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The map label for this gene is trpS

Identifier: 17545862

GI number: 17545862

Start: 1198850

End: 1200052

Strand: Direct

Name: trpS

Synonym: RSc1143

Alternate gene names: 17545862

Gene position: 1198850-1200052 (Clockwise)

Preceding gene: 17545861

Following gene: 17545863

Centisome position: 32.26

GC content: 65.92

Gene sequence:

>1203_bases
ATGTTTCCTGAACGCGTTCTTTCCGGCATGCGGCCGACCGGTGCCTTGCACCTGGGTCACTACCACGGCGTCCTGAAAAA
CTGGGTCCGGCTGCAGGCCGAATACCCATGCTTTTTCTTCGTCGCCGACTGGCATGCGCTGACCACGCACTACGAATCGC
CCGAGGTGATCGAGGAATCGGTGTGGGAGATGCTGATCGACTGGCTGGCCGCCGGCGTCGATCCGACCCAGGCCACGCTG
TTCATCCAGAGCCGCGTACCCGAGCATGCCGAGCTGTTCCTGCTGCTGTCGATGGGCACGCCGCTGGGCTGGCTCGAGCG
CGTGCCGACCTACAAGGACCAGATCGAGAAGCTCAAGGAAAAGGACTTGTCCACCTACGGCTTCCTCGGCTATCCGCTGC
TGCAGGCCGCCGACATCCTGATCTACCGCGCCGGCTTCGTGCCGGTGGGCGAAGACCAGGTGCCGCACGTCGAGATGACG
CGCGAGGTGGCGCGCCGCTTCAACTACCTGTACGGCCGCGAGCCGGGCTTCGAGCAGAAGGCGCTGGATGCGGCCAAGAA
GCTCGGCGGCAAGCGCGCCAAGCTCTATCTGGAGCTGCGCACGGCCCACCAGGAGCGCGGCGAGGACGATGCCCTGGAGC
AGGCCCGCGCATTGCTGGCCGAATCGCAGAGCCTGTCGATGGGCGACCGCGAGCGCCTGTTCGGCTACCTGGAAGGCGCG
CGCAAGATCATCCTGCCGGAGCCGCAGGTGCTGCTGACCGAGGCGTCGCGCATGCCGGGCCTGGACGGGCAGAAGATGTC
CAAGTCCTACGGCAACACCATCCGCATGCGCGAGGACAAGGCCAGCGTCGAGAAAAAGGTACGCACCATGCCGACCGATC
CGGCCCGCGTGCGTCGCACCGATCCGGGCGATCCGGGAAAGTGCCCGGTCTGGCAGCTGCACCAGGTGTACTCCGATGCG
GATACCAGGGAATGGGTGCAGAAGGGATGCCGCAGTGCCGGCATCGGCTGCCTGGAATGCAAGCAGCCCGTCATCGACGG
CATCTTGCGCGAGCAGCAGCCGATGCTGGAGCGCGCGCAGAAGTACATGGACGACCCGTCGCTGCTGCGCGCCATCATCG
CCGACGGCTGCGATACCGCACACAAGGTCACGCAGGAGACCATGCGCGAGGTGCGCGAGGCGATGGGGCTGACGTACAGC
TGA

Upstream 100 bases:

>100_bases
ATGCGCCCGGTCGCGGGGTTGCTGGCCAAGGCGCTGATGATGGTCCTCAGTCCGCTTCAGGCGGCGCTTTCCTGGTTCGT
CTCCTAAATCCTTTCCCCAC

Downstream 100 bases:

>100_bases
GCCACCGGGCGATTGACGCATGTGTCCAGCCGTCGTTCCCGATGATCCGCACGCGCTCACGGCGCCATCGCCGTGGGTGG
TGCGCTGGGCCGCACCGCTG

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MFPERVLSGMRPTGALHLGHYHGVLKNWVRLQAEYPCFFFVADWHALTTHYESPEVIEESVWEMLIDWLAAGVDPTQATL
FIQSRVPEHAELFLLLSMGTPLGWLERVPTYKDQIEKLKEKDLSTYGFLGYPLLQAADILIYRAGFVPVGEDQVPHVEMT
REVARRFNYLYGREPGFEQKALDAAKKLGGKRAKLYLELRTAHQERGEDDALEQARALLAESQSLSMGDRERLFGYLEGA
RKIILPEPQVLLTEASRMPGLDGQKMSKSYGNTIRMREDKASVEKKVRTMPTDPARVRRTDPGDPGKCPVWQLHQVYSDA
DTREWVQKGCRSAGIGCLECKQPVIDGILREQQPMLERAQKYMDDPSLLRAIIADGCDTAHKVTQETMREVREAMGLTYS

Sequences:

>Translated_400_residues
MFPERVLSGMRPTGALHLGHYHGVLKNWVRLQAEYPCFFFVADWHALTTHYESPEVIEESVWEMLIDWLAAGVDPTQATL
FIQSRVPEHAELFLLLSMGTPLGWLERVPTYKDQIEKLKEKDLSTYGFLGYPLLQAADILIYRAGFVPVGEDQVPHVEMT
REVARRFNYLYGREPGFEQKALDAAKKLGGKRAKLYLELRTAHQERGEDDALEQARALLAESQSLSMGDRERLFGYLEGA
RKIILPEPQVLLTEASRMPGLDGQKMSKSYGNTIRMREDKASVEKKVRTMPTDPARVRRTDPGDPGKCPVWQLHQVYSDA
DTREWVQKGCRSAGIGCLECKQPVIDGILREQQPMLERAQKYMDDPSLLRAIIADGCDTAHKVTQETMREVREAMGLTYS
>Mature_400_residues
MFPERVLSGMRPTGALHLGHYHGVLKNWVRLQAEYPCFFFVADWHALTTHYESPEVIEESVWEMLIDWLAAGVDPTQATL
FIQSRVPEHAELFLLLSMGTPLGWLERVPTYKDQIEKLKEKDLSTYGFLGYPLLQAADILIYRAGFVPVGEDQVPHVEMT
REVARRFNYLYGREPGFEQKALDAAKKLGGKRAKLYLELRTAHQERGEDDALEQARALLAESQSLSMGDRERLFGYLEGA
RKIILPEPQVLLTEASRMPGLDGQKMSKSYGNTIRMREDKASVEKKVRTMPTDPARVRRTDPGDPGKCPVWQLHQVYSDA
DTREWVQKGCRSAGIGCLECKQPVIDGILREQQPMLERAQKYMDDPSLLRAIIADGCDTAHKVTQETMREVREAMGLTYS

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7710154, Length=190, Percent_Identity=41.0526315789474, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI41352700, Length=170, Percent_Identity=43.5294117647059, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1789786, Length=167, Percent_Identity=41.9161676646707, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71982800, Length=176, Percent_Identity=35.7954545454545, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71982793, Length=176, Percent_Identity=35.7954545454545, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320474, Length=185, Percent_Identity=37.2972972972973, Blast_Score=123, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24666151, Length=172, Percent_Identity=40.6976744186046, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_RALSO (Q8Y0A1)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519264.1
- ProteinModelPortal:   Q8Y0A1
- SMR:   Q8Y0A1
- GeneID:   1219958
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1143
- NMPDR:   fig|267608.1.peg.1143
- HOGENOM:   HBG293263
- OMA:   IGCLECK
- ProtClustDB:   PRK12283
- BioCyc:   RSOL267608:RSC1143-MONOMER
- BRENDA:   6.1.1.2
- GO:   GO:0005737
- HAMAP:   MF_00140_B
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 45485; Mature: 45485

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 268-268

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPERVLSGMRPTGALHLGHYHGVLKNWVRLQAEYPCFFFVADWHALTTHYESPEVIEES
CCHHHHHCCCCCCCEEECHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCCHHHHHHH
VWEMLIDWLAAGVDPTQATLFIQSRVPEHAELFLLLSMGTPLGWLERVPTYKDQIEKLKE
HHHHHHHHHHCCCCCCHHEEEECCCCCCHHHEEEEEECCCCHHHHHHCCCHHHHHHHHHH
KDLSTYGFLGYPLLQAADILIYRAGFVPVGEDQVPHVEMTREVARRFNYLYGREPGFEQK
HCCCHHCCHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
ALDAAKKLGGKRAKLYLELRTAHQERGEDDALEQARALLAESQSLSMGDRERLFGYLEGA
HHHHHHHCCCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
RKIILPEPQVLLTEASRMPGLDGQKMSKSYGNTIRMREDKASVEKKVRTMPTDPARVRRT
CEEECCCCHHHHHHHHCCCCCCCHHHHHHHCCEEEECHHHHHHHHHHHCCCCCHHHCCCC
DPGDPGKCPVWQLHQVYSDADTREWVQKGCRSAGIGCLECKQPVIDGILREQQPMLERAQ
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHH
KYMDDPSLLRAIIADGCDTAHKVTQETMREVREAMGLTYS
HHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFPERVLSGMRPTGALHLGHYHGVLKNWVRLQAEYPCFFFVADWHALTTHYESPEVIEES
CCHHHHHCCCCCCCEEECHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCCHHHHHHH
VWEMLIDWLAAGVDPTQATLFIQSRVPEHAELFLLLSMGTPLGWLERVPTYKDQIEKLKE
HHHHHHHHHHCCCCCCHHEEEECCCCCCHHHEEEEEECCCCHHHHHHCCCHHHHHHHHHH
KDLSTYGFLGYPLLQAADILIYRAGFVPVGEDQVPHVEMTREVARRFNYLYGREPGFEQK
HCCCHHCCHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
ALDAAKKLGGKRAKLYLELRTAHQERGEDDALEQARALLAESQSLSMGDRERLFGYLEGA
HHHHHHHCCCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
RKIILPEPQVLLTEASRMPGLDGQKMSKSYGNTIRMREDKASVEKKVRTMPTDPARVRRT
CEEECCCCHHHHHHHHCCCCCCCHHHHHHHCCEEEECHHHHHHHHHHHCCCCCHHHCCCC
DPGDPGKCPVWQLHQVYSDADTREWVQKGCRSAGIGCLECKQPVIDGILREQQPMLERAQ
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHH
KYMDDPSLLRAIIADGCDTAHKVTQETMREVREAMGLTYS
HHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852