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The map label for this gene is arnA [H]

Identifier: 17546038

GI number: 17546038

Start: 1404147

End: 1405202

Strand: Reverse

Name: arnA [H]

Synonym: RSc1319

Alternate gene names: 17546038

Gene position: 1405202-1404147 (Counterclockwise)

Preceding gene: 17546039

Following gene: 17546037

Centisome position: 37.81

GC content: 62.59

Gene sequence:

>1056_bases
ATGAAGAAAGTACTGATCCTCGGCGTCAACGGCTTTATCGGCCACCACCTGTCCAAGCGCATCCTGGAGAGCACGGACCC
GGAAATCTCCCAGTGGGAGGTCTATGGCATGGACATGCAGACCGAGCGCCTGGGCGATCTGGTCAACCATCCGCGCATGC
ACTTCTTTGAAGGCGACATCACCATCAACAAGGAGTGGGTGGAATACCACGTGCGCAAGTGCGACGTGATCCTGCCGCTG
GTGGCCATCGCCACGCCGTCGACCTACGTCAAGGCGCCGCTGCGCGTGTTCGAGCTGGACTTCGAGGCCAACCTGCCGAT
CGTCCGCTCCGCCGCCAAGTACGGCAAGCATCTGGTGTTCCCGTCGACCTCCGAGGTCTACGGCATGTGCGGCGACGACG
AATTCGACCCGGAAGCCTCGCCGCTGGTCTACGGCCCGATCAACAAGCCGCGCTGGATCTACGCCTGCTCCAAGCAGCTG
ATGGACCGCGTGATCTGGGGCTACGGCATGGAAGGCCTGAACTTCACGCTGTTCCGCCCGTTCAACTGGATCGGCCCGGG
CCTGGACTCGATCCACACCCCGAAGGAAGGCTCGTCGCGCGTGGTCACGCAGTTCCTCGGCCACATCGTGCGCGGCGAGA
ACATCCAGCTGGTCGACGGCGGCCAGCAAAAGCGCGCCTTCACCTATGTCGATGACGGCATCGACGCGCTGGTGCGCATC
ATCGCCAACAAGGACGGCGTCGCCTCGGGCAAGATCTACAACATCGGCAACCCGTCGAACAACTACTCGGTGCGCGAACT
GGCCGAGATGATGCTGAAGAAGGCCGGCACCATCGCCGAGTACAAGGAAAACGCCCAGAAGGTCAAGCTGGTGGAAACGA
CCTCGGGCGCCTACTACGGCAAGGGCTACCAGGACGTGCAGAACCGCGTGCCGAAGATCGCCAACACCATGGAAGAACTC
GGCTGGAAGCCGACCACCACCATGGAAGACACCCTGGCGAACATCTTCGAAGCCTACCGCGAGCACGCCGCCGAGGCGCG
CAGCCTGGTCGACTGA

Upstream 100 bases:

>100_bases
CTCTGGCGCGTCGAGCCCCAGGCGCCGTCCACGACCACGGTCGTGACTGCGCAACAGCTCGCCAACCGGCTCGCCCTCTC
CTGTTCTTGAGTTTGCCTTC

Downstream 100 bases:

>100_bases
GCCGAAGCCCCCGCGCAGGTCCATGGCCCTCATCGTCCTCAAGATCGACGTCGACACCCTGCGCGGCACGCGCGAAGGCG
TGCCCAACCTCGTCCGCATG

Product: NAD-dependent epimerase/dehydratase family protein

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKKVLILGVNGFIGHHLSKRILESTDPEISQWEVYGMDMQTERLGDLVNHPRMHFFEGDITINKEWVEYHVRKCDVILPL
VAIATPSTYVKAPLRVFELDFEANLPIVRSAAKYGKHLVFPSTSEVYGMCGDDEFDPEASPLVYGPINKPRWIYACSKQL
MDRVIWGYGMEGLNFTLFRPFNWIGPGLDSIHTPKEGSSRVVTQFLGHIVRGENIQLVDGGQQKRAFTYVDDGIDALVRI
IANKDGVASGKIYNIGNPSNNYSVRELAEMMLKKAGTIAEYKENAQKVKLVETTSGAYYGKGYQDVQNRVPKIANTMEEL
GWKPTTTMEDTLANIFEAYREHAAEARSLVD

