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The map label for this gene is ndk [H]

Identifier: 17545930

GI number: 17545930

Start: 1280175

End: 1280600

Strand: Direct

Name: ndk [H]

Synonym: RSc1211

Alternate gene names: 17545930

Gene position: 1280175-1280600 (Clockwise)

Preceding gene: 17545928

Following gene: 17545931

Centisome position: 34.45

GC content: 60.09

Gene sequence:

>426_bases
ATGGCGATCGAACGCACTCTGTCGATTATCAAACCGGATGCCGTGGCCAAGAATGTCATCGGCCAGATCTATGCGCGCTT
CGAAGGCGCCGGCCTGAAGGTCGTGGCAGCCAAGATGATCCACCTGTCGCGCGCTGAAGCCGAGCAGTTCTACGCCGTCC
ACAAGGAGCGCCCGTTCTTCAAGGACCTGGTCGACTTCATGATCTCCGGCCCCGTGATGGTGCAGGCACTGGAAGGCGAA
AGCGCCATCGTCAAGAACCGTGACCTGATGGGTGCAACCGATCCGAAGAAGGCAGAGAAGGGCACGATCCGCGCCGATTT
CGCCGACAGCATCGATGCCAACGCCGTGCACGGTTCGGACGCAGCCGAAACGGCTGCCGTGGAAGTCGCTTTCTTCTTCC
CCGGCCTGAACATTTACAGCCGCTAA

Upstream 100 bases:

>100_bases
CCGTGCGCCGGTTGCACCGGTGCCATCCAATCCCGGCGGCGTACGTGCTAGAATCCAACGTTTATCTTTGACGTAACACC
TTCATTTTTTGGAGTTTTTA

Downstream 100 bases:

>100_bases
GCGTCAGCACTAGACTGGCATTGGCGGTTTCGGGCAGCAAGTCATGAACGATATGGTGAATCTTCTTGATTTCGACGCAC
AGGGCCTGCTCGCATATTGC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MAIERTLSIIKPDAVAKNVIGQIYARFEGAGLKVVAAKMIHLSRAEAEQFYAVHKERPFFKDLVDFMISGPVMVQALEGE
SAIVKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAAETAAVEVAFFFPGLNIYSR

Sequences:

>Translated_141_residues
MAIERTLSIIKPDAVAKNVIGQIYARFEGAGLKVVAAKMIHLSRAEAEQFYAVHKERPFFKDLVDFMISGPVMVQALEGE
SAIVKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAAETAAVEVAFFFPGLNIYSR
>Mature_140_residues
AIERTLSIIKPDAVAKNVIGQIYARFEGAGLKVVAAKMIHLSRAEAEQFYAVHKERPFFKDLVDFMISGPVMVQALEGES
AIVKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAAETAAVEVAFFFPGLNIYSR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=132, Percent_Identity=42.4242424242424, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=39.6946564885496, Blast_Score=113, Evalue=4e-26,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=39.6946564885496, Blast_Score=113, Evalue=4e-26,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=39.6946564885496, Blast_Score=113, Evalue=4e-26,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=39.6946564885496, Blast_Score=113, Evalue=4e-26,
Organism=Homo sapiens, GI66392203, Length=131, Percent_Identity=39.6946564885496, Blast_Score=113, Evalue=4e-26,
Organism=Homo sapiens, GI38045913, Length=131, Percent_Identity=38.9312977099237, Blast_Score=110, Evalue=3e-25,
Organism=Homo sapiens, GI4557797, Length=131, Percent_Identity=38.9312977099237, Blast_Score=110, Evalue=4e-25,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=36.1538461538462, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=37.410071942446, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=37.410071942446, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=34.3065693430657, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI30023828, Length=138, Percent_Identity=34.0579710144928, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI148839372, Length=134, Percent_Identity=33.5820895522388, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=32.3529411764706, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788866, Length=133, Percent_Identity=60.9022556390977, Blast_Score=176, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17506807, Length=130, Percent_Identity=42.3076923076923, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322783, Length=130, Percent_Identity=40, Blast_Score=114, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45549037, Length=130, Percent_Identity=43.0769230769231, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI18860097, Length=135, Percent_Identity=32.5925925925926, Blast_Score=76, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15317; Mature: 15186

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTLSIIKPDAVAKNVIGQIYARFEGAGLKVVAAKMIHLSRAEAEQFYAVHKERPFF
CCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KDLVDFMISGPVMVQALEGESAIVKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
AAETAAVEVAFFFPGLNIYSR
CCHHHEEEEEEEECCCCCCCC
>Mature Secondary Structure 
AIERTLSIIKPDAVAKNVIGQIYARFEGAGLKVVAAKMIHLSRAEAEQFYAVHKERPFF
CCHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KDLVDFMISGPVMVQALEGESAIVKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
AAETAAVEVAFFFPGLNIYSR
CCHHHEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA