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The map label for this gene is algC [H]

Identifier: 17545410

GI number: 17545410

Start: 739188

End: 740573

Strand: Direct

Name: algC [H]

Synonym: RSc0691

Alternate gene names: 17545410

Gene position: 739188-740573 (Clockwise)

Preceding gene: 17545409

Following gene: 17545411

Centisome position: 19.89

GC content: 67.39

Gene sequence:

>1386_bases
ATGCAAATTGACCCCTCCATCTTCAAGGCCTATGACATTCGCGGCATCGTCGGCAAGAACGTCGACCGTGAAACCGCGCG
GCTGATCGGCCGGGCCTTCGGTTCGGCGGCCCGCGCCAAGGGCGAGGCCGCGGTGGTGATCGGCCGCGACGGCCGCCTGT
CCGGTCCGGATCTCGTGGGCGGCCTGGCCGAAGGCCTGCGCCAGAGCGGCGTGGACGTGATCGACCTCGGGCTGGTGGCC
ACGCCGATGGTCTACTTCGGCACCAACATCGAGCTGGCCGGCCGTCGCGCCACGTCCGGCGTGATGGTCACCGGCAGCCA
CAACCCGCCCGACTACAACGGCTTCAAGATGGTGCTGGCAGGCCAGGCCATCTACGGCGAGCAGATCCAGGCGCTGCGCC
AGCGCATCGAGCAGGGTGACTTCACCGAGGGCGCCGGTGCATATGTCCAGGTGGACCTGCGGCAGCAGTACATCGACCGC
ATCGTCTCCGACGTCAAGATGGCGCGGCCGATGAAGATCGCGGTGGACTGCGGCAACGGCGTGGCGGGCGCCTTCGCGCC
GGCGCTGTTCCGCGCCATGGGCTGCGAGGTGACGGAGCTGTTCTGCGAAGTGGACGGCCATTTCCCGAACCACCACCCGG
ATCCGGCCCACGTCGAGAACCTGCAGGATCTCGTGCGCACGCTGCAGACGACCGACTGCGAGCTCGGCCTCGCCTTCGAC
GGCGACGGCGATCGCCTGGGCGTGGTCACCAAGGATGGCCAGGTGATCTTCCCGGACCGCCAGCTGATGCTGTTCGCGCA
GGAGGTGCTGTCGCGCAACCCGGGCGGCGAGATCATCTTCGACGTAAAGTGCACCGGCAAGCTGGCGCCGTTCATCCGCG
AACATGGCGGCAAGGCCACGATGTGGAAGACGGGACACTCGCTGGTCAAGGCCAAGCTGAAGGAAACCGGCGCGCCGCTG
GCCGGCGAGATGAGCGGCCATATCTTCTTCAAGGACCGCTGGTACGGCTTCGACGACGGTCTCTATACCGGCGCGCGCCT
GCTGGAGATCGTGTCGCGCCACGCCGATCCGAGCGCCGTGCTGAACGCGCTGCCGAATTCGCACTGCACGCCCGAGCTGC
AGCTCAAGTGCGCCGAGGGCGAGCCGTTCGCGCTGCTCGACAGGATCAAGGCGAACGCGACCTTCGATGGCGCGAAGGAA
GTGAACCGCATCGACGGCGTGCGCGTGGAGTATGCCGATGGCTTCGGCCTGGCGCGTCCGTCCAACACCACGCCGGTGGT
GGTGATGCGCTTCGAGGCTGACAACGATGCCGCCATGGCGCGCATCCAGGGCGAATTCCGCCGCGTGATCCTGGCCGAGA
AGCCGGACGCGAAGCTGCCGTTCTGA

Upstream 100 bases:

>100_bases
GCCTCGGCAGCCGCAAGTGATGTGATGCGCCGTGCCCGACCCATGGTGGACGGGCACGCCTGCATTTTGATGATCGATGA
TTGAAACAGGGTGTGTGCCC

Downstream 100 bases:

>100_bases
TCCGCATTGCCGATGCAGATTCGCGGGAAAGGGATGGCGGCATGCGGGTGCTGATCGTCAAGGTGTCGTCGCTTGGCGAT
GTGGTGCACTGCACGCCGGT

Product: phosphomannomutase or phosphoglucomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MQIDPSIFKAYDIRGIVGKNVDRETARLIGRAFGSAARAKGEAAVVIGRDGRLSGPDLVGGLAEGLRQSGVDVIDLGLVA
TPMVYFGTNIELAGRRATSGVMVTGSHNPPDYNGFKMVLAGQAIYGEQIQALRQRIEQGDFTEGAGAYVQVDLRQQYIDR
IVSDVKMARPMKIAVDCGNGVAGAFAPALFRAMGCEVTELFCEVDGHFPNHHPDPAHVENLQDLVRTLQTTDCELGLAFD
GDGDRLGVVTKDGQVIFPDRQLMLFAQEVLSRNPGGEIIFDVKCTGKLAPFIREHGGKATMWKTGHSLVKAKLKETGAPL
AGEMSGHIFFKDRWYGFDDGLYTGARLLEIVSRHADPSAVLNALPNSHCTPELQLKCAEGEPFALLDRIKANATFDGAKE
VNRIDGVRVEYADGFGLARPSNTTPVVVMRFEADNDAAMARIQGEFRRVILAEKPDAKLPF

Sequences:

>Translated_461_residues
MQIDPSIFKAYDIRGIVGKNVDRETARLIGRAFGSAARAKGEAAVVIGRDGRLSGPDLVGGLAEGLRQSGVDVIDLGLVA
TPMVYFGTNIELAGRRATSGVMVTGSHNPPDYNGFKMVLAGQAIYGEQIQALRQRIEQGDFTEGAGAYVQVDLRQQYIDR
IVSDVKMARPMKIAVDCGNGVAGAFAPALFRAMGCEVTELFCEVDGHFPNHHPDPAHVENLQDLVRTLQTTDCELGLAFD
GDGDRLGVVTKDGQVIFPDRQLMLFAQEVLSRNPGGEIIFDVKCTGKLAPFIREHGGKATMWKTGHSLVKAKLKETGAPL
AGEMSGHIFFKDRWYGFDDGLYTGARLLEIVSRHADPSAVLNALPNSHCTPELQLKCAEGEPFALLDRIKANATFDGAKE
VNRIDGVRVEYADGFGLARPSNTTPVVVMRFEADNDAAMARIQGEFRRVILAEKPDAKLPF
>Mature_461_residues
MQIDPSIFKAYDIRGIVGKNVDRETARLIGRAFGSAARAKGEAAVVIGRDGRLSGPDLVGGLAEGLRQSGVDVIDLGLVA
TPMVYFGTNIELAGRRATSGVMVTGSHNPPDYNGFKMVLAGQAIYGEQIQALRQRIEQGDFTEGAGAYVQVDLRQQYIDR
IVSDVKMARPMKIAVDCGNGVAGAFAPALFRAMGCEVTELFCEVDGHFPNHHPDPAHVENLQDLVRTLQTTDCELGLAFD
GDGDRLGVVTKDGQVIFPDRQLMLFAQEVLSRNPGGEIIFDVKCTGKLAPFIREHGGKATMWKTGHSLVKAKLKETGAPL
AGEMSGHIFFKDRWYGFDDGLYTGARLLEIVSRHADPSAVLNALPNSHCTPELQLKCAEGEPFALLDRIKANATFDGAKE
VNRIDGVRVEYADGFGLARPSNTTPVVVMRFEADNDAAMARIQGEFRRVILAEKPDAKLPF

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=464, Percent_Identity=32.5431034482759, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1789566, Length=426, Percent_Identity=27.6995305164319, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 49974; Mature: 49974

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIDPSIFKAYDIRGIVGKNVDRETARLIGRAFGSAARAKGEAAVVIGRDGRLSGPDLVG
CCCCHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHH
GLAEGLRQSGVDVIDLGLVATPMVYFGTNIELAGRRATSGVMVTGSHNPPDYNGFKMVLA
HHHHHHHHCCCCEEEHHHHHHCHHHCCCCEEECCCCCCCCEEEECCCCCCCCCCEEEEEE
GQAIYGEQIQALRQRIEQGDFTEGAGAYVQVDLRQQYIDRIVSDVKMARPMKIAVDCGNG
CCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCC
VAGAFAPALFRAMGCEVTELFCEVDGHFPNHHPDPAHVENLQDLVRTLQTTDCELGLAFD
CHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
GDGDRLGVVTKDGQVIFPDRQLMLFAQEVLSRNPGGEIIFDVKCTGKLAPFIREHGGKAT
CCCCEEEEEECCCEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCCEE
MWKTGHSLVKAKLKETGAPLAGEMSGHIFFKDRWYGFDDGLYTGARLLEIVSRHADPSAV
EECCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHH
LNALPNSHCTPELQLKCAEGEPFALLDRIKANATFDGAKEVNRIDGVRVEYADGFGLARP
HHHCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHCCCEEEEECCCCCCCC
SNTTPVVVMRFEADNDAAMARIQGEFRRVILAEKPDAKLPF
CCCCCEEEEEEECCCCHHHHHHHHHHHEEEEECCCCCCCCC
>Mature Secondary Structure
MQIDPSIFKAYDIRGIVGKNVDRETARLIGRAFGSAARAKGEAAVVIGRDGRLSGPDLVG
CCCCHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHH
GLAEGLRQSGVDVIDLGLVATPMVYFGTNIELAGRRATSGVMVTGSHNPPDYNGFKMVLA
HHHHHHHHCCCCEEEHHHHHHCHHHCCCCEEECCCCCCCCEEEECCCCCCCCCCEEEEEE
GQAIYGEQIQALRQRIEQGDFTEGAGAYVQVDLRQQYIDRIVSDVKMARPMKIAVDCGNG
CCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCC
VAGAFAPALFRAMGCEVTELFCEVDGHFPNHHPDPAHVENLQDLVRTLQTTDCELGLAFD
CHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
GDGDRLGVVTKDGQVIFPDRQLMLFAQEVLSRNPGGEIIFDVKCTGKLAPFIREHGGKAT
CCCCEEEEEECCCEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCCEE
MWKTGHSLVKAKLKETGAPLAGEMSGHIFFKDRWYGFDDGLYTGARLLEIVSRHADPSAV
EECCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHH
LNALPNSHCTPELQLKCAEGEPFALLDRIKANATFDGAKEVNRIDGVRVEYADGFGLARP
HHHCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHCCCEEEEECCCCCCCC
SNTTPVVVMRFEADNDAAMARIQGEFRRVILAEKPDAKLPF
CCCCCEEEEEEECCCCHHHHHHHHHHHEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]