Sequences:

>Translated_351_residues
MKKVLILGVNGFIGHHLSKRILESTDPEISQWEVYGMDMQTERLGDLVNHPRMHFFEGDITINKEWVEYHVRKCDVILPL
VAIATPSTYVKAPLRVFELDFEANLPIVRSAAKYGKHLVFPSTSEVYGMCGDDEFDPEASPLVYGPINKPRWIYACSKQL
MDRVIWGYGMEGLNFTLFRPFNWIGPGLDSIHTPKEGSSRVVTQFLGHIVRGENIQLVDGGQQKRAFTYVDDGIDALVRI
IANKDGVASGKIYNIGNPSNNYSVRELAEMMLKKAGTIAEYKENAQKVKLVETTSGAYYGKGYQDVQNRVPKIANTMEEL
GWKPTTTMEDTLANIFEAYREHAAEARSLVD
>Mature_351_residues
MKKVLILGVNGFIGHHLSKRILESTDPEISQWEVYGMDMQTERLGDLVNHPRMHFFEGDITINKEWVEYHVRKCDVILPL
VAIATPSTYVKAPLRVFELDFEANLPIVRSAAKYGKHLVFPSTSEVYGMCGDDEFDPEASPLVYGPINKPRWIYACSKQL
MDRVIWGYGMEGLNFTLFRPFNWIGPGLDSIHTPKEGSSRVVTQFLGHIVRGENIQLVDGGQQKRAFTYVDDGIDALVRI
IANKDGVASGKIYNIGNPSNNYSVRELAEMMLKKAGTIAEYKENAQKVKLVETTSGAYYGKGYQDVQNRVPKIANTMEEL
GWKPTTTMEDTLANIFEAYREHAAEARSLVD

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=346, Percent_Identity=27.1676300578035, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI7657641, Length=361, Percent_Identity=24.0997229916898, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788589, Length=340, Percent_Identity=53.2352941176471, Blast_Score=379, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17539532, Length=349, Percent_Identity=24.0687679083095, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21356223, Length=355, Percent_Identity=24.7887323943662, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.13; =1.1.1.305 [H]

Molecular weight: Translated: 39561; Mature: 39561

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLILGVNGFIGHHLSKRILESTDPEISQWEVYGMDMQTERLGDLVNHPRMHFFEGDI
CCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCE
TINKEWVEYHVRKCDVILPLVAIATPSTYVKAPLRVFELDFEANLPIVRSAAKYGKHLVF
EECHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEECCCCCCHHHHHHHHHCCEEEC
PSTSEVYGMCGDDEFDPEASPLVYGPINKPRWIYACSKQLMDRVIWGYGMEGLNFTLFRP
CCCHHHEECCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECC
FNWIGPGLDSIHTPKEGSSRVVTQFLGHIVRGENIQLVDGGQQKRAFTYVDDGIDALVRI
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEHHHHHHHHHHH
IANKDGVASGKIYNIGNPSNNYSVRELAEMMLKKAGTIAEYKENAQKVKLVETTSGAYYG
HHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCEEEEEEECCCCCCC
KGYQDVQNRVPKIANTMEELGWKPTTTMEDTLANIFEAYREHAAEARSLVD
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKVLILGVNGFIGHHLSKRILESTDPEISQWEVYGMDMQTERLGDLVNHPRMHFFEGDI
CCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCE
TINKEWVEYHVRKCDVILPLVAIATPSTYVKAPLRVFELDFEANLPIVRSAAKYGKHLVF
EECHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEECCCCCCHHHHHHHHHCCEEEC
PSTSEVYGMCGDDEFDPEASPLVYGPINKPRWIYACSKQLMDRVIWGYGMEGLNFTLFRP
CCCHHHEECCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECC
FNWIGPGLDSIHTPKEGSSRVVTQFLGHIVRGENIQLVDGGQQKRAFTYVDDGIDALVRI
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEHHHHHHHHHHH
IANKDGVASGKIYNIGNPSNNYSVRELAEMMLKKAGTIAEYKENAQKVKLVETTSGAYYG
HHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCEEEEEEECCCCCCC
KGYQDVQNRVPKIANTMEELGWKPTTTMEDTLANIFEAYREHAAEARSLVD
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA