Definition Ralstonia solanacearum GMI1000, complete genome.
Accession NC_003295
Length 3,716,413

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The map label for this gene is dkgB [H]

Identifier: 17545873

GI number: 17545873

Start: 1212165

End: 1213016

Strand: Direct

Name: dkgB [H]

Synonym: RSc1154

Alternate gene names: 17545873

Gene position: 1212165-1213016 (Clockwise)

Preceding gene: 17545872

Following gene: 17545874

Centisome position: 32.62

GC content: 68.54

Gene sequence:

>852_bases
TTGAGACGGATTCAACATCGAACACAAGGGAACGCCATGAACGACACTTTCACGATGCCCGCTTTCGGCCTCGGTACCTT
CCGCCTGACGGGCGAGGCCGCGATCGACTCGGTCAGGACCGCGCTGGAACTGGGCTACCGCGCGATCGACACGGCACAGA
TCTATGCGAACGAGGCCGAGGTCGGCCAGGCGATCGCCGCGTCGGGCGTGCCGCGCCGCGATCTGTTTCTTACCACCAAG
ATCTGGGTCGACAACCTGGCCGCCGATCGGCTGATCCCGAGCCTCAAGGCCAGCCTGGCCAGGCTGCGCACCGAGCAGGT
GGATCTGGCGCTGATCCACTGGCCGTCGCCCGGGGGCGCGGTGCCGATGGCCGAATACCTGGGCGCGCTGGACGAGGCCA
GGCGCGAAGGGCTGACGCGGGCGCTGGGCGTCTCGAACTTCACCGTGGCCTTGCTGCGCGAGGCCATCGAGACGGTGGGC
GCGGCGCAGATCGCCACCAACCAGATCGAGCTGCACCCGTACCTGCAGAACCGCAAGGTGGCGGCGTTTGCACAAAGCCA
GGGCATCCATGTCACCTCGTACATGACACTCGGCGTGGGCAGGGTGCTGGCCGATCCGGTCTTGGCAGACATCGCCCGGG
CGCATGGCGCGACGCCGGCCCAGGTGGTGCTGGCGTGGGCAATGCAGCTGGGCTGTTCCGTGATCCCGTCCTCTACGCGC
CGGGCCAACCTGCAGAGCAACCTGGCCGCCCGCGACCTGCGCCTGACCGGCGACGACATGGCCCGCATCGGCGCGCTGGA
CCGGGGCGAGCGCATTGCCGATCCGGCCGGCATCGCGCCCGACTGGGATTGA

Upstream 100 bases:

>100_bases
TGGTGGTGCTGGTCTCGCTGGGCCTGACCGCCTGGAGCGGAGCGCTGGATCGCCGCGGCGGCATCGGCCCGCGCCTGGAT
GGCCCGGCCCCGGTGGGGCA

Downstream 100 bases:

>100_bases
CCATACCCCCGACGTGACGGGGGCGACTCAAGGTCTGCGCGCAAGTTGCCGATAGACAGTCCGTAGCCCTGAAAAAACAT
GGGGGGACGCCTCGTGCACG

Product: 2,5-diketo-D-gluconate reductase B

Products: NA

Alternate protein names: 2,5-DKG reductase B; 2,5-DKGR B; 25DKGR-B; AKR5D [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MRRIQHRTQGNAMNDTFTMPAFGLGTFRLTGEAAIDSVRTALELGYRAIDTAQIYANEAEVGQAIAASGVPRRDLFLTTK
IWVDNLAADRLIPSLKASLARLRTEQVDLALIHWPSPGGAVPMAEYLGALDEARREGLTRALGVSNFTVALLREAIETVG
AAQIATNQIELHPYLQNRKVAAFAQSQGIHVTSYMTLGVGRVLADPVLADIARAHGATPAQVVLAWAMQLGCSVIPSSTR
RANLQSNLAARDLRLTGDDMARIGALDRGERIADPAGIAPDWD

Sequences:

>Translated_283_residues
MRRIQHRTQGNAMNDTFTMPAFGLGTFRLTGEAAIDSVRTALELGYRAIDTAQIYANEAEVGQAIAASGVPRRDLFLTTK
IWVDNLAADRLIPSLKASLARLRTEQVDLALIHWPSPGGAVPMAEYLGALDEARREGLTRALGVSNFTVALLREAIETVG
AAQIATNQIELHPYLQNRKVAAFAQSQGIHVTSYMTLGVGRVLADPVLADIARAHGATPAQVVLAWAMQLGCSVIPSSTR
RANLQSNLAARDLRLTGDDMARIGALDRGERIADPAGIAPDWD
>Mature_283_residues
MRRIQHRTQGNAMNDTFTMPAFGLGTFRLTGEAAIDSVRTALELGYRAIDTAQIYANEAEVGQAIAASGVPRRDLFLTTK
IWVDNLAADRLIPSLKASLARLRTEQVDLALIHWPSPGGAVPMAEYLGALDEARREGLTRALGVSNFTVALLREAIETVG
AAQIATNQIELHPYLQNRKVAAFAQSQGIHVTSYMTLGVGRVLADPVLADIARAHGATPAQVVLAWAMQLGCSVIPSSTR
RANLQSNLAARDLRLTGDDMARIGALDRGERIADPAGIAPDWD

Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI310109922, Length=284, Percent_Identity=32.3943661971831, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI45446745, Length=301, Percent_Identity=31.8936877076412, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI4503285, Length=301, Percent_Identity=31.8936877076412, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI310109920, Length=301, Percent_Identity=31.8936877076412, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI5453543, Length=301, Percent_Identity=31.5614617940199, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI223468663, Length=288, Percent_Identity=32.2916666666667, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI24497585, Length=314, Percent_Identity=29.9363057324841, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI24497577, Length=289, Percent_Identity=32.1799307958478, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI5174391, Length=289, Percent_Identity=32.1799307958478, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI24497583, Length=299, Percent_Identity=31.1036789297659, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI93277124, Length=301, Percent_Identity=30.8970099667774, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI5174695, Length=299, Percent_Identity=31.7725752508361, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI4502049, Length=293, Percent_Identity=32.0819112627986, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI291291012, Length=271, Percent_Identity=31.7343173431734, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI300116273, Length=273, Percent_Identity=31.8681318681319, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI300116271, Length=281, Percent_Identity=31.6725978647687, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI310109924, Length=154, Percent_Identity=31.1688311688312, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI207028673, Length=116, Percent_Identity=37.0689655172414, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI310109926, Length=116, Percent_Identity=37.0689655172414, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1786400, Length=265, Percent_Identity=63.7735849056604, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI87082198, Length=266, Percent_Identity=37.218045112782, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI1788081, Length=264, Percent_Identity=32.5757575757576, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787674, Length=289, Percent_Identity=26.2975778546713, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI48994888, Length=278, Percent_Identity=26.6187050359712, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788070, Length=216, Percent_Identity=26.8518518518519, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17537077, Length=301, Percent_Identity=32.890365448505, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17537075, Length=303, Percent_Identity=32.3432343234323, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17561298, Length=274, Percent_Identity=29.9270072992701, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17550248, Length=290, Percent_Identity=33.1034482758621, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17537079, Length=300, Percent_Identity=31.3333333333333, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71998625, Length=278, Percent_Identity=30.2158273381295, Blast_Score=141, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17552492, Length=265, Percent_Identity=30.188679245283, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17566692, Length=285, Percent_Identity=31.2280701754386, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17564128, Length=307, Percent_Identity=29.9674267100977, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17562292, Length=278, Percent_Identity=30.9352517985612, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17561300, Length=279, Percent_Identity=27.2401433691756, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17538386, Length=265, Percent_Identity=29.0566037735849, Blast_Score=123, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6320576, Length=296, Percent_Identity=34.4594594594595, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324694, Length=301, Percent_Identity=33.2225913621262, Blast_Score=155, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6321896, Length=311, Percent_Identity=29.5819935691318, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322556, Length=266, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6319625, Length=314, Percent_Identity=29.6178343949045, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6320079, Length=248, Percent_Identity=28.2258064516129, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24644950, Length=303, Percent_Identity=33.993399339934, Blast_Score=157, Evalue=6e-39,
Organism=Drosophila melanogaster, GI221378297, Length=328, Percent_Identity=32.3170731707317, Blast_Score=150, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24657054, Length=290, Percent_Identity=32.7586206896552, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24663317, Length=291, Percent_Identity=30.9278350515464, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI20129731, Length=295, Percent_Identity=32.5423728813559, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24662789, Length=289, Percent_Identity=31.8339100346021, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI21356425, Length=289, Percent_Identity=29.757785467128, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24662785, Length=269, Percent_Identity=33.0855018587361, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45553081, Length=292, Percent_Identity=29.4520547945205, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24662781, Length=278, Percent_Identity=32.7338129496403, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281366140, Length=261, Percent_Identity=28.3524904214559, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.274 [H]

Molecular weight: Translated: 30430; Mature: 30430

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIQHRTQGNAMNDTFTMPAFGLGTFRLTGEAAIDSVRTALELGYRAIDTAQIYANEAE
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCHHHHHHHHHCCCHHH
VGQAIAASGVPRRDLFLTTKIWVDNLAADRLIPSLKASLARLRTEQVDLALIHWPSPGGA
HHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
VPMAEYLGALDEARREGLTRALGVSNFTVALLREAIETVGAAQIATNQIELHPYLQNRKV
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEE
AAFAQSQGIHVTSYMTLGVGRVLADPVLADIARAHGATPAQVVLAWAMQLGCSVIPSSTR
EEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHH
RANLQSNLAARDLRLTGDDMARIGALDRGERIADPAGIAPDWD
HHHHHHHHHHHHEEECCCHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRIQHRTQGNAMNDTFTMPAFGLGTFRLTGEAAIDSVRTALELGYRAIDTAQIYANEAE
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCHHHHHHHHHCCCHHH
VGQAIAASGVPRRDLFLTTKIWVDNLAADRLIPSLKASLARLRTEQVDLALIHWPSPGGA
HHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
VPMAEYLGALDEARREGLTRALGVSNFTVALLREAIETVGAAQIATNQIELHPYLQNRKV
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEE
AAFAQSQGIHVTSYMTLGVGRVLADPVLADIARAHGATPAQVVLAWAMQLGCSVIPSSTR
EEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHH
RANLQSNLAARDLRLTGDDMARIGALDRGERIADPAGIAPDWD
HHHHHHHHHHHHEEECCCHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796; 11108008 [H]