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The map label for this gene is rfbA [H]

Identifier: 17545403

GI number: 17545403

Start: 732123

End: 733001

Strand: Direct

Name: rfbA [H]

Synonym: RSc0684

Alternate gene names: 17545403

Gene position: 732123-733001 (Clockwise)

Preceding gene: 17545402

Following gene: 17545404

Centisome position: 19.7

GC content: 63.71

Gene sequence:

>879_bases
ATGCGTAAAGGCATTATCCTGGCCGGAGGCTCCGGCACGCGACTCTATCCGATCACCCGCTCGGTTTCGAAGCAGCTGCT
GCCGGTGTACGACAAGCCGATGATCTACTATCCGCTGTCCACGCTGATGCTGGCGGGGATTCGCGACATCCTGATCATCT
CCACGCCGGAAGACACGCCGCGCTTCACCGACATGCTCGGCGACGGCAGCAAGTGGGGGATCAACCTGCAGTACGCGGTG
CAGCCTTCGCCGGATGGGCTGGCGCAGGCGTTCATCATCGGGCGCGATTTCGTCGGCAACGATCCGTCGACGCTGATCCT
CGGCGACAACATCTTCCACGGCCACGACCTCGTGGCCCAGCTGACGCGTTCGGCCGAGCAGCAGGCGGGCGCCACCGTCT
TCGCCTATCACGTCCACGATCCGGAGCGCTACGGCGTGGTCGAGTTCGACCAGAACTTCCGTGCGCTCTCCCTGGAGGAG
AAGCCGGCCAAGCCGCGTTCGCACTACGCCGTTACCGGGCTGTACTTCTACGACAACCAGGTGTGCGACATCGCCGCCGA
CATCAAGCCGTCGGCTCGCGGCGAGCTCGAGATCACGGACGTCAACAAGCACTACCTGGCGCAGGGCCAGCTCGACGTCG
AGATCATGGGCCGCGGCTATGCCTGGCTCGACACCGGCACGCACGATTCGCTGCTGGAAGCGGCGATGTTCATCGCGACG
CTGCAAAACCGGCAGGGGCTGATGGTGGCCTGCCCCGAAGAGATCGCGTACCGCAATCGCTGGATCAGCGCCGAGCAGGT
TGCCGCGCTGGCCAAGCCGCTGAGCAAGAATGGCTACGGCCAGTATCTGCAGCACATCATTTCGGAAACCGTCAAATGA

Upstream 100 bases:

>100_bases
GACACCGGCAAGCTCACTGAAACGTTCGGCATCCACCTGCCGGACTGGCAGCAGGGTGTCCATCTCCTGCTGGACCAGAT
CTTTTCCTGAACGAATCGCC

Downstream 100 bases:

>100_bases
ACCTGAACGTCGTTCCCACCGCCATTCCGGAGGTCCTGATCCTCGAGCCGAAAGTGTTTGGCGACGACCGGGGCTTCTTC
TTCGAGAGCTTCAACGCGCG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MRKGIILAGGSGTRLYPITRSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPEDTPRFTDMLGDGSKWGINLQYAV
QPSPDGLAQAFIIGRDFVGNDPSTLILGDNIFHGHDLVAQLTRSAEQQAGATVFAYHVHDPERYGVVEFDQNFRALSLEE
KPAKPRSHYAVTGLYFYDNQVCDIAADIKPSARGELEITDVNKHYLAQGQLDVEIMGRGYAWLDTGTHDSLLEAAMFIAT
LQNRQGLMVACPEEIAYRNRWISAEQVAALAKPLSKNGYGQYLQHIISETVK

Sequences:

>Translated_292_residues
MRKGIILAGGSGTRLYPITRSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPEDTPRFTDMLGDGSKWGINLQYAV
QPSPDGLAQAFIIGRDFVGNDPSTLILGDNIFHGHDLVAQLTRSAEQQAGATVFAYHVHDPERYGVVEFDQNFRALSLEE
KPAKPRSHYAVTGLYFYDNQVCDIAADIKPSARGELEITDVNKHYLAQGQLDVEIMGRGYAWLDTGTHDSLLEAAMFIAT
LQNRQGLMVACPEEIAYRNRWISAEQVAALAKPLSKNGYGQYLQHIISETVK
>Mature_292_residues
MRKGIILAGGSGTRLYPITRSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPEDTPRFTDMLGDGSKWGINLQYAV
QPSPDGLAQAFIIGRDFVGNDPSTLILGDNIFHGHDLVAQLTRSAEQQAGATVFAYHVHDPERYGVVEFDQNFRALSLEE
KPAKPRSHYAVTGLYFYDNQVCDIAADIKPSARGELEITDVNKHYLAQGQLDVEIMGRGYAWLDTGTHDSLLEAAMFIAT
LQNRQGLMVACPEEIAYRNRWISAEQVAALAKPLSKNGYGQYLQHIISETVK

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=252, Percent_Identity=24.6031746031746, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI11761621, Length=252, Percent_Identity=24.6031746031746, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1788351, Length=290, Percent_Identity=71.3793103448276, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=65.2631578947368, Blast_Score=397, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI133931050, Length=239, Percent_Identity=23.0125523012552, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=247, Percent_Identity=26.3157894736842, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21355443, Length=247, Percent_Identity=23.0769230769231, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24644084, Length=247, Percent_Identity=23.0769230769231, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32407; Mature: 32407

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKGIILAGGSGTRLYPITRSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPEDTP
CCCCEEEECCCCCEEEEEHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCC
RFTDMLGDGSKWGINLQYAVQPSPDGLAQAFIIGRDFVGNDPSTLILGDNIFHGHDLVAQ
HHHHHHCCCCCCEEEEEEEECCCCCHHHEEEEEECCCCCCCCCEEEEECCEECHHHHHHH
LTRSAEQQAGATVFAYHVHDPERYGVVEFDQNFRALSLEEKPAKPRSHYAVTGLYFYDNQ
HHHHHHHHCCCEEEEEEECCCCCCCEEEECCCCEEEECCCCCCCCCCCEEEEEEEEECCC
VCDIAADIKPSARGELEITDVNKHYLAQGQLDVEIMGRGYAWLDTGTHDSLLEAAMFIAT
EEEEEECCCCCCCCEEEEEECCHHEEECCCEEEEEECCCEEEEECCCCHHHHHHHHHHHH
LQNRQGLMVACPEEIAYRNRWISAEQVAALAKPLSKNGYGQYLQHIISETVK
HCCCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKGIILAGGSGTRLYPITRSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPEDTP
CCCCEEEECCCCCEEEEEHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCC
RFTDMLGDGSKWGINLQYAVQPSPDGLAQAFIIGRDFVGNDPSTLILGDNIFHGHDLVAQ
HHHHHHCCCCCCEEEEEEEECCCCCHHHEEEEEECCCCCCCCCEEEEECCEECHHHHHHH
LTRSAEQQAGATVFAYHVHDPERYGVVEFDQNFRALSLEEKPAKPRSHYAVTGLYFYDNQ
HHHHHHHHCCCEEEEEEECCCCCCCEEEECCCCEEEECCCCCCCCCCCEEEEEEEEECCC
VCDIAADIKPSARGELEITDVNKHYLAQGQLDVEIMGRGYAWLDTGTHDSLLEAAMFIAT
EEEEEECCCCCCCCEEEEEECCHHEEECCCEEEEEECCCEEEEECCCCHHHHHHHHHHHH
LQNRQGLMVACPEEIAYRNRWISAEQVAALAKPLSKNGYGQYLQHIISETVK
HCCCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]