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The map label for this gene is argA

Identifier: 17545969

GI number: 17545969

Start: 1325532

End: 1326887

Strand: Reverse

Name: argA

Synonym: RSc1250

Alternate gene names: 17545969

Gene position: 1326887-1325532 (Counterclockwise)

Preceding gene: 17545976

Following gene: 17545959

Centisome position: 35.7

GC content: 68.22

Gene sequence:

>1356_bases
GTGGCGCACACGCCCGCCACCGCCGACGTCGCTCCGATCCCGCCCACGCCCGAGCAGCAGCAGTTCGTGGACTGGCTGCG
CGCGGTGGCGCCCTATATCCACGCCTTCCGCGACAAGACCTTCGTGATCGGCTTCGGCGGCGAGCTGGTCAAGGCCGGCA
TGCTCGGGGCGCTGGTCAACGACATCGCGCTGCTGCACGCCATGGGCATGCACATCGTGCTGGTGCACGGCTCGCGGCCG
CAGGTGGAAGAACAGCTGGCGCTGCGCCACGTGCAGACCCAGTTCGTCGACGGCATCCGCGTGACCGACAACGCCGCGCT
GGAATCGGCCAAGGAGGCCTCGGGCGAACTGCGGCTCGACATCGAGGCCACCTTCAGCCAGGCGCTGCCCAATACGCCGA
TGGCGGGGGCCCGCATTTCGGTGGTGTCGGGCAACTTCGTGACGGCGCGGCCGGTGGGCATCGTCAACGGCGTCGATTTC
CAGCACACGGGGCTGGTGCGCAAGATCGACGCGGAATCGATCCAGCACTCGCTGTCCAACCGCAAGATCGTGCTGCTGTC
GCCGCTGGGCTTCTCGCCCACGGGGCAGGCGTTCAACCTGTCGATGGAAGACGTGGCCACCAACACGGCGACCGCGCTCA
AGGCCGACAAGCTGATCTTCATCACCGAGGTGCCGGGCATCATGGACCGGGTCGGCAAGCTACAGCAGGAGCTGTCGATG
GAATCGGCCATCGAGCGCCTGCGCGAAGGGCGGCTCTCCGCCGACACCGCGTACTACCTGCAGCACATCGTCAAGGCCAT
GCGCGGCGGCGTGCGCCGGGCGCACCTGATCCCGTTCGCGCTGGACGGCAGCATCCTGCTGGAGCTGTTCCTGCACGACG
GCGTCGGCACCATGGTCTCGCACACCGACCTGGAATACCTGCGCGAGGCCACGCTGGACGACGTGGGCGGCATCGTCCAG
CTGATCGAGCCGCTGGAAGCCGACGGCACGCTGGTGCCACGCGAGCGCCGGCTGCTGGAGCGCGACATCGCCAACTTCTC
CGTGATCGAGCACGACGGCATCATCTTCGGCTGCGCGGCGCTCTACCCCTACCCGAAGGAAGGCGTGGGCGAGATGGCCT
GCCTGACGGTGGCGCCCGATACCCAGGGCACCGGCGACGGCGAACGCCTGCTCAAGCACGTCGAGGCCCGCGCCCGCGCC
GTGGGGCTCAAGCGCCTGTTCGTGCTCACCACGCGCACCGAGCACTGGTTCCTCAAGCGCGGCTTCGTGCACGCCACCGT
GGACGACCTGCCGGAAGACCGCCGCAAGCTGTACAACTGGCAGCGGCGGTCGATGGTGCTGATGAAGAAGCTGTAA

Upstream 100 bases:

>100_bases
CTTTCCATTGCCGGCCCGCCCCCCCTGCCGCGGCCCGGCCAGCACACTCCATCCGCCCGTGACCGCACGCCCTTCCGCCC
CCGCATCCGGCGTCTCGCTG

Downstream 100 bases:

>100_bases
GCCCAGGCTTCAGCGCGCCGATCGCGGCGCCTCAGGCCATCACGTCCTTCTCGTGCTCGCCGCCGGCCGAGGAGAGTTCA
AGCCGATACGCCAGCGCGAT

Product: N-acetylglutamate synthase

Products: NA

Alternate protein names: N-acetylglutamate synthase; AGS; NAGS

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MAHTPATADVAPIPPTPEQQQFVDWLRAVAPYIHAFRDKTFVIGFGGELVKAGMLGALVNDIALLHAMGMHIVLVHGSRP
QVEEQLALRHVQTQFVDGIRVTDNAALESAKEASGELRLDIEATFSQALPNTPMAGARISVVSGNFVTARPVGIVNGVDF
QHTGLVRKIDAESIQHSLSNRKIVLLSPLGFSPTGQAFNLSMEDVATNTATALKADKLIFITEVPGIMDRVGKLQQELSM
ESAIERLREGRLSADTAYYLQHIVKAMRGGVRRAHLIPFALDGSILLELFLHDGVGTMVSHTDLEYLREATLDDVGGIVQ
LIEPLEADGTLVPRERRLLERDIANFSVIEHDGIIFGCAALYPYPKEGVGEMACLTVAPDTQGTGDGERLLKHVEARARA
VGLKRLFVLTTRTEHWFLKRGFVHATVDDLPEDRRKLYNWQRRSMVLMKKL

Sequences:

>Translated_451_residues
MAHTPATADVAPIPPTPEQQQFVDWLRAVAPYIHAFRDKTFVIGFGGELVKAGMLGALVNDIALLHAMGMHIVLVHGSRP
QVEEQLALRHVQTQFVDGIRVTDNAALESAKEASGELRLDIEATFSQALPNTPMAGARISVVSGNFVTARPVGIVNGVDF
QHTGLVRKIDAESIQHSLSNRKIVLLSPLGFSPTGQAFNLSMEDVATNTATALKADKLIFITEVPGIMDRVGKLQQELSM
ESAIERLREGRLSADTAYYLQHIVKAMRGGVRRAHLIPFALDGSILLELFLHDGVGTMVSHTDLEYLREATLDDVGGIVQ
LIEPLEADGTLVPRERRLLERDIANFSVIEHDGIIFGCAALYPYPKEGVGEMACLTVAPDTQGTGDGERLLKHVEARARA
VGLKRLFVLTTRTEHWFLKRGFVHATVDDLPEDRRKLYNWQRRSMVLMKKL
>Mature_450_residues
AHTPATADVAPIPPTPEQQQFVDWLRAVAPYIHAFRDKTFVIGFGGELVKAGMLGALVNDIALLHAMGMHIVLVHGSRPQ
VEEQLALRHVQTQFVDGIRVTDNAALESAKEASGELRLDIEATFSQALPNTPMAGARISVVSGNFVTARPVGIVNGVDFQ
HTGLVRKIDAESIQHSLSNRKIVLLSPLGFSPTGQAFNLSMEDVATNTATALKADKLIFITEVPGIMDRVGKLQQELSME
SAIERLREGRLSADTAYYLQHIVKAMRGGVRRAHLIPFALDGSILLELFLHDGVGTMVSHTDLEYLREATLDDVGGIVQL
IEPLEADGTLVPRERRLLERDIANFSVIEHDGIIFGCAALYPYPKEGVGEMACLTVAPDTQGTGDGERLLKHVEARARAV
GLKRLFVLTTRTEHWFLKRGFVHATVDDLPEDRRKLYNWQRRSMVLMKKL

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain

Homologues:

Organism=Escherichia coli, GI1789181, Length=437, Percent_Identity=45.0800915331808, Blast_Score=400, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6320913, Length=286, Percent_Identity=21.3286713286713, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ARGA_RALSO (Q8XZZ5)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519371.1
- ProteinModelPortal:   Q8XZZ5
- SMR:   Q8XZZ5
- GeneID:   1220073
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1250
- NMPDR:   fig|267608.1.peg.1250
- HOGENOM:   HBG545264
- OMA:   APYIHAF
- ProtClustDB:   PRK05279
- BioCyc:   RSOL267608:RSC1250-MONOMER
- BRENDA:   2.3.1.1
- GO:   GO:0005737
- HAMAP:   MF_01105
- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR001048
- InterPro:   IPR010167
- Gene3D:   G3DSA:3.40.1160.10
- Gene3D:   G3DSA:3.40.630.30
- PIRSF:   PIRSF000423
- TIGRFAMs:   TIGR01890

Pfam domain/function: PF00696 AA_kinase; PF00583 Acetyltransf_1; SSF53633 Aa_kinase; SSF55729 Acyl_CoA_acyltransferase

EC number: =2.3.1.1

Molecular weight: Translated: 49667; Mature: 49536

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS51186 GNAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHTPATADVAPIPPTPEQQQFVDWLRAVAPYIHAFRDKTFVIGFGGELVKAGMLGALVN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
DIALLHAMGMHIVLVHGSRPQVEEQLALRHVQTQFVDGIRVTDNAALESAKEASGELRLD
HHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHCCCCEEEE
IEATFSQALPNTPMAGARISVVSGNFVTARPVGIVNGVDFQHTGLVRKIDAESIQHSLSN
EEHHHHHHCCCCCCCCCEEEEEECCEEEECCCEEECCCCCCCCCCEEECCHHHHHHHHCC
RKIVLLSPLGFSPTGQAFNLSMEDVATNTATALKADKLIFITEVPGIMDRVGKLQQELSM
CEEEEEECCCCCCCCCEEECCHHHHHCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHH
ESAIERLREGRLSADTAYYLQHIVKAMRGGVRRAHLIPFALDGSILLELFLHDGVGTMVS
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECHHHHHHHHHHCCCCHHHH
HTDLEYLREATLDDVGGIVQLIEPLEADGTLVPRERRLLERDIANFSVIEHDGIIFGCAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCCEEEEEHH
LYPYPKEGVGEMACLTVAPDTQGTGDGERLLKHVEARARAVGLKRLFVLTTRTEHWFLKR
HCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHC
GFVHATVDDLPEDRRKLYNWQRRSMVLMKKL
CCEEEEHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AHTPATADVAPIPPTPEQQQFVDWLRAVAPYIHAFRDKTFVIGFGGELVKAGMLGALVN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
DIALLHAMGMHIVLVHGSRPQVEEQLALRHVQTQFVDGIRVTDNAALESAKEASGELRLD
HHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHCCCCEEEE
IEATFSQALPNTPMAGARISVVSGNFVTARPVGIVNGVDFQHTGLVRKIDAESIQHSLSN
EEHHHHHHCCCCCCCCCEEEEEECCEEEECCCEEECCCCCCCCCCEEECCHHHHHHHHCC
RKIVLLSPLGFSPTGQAFNLSMEDVATNTATALKADKLIFITEVPGIMDRVGKLQQELSM
CEEEEEECCCCCCCCCEEECCHHHHHCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHH
ESAIERLREGRLSADTAYYLQHIVKAMRGGVRRAHLIPFALDGSILLELFLHDGVGTMVS
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECHHHHHHHHHHCCCCHHHH
HTDLEYLREATLDDVGGIVQLIEPLEADGTLVPRERRLLERDIANFSVIEHDGIIFGCAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCCEEEEEHH
LYPYPKEGVGEMACLTVAPDTQGTGDGERLLKHVEARARAVGLKRLFVLTTRTEHWFLKR
HCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHC
GFVHATVDDLPEDRRKLYNWQRRSMVLMKKL
CCEEEEHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852