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The map label for this gene is lldP [H]

Identifier: 17545700

GI number: 17545700

Start: 1031326

End: 1033014

Strand: Reverse

Name: lldP [H]

Synonym: RSc0981

Alternate gene names: 17545700

Gene position: 1033014-1031326 (Counterclockwise)

Preceding gene: 17545701

Following gene: 17545693

Centisome position: 27.8

GC content: 67.38

Gene sequence:

>1689_bases
ATGTGGAATCAAGTCTATGACCCGCTCGGCAACGCCGTATGGTCGACCGTCGCGGCCGGCTTGCCGGTGGCGGTACTGCT
CTGTTCGCTCGCCTTCTTCCACATGCAGGCGCACCTGGCCGCGGGGCTGGCGCTGCTGGTGGGCGTGGGCATCGCCGCGT
TCGTGTTCGGCATGCCGGCGGCGATGGCGGGCAAGGCGGCCGGGCTGGGCATCGTGTCCGGCCTGTTCCCGATCGGCTGG
ATCGTCCTCAACATCATCTTCCTGCACCGGCTCACCACCCTGAACGGCTCGTTCAAGGTGCTGCAGGGTTCGATCTCGGG
CATCACCGAAGACCGGCGCCTGCAGCTGCTGCTGGTGGCGTTCAGCTTCGGCGCGTTCTTCGAGGGCGCGGCGGGCTTCG
GCACGCCGGTGGCCGTGACGGGCGCGATCCTGATCGGGCTGGGCTTCTCGCCGCTGGCGGCCTCGGGGCTGGCACTGATC
GCCAACACCGCGCCGGTCGCCTACGGCGCCCTGGGCGCGCCCATCATCGGACTGGCCGCGGTGACGGGGCTCGACCTGAA
GGACCTCTCCGCCATGATCGGCCGCCAGTTGCCGTTCTTCTCGGTGCTGGTGCCGTTCTGGCTGATCTGGGCGTTCGCGG
GGTTGCGCGGCATGCTGCAGATCTGGCCGGCGATCCTGGTGGCGGGCGTGACCTTCGCCGTTCCGCAGTTCCTGGTGTCG
AACTTCCACGGCCCGTGGCTGGTGGACGTGATTGCCGCGCTGGTCTCGATGGGCTCGCTCACGCTGTTCCTGAAAGTGTG
GAAACCCAAATCCATCTGGACCTCCACCGCCCTGCGCAACCACCCCGACACGTCCAAGGTCGATCCCGAAGCCGCCGCCG
AGGCACGTGCCGCCACCACCGCCGCCGCCGATGCGAAGATCAGCCGCGTGCAGGCCTGGCTGCCGTGGGTGATCCTGACC
GTGTTCGTCTTCATCTGGGGCGTACCGCAGTTCAAGGCCTTCGTTGACGGCCTGTGGCAGTTCAAGCTGCCCATCCCCGG
CCTCGACAAGATGGTGCTCAAGGGCCCGCCGGTCGTGCCCAAGGTCACGGCCGAAGCCGCGGTGTTCACCTTCAACGTGC
TGTCGATGGCGGGCACCGGCATCCTGGCATCGGCCGTCGTCGGGGGCCTGCTGATGGGCTATTCGGTGCCGCGCATGGTC
AAGGAGTACTGGAACACCATCAAGCTGACGCGCTATTCGCTGCTGACCATCTGCGCGATGTTCGGCATCGGCTACCTGAC
CCGCTACTCGGGCCTGGACGCGACGCTGGGCCTGGCGTTCGCCCACACCGGCGTGCTGTACCCGCTGTTCGGCACCATGC
TGGGCTGGCTGGGCGTGGCGCTCACCGGTTCGGACACCGCATCGAACGTGCTGTTCGGCGGCCTGCAGAAGACCACCTCC
GAGCAGCTCGGCCTGTCGCCGATCCTGATGTCGGCCGCCAACAGCTCGGGCGGGGTGATGGGCAAGATGATCGACGCGCA
GTCCATCGTGGTGGCCTCCACCGCCACCAAGTGGTACGGCCATGAGGGCGACATCCTGCGCTATGTGTTCTTCCACTCGA
TCGCGCTGGCCTTCCTGGTGGGCCTGCTGATCACGCTGCAGGCCTACGTGGAACCGTTCACGCGGATGGTGGTGCCGATG
GCGCACTAG

Upstream 100 bases:

>100_bases
CTACAATCCGCGCTTGTCCGCTGTGCGGGCAGCAAAAGAAACGACGTTTGGCCGTACCTGCTCCACCCCTCGCCAAAACG
CTCTACAGGAGGAGACCAAG

Downstream 100 bases:

>100_bases
CCCGGCCGCCCGCGCCGCAACGAAAAAGCCGCTCATCGAGCGGCTTTTTTTCATGGCGAGGCCTCCGAGATCGTCCGGCG
GCGCCCTACGCCCAGCCGAG

Product: L-lactate permease transmembrane protein

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MWNQVYDPLGNAVWSTVAAGLPVAVLLCSLAFFHMQAHLAAGLALLVGVGIAAFVFGMPAAMAGKAAGLGIVSGLFPIGW
IVLNIIFLHRLTTLNGSFKVLQGSISGITEDRRLQLLLVAFSFGAFFEGAAGFGTPVAVTGAILIGLGFSPLAASGLALI
ANTAPVAYGALGAPIIGLAAVTGLDLKDLSAMIGRQLPFFSVLVPFWLIWAFAGLRGMLQIWPAILVAGVTFAVPQFLVS
NFHGPWLVDVIAALVSMGSLTLFLKVWKPKSIWTSTALRNHPDTSKVDPEAAAEARAATTAAADAKISRVQAWLPWVILT
VFVFIWGVPQFKAFVDGLWQFKLPIPGLDKMVLKGPPVVPKVTAEAAVFTFNVLSMAGTGILASAVVGGLLMGYSVPRMV
KEYWNTIKLTRYSLLTICAMFGIGYLTRYSGLDATLGLAFAHTGVLYPLFGTMLGWLGVALTGSDTASNVLFGGLQKTTS
EQLGLSPILMSAANSSGGVMGKMIDAQSIVVASTATKWYGHEGDILRYVFFHSIALAFLVGLLITLQAYVEPFTRMVVPM
AH

Sequences:

>Translated_562_residues
MWNQVYDPLGNAVWSTVAAGLPVAVLLCSLAFFHMQAHLAAGLALLVGVGIAAFVFGMPAAMAGKAAGLGIVSGLFPIGW
IVLNIIFLHRLTTLNGSFKVLQGSISGITEDRRLQLLLVAFSFGAFFEGAAGFGTPVAVTGAILIGLGFSPLAASGLALI
ANTAPVAYGALGAPIIGLAAVTGLDLKDLSAMIGRQLPFFSVLVPFWLIWAFAGLRGMLQIWPAILVAGVTFAVPQFLVS
NFHGPWLVDVIAALVSMGSLTLFLKVWKPKSIWTSTALRNHPDTSKVDPEAAAEARAATTAAADAKISRVQAWLPWVILT
VFVFIWGVPQFKAFVDGLWQFKLPIPGLDKMVLKGPPVVPKVTAEAAVFTFNVLSMAGTGILASAVVGGLLMGYSVPRMV
KEYWNTIKLTRYSLLTICAMFGIGYLTRYSGLDATLGLAFAHTGVLYPLFGTMLGWLGVALTGSDTASNVLFGGLQKTTS
EQLGLSPILMSAANSSGGVMGKMIDAQSIVVASTATKWYGHEGDILRYVFFHSIALAFLVGLLITLQAYVEPFTRMVVPM
AH
>Mature_562_residues
MWNQVYDPLGNAVWSTVAAGLPVAVLLCSLAFFHMQAHLAAGLALLVGVGIAAFVFGMPAAMAGKAAGLGIVSGLFPIGW
IVLNIIFLHRLTTLNGSFKVLQGSISGITEDRRLQLLLVAFSFGAFFEGAAGFGTPVAVTGAILIGLGFSPLAASGLALI
ANTAPVAYGALGAPIIGLAAVTGLDLKDLSAMIGRQLPFFSVLVPFWLIWAFAGLRGMLQIWPAILVAGVTFAVPQFLVS
NFHGPWLVDVIAALVSMGSLTLFLKVWKPKSIWTSTALRNHPDTSKVDPEAAAEARAATTAAADAKISRVQAWLPWVILT
VFVFIWGVPQFKAFVDGLWQFKLPIPGLDKMVLKGPPVVPKVTAEAAVFTFNVLSMAGTGILASAVVGGLLMGYSVPRMV
KEYWNTIKLTRYSLLTICAMFGIGYLTRYSGLDATLGLAFAHTGVLYPLFGTMLGWLGVALTGSDTASNVLFGGLQKTTS
EQLGLSPILMSAANSSGGVMGKMIDAQSIVVASTATKWYGHEGDILRYVFFHSIALAFLVGLLITLQAYVEPFTRMVVPM
AH

Specific function: Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=562, Percent_Identity=45.5516014234875, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1790031, Length=555, Percent_Identity=42.5225225225225, Blast_Score=410, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 59397; Mature: 59397

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWNQVYDPLGNAVWSTVAAGLPVAVLLCSLAFFHMQAHLAAGLALLVGVGIAAFVFGMPA
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AMAGKAAGLGIVSGLFPIGWIVLNIIFLHRLTTLNGSFKVLQGSISGITEDRRLQLLLVA
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECHHCCCCCCHHHHHHHHH
FSFGAFFEGAAGFGTPVAVTGAILIGLGFSPLAASGLALIANTAPVAYGALGAPIIGLAA
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHCCHHEEECCCCHHHHHHCCHHHHHHH
VTGLDLKDLSAMIGRQLPFFSVLVPFWLIWAFAGLRGMLQIWPAILVAGVTFAVPQFLVS
HCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NFHGPWLVDVIAALVSMGSLTLFLKVWKPKSIWTSTALRNHPDTSKVDPEAAAEARAATT
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
AAADAKISRVQAWLPWVILTVFVFIWGVPQFKAFVDGLWQFKLPIPGLDKMVLKGPPVVP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHEEECCCCCCCHHHHCCCCCCC
KVTAEAAVFTFNVLSMAGTGILASAVVGGLLMGYSVPRMVKEYWNTIKLTRYSLLTICAM
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
FGIGYLTRYSGLDATLGLAFAHTGVLYPLFGTMLGWLGVALTGSDTASNVLFGGLQKTTS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHCCHHHHHH
EQLGLSPILMSAANSSGGVMGKMIDAQSIVVASTATKWYGHEGDILRYVFFHSIALAFLV
HHHCCCHHHHHCCCCCCCCCEEEECCCCEEEEECHHHHCCCCCCHHHHHHHHHHHHHHHH
GLLITLQAYVEPFTRMVVPMAH
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 11283302; 11785976 [H]