATTTCGCGCTGCCCAAGGGCGATCGCCGCAACGAGTTCCTGCGCGCCCGCATCAATGCCGGCGGCG
GGCTGGACCTGTTCCCGAACCAGAGCTCGGGCGTGCTGACTTCCACCGTCTGGGGCGACGGGCTGATCGACAATCCGCCC
AACCAGCCGATCGCGGCGGGCGACACGGTGGCCTTCCTGCCGTTCGCGGGCCTGGTGTAA

Upstream 100 bases:

>100_bases
CTGGCTGCCGCATTCGTGTGATCGATCGGACGGCGCCGATGCCTGGCGCTGTAGCAGAACCGATACAATCGGAGTCTCTC
TCCCGATTCTGTTTTTCCGC

Downstream 100 bases:

>100_bases
TGAGATGAGTGAGATGGACATGCAGATCGAATTGCGTTTTTTCGCCAGCGTGCGCGAGCAACTGGGCACCTCGCACGAGG
CGGCCGCCGTGCCGGACACG

Product: molybdopterin biosynthesis MOEA protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSANDAPAVKPSLLTLEAALLQLLAAARGLTETETVPTLHANGRVLAQAVRSGLNVPPADNTQMDGYAVRAADITAPGTR
LKVAQRIPAGQVGRPLQAGEAARIFTGALIPPGADAVVMQEQCKPDPDTGTVVIDHVPEAGEWIRRAGEDITAGAEILPR
GTRLGAQQLGLAASVGCAGLQVVRRPRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRALLENLGCEITDFGIVPDTLQA
TRDTLREAAEAHDLIITSGGVSVGEEDHIKPAVEAEGRLNLWQIAIKPGKPLAFGEVRRPQGMAGGPAAFFIGLPGNPVS
SFVTFLLFVRPFILRLLGVDDVTPKRIPMRADFALPKGDRRNEFLRARINAGGGLDLFPNQSSGVLTSTVWGDGLIDNPP
NQPIAAGDTVAFLPFAGLV

Sequences:

>Translated_419_residues
MSANDAPAVKPSLLTLEAALLQLLAAARGLTETETVPTLHANGRVLAQAVRSGLNVPPADNTQMDGYAVRAADITAPGTR
LKVAQRIPAGQVGRPLQAGEAARIFTGALIPPGADAVVMQEQCKPDPDTGTVVIDHVPEAGEWIRRAGEDITAGAEILPR
GTRLGAQQLGLAASVGCAGLQVVRRPRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRALLENLGCEITDFGIVPDTLQA
TRDTLREAAEAHDLIITSGGVSVGEEDHIKPAVEAEGRLNLWQIAIKPGKPLAFGEVRRPQGMAGGPAAFFIGLPGNPVS
SFVTFLLFVRPFILRLLGVDDVTPKRIPMRADFALPKGDRRNEFLRARINAGGGLDLFPNQSSGVLTSTVWGDGLIDNPP
NQPIAAGDTVAFLPFAGLV
>Mature_418_residues
SANDAPAVKPSLLTLEAALLQLLAAARGLTETETVPTLHANGRVLAQAVRSGLNVPPADNTQMDGYAVRAADITAPGTRL
KVAQRIPAGQVGRPLQAGEAARIFTGALIPPGADAVVMQEQCKPDPDTGTVVIDHVPEAGEWIRRAGEDITAGAEILPRG
TRLGAQQLGLAASVGCAGLQVVRRPRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRALLENLGCEITDFGIVPDTLQAT
RDTLREAAEAHDLIITSGGVSVGEEDHIKPAVEAEGRLNLWQIAIKPGKPLAFGEVRRPQGMAGGPAAFFIGLPGNPVSS
FVTFLLFVRPFILRLLGVDDVTPKRIPMRADFALPKGDRRNEFLRARINAGGGLDLFPNQSSGVLTSTVWGDGLIDNPPN
QPIAAGDTVAFLPFAGLV

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=405, Percent_Identity=35.3086419753086, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI66932975, Length=405, Percent_Identity=35.3086419753086, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1787049, Length=390, Percent_Identity=43.3333333333333, Blast_Score=266, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI25147659, Length=343, Percent_Identity=31.7784256559767, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=379, Percent_Identity=24.2744063324538, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136978, Length=375, Percent_Identity=34.1333333333333, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24638841, Length=375, Percent_Identity=34.1333333333333, Blast_Score=161, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44098; Mature: 43967

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANDAPAVKPSLLTLEAALLQLLAAARGLTETETVPTLHANGRVLAQAVRSGLNVPPAD
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHCCCCCCCCC
NTQMDGYAVRAADITAPGTRLKVAQRIPAGQVGRPLQAGEAARIFTGALIPPGADAVVMQ
CCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEH
EQCKPDPDTGTVVIDHVPEAGEWIRRAGEDITAGAEILPRGTRLGAQQLGLAASVGCAGL
HHCCCCCCCCEEEEECCCCHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHCHHHHCCHHHH
QVVRRPRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRALLENLGCEITDFGIVPDTLQA
HHHCCCCEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCEEECCCCCHHHHH
TRDTLREAAEAHDLIITSGGVSVGEEDHIKPAVEAEGRLNLWQIAIKPGKPLAFGEVRRP
HHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCC
QGMAGGPAAFFIGLPGNPVSSFVTFLLFVRPFILRLLGVDDVTPKRIPMRADFALPKGDR
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCC
RNEFLRARINAGGGLDLFPNQSSGVLTSTVWGDGLIDNPPNQPIAAGDTVAFLPFAGLV
CCCEEEEEECCCCCCEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
SANDAPAVKPSLLTLEAALLQLLAAARGLTETETVPTLHANGRVLAQAVRSGLNVPPAD
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHCCCCCCCCC
NTQMDGYAVRAADITAPGTRLKVAQRIPAGQVGRPLQAGEAARIFTGALIPPGADAVVMQ
CCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEH
EQCKPDPDTGTVVIDHVPEAGEWIRRAGEDITAGAEILPRGTRLGAQQLGLAASVGCAGL
HHCCCCCCCCEEEEECCCCHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHCHHHHCCHHHH
QVVRRPRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRALLENLGCEITDFGIVPDTLQA
HHHCCCCEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCEEECCCCCHHHHH
TRDTLREAAEAHDLIITSGGVSVGEEDHIKPAVEAEGRLNLWQIAIKPGKPLAFGEVRRP
HHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCC
QGMAGGPAAFFIGLPGNPVSSFVTFLLFVRPFILRLLGVDDVTPKRIPMRADFALPKGDR
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCC
RNEFLRARINAGGGLDLFPNQSSGVLTSTVWGDGLIDNPPNQPIAAGDTVAFLPFAGLV
CCCEEEEEECCCCCCEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]