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The map label for this gene is trxA [H]

Identifier: 17545907

GI number: 17545907

Start: 1252542

End: 1252868

Strand: Reverse

Name: trxA [H]

Synonym: RSc1188

Alternate gene names: 17545907

Gene position: 1252868-1252542 (Counterclockwise)

Preceding gene: 17545914

Following gene: 17545906

Centisome position: 33.71

GC content: 61.77

Gene sequence:

>327_bases
ATGAGCGAACAGATCAAGTATGTGAGCGACGCGTCCTTCGAAGCCGACGTGCTCAAGTCCGACAAACCCGTGCTCGTCGA
TTTCTGGGCGGAGTGGTGCGGCCCCTGCAAGATGATCGCCCCGATCCTCGACGAGGTCTCGAAGGACTACGGCGACAAGG
TGCAGATCGCCAAGCTCAACGTCGATGAGAACGCAGGCGTGCCGGCCAAGTTCGGCATTCGCGGCATCCCGACGCTGATC
CTGTTCAAGAACGGCGCCGTGGCTGCGCAGAAGGTGGGCGCGCTGTCCAAGTCGCAGCTGACCGCCTTCCTGGACAGCCA
CCTCTAA

Upstream 100 bases:

>100_bases
CGCCGCGGCCGTGCCCGAACGCACGCCGTGCGGCGTAATCGTGTAATGTATGGGTTCGGCGCACGGCGCCAGCTTTTACG
AAATAACAGAGGTTCCCGCC

Downstream 100 bases:

>100_bases
GCCGCATCACCGGGGCGGCGCGGAACCCCTTCCCGCCGCCAGCCGCACGTGCCGGCGATCTTCCGCCTGGAAGGCCGCCG
GCGTTGTGCTAAGATTGCAG

Product: thioredoxin 1 (redox factor) protein

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSEQIKYVSDASFEADVLKSDKPVLVDFWAEWCGPCKMIAPILDEVSKDYGDKVQIAKLNVDENAGVPAKFGIRGIPTLI
LFKNGAVAAQKVGALSKSQLTAFLDSHL

Sequences:

>Translated_108_residues
MSEQIKYVSDASFEADVLKSDKPVLVDFWAEWCGPCKMIAPILDEVSKDYGDKVQIAKLNVDENAGVPAKFGIRGIPTLI
LFKNGAVAAQKVGALSKSQLTAFLDSHL
>Mature_107_residues
SEQIKYVSDASFEADVLKSDKPVLVDFWAEWCGPCKMIAPILDEVSKDYGDKVQIAKLNVDENAGVPAKFGIRGIPTLIL
FKNGAVAAQKVGALSKSQLTAFLDSHL

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=40.8602150537634, Blast_Score=79, Evalue=9e-16,
Organism=Homo sapiens, GI20070125, Length=80, Percent_Identity=36.25, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI38505222, Length=97, Percent_Identity=36.0824742268041, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI5031973, Length=99, Percent_Identity=31.3131313131313, Blast_Score=62, Evalue=9e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=65.7407407407407, Blast_Score=156, Evalue=3e-40,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=42.3913043478261, Blast_Score=93, Evalue=5e-21,
Organism=Escherichia coli, GI87081747, Length=63, Percent_Identity=41.2698412698413, Blast_Score=63, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=39.7849462365591, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=36.7816091954023, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=76, Percent_Identity=39.4736842105263, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=103, Percent_Identity=30.0970873786408, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=75, Percent_Identity=44, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=70, Percent_Identity=41.4285714285714, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=70, Percent_Identity=41.4285714285714, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=102, Percent_Identity=32.3529411764706, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=73, Percent_Identity=38.3561643835616, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=73, Percent_Identity=38.3561643835616, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=73, Percent_Identity=38.3561643835616, Blast_Score=61, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6323072, Length=77, Percent_Identity=49.3506493506493, Blast_Score=77, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321648, Length=94, Percent_Identity=41.4893617021277, Blast_Score=76, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=79, Percent_Identity=34.1772151898734, Blast_Score=63, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24639826, Length=91, Percent_Identity=41.7582417582418, Blast_Score=89, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=35.8695652173913, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=42.3076923076923, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=42.3076923076923, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664269, Length=75, Percent_Identity=38.6666666666667, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=30.1075268817204, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11713; Mature: 11581

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQIKYVSDASFEADVLKSDKPVLVDFWAEWCGPCKMIAPILDEVSKDYGDKVQIAKLN
CCCCCCCCCCCCCCCHHHCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEC
VDENAGVPAKFGIRGIPTLILFKNGAVAAQKVGALSKSQLTAFLDSHL
CCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SEQIKYVSDASFEADVLKSDKPVLVDFWAEWCGPCKMIAPILDEVSKDYGDKVQIAKLN
CCCCCCCCCCCCCCHHHCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEC
VDENAGVPAKFGIRGIPTLILFKNGAVAAQKVGALSKSQLTAFLDSHL
CCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7496529 [H